Article
Multidisciplinary Sciences
Ziwei Wang, Tao Wang, Danni Hong, Baijun Dong, Yan Wang, Huaqiang Huang, Wenhui Zhang, Bijun Lian, Boyao Ji, Haoqing Shi, Min Qu, Xu Gao, Daofeng Li, Colin Collins, Gonghong Wei, Chuanliang Xu, Hyung Joo Lee, Jialiang Huang, Jing Li
Summary: This study characterized ADPC and NEPC in prostate tumors using scRNA-seq and identified NEPC-specific gene expression signatures. The findings revealed different paths by which NEPC diverges from ADPC and inferred a hierarchical transcription factor network involved in NEPC progression.
Article
Biochemistry & Molecular Biology
Kazuma Iida, Kensuke Suga, Kotaro Suzuki, Shunjiro Kurihara, Yoko Yabe, Takahiro Kageyama, Kazuyuki Meguro, Shigeru Tanaka, Arifumi Iwata, Akira Suto, Hiroshi Nakajima
Summary: The study found that Achaete-scute complex homolog 2 (Ascl2) is highly and preferentially expressed in CD25+ and CD25- T follicular regulatory (Tfr) cells. The absence of Ascl2 impairs the differentiation from CD25+ Tfr cells to CD25- Tfr cells. Additionally, forced expression of Ascl2 in regulatory T (Treg) cells downregulates CD25 expression and suppresses IL-2-induced phosphorylation of STAT5, which inhibits the development of CD25- Tfr cells. These findings suggest that Ascl2 plays a vital role in Tfr cell development by downregulating CD25 expression in a Bach2-independent mechanism.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Ming Deng, Ping Xie, Zhonghui Chen, Yan Zhou, Junqi Liu, Jianghua Ming, Jianwei Yang
Summary: The study showed that modification of NSCs with Mash-1 improved functional recovery in SCI rats by increasing BBB scores and promoting recovery at the lesion site. Mash-1 overexpression enhanced NSC differentiation into neurons, contributing to locomotor recovery in SCI rats.
Article
Oncology
Junhui Yu, Shan Li, Zhengshui Xu, Jing Guo, Xiaopeng Li, Yunhua Wu, Jianbao Zheng, Xuejun Sun
Summary: The study revealed that CDX2 inhibits EMT and metastasis of CRC by regulating Snail expression and beta-catenin stabilisation via transactivation of PTEN expression.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Jiayang Liu, Zhao Huang, Hai-Ning Chen, Siyuan Qin, Yan Chen, Jingwen Jiang, Zhe Zhang, Maochao Luo, Qin Ye, Na Xie, Zong-Guang Zhou, Yuquan Wei, Ke Xie, Canhua Huang
Summary: ZNF37A plays a critical role in promoting metastasis in poorly differentiated colorectal cancer by enhancing TGF-beta signaling and activating cancer-associated fibroblasts through transcriptional repression of THSD4. This suggests ZNF37A as a potential biomarker for CRC progression and differentiation.
Review
Oncology
Jordi Badia-Ramentol, Francisco Gimeno-Valiente, Elena Durendez, Carolina Martinez-Ciarpaglini, Jenniffer Linares, Mar Iglesias, Andres Cervantes, Alexandre Calon, Noelia Tarazona
Summary: Adjuvant chemotherapy is the main treatment option for localized colorectal cancer (CRC), but many patients have unfavorable outcomes. CDX2, a biomarker of prognosis and relapse, is associated with the complexity of CRC. Immunohistochemistry evaluation of CDX2 can identify high-risk CRC patients, but assessing its expression remains challenging in many patients.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Bjorn Konukiewitz, Maxime Schmitt, Miguel Silva, Junika Pohl, Corinna Lang, Katja Steiger, Kathrin Halfter, Jutta Engel, Anna Melissa Schlitter, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Sebastian Foersch, Markus Tschurtschenthaler, Wilko Weichert, Moritz Jesinghaus
Summary: The study found that CRCs with low/absent CDX2 expression are enriched in specific morphologic subtypes, right-sided, and MSI-H CRCs, showing worse survival outcomes in the overall cohort and UICC II/III stage. However, in multivariate analysis, CDX2 was not an independent prognostic factor. Additionally, compared to central HE-based morphologic parameters defined by the WHO classification, the prognostic relevance of CDX2 is considerably lower and disappears in multivariate analyses.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Aileen Julia Riesle, Meijiang Gao, Marcus Rosenblatt, Jacques Hermes, Helge Hass, Anna Gebhard, Marina Veil, Bjorn Gruening, Jens Timmer, Daria Onichtchouk
Summary: This study investigates the combinatorial mechanisms of genome activation and shows that zebrafish genome activators Pou5f3 and Nanog exhibit different roles in the activation process. They act as pioneer-like transcription factors on synergistic enhancers, promoting histone acetylation and transcription activation. However, on antagonistic enhancers, one of the factors acts as a non-pioneer-like transcription factor, competing with the activator and blocking its effects. This activator-blocker mechanism restricts widespread transcriptional activation and prevents premature expression of late developmental genes in early embryos.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Kaiqin Sheng, Yuecheng Wu, Hanbin Lin, Menghan Fang, Chaorong Xue, Xu Lin, Xinjian Lin
Summary: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a critical immune suppressor in human cancers, similar to programmed cell death 1 ligand (PD-L1). The study reveals that transcription factors ETS-1 and ETS-2 bind to the Siglec-15 promoter, enhancing its transcription and expression in hepatocellular carcinoma (HCC) cells. Transforming growth factor beta-1 (TGF-beta 1) upregulates ETS-1 and ETS-2 expression and facilitates their binding to the Siglec-15 promoter. TGF-beta 1 also activates the Ras/C-Raf/MEK/ERK1/2 signaling pathway, leading to phosphorylation of ETS-1 and ETS-2, which in turn increases the transcription and expression of Siglec-15. These findings provide valuable insights into the molecular regulation of Siglec-15 and its potential for HCC immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rupesh Kumar, Maged Mostafa Mahmoud, Hanaa M. Tashkandi, Shafiul Haque, Steve Harakeh, Kalaiarasan Ponnusamy, Shazia Haider
Summary: This study aimed to identify key molecules in colorectal cancer using a computational systems biology approach. A protein-protein interaction network was constructed, and TP53, CTNBB1, AKT1, EGFR, HRAS, JUN, RHOA, and EGF were identified as key molecules. Regulatory networks of these key molecules were also constructed, revealing important regulatory factors. Biochemical investigation of these key regulators could provide further understanding of their role in the pathophysiology of colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Chao-Chun Chen, Xing-Ming Xie, Xue-Ke Zhao, Shi Zuo, Hai-Yang Li
Summary: The study showed that KLF13 is upregulated in liver cancer and acts as a tumor promoter by positively regulating HMGCS1-mediated cholesterol biosynthesis, promoting the proliferation, migration, and invasion of liver cancer cells.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Oncology
Chun-Ying Luo, Wei-Chao Su, Hai-Feng Jiang, Ling-Tao Luo, Dong-Yan Shen, Guo-Qiang Su
Summary: This study reveals the important role of DPY30 in CRC progression and metastasis. DPY30 promotes EMT and CRC metastasis by upregulating the transcriptional expression of ZEB1. Therefore, DPY30 may serve as a therapeutic target and prognostic marker for CRC.
CANCER CELL INTERNATIONAL
(2023)
Article
Immunology
Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, Jan Dobes, Dieter Weichenhan, Marion Bahr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A. Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson
Summary: This study reveals the importance of FOXN1 in the development of thymic epithelial cells and hair follicle cells, and identifies key regulatory regions and transcription factors involved in its expression.
SCIENCE IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chao-Chun Chen, Xing-Ming Xie, Xue-Ke Zhao, Shi Zuo, Hai-Yang Li
Summary: The expression of KLF13 is upregulated in hepatocellular carcinoma (HCC). KLF13 acts as a tumor promoter in HCC by positively regulating HMGCS1-mediated cholesterol biosynthesis, promoting the growth and metastasis of HCC cells.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Neurosciences
Erick Sousa, Nuria Flames
Summary: Neuronal diversity is an intrinsic feature of the nervous system, with transcription factors playing key roles in establishing different neuronal identities. Common features in transcription factor categories can be identified in both mammals and nematodes, highlighting their pleiotropic functions. Transcriptional repression is crucial in controlling neuronal diversity, and the acquisition of neuronal identities is considered a metastable process.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Jun Ye, Shanxi Liu, Yangyang Shang, Haoyuan Chen, Rongquan Wang
Article
Medicine, General & Internal
Qing Su, Sheng-Liang Chen, Hua-Hong Wang, Lie-Xin Liang, Ning Dai, Bin Lyu, Jun Zhang, Rong-Quan Wang, Ya-Li Zhang, Yue Yu, Jin-Song Liu, Xiao-Hua Hou
CHINESE MEDICAL JOURNAL
(2018)
Article
Gastroenterology & Hepatology
Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Ying Cheng, Nan Zhao, Fengju Li, Xueqian Zhou, Sheng Chen, Jianwei Li, Senlin Xu, Dingde Huang, Yue Chen, Lihua Li, Huaizhi Wang, Wensheng Chen, Shi-ying Cai, James L. Boyer, Jin Chai
Article
Gastroenterology & Hepatology
Jun Song, Ling Yang, Shuai Su, Mei Yu Piao, Bao Li Li, Yue Yu, Wen Yong Yu, Mei Zhang, Lie Xin Liang, Guo Wen Zuo, Zhi Min Tang, Yan Qin Long, Xiao Li Chen, Ning Dai, Jian Ling Mo, Rong Quan Wang, Jing Chen, Xiao Hua Hou
JOURNAL OF DIGESTIVE DISEASES
(2020)
Review
Gastroenterology & Hepatology
Xuan Li, Min Liao, Qiong Pan, Qiaoling Xie, Hong Yang, Ying Peng, Qiao Li, Jiaquan Qu, Jin Chai
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Medicine, Research & Experimental
Qiong Pan, Gang Luo, Jiaquan Qu, Sheng Chen, Xiaoxun Zhang, Nan Zhao, Jingjing Ding, Hong Yang, Mingqiao Li, Ling Li, Ying Cheng, Xuan Li, Qiaoling Xie, Qiao Li, Xueqian Zhou, Huiling Zou, Shijun Fan, Lingyun Zou, Wei Liu, Guohong Deng, Shi-Ying Cai, James L. Boyer, Jin Chai
Summary: The homozygous mutation of SEMA7A(R145W) leads to intrahepatic cholestasis in both mice and children, with further studies showing that this mutation affects the expression of hepatic bile acid transporters and export pumps.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mingqiao Li, Weihua Wang, Ying Cheng, Xiaoxun Zhang, Nan Zhao, Ya Tan, Qiaoling Xie, Jin Chai, Qiong Pan
Summary: This study found that TNF-alpha stimulates hepatic OATP3A1 expression in obstructive cholestasis patients by activating NF-KB p65 and ERK-SP1 signaling pathways. These findings suggest that targeting TNF-alpha-activated NF-KB p65 and ERK-SP1 signaling may be a potential therapeutic approach to ameliorate cholestasis-associated liver injury.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Letter
Oncology
Xiaoxun Zhang, Ling Li, Nan Zhao, Qiong Pan, Liangjun Zhang, Qiaoling Xie, Xuan Li, Min Liao, Qiao Li, Xinglin Huang, Sheng Chen, Jianwei Li, Huaizhi Wang, Xuequan Huang, Shijun Fan, Yunxia Wang, Man Li, Jin Chai
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yangyang Shang, Tao Jiang, Lijian Ran, Wenjing Hu, Yun Wu, Jun Ye, Zhihong Peng, Lei Chen, Rongquan Wang
Summary: The methylation of the Ascl2 promoter is significantly increased in colorectal cancer cells, leading to elevated expression of Ascl2 mRNA. The methylation status of the promoter is predictive of patient survival. Decreased expression of TET2 contributes to hypermethylation of the Ascl2 promoter and increased Ascl2 expression. TET2 forms a complex with BCLAF1 and binds to the Ascl2 promoter to induce hydroxymethylation and suppress hypermethylation. The TET2-BCLAF1 complex plays a role in CRC progression.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Nan Zhao, Xiaoxun Zhang, Jingjing Ding, Qiong Pan, Ming-Hua Zheng, Wen-Yue Liu, Gang Luo, Jiaquan Qu, Mingqiao Li, Ling Li, Ying Cheng, Ying Peng, Qiaoling Xie, Qinglin Wei, Qiao Li, Lingyun Zou, Xinshou Ouyang, Shi-Ying Cai, James L. Boyer, Jin Chai
Summary: The SEMA7AR(148W) mutation is identified as a potentially strong genetic determinant of NAFLD, promoting intrahepatic lipid accumulation and NAFLD by enhancing PKC-alpha-stimulated fatty acid and triglyceride synthesis and fatty acid uptake.
Meeting Abstract
Gastroenterology & Hepatology
Jiaquan Qu, Pan Shi, Chonghua Lin, Nan Zhao, Ling Li, Liangjun Zhang, Mingqiao Li, Ya Tang, Qiong Pan, Jin Chai
Meeting Abstract
Gastroenterology & Hepatology
Xiaoxun Zhang, Qiong Pan, Fengju Li, Xuan Li, Jin Chai
Article
Oncology
Qiong Pan, Linkun Meng, Jun Ye, Xiaolong Wei, Yangyang Shang, Yin Tian, Yonghong He, Zhihong Peng, Lei Chen, Wensheng Chen, Xiuwu Bian, Rongquan Wang