Journal
ONCOTARGET
Volume 6, Issue 38, Pages 41370-41382Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.5629
Keywords
gastric carcinoma; hemoglobin; albumin; lymphocyte; platelet
Categories
Funding
- National Natural Science Foundation of China [81372344]
- Sichuan Province Youth Science & Technology Innovative Research Team [2015TD0009]
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Nutritional and immune status is important to the prognosis of patients with gastric carcinoma (GC). Here, we evaluated the prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) in patients with GC. From January 2005 to December 2011, 1332 patients with GC who underwent gastrectomy were randomly divided into the training (n = 888) and the validation sets (n = 444) by X-tile according to the sample size ratio 2: 1. The cut-point of HALP was 56.8 and the patients were subsequently subdivided into HALP < 56.8 and HALP >= 56.8 groups in both two sets. Multivariate analysis revealed that gender (p < 0.001, p < 0.001), tumor size (p = 0.003, p = 0.035) and T stage (p < 0.001, p = 0.044) were independently related to HALP both in the training and the validation sets. Kaplan-Meier (p < 0.001, p = 0.003) and Cox regression (p = 0.043, p = 0.042) showed that the prognosis of HALP >= 56.8 group was significantly better than that of HALP < 56.8 group both in two sets (p < 0.001, p < 0.001). Nomograms of these two sets based on HALP was more accurate in prognostic prediction than TNM stage alone. Our findings suggested that HALP was closely associated with clinicopathological features and was an independent prognostic factor in GC patients. Nomogram based on HALP could accurately predict the prognosis of GC patients.
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