Article
Chemistry, Multidisciplinary
Jay S. Wright, Richard Ma, E. William Webb, Wade P. Winton, Jenelle Stauff, Kevin Cheng, Allen F. Brooks, Melanie S. Sanford, Peter J. H. Scott
Summary: This report presents the development of a Zn(OTf)(2)-mediated method for converting alpha-tertiary haloamides to the corresponding alpha-tertiary fluoroamides. Under optimized conditions, high radiochemical conversion can be achieved. This method has been successfully applied to prepare various model radiofluorides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Christophe van de Wiele, Sezgin Ustmert, Bart De Spiegeleer, Pieter-Jan De Jonghe, Mike Sathekge, Maes Alex
Summary: Various potential PET-apoptosis imaging radiopharmaceuticals have been developed to assess the response to cancer treatment. Some of these radiopharmaceuticals showed enhanced uptake in xenografted tumors in mice, but to varying degrees. Two validated radioligands showed favorable characteristics in healthy individuals, but did not significantly affect bone marrow. Further research is needed to evaluate the clinical value of these radiopharmaceuticals for apoptosis imaging in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Organic
Manuele Musolino, Ian N. Fleming, Lutz F. Schweiger, David O'Hagan, Sergio Dall'Angelo, Matteo Zanda
Summary: The synthesis of five radiotracers with different oxyamine spacers between the hypoxia-reactive 2-nitroimidazole moiety and the 5-[F-18]-fluorodeoxyribose prosthetic group was reported. Among them, tracer 15 d displayed superior uptake kinetics and similar selectivity for hypoxic cells compared to standard hypoxia tracers. Lipophilicity and structural rigidity significantly influenced the selectivity of the tracers towards hypoxic cells.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Ling Xiao, Chijun Deng, Haoyue Zhu, Xiaomei Gao, Jian Li, Zhiquan Yang, Dingyang Liu, Li Feng, Shuo Hu
Summary: This study investigated the patterns of metabolic abnormalities using [F-18]FDG PET in MTLE patients with different pathologic types. It was found that MTLE patients with isolated gliosis had the worst prognosis and exhibited significant hypometabolism in the insula. Therefore, hypometabolic regions should be prioritized for presurgical evaluation of MTLE patients rather than focusing solely on metabolic uptake values.
EUROPEAN RADIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Huiyi Wei, Junjie Wei, Shaojuan Zhang, Shiliang Dong, Guocong Li, Wenqing Ran, Chenchen Dong, Weibin Zhang, Chao Che, Wenzhao Luo, Hao Xu, Zhiyong Dong, Jinghao Wang, Lu Wang
Summary: This study successfully demonstrated the automatic cGMP-level production of [F-18]P10A-1910 and conducted a PET/MRI study in living human brains, confirming its potential as a radioligand for PDE10A.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Guolong Huang, Xiaolei Lu, Yifan Qiu, Lei Bi, Peizhen Ye, Min Yang, Yanfang Shen, Hongjun Jin, Junbin Han
Summary: A novel P2X7R targeting radiotracer was synthesized and proved to stably retain and target P2X7R in vivo without defluorination in major organs. It shows potential as a promising PET radioligand for clinical translation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Tharick A. Pascoal, Andrea L. Benedet, Dana L. Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z. Lussier, Cecile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: It is crucial to track longitudinal tau tangles accumulation across the Alzheimer's disease spectrum to understand the natural history of tau pathology. The novel subnanomolar affinity tau tracer F-18-MK-6240 demonstrated the ability to detect tau accumulation in asymptomatic and symptomatic individuals. The study found different patterns of tau accumulation in early vs. late Braak stages, with implications for diagnosis and treatment of Alzheimer's disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan Moore, Manil Subesinghe, Aida Santaolalla, Michael Green, Harriet Deere, Mieke Van Hemelrijck, Jesper Lagergren, Sugama Chicklore, Nick Maisey, James Gossage, Mark Kelly, Cara Baker, Andrew Davies
Summary: This study evaluated the role of FDG PET-CT in predicting pathological tumor response, nodal response, and survival in neoadjuvant therapy for esophageal cancer. The study found that metabolic tumor and nodal response can predict pathological tumor response and nodal response, and these responses are independent predictors of patient survival.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson
Summary: A simple and efficient process for fluorine-18-labeled 1,2,3-triazole was reported, achieving successful radiofluorination through iodine-fluorine-18 exchange in an aqueous medium. The methodology was optimized on a model reaction and validated on multiple 1,2,3-triazole substrates, with radiochemical conversions ranging from 18-60%. Using this strategy, a triazole-based thiamin analogue was synthesized with isolated radiochemical yield of 10-16% in 40 minutes, showing potential for positron emission tomography (PET) imaging of thiamin-dependent enzymes.
Article
Chemistry, Organic
Aaron Schuell, Lisa Grothe, Eduardo Rodrigo, Thomas Erhard, Siegfried R. Waldvogel
Summary: A novel electrosynthetic approach for the synthesis of aryl dibenzothiophenium salts, including the metal-free, electrochemical formation of a C-S bond under ambient conditions, has been reported. The broad applicability of this method has been demonstrated with 14 examples, achieving isolated yields of up to 72%, including nitrogen-containing heterocycles. The resulting sulfonium salts can serve as precursors for the synthesis of [F-18]fluoroarenes found in PET tracer ligands.
Article
Endocrinology & Metabolism
George Firth, Eleni Georgiadou, Alexander Griffiths, Maral Amrahli, Jana Kim, Zilin Yu, Ming Hu, Theodora J. Stewart, Isabelle Leclerc, Haruka Okamoto, Daniel Gomez, Philip J. Blower, Guy A. Rutter
Summary: Common variants in the SLC30A8 gene are associated with altered risk of type 2 diabetes, while rare loss-of-function variants in the gene are protective against the disease. This study found that the R138X mutation in the mouse SLC30A8 gene affects zinc and manganese homeostasis, leading to increased levels of these metals in pancreatic beta cells and improved insulin secretion.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Xiyi Qin, Han Jiang, Yu Liu, Hong Zhang, Mei Tian
Summary: Apoptosis is a natural, non-inflammatory form of programmed cell death that can be detected through characteristic biochemical changes. Imaging with radionuclide tracers allows for selective detection of apoptotic cell death in vivo, potentially serving as diagnostic markers, early-response indicators, and prognostic predictors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemical Research Methods
Yingqing Lu, Yingfang He, Roger Schibli, Linjing Mu, R. Michael van Dam
Summary: Copper-mediated radiofluorination has great potential in the synthesis of PET radioligands. We demonstrated the feasibility of Cu-mediated radiosynthesis on a high-throughput microdroplet platform and optimized the reaction conditions. By utilizing microscale conditions, we achieved higher radiochemical yield and excellent radiochemical purity and molar activity. We also successfully translated these optimized conditions to a vial-based method, expanding the applicability of the synthesis approach.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Zhang, Yu Lin, Zhen Xing, Shaobo Yao, Dairong Cao, Wei-bing Miao
Summary: Diffusion and perfusion MRI can detect glioma heterogeneity with excellent molecular imaging correlations, guiding glioma grading and tissue sampling by identifying regions with highest metabolism and malignancy.
Editorial Material
Cardiac & Cardiovascular Systems
Kaixian Lin, Xin Chen, Qianqian Xue, Shaobo Yao, Weibing Miao
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Zhenying Chen, Qianqian Xue, Chao Huang, Shaobo Yao, Weibing Miao
Summary: This study highlights the potential role of Ga-68-Pentixafor PET/CT in diagnosing and treating Burkitt lymphoma, and suggests further research directions.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Jiaying Zhang, Shaobo Yao, Weibing Miao
Summary: This is a case of metastatic papillary thyroid cancer in a patient previously treated with multiple therapies. CT scan of the chest revealed pleural thickening and effusion, and pleural biopsy confirmed the metastatic lesion. Ga-68-fibroblast activation protein inhibitor PET/CT can be helpful in identifying the metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jieling Zheng, Kaixian Lin, Shan Zheng, Shaobo Yao, Weibing Miao
Summary: A 28-year-old woman presented with abdominal pain, bowel dysfunction, and weight loss. PET/CT imaging showed hypermetabolic lesions in the intestines and peritoneal thickening/caking. Biopsy confirmed the diagnosis of tuberculosis. The positive findings of Ga-68-FAPI indicated its potential value in evaluating intestinal tuberculosis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjia Zhu, Ru Jia, Qiao Yang, Yuejuan Cheng, Hong Zhao, Chunmei Bai, Jianming Xu, Shaobo Yao, Li Huo
Summary: This study evaluated the diagnostic efficacy of (68) Ga-NODAGA-LM3 and (68) Ga-DOTA-LM3 compared to (68) Ga-DOTATATE in patients with neuroendocrine tumors. Both (68) Ga-NODAGA-LM3 and (68) Ga-DOTA-LM3 showed superiority in lesion detection and tumor uptake compared to (68) Ga-DOTATATE, demonstrating their potential as promising SSTR2 antagonists for neuroendocrine tumors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenying Chen, Apeng Yang, Jiaying Zhang, Aihong Chen, Yuanqing Zhang, Chao Huang, Shaoming Chen, Shaobo Yao, Weibing Miao
Summary: The study evaluated the value of [(68) Ga]Pentixafor PET/CT for CNSL patients, showing higher accuracy and better contrast compared to [F-18]FDG PET/CT. [(68) Ga]Pentixafor PET/CT detected more lesions and had a higher T/N ratio, making it a promising agent for lesion detection in CNSL patients.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zefang Lin, Qianqian Xue, Rong Lin, Shaobo Yao, Weibing Miao
Summary: The condylar growth activity can be assessed using quantitative bone SPECT/CT imaging. The condylar SUVmax varies with age, and different cutoff values should be used to diagnose active UCH in patients of different age groups.
NUCLEAR MEDICINE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Mengqi Sun, Shaobo Yao, Linyang Fan, Zhiguo Fang, Weibing Miao, Zhiyuan Hu, Zihua Wang
Summary: The study introduces a novel amphiphilic bifunctional PD-1/PD-L1 peptide antagonist PCP, co-delivering doxorubicin (DOX) and R848 through co-assembly of a multi-agent prodrug (PCP@R848/DOX) specifically cleaved by fibroblast activation protein-alpha (FAP-alpha) in the tumor stroma. This activation leads to the localized release of DOX and R848, triggering immunogenic cell death (ICD) and reprogramming tumor-associated macrophages (TAMs) to elicit antitumor immunity, while sustained release of PD-1/PD-L1 antagonists further blocks the PD-L1 pathway for cytotoxic T lymphocyte activation, presenting a new paradigm in combination immunotherapy for cancer treatment.
Article
Medicine, General & Internal
Yu-Sen Qiu, Yi-Heng Zeng, Ru-Ying Yuan, Zhi-Xian Ye, Jin Bi, Xiao-Hong Lin, Yi-Jun Chen, Meng-Wen Wang, Ying Liu, Shao-Bo Yao, Yi-Kun Chen, Jun-Yi Jiang, Yi Lin, Xiang Lin, Ning Wang, Ying Fu, Wan-Jin Chen
Summary: This article presents a prospective cohort study on hereditary spastic paraplegias (HSPs), aiming to investigate genetic-clinical characteristics, monitor disease progression, and identify clinical outcomes of treatment. The study will assess multiple aspects and observe the impact of different molecular mechanisms on clinical manifestations and disease severity.
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Shaobo Yao, Shaozhen Lv, Zhuohong Feng
Summary: The temperature sensing behaviors of emissions of Stark sublevels in Er3+/Yb3+ codoped lead lanthanum zirconate titanate (PLZT) transparent ceramic were examined using the temperature-dependent upconversion fluorescence spectra. The emission intensities of the Stark sublevels H-2(11/2(1, 2)), S-4(3/2(1, 2)), and F-4(9/2(1, 2, 3)) showed strong temperature dependence under the effects of thermal excitation and nonradiative relaxation. The optical temperature sensing properties of different transitions were investigated using the fluorescence intensity ratio (FIR) technique, and Er3+/Yb3+: PLZT ceramics were found to be a promising thermometer material at low temperatures.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Thermodynamics
Gang Dai, Wenwen Zhao, Shaobo Yao, Weifang Chen
Summary: The efficient and accurate prediction of aeroheating performance in hypersonic vehicles is a challenging task due to grid distribution, numerical schemes, and iterative steps. Inspired by theoretical analysis and machine learning, a new wall heat flux prediction framework called the ML-ETP method is proposed. It establishes the relationship between wall heat flux and flow variables at an extreme temperature point in the normal direction of the corresponding wall grid cell. By training a regression model using flow properties and gradients at the extreme temperature point, the ML-ETP method can accurately and efficiently predict wall heat flux with a coarse grid.
JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER
(2023)
Review
Chemistry, Medicinal
Zhenying Chen, Qianqian Xue, Shaobo Yao
Summary: CXCR4 is a predictive biomarker for metastasis and poor prognosis in malignancies. Ga-68-Pentixafor can be used to evaluate CXCR4 expression non-invasively. Lu-177-Pentixather or Y-90-Pentixather shows potential in tumor endoradiotherapy for tumors with CXCR4 overexpression.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shaoming Chen, Zhenying Chen, Gengsen Zou, Shan Zheng, Ke Zheng, Jiaying Zhang, Chao Huang, Shaobo Yao, Weibing Miao
Summary: This study evaluated the potential value of [Ga-68]Ga-labelled fibroblast activation protein inhibitor ([Ga-68]Ga-FAPI) positron emission tomography/computed tomography (PET/CT) in preoperative staging for oral squamous cell carcinoma (OSCC) patients. The results showed that [Ga-68]Ga-FAPI PET/CT had similar accuracy in detecting primary lesions compared to 2-[F-18]fluoro-2-deoxy-D-glucose (2-[F-18]FDG) PET/CT, but it had higher specificity and accuracy in evaluating neck lymph node metastases.
EUROPEAN RADIOLOGY
(2022)