Article
Medicine, General & Internal
Jie Xu, Fang-Ping Xu, Zhi-Hua Liu, Qian Cui, Ke-Ping Zhang, Zhi Li
Summary: This study investigated the correlations between mutations in the TERT promoter and IDH1/2 mutations or 1p/19q deletion in human gliomas. The results showed a positive correlation between TERT promoter mutations and 1p/19q deletion, as well as a negative correlation between TERT promoter mutations and IDH gene mutations, except in certain cases. This suggests a complex inter-regulatory relationship between these mutations in human gliomas.
Article
Oncology
Julia Gilhodes, Adele Meola, Bastien Cabarrou, Guillaume Peyraga, Caroline Dehais, Dominique Figarella-Branger, Francois Ducray, Claude-Alain Maurage, Delphine Loussouarn, Emmanuelle Uro-Coste, Elizabeth Cohen-Jonathan Moyal, POLA Network
Summary: Since the WHO's classification of primary brain tumors in 2016, oligodendrogliomas with the 1p/19q codeletion have been identified as having a better prognosis. However, the response to treatment for these tumors remains heterogeneous. Our study identified a gene signature composed of eight genes that were associated with a poor response to treatment in 1p/19q codeleted tumors. This signature could be used to identify patients who require more intensive treatment.
Article
Computer Science, Information Systems
Sonal Gore, Jayant Jagtap
Summary: Advanced biomedical texture descriptors combined with machine learning-assisted techniques can accurately identify the 1p/19q codeletion status of glioma patients, showing promising potential for personalized treatment.
JOURNAL OF KING SAUD UNIVERSITY-COMPUTER AND INFORMATION SCIENCES
(2022)
Article
Pathology
Sakun Santisukwongchote, Chinnachote Teerapakpinyo, Piyamai Chankate, Piti Techavichit, Atthaporn Boongird, Sith Sathornsumetee, Samasuk Thammachantha, Pornsuk Cheunsuchon, Jantima Tanboon, Paul Scott Thorner, Shanop Shuangshoti
Summary: This study successfully achieved integrated diagnosis of diffuse gliomas in adult Thai patients using a simplified approach combining clinical, morphological, immunohistochemical, and fewer molecular tests, saving 50% of testing costs. The demographic data and tumor subtypes were similar to series from other regions of the world.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Immunology
Guanzhang Li, Ruoyu Huang, Wenhua Fan, Di Wang, Fan Wu, Fan Zeng, Mingchen Yu, You Zhai, Yuanhao Chang, Changqing Pan, Tao Jiang, Wei Yan, Hongjun Wang, Wei Zhang
Summary: The study revealed that 1p/19q chromosome deletion in gliomas is associated with activation of immune and inflammatory responses. The decreased expression level of CCAAT enhancer-binding protein alpha in samples with 1p/19q codeletion led to the downregulation of immune checkpoints Galectin-9 and TIM-3. The loss of chromosome 19q was identified as the main reason for promoting the antitumor immune response in gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jie Xu, Fang Liu, Yuntao Li, Liang Shen
Summary: This study established an immune signature associated with 1p/19q chromosomal codeletion in lower grade gliomas (LGGs) for accurate prediction of prognosis. The prognostic signature was validated in training and testing groups, and immune checkpoints correlated with the risk score were identified.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Simin Zhang, Lijuan Yin, Lu Ma, Huaiqiang Sun
Summary: This study systematically reviewed the literature on the use of artificial intelligence methods in magnetic resonance imaging (MRI) for predicting 1p/19q co-deletion status in glioma. The findings suggest that integrating MRI with AI technology can help determine 1p/19q status pre-operatively and noninvasively, aiding in clinical decision-making. However, further validation and improvement are needed before this approach can be considered reliable and feasible in a real clinical setting.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Shingo Kihira, Ahrya Derakhshani, Michael Leung, Keon Mahmoudi, Adam Bauer, Haoyue Zhang, Jennifer Polson, Corey Arnold, Nadejda M. Tsankova, Adilia Hormigo, Banafsheh Salehi, Nancy Pham, Benjamin M. Ellingson, Timothy F. Cloughesy, Kambiz Nael
Summary: This study developed a multi-parametric radiomic model using MRI to predict the 1p/19q co-deletion status in patients with newly diagnosed IDH1 mutant glioma. The model demonstrated improved diagnostic performance compared to the T2-FLAIR mismatch sign in determining the 1p/19q co-deletion status.
Article
Neurosciences
Derek Wong, Tae Hoon Lee, Amy Lum, Valerie Lan Tao, Stephen Yip
Summary: In this study, the transcriptomic and proteomic profiles of low-grade gliomas (LGG) were investigated using RNA-seq data and tandem mass-spectrometry analysis. The results showed that gene expression in LGG subtypes was mainly influenced by IDH mutations and 1p19q co-deletion. Proteomic analysis identified subtype-specific proteins that could be used to classify the LGG subtypes.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Pathology
Dario de Biase, Giorgia Acquaviva, Michela Visani, Gianluca Marucci, Antonio De Leo, Thais Maloberti, Viviana Sanza, Enrico Di Oto, Enrico Franceschi, Antonella Mura, Moira Ragazzi, Silvia Serra, Elisabetta Froio, Alessandra Bisagni, Alba A. Brandes, Annalisa Pession, Giovanni Tallini
Summary: The study developed a next-generation sequencing panel to simultaneously define 1p/19g codeletion and IDH1/IDH2 mutation status, providing a reliable and cost-effective alternative for molecular diagnostics in gliomas.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Oncology
Yanyu Zhang, Yuan Xie, Liqun He, Jiefu Tang, Qiyuan He, Qingze Cao, Langjun Cui, Wei Guo, Kai Hua, Anna Dimberg, Liang Wang, Lei Zhang
Summary: This study found that in IDH-mutated LGGs, most TAMs expressed M1 activation markers CD86 and TNF, with some TAMs co-expressing both M1 and M2-related markers. Higher levels of TAMs expressing M2-related markers were observed in 1p/19q non-codeletion IDH-mutated LGGs compared to 1p/19q codeletion LGGs. Inhibition of M-CSF and TGF beta 1 signaling decreased tumor growth and modulated TAM phenotype in a glioma mouse model, indicating a potential role of these proteins in regulating TAM phenotype in glioma.
Article
Oncology
Mark P. van Opijnen, C. Mircea S. Tesileanu, Linda Dirven, Pim B. van der Meer, Maarten M. J. Wijnenga, Arnaud J. P. E. Vincent, Marike L. D. Broekman, Hendrikus J. Dubbink, Johan M. Kros, Sjoerd G. van Duinen, Marion Smits, Pim J. French, Martin J. van den Bent, Martin J. B. Taphoorn, Johan A. F. Koekkoek
Summary: IDHwt hLGG patients and IDHwt glioblastoma patients have similar incidence proportions of epilepsy during the entire disease course. However, the former has a significantly higher incidence of epilepsy before diagnosis and a significantly longer time between first seizure and diagnosis, indicating a distinct clinical course between the two subtypes.
Article
Oncology
Kenan Zhang, Xing Liu, Guanzhang Li, Xin Chang, Shouwei Li, Jing Chen, Zheng Zhao, Jiguang Wang, Tao Jiang, Ruichao Chai
Summary: By controlling for molecular subtypes, we found that resection rate and chemotherapy were two prognostic factors associated with survival outcomes in a Chinese cohort with DG.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Keiichiro Kitahama, Shohei Iijima, Ayumi Sumiishi, Akimasa Hayashi, Kiyotaka Nagahama, Kuniaki Saito, Nobuyoshi Sasaki, Keiichi Kobayashi, Saki Shimizu, Motoo Nagane, Junji Shibahara
Summary: This study found a higher loss rate of H3K27me3 in malignant peripheral nerve sheath tumors compared to diffuse gliomas. The loss of H3K27me3 in diffuse gliomas was significantly associated with 1p/19q codeletion, predicting 1p/19q codeletion in IDH-mutant gliomas.
BRAIN TUMOR PATHOLOGY
(2021)
Article
Oncology
Grace S. Ahn, Kihwan Hwang, Tae Min Kim, Chul Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeong Hoon Kim, Chae-Yong Kim
Summary: The addition of concurrent and adjuvant temozolomide did not negatively impact health-related quality of life (HRQoL) and was associated with improved progression-free survival (PFS) for patients with anaplastic gliomas.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Medicine, Research & Experimental
Liang Hong, Zhi-Feng Shi, Kay Ka-Wai Li, Wei-Wei Wang, Rui Ryan Yang, Johnny Sheung-Him Kwan, Hong Chen, Fang-Cheng Li, Xian-Zhi Liu, Danny Tat-Ming Chan, Wen-Cai Li, Zhen-Yu Zhang, Ying Mao, Ho-Keung Ng
Summary: The molecular heterogeneity of IDH wildtype, H3 wildtype pediatric hemispheric glioblastomas was found in this study. TP53, ATRX, and MMR status can be used for risk stratification.
LABORATORY INVESTIGATION
(2022)
Article
Immunology
Cheng Wei, Bo Wang, Dazhao Peng, Xiaoyang Zhang, Zesheng Li, Lin Luo, Yingjie He, Hao Liang, Xuezhi Du, Shenghui Li, Shu Zhang, Zhenyu Zhang, Lei Han, Jianning Zhang
Summary: Comprehensive bioinformatics analysis showed that ALKBH5 is upregulated in multiple solid tumors and promotes the development and progression of cancer through regulation of tumor immunity, as well as cell proliferation, migration, and infiltration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xu Chen, Chao Liu, Zhenyu Zhang, Meng Wang, Shewei Guo, Tianhao Li, Hongwei Sun, Peng Zhang
Summary: This study investigated the clinical significance, biological behavior, and molecular mechanism of ZNF655 in glioma. The results showed that ZNF655 promoted glioma progression by binding to the promoter of AURKA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Aden Ka-Yin Chan, Zhi-Feng Shi, Kay Ka-Wai Li, Wei-Wei Wang, Hong Chen, Nellie Yuk-Fei Chung, Danny Tat-Ming Chan, Wai-Sang Poon, Herbert Ho-fung Loong, Xian-Zhi Liu, Zhen-Yu Zhang, Ying Mao, Ho-Keung Ng
Summary: This study aimed to establish a molecular grading scheme for adult gliomas using commonly available single-gene tests, and retrospectively evaluated 1,275 cases of gliomas. The results showed that a grouping system based on six molecular groups could effectively stratify gliomas for risk, and in some cases, the molecular groups were better predictors of prognosis than conventional histological grades.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Dazhao Peng, Lin Luo, Xiaoyang Zhang, Cheng Wei, Zhenyu Zhang, Lei Han
Summary: Circular RNAs (circRNAs), as a class of single-stranded noncoding RNAs, have potential in disease diagnosis and treatment, especially in cancers. Research has shown that circRNAs are frequently expressed in brain tissues and may play important roles in neurological diseases. Understanding the biogenesis and functions of circRNAs is crucial for further exploration of disease mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Correction
Immunology
Cheng Wei, Bo Wang, Dazhao Peng, Xiaoyang Zhang, Zesheng Li, Lin Luo, Yingjie He, Hao Liang, Xuezhi Du, Shenghui Li, Shu Zhang, Zhenyu Zhang, Lei Han, Jianning Zhang
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Lin Luo, Yingwei Zhen, Dazhao Peng, Cheng Wei, Xiaoyang Zhang, Xianzhi Liu, Lei Han, Zhenyu Zhang
Summary: There is a close association between non-coding RNAs (ncRNAs) and m6A modification, which plays a crucial role in tumor progression. This interaction may provide potential therapeutic targets for cancer treatment.
CELL DEATH DISCOVERY
(2022)
Review
Chemistry, Multidisciplinary
Jiang Ren, Zhenyu Zhang, Zhi Zong, Long Zhang, Fangfang Zhou
Summary: In eukaryotic cells, membrane-bound organelles and membrane-less organelles (MLOs) play important roles in biological activities. MLOs are formed through a process called liquid-liquid phase separation (LLPS), which is initiated by multivalent molecules. Accumulating evidence suggests that LLPS helps concentrate and organize molecules in cells, with aberrant LLPS implicated in cancer hallmarks. Understanding the molecular mechanisms of LLPS provides insights for cancer therapeutics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Guo, Zeyu Ma, Dongling Pei, Wenchao Duan, Yu Guo, Zhongyi Liu, Fangzhan Guan, Zilong Wang, Aoqi Xing, Zhixuan Guo, Lin Luo, Weiwei Wang, Bin Yu, Jinqiao Zhou, Yuchen Ji, Dongming Yan, Jingliang Cheng, Xianzhi Liu, Jing Yan, Zhenyu Zhang
Summary: By analyzing radiomic features from diffusion-weighted imaging (DWI), a three-class radiomic model can be trained to classify three molecular subtypes (IDHmut-noncodel, IDHwt, and IDHmut-codel) of adult gliomas, providing an alternative method for patients who don't have access to genetic testing.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Jingxian Duan, Zhenyu Zhang, Yinsheng Chen, Yuanshen Zhao, Qiuchang Sun, Weiwei Wang, Hairong Zheng, Dong Liang, Jingliang Cheng, Jing Yan, Zhi-Cheng Li
Summary: This study identified immune subtypes of adult diffuse gliomas using RNA sequencing data and predicted these subtypes noninvasively using a radiomic signature from MRI. Three distinctive immune subtypes were identified, and a radiomic signature was developed to predict these subtypes.
MOLECULAR ONCOLOGY
(2023)
Article
Immunology
Lin Luo, Xiao-Yang Zhang, Ying-Wei Zhen, Gao-Chao Guo, Da-Zhao Peng, Cheng Wei, Dong-Ling Pei, Bin Yu, Yu-Chen Ji, Xian-Zhi Liu, Lei Han, Zhen-Yu Zhang
Summary: This study revealed that PLK1 is highly expressed in various cancers, particularly in glioma, and serves as a prognostic biomarker. PLK1 expression is associated with prognosis, histological features, and genetic characteristics in glioma. Functional enrichment analysis suggests that PLK1 may be involved in immune response, cell cycle, DNA replication, and mismatch repair in glioma. The findings also demonstrate that PLK1 inhibition suppresses glioma cell proliferation, increases M1 macrophage infiltration and polarization, blocks tumor growth, and enhances M1 macrophage infiltration in glioma xenograft mouse models. Methylation analysis and lncRNA-miRNA network provide insights into the potential mechanism of abnormal PLK1 expression in glioma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Computer Science, Hardware & Architecture
Wenxia Wu, Jing Yan, Yuanshen Zhao, Qiuchang Sun, Huailing Zhang, Jingliang Cheng, Dong Liang, Yinsheng Chen, Zhenyu Zhang, Zhi-Cheng Li
Summary: Accurate survival prediction is crucial in precision oncology for glioma patients. Current deep learning-based survival analysis methods heavily depend on segmented tumor regions, requiring manual annotation. We propose a multi-task learning approach that combines both survival prediction and semi-supervised tumor segmentation, achieving comparable results to state-of-the-art methods.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dongling Pei, Fangzhan Guan, Xuanke Hong, Zhen Liu, Weiwei Wang, Yuning Qiu, Wenchao Duan, Minkai Wang, Chen Sun, Wenqing Wang, Xiangxiang Wang, Yu Guo, Zilong Wang, Zhongyi Liu, Aoqi Xing, Zhixuan Guo, Lin Luo, Xianzhi Liu, Jingliang Cheng, Bin Zhang, Zhenyu Zhang, Jing Yan
Summary: Radiomic features extracted from DSC-PWI can improve the prediction of molecular subtypes in adult diffuse gliomas. Integrating radiomic features from conventional and perfusion MRI can lead to the development of a multimodal radiomic model. Adding DSC-PWI to conventional MRI improves molecular subtype prediction in diffuse gliomas.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jing Yan, Qiuchang Sun, Xiangliang Tan, Chaofeng Liang, Hongmin Bai, Wenchao Duan, Tianhao Mu, Yang Guo, Yuning Qiu, Weiwei Wang, Qiaoli Yao, Dongling Pei, Yuanshen Zhao, Danni Liu, Jingxian Duan, Shifu Chen, Chen Sun, Wenqing Wang, Zhen Liu, Xuanke Hong, Xiangxiang Wang, Yu Guo, Yikai Xu, Xianzhi Liu, Jingliang Cheng, Zhi-Cheng Li, Zhenyu Zhang
Summary: This study developed a deep learning imaging signature (DLIS) for risk stratification in patients with multiforme (GBM) and investigated the biological pathways and genetic alterations underlying DLIS. DLIS was associated with survival and an independent predictor. The integrated nomogram incorporating DLIS achieved improved prediction performance compared to the clinicomolecular nomogram. DLIS was correlated with core pathways of GBM and key genetic alterations.
EUROPEAN RADIOLOGY
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Zhi-Cheng Li, Jing Yan, Shenghai Zhang, Chaofeng Liang, Xiaofei Lv, Yan Zou, Huailing Zhang, Dong Liang, Zhenyu Zhang, Yinsheng Chen
EUROPEAN RADIOLOGY
(2022)