Article
Biochemistry & Molecular Biology
Jiawei Zhou, Caitao Dong, Jing Tan, Guijun Wang, Zhen Li, Sheng Li, Ziqi He
Summary: Bladder cancer is one of the top ten most prevalent cancers worldwide and the second most common malignant tumor in urology. The limited effectiveness of immune targeted therapy in treating bladder cancer highlights the need for new therapeutic targets. This study found that SCG2 plays a crucial role in the proliferation, migration, and invasion of bladder cancer, as well as in promoting M2 macrophage polarization. These findings suggest that SCG2 could be a potential molecular target for immunotherapy in bladder cancer.
Article
Biotechnology & Applied Microbiology
Yue Xia, Minghuan Ge, Ling Xia, Guang Shan, Huijun Qian
Summary: This study reveals that the aberrant expression of cathepsin V (CTSV) is associated with a poor outcome in bladder cancer patients. CTSV enhances the inflammatory reaction, thereby promoting the development of bladder cancer. Overexpression of CTSV increases the proliferation and viability of bladder cancer cells, while deletion of CTSV significantly inhibits their proliferation and viability. Furthermore, overexpression of CTSV activates the inflammatory signaling pathway, which can be restored by introducing an NF-kappa B inhibitor.
Review
Pharmacology & Pharmacy
Mingshun Zuo, Hongchuan Chen, Yuanjian Liao, Pingang He, Te Xu, Jiajia Tang, Neng Zhang
Summary: Bladder cancer is a common tumor with increasing incidence. Sulforaphane, a compound found in cruciferous plants, has shown promising anticancer effects against bladder cancer. It can inhibit the growth and metastasis of bladder cancer cells, as well as target bladder cancer stem cells through various molecular pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feng Tang, Hua Yu, Xia Wang, Jiageng Shi, Zhizhuang Chen, Hao Wang, Ziyu Wan, Qiqi Fu, Xuan Hu, Yisha Zuhaer, Tao Liu, Zhonghua Yang, Jianping Peng
Summary: NCAPG is overexpressed in bladder cancer, and its knockdown can inhibit cell proliferation through the inhibition of the NF-kappa B signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Zhihao Yuan, Guancheng Guo, Guifang Sun, Qi Li, Lihui Wang, Baoping Qiao
Summary: This study found that Magnesium isoglycyrrhizinate (MI) has significant anti-tumor effects against bladder cancer, inhibiting cell proliferation, invasion, migration, and inducing apoptosis. MI increases the expression of miR-26b and Nox4 is identified as its direct target. Furthermore, MI downregulates the expression of Nox4, NF-kappa B, and HIF-1 alpha, exerting its anti-tumor effects through modulating the miR-26b/Nox4 axis.
Article
Oncology
Wenjie Wei, Jiayin Sun, Hui Zhang, Xingyuan Xiao, Chao Huang, Liang Wang, He Zhong, Yangkai Jiang, Xiaoping Zhang, Guosong Jiang
Summary: This study identified a novel circRNA circ0008399 that regulates the expression of target RNA through m(6)A modification by binding to WTAP, reducing cisplatin sensitivity in bladder cancer. Targeting this axis may hold potential therapeutic value.
Article
Environmental Sciences
Xiaodong Yu, Tao Wu, Bo Liao, Zhongbo Du, Pingyu Zhu
Summary: Corilagin (CLG) possesses anti-tumor and anti-proliferative actions in bladder cancer cells by inhibiting cell viability, adhesion, movement, invasion, and inflammation, and inducing apoptosis. CLG also inhibits migration and invasion through the repression of NF-kappa B mediated P13K/Akt signaling pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maria Varela, Miriam Lopez, Mariana Ingold, Diego Alem, Valentina Perini, Karen Perelmuter, Mariela Bollati-Fogolin, Gloria V. Lopez, Paola Hernandez
Summary: This study evaluated three nitric oxide-releasing compounds as potential therapies for bladder cancer. The results showed that compounds 1 and 3 inhibited the proliferation of bladder cancer cells through DNA damage and downregulation of Survivin. Compound 3 also reduced the migration of bladder cancer cells.
Review
Biochemistry & Molecular Biology
Wei Li, Tao Huang, Shenghan Xu, Bangwei Che, Ying Yu, Wenjun Zhang, Kaifa Tang
Summary: Tanshinone can target multiple pathways to inhibit the occurrence and development of prostate cancer, showing potential for the treatment of advanced PCa.
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xiangqin Kuang, Zhuojun Zhang, Difeng Li, Wenhao Bao, Jinyuan Pan, Ping Zhou, Han Chen, Zhiqing Gao, Xiaoyi Xie, Chunxiao Yang, Ge Zhu, Zhongqiu Zhou, Ruiming Tang, Zhengfu Feng, Lihuan Zhou, Xiaoli Feng, Lan Wang, Jianan Yang, Lili Jiang
Summary: In bladder cancer, the downregulation of PI16 is associated with disease progression and poor survival. PI16 inhibits tumor growth and metastasis by suppressing the activation of the NF-kappa B pathway through its interaction with ANXA1. These findings suggest that PI16 may serve as both a tumor suppressor and a potential biomarker for metastatic bladder cancer.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Oncology
Ji Xing, Wu Chen, Kang Chen, Shaoming Zhu, Fangyou Lin, Yucheng Qi, Yunlong Zhang, Shangting Han, Ting Rao, Yuan Ruan, Sheng Zhao, Weimin Yu, Fan Cheng
Summary: This study found that high expression of transcription factor TFAP2C is associated with poor chemotherapy response and prognosis in bladder cancer. In vitro and in vivo experiments demonstrated that knocking down TFAP2C enhances the anti-tumor effects of cisplatin, suppresses cell migration and invasion, and inhibits the activation of epidermal growth factor receptor and nuclear factor-kappa B by cisplatin. These findings provide a new direction to improve the efficacy of traditional cisplatin chemotherapy.
Article
Pharmacology & Pharmacy
Qun Wang, Yun Huang, Min Jia, Dong Lu, Hong-Wei Zhang, Dan Huang, San-Hong Liu, Chao Lv
Summary: SPS-1, an active fraction from safflower polysaccharide, demonstrated strong antitumor effects in a mouse model of colorectal cancer by regulating the immune pathway and changing macrophage phenotype. It inhibited tumor growth, suppressed cell proliferation, induced apoptosis in CRC cells, and could potentially be used as a therapeutic option for CRC prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shifaa M. Abdin, Mai F. Tolba, Dana M. Zaher, Hany A. Omar
Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)