Review
Biochemistry & Molecular Biology
Jinkal Modi, Abhishek Roy, Anjan K. Pradhan, Amit Kumar, Sarmistha Talukdar, Praveen Bhoopathi, Santanu Maji, Padmanabhan Mannangatti, Daniel Sanchez de la Rosa, Jiong Li, Chunqing Guo, Mark A. Subler, Jolene J. Windle, Webster K. Cavenee, Devanand Sarkar, Xiang-Yang Wang, Swadesh K. Das, Luni Emdad, Paul B. Fisher
Summary: MDA-7/IL-24 is a potent tumor suppressor with multiple functions, including inhibition of tumor growth, invasion, angiogenesis, and metastasis, induction of bystander antitumor activity, and synergy with conventional cancer therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Alessandra Ricciardi, Thomas B. Nutman
Summary: The study found that IL-10 and its related family members IL-19 and IL-24 play important roles in modulating the immune response in human filarial infections. Patients with different microfilaria infection statuses showed differences in cytokine production, which may affect the outcomes of the infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Christopher Sie, Ravi Kant, Christian Peter, Andreas Muschaweckh, Monika Pfaller, Lucy Nirschl, Helena Dominguez Moreno, Tereza Chadimova, Gildas Lepennetier, Tanja Kuhlmann, Rupert Ollinger, Thomas Engleitner, Roland Rad, Thomas Korn
Summary: Th17 cells have an intrinsic feedback mechanism to control their pathogenicity, involving the production of IL-24 and secretion of IL-10. IL-24 interacts with Grim19 on the inner mitochondrial membrane to promote STAT3 accumulation in the mitochondrial compartment, which serves as a rheostat to regulate nuclear STAT3 activity. This mechanism plays an important role in restricting immunopathology associated with Th17 cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Immunology
Eric Jou, Noe Rodriguez-Rodriguez, Andrew N. J. McKenzie
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and current immunotherapeutic interventions have limited effectiveness. Cytokines interleukin-25 (IL-25) and IL-33, expressed by barrier epithelial cells, play important roles in the intestinal immune responses and can influence tumorigenesis in CRC. IL-25 and IL-33 have different effects on different subtypes of CRC and can modulate various immune cell types and pathways, including angiogenesis, tumor stemness, invasion, and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lian Li, Jianxin Wei, Tomeka L. Suber, Qinmao Ye, Jiaxing Miao, Shuang Li, Sarah J. Taleb, Kevin C. Tran, Arya S. Tamaskar, Jing Zhao, Yutong Zhao
Summary: IL-37 induces Sigirr phosphorylation and degradation through GSK3 beta-mediated pathways, revealing a potential mechanism in regulating inflammatory responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Keshan Yang, Cheng Tian, Chengliang Zhang, Ming Xiang
Summary: This article summarizes the structure and function of IL-33, as well as its role in immune regulation, pulmonary fibrosis, and lung cancer. The dual regulation of IL-33 in lung cancer is highlighted, and potential treatment regimens, especially immunotherapies, based on its mechanism of action are proposed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yusuke Inoue, Naoki Inui, Masato Karayama, Kazuhiro Asada, Masato Fujii, Shun Matsuura, Tomohiro Uto, Dai Hashimoto, Takashi Matsui, Masaki Ikeda, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Takafumi Suda
Summary: This study collected serum samples from two independent cohorts to investigate the relationship between baseline cytokine levels and treatment efficacy of immune checkpoint blockade therapy in non-small cell lung cancer patients. It was found that high levels of IL-6 and IL-15 were independent unfavorable prognostic factors, which could be used to predict the survival outcomes of patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Pharmacology & Pharmacy
Yuling Zhang, Xiaoting Huang, Shanna Feng, Chen Chen, Dainian Guo, Ling Fang
Summary: This study explored the correlation between platinum accumulation and cancer-related fatigue (CRF), finding that the platinum concentration was positively correlated with the degree of CRF. Increased platinum accumulation may lead to CRF through mechanisms such as increasing IL-8 levels and causing inflammation or worsening anemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Tanja Salomaa, Laura Kummola, Martin Ignacio Gonzalez-Rodriguez, Lotta Hiihtola, Tero A. H. Jarvinen, Ilkka S. Junttila
Summary: Cytokine-mediated mast cell regulation enables precise optimization of their own proinflammatory cytokine production. IL-4 regulates mast cell functions during allergic inflammation, but the direct role of closely related IL-13 remains unclear.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Helene Salvator, Stanislas Grassin-Delyle, Marion Brollo, Louis-Jean Couderc, Charlotte Abrial, Tatiana Victoni, Emmanuel Naline, Philippe Devillier
Summary: The study found that adiponectin released by lung tissue is negatively correlated with body mass index, AdipoR1 and AdipoR2 receptors are expressed in lung macrophages, and recombinant adiponectin and AdipoRon can significantly inhibit the release of inflammatory factors.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Meichen Ma, Yuanyuan Xie, Jianhua Liu, Lina Wu, Yong Liu, Xiaosong Qin
Summary: Interleukin-21 (IL-21) is an important effector and messenger molecule in the immune system, with pleiotropic effects on innate and adaptive immune responses. It plays a role in regulating natural killer, T, and B cells. IL-21 also has anti-tumor effects and can enhance the effectiveness of other anti-tumor agents. Understanding the biology of IL-21 in the tumor microenvironment and reducing its toxic and side effects is crucial for maximum benefits in anti-tumor treatment strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Multidisciplinary Sciences
Eric H. Bent, Luis R. Millan-Barea, Iris Zhuang, Daniel R. Goulet, Julia Frose, Michael T. Hemann
Summary: In a mouse model of BCR-ABL(+) B-cell acute lymphoblastic leukemia, chemotherapy-induced anti-cancer immunity is suppressed by the tumor microenvironment through production of cytokine IL-6. IL-6 inhibits the efficacy of immunotherapy and promotes resistance to doxorubicin, impacting CD8(+) T-cell-mediated anti-cancer responses.
NATURE COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Rosa K. Kortekaas, Janette K. Burgess, Roel van Orsoy, David Lamb, Megan Webster, Reinoud Gosens
Summary: IL-11 was originally recognized as an immunomodulatory and hematopoiesis-inducing cytokine, but it is now emerging as having a potential role in various pulmonary conditions such as IPF, asthma, and lung cancer. Experimental strategies targeting IL-11, like humanized antibodies, have shown promise in therapeutics, indicating the therapeutic potential of IL-11 in lung diseases.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)