Article
Oncology
Maria Rosaria Ambrosio, Giusy Mosca, Teresa Migliaccio, Domenico Liguoro, Gisella Nele, Fabrizio Schonauer, Francesco D'Andrea, Federica Liotti, Nella Prevete, Rosa Marina Melillo, Carla Reale, Concetta Ambrosino, Claudia Miele, Francesco Beguinot, Vittoria D'Esposito, Pietro Formisano
Summary: This study demonstrates that high glucose levels enhance the aggressiveness of breast cancer cells and promote a pro-tumorigenic phenotype in mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs). The findings suggest that metabolic control may be important for reducing cancer outgrowth and preserving the functions of the adipose microenvironment.
Article
Oncology
Andreas Ritter, Nina-Naomi Kreis, Susanne Roth, Alexandra Friemel, Babek Kahn Safdar, Samira Catharina Hoock, Julia Maria Wildner, Roman Allert, Frank Louwen, Christine Solbach, Juping Yuan
Summary: This study reveals how obesity affects the phenotype of breast adipose tissue-derived mesenchymal stromal/stem cells (bASCs) and highlights the molecular changes inside breast cancer cells upon cell-cell interaction with these cancer-educated bASCs. These findings provide a new intervention strategy for breast cancer patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Cell & Tissue Engineering
Ghaidaa Raheem Lateef Al-Awsi, Fahad Alsaikhan, Ria Margiana, Irfan Ahmad, Indrajit Patra, Mazin A. A. Najm, Ghulam Yasin, Iroda Rasulova, Ali Thaeer Hammid, Hamzah H. Kzar, Moaed E. Al-Gazally, Homayoon Siahmansouri
Summary: Breast cancer is the second most frequently diagnosed cancer and the leading cause of cancer death in women. Mesenchymal stem cells (MSCs) are a subgroup of cells that can differentiate into multiple cell types and have been found to have various effects on tumor growth and development. Recent studies have shown that MSCs can both promote and inhibit tumor development. Exosomes (Exo) have emerged as a new mechanism of cell communication, and MSC-derived exosomes (MSCs-Exo) have been found to carry molecules that can affect the proliferation, metastasis, and drug response of breast cancer cells.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shalise Burch, Carlos Luna Lopez
Summary: Stem cells have the potential to restore damaged tissue by transferring healthy mitochondria to injured cells. The efficiency of mitochondrial transfer depends on cell density and the distance between donor and recipient cells. When co-cultured with tumorigenic cells, stem cells show significantly higher rates of mitochondrial transfer and enhance the migratory ability of the tumorigenic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yen-Yun Wang, Amos C. Hung, Yi-Chia Wu, Steven Lo, Huan-Da Chen, Yuk-Kwan Chen, Ya-Ching Hsieh, Stephen Chu-Sung Hu, Ming-Feng Hou, Shyng-Shiou F. Yuan
Summary: This study demonstrated that resistin-stimulated ADSCs can interact with breast cancer cells in the tumor microenvironment by secreting CXCL5, leading to increased malignancy in breast cancer cells.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Saevar Ingthorsson, Gunnhildur Asta Traustadottir, Thorarinn Gudjonsson
Summary: This review discusses the structure, function, and dynamics of the breast gland, as well as how changes in breast cell function can lead to different types of cancer. The development of the breast gland is closely related to the menstrual cycle, and stem cells and progenitor cells play important roles in the proliferation, differentiation, and involution cycles of the breast. Breast cancer originates from stem cells and progenitor cells, and both stem cells and cancer cells exhibit cellular plasticity. Additionally, the stromal environment plays a vital role in cancer initiation and progression.
Review
Biochemistry & Molecular Biology
Anna Trzyna, Agnieszka Banas-Zabczyk
Summary: The secretome of ASCs, including exosomes, contains a variety of cytokines and non-coding RNAs that have therapeutic potential in a wide range of diseases. Utilizing ASC secretome as a cell-free therapy shows promise in overcoming limitations of cell-based therapies and improving treatment efficacy.
Article
Biochemistry & Molecular Biology
Anna Cazzola, David Calzon Lozano, Dennis Hirsch Menne, Raquel Davila Pedrera, Jingcheng Liu, Daniel Pena-Jimenez, Silvia Fontenete, Cornelia Halin, Mirna Perez-Moreno
Summary: Lymph vessels and lymph node involvement are crucial in the staging of various cancers. In skin squamous cell carcinoma, lymph vessels have a significant role in cancer development and metastasis. However, their interaction with the cancer stem cell niche during early tumor stages has not been well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rui Zhang, Mengxue Dong, Juchuanli Tu, Fengkai Li, Qiaodan Deng, Jiahui Xu, Xueyan He, Jiajun Ding, Jie Xia, Dandan Sheng, Zhaoxia Chang, Wei Ma, Haonan Dong, Yi Zhang, Lixing Zhang, Lu Zhang, Suling Liu
Summary: Our previous studies have shown that CCL20 contributes to tumor progression and chemoresistance by regulating breast cancer stem cell self-renewal. This study demonstrates that CCL20 also affects breast cancer progression by remodeling the tumor microenvironment, particularly through the enrichment of PMN-MDSCs. The interaction between PMN-MDSCs and BCSCs in CCL20(high)-expressing breast cancer can be targeted for therapeutic intervention.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Nanoscience & Nanotechnology
Zhangsong Peng, Qiang Chang, Malcolm Xing, Feng Lu
Summary: Researchers developed a stem cell-based anticancer system using modified graphene oxide nanocomposites for breast cancer therapy. The nanocomposites were released through near-infrared radiation and directly targeted cancer cells for ablation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Lu Zhang, Wenmin Chen, Suling Liu, Ceshi Chen
Summary: The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence have been recognized for many decades. Due to their strong capacity for self-renewal and differentiation, BCSCs are the major reasons for poor clinical outcomes and low therapeutic response. Several hypotheses on the origin of cancer stem cells have been proposed, including critical gene mutations in stem cells, dedifferentiation of somatic cells, and cell plasticity remodeling by epithelial-mesenchymal transition (EMT) and the tumor microenvironment. Moreover, the tumor microenvironment, including cellular components and cytokines, modulates the self-renewal and therapeutic resistance of BCSCs. Small molecules, antibodies, and chimeric antigen receptor (CAR)-T cells targeting BCSCs have been developed, and their applications in combination with conventional therapies are undergoing clinical trials. In this review, we focus on the features of BCSCs, emphasize the major factors and tumor environment that regulate the stemness of BCSCs, and discuss potential BCSC-targeting therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hui-Kung Ting, Chin-Li Chen, En Meng, Juin-Hong Cherng, Shu-Jen Chang, Chien-Chang Kao, Ming-Hsin Yang, Fang-Shiuan Leung, Sheng-Tang Wu
Summary: Mesenchymal stem cells, particularly adipose-derived stem cells, have the remarkable ability to reduce inflammation through paracrine factors. This study investigated the effects of TNF-alpha stimulation on ADSCs in the tumor microenvironment, revealing that TNF-alpha enhanced the immunomodulatory potential of ADSCs during tumorigenesis, providing insights for potential MSC-based therapeutic options for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Siti Syahira Airuddin, Ahmad Sukari Halim, Wan Azman Wan Sulaiman, Ramlah Kadir, Nur Azida Mohd Nasir
Summary: Stem cells, particularly adipose-derived stem cells, have shown promising potential in disease treatment due to their differentiation abilities and secretion of growth factors. However, more research is needed to fully understand the safety and effectiveness of adipose-derived stem cells in medical treatment.
Article
Cell & Tissue Engineering
Katie M. Hamel, Connor T. King, Maryn B. Cavalier, Kara Q. Liimatta, Grace L. Rozanski, Timothy A. King, Meggie Lam, Grace C. Bingham, C. Ethan Byrne, Diensn Xing, Bridgette M. Collins-Burow, Matthew E. Burow, Jorge A. Belgodere, Melyssa R. Bratton, Bruce A. Bunnell, Elizabeth C. Martin
Summary: Adipose tissue acts as an endocrine organ and its signals contribute to the progression of breast cancer. Young breast tumors have more matrix and paracrine factors compared to aged tumors. Factors produced by young adipose tissue enhance the endocrine response in breast cancer cells.
STEM CELLS AND DEVELOPMENT
(2022)
Article
Medicine, General & Internal
Minsung Kim, Il Tae Son, Gyoung Tae Noh, So-Youn Woo, Ryung-Ah Lee, Bo Young Oh
Summary: This study investigated the role of colon cancer-cell-derived exosomes in colon cancer. The results showed that exosome treatment significantly increased cancer cell proliferation, altered cell adhesion molecule expression, enhanced cell motility, and had an impact on the gene regulation of cancer-associated fibroblasts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Wei-Hong Chen, Hen-Yu Liu, Ching-Yu Tsai, Chia-che Wu, Hong-Jian Wei, Alice Liu, Ming-Tang Lai, Chiung-Fang Huang, Win-Ping Deng
JOURNAL OF NANOMATERIALS
(2015)
Article
Cell & Tissue Engineering
Jui-Hua Lu, Hong-Jian Wei, Bou-Yue Peng, Hsin-Hua Chou, Wei-Hong Chen, Hen-Yu Liu, Win-Ping Deng
STEM CELLS AND DEVELOPMENT
(2016)
Article
Biochemistry & Molecular Biology
Navneet Kumar Dubey, Bou-Yue Peng, Chien-Min Lin, Peter D. Wang, Joseph R. Wang, Chun-Hao Chan, Hong-Jian Wei, Win-Ping Deng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Endocrinology & Metabolism
Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei
JOURNAL OF DIABETES RESEARCH
(2018)
Article
Engineering, Biomedical
Wei-Hong Chen, Wen-Cheng Lo, Wei-Che Hsu, Hong-Jian Wei, Hen-Yu Liu, Chian-Her Lee, Szu-Yu Tina Chen, Ying-Hua Shieh, David F. Williams, Win-Ping Deng
Article
Oncology
Jui-Hua Lu, Bou-Yue Peng, Chun-Chao Chang, Navneet Kumar Dubey, Wen-Cheng Lo, Hsin-Chung Cheng, Joseph R. Wang, Hong-Jian Wei, Win-Ping Deng
Article
Biochemistry & Molecular Biology
Chia-Yu Wu, Chun-Hao Chan, Navneet Kumar Dubey, Hong-Jian Wei, Jui-Hua Lu, Chun-Chao Chang, Hsin-Chung Cheng, Keng-Liang Ou, Win-Ping Deng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Chun-Hao Chan, Chia-Yu Wu, Navneet Kumar Dubey, Hong-Jian Wei, Jui-Hua Lu, Samantha Mao, Joy Liang, Yu-Hsuan Liang, Hsin-Chung Cheng, Win-Ping Deng
Article
Oncology
Hong-Jian Wei, Pavan S. Upadhyayula, Antonios N. Pouliopoulos, Zachary K. Englander, Xu Zhang, Chia-Ing Jan, Jia Guo, Angeliki Mela, Zhiguo Zhang, Tony J. C. Wang, Jeffrey N. Bruce, Peter D. Canoll, Neil A. Feldstein, Stergios Zacharoulis, Elisa E. Konofagou, Cheng-Chia Wu
Summary: Glioblastoma is a devastating disease with poor treatment outcomes. It has been found that using focused ultrasound to open the blood-brain barrier can enhance drug delivery, increasing etoposide concentration in the brain and leading to local control and survival benefits for tumors.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Multidisciplinary Sciences
Zachary K. Englander, Hong-Jian Wei, Antonios N. Pouliopoulos, Ethan Bendau, Pavan Upadhyayula, Chia-Ing Jan, Eleanora F. Spinazzi, Nina Yoh, Masih Tazhibi, Nicholas M. McQuillan, Tony J. C. Wang, Jeffrey N. Bruce, Peter Canoll, Neil A. Feldstein, Stergios Zacharoulis, Elisa E. Konofagou, Cheng-Chia Wu
Summary: The study demonstrated that FUS is a safe and feasible technique for opening the BBB and delivering drugs to the brainstem efficiently without causing significant adverse reactions. Furthermore, FUS can significantly increase drug concentration within the tumor, providing a new direction for the treatment of pontine glioma.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yan Mo, Shoufu Duan, Xu Zhang, Xu Hua, Hui Zhou, Hong-Jian Wei, Jun Watanabe, Nicholas McQuillan, Zhenyi Su, Wei Gu, Cheng-Chia Wu, Christopher R. Vakoc, Rintaro Hashizume, Kenneth Chang, Zhiguo Zhang
Summary: The catalytic subunit of the SWI/SNF chromatin remodeling complex, SMARCA4, is essential for the proliferation and growth of diffuse midline gliomas with H3K27M mutation. This discovery provides a potential therapeutic approach to this deadly pediatric glioma.
Meeting Abstract
Oncology
H. J. Wei, A. Pouliopoulos, N. Yoh, M. Tazhibi, N. McQuillan, X. Zhang, L. Szalontay, R. Gartrell, P. Jovana, Z. Zhang, N. Feldstein, S. Zacharoulis, E. E. Konofagou, C. C. Wu
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Proceedings Paper
Engineering, Biomedical
Haoran Sun, Xueqing Liu, Xinyang Feng, Chen Liu, Nanyan Zhu, Sabrina J. Gjerswold-Selleck, Hong-Jian Wei, Pavan S. Upadhyayula, Angeliki Mela, Cheng-Chia Wu, Peter D. Canoll, Andrew F. Laine, J. Thomas Vaughan, Scott A. Small, Jia Guo
2020 IEEE 17TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2020)
(2020)
Article
Geriatrics & Gerontology
Navneet Kumar Dubey, Hong-Jian Wei, Sung-Hsun Yu, David F. Williams, Joseph R. Wang, Yue-Hua Deng, Feng-Chou Tsai, Peter D. Wang, Win-Ping Deng
