Journal
REVISTA ESPANOLA DE CARDIOLOGIA
Volume 66, Issue 8, Pages 657-661Publisher
EDICIONES DOYMA S A
DOI: 10.1016/j.recesp.2013.04.010
Keywords
Proteomics; Metabolomics; Mass spectrometry; Magnetic resonance spectroscopy
Categories
Funding
- NIHR (National Institute for Health Research) Biomedical Research Centre at Guy's and St. Thomas' NHS Foundation Trust
- King's College London
- King's College Hospital
- British Heart Foundation [FS/13/2/29892] Funding Source: researchfish
- Cancer Research UK [16464] Funding Source: researchfish
Ask authors/readers for more resources
In the last decade, proteomics and metabolomics have contributed substantially to our understanding of cardiovascular diseases. The unbiased assessment of pathophysiological processes without a priori assumptions complements other molecular biology techniques that are currently used in a reductionist approach. In this review, we highlight some of the omics methods used to assess protein and metabolite changes in cardiovascular disease. A discrete biological function is very rarely attributed to a single molecule; more often it is the combined input of many proteins. In contrast to the reductionist approach, in which molecules are studied individually, omics platforms allow the study of more complex interactions in biological systems. Combining proteomics and metabolomics to quantify changes in metabolites and their corresponding enzymes will advance our understanding of pathophysiological mechanisms and aid the identification of novel biomarkers for cardiovascular disease. (C) 2013 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S. L. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available