Review
Oncology
Dorian V. Ziegler, Katharina Huber, Lluis Fajas
Summary: Cell cycle regulators play a crucial role in the control of autophagy. Dysregulation of autophagy is closely related to cell cycle regulators and blocking cancer progression can be achieved by modulating both aspects.
Article
Oncology
Bin Wang, Qiaohong Gong, Fuhai Chen
Summary: The present study aimed to investigate the role of CDC25A in the progression of nasopharyngeal carcinoma and its potential mechanism. The results showed that CDC25A was highly expressed in NPC cell lines and silencing CDC25A inhibited cell proliferation, reduced the expression levels of Ki67 and PCNA, and induced G(1) arrest. Furthermore, E2F1 was found to bind CDC25A and regulate its expression at the transcriptional level.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Oncology
Min He, Yitao Wang, Jing Cai, Yan Xie, Chuntao Tao, Yuyou Jiang, Haiyu Li, Fangzhou Song
Summary: The study identified that lncRNA DLEU2 is significantly upregulated in cervical cancer tissues, promoting cell proliferation and accelerating the cell cycle. Through mechanisms such as inhibiting p53 expression, lncRNA DLEU2 may promote cell cycle progression by inhibiting the activity of the Notch signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Jie Li, Xu Han, Yan Gu, Jixiang Wu, Jianxiang Song, Zhan Shi, Huiwen Chang, Ming Liu, Yajun Zhang
Summary: The lncRNA MTX2-6 is significantly downregulated in ESCC tissues and cell lines, and its reduced expression is associated with larger tumors and poorer prognosis in ESCC patients. Overexpressed MTX2-6 functions as a competing endogenous RNA (ceRNA) by binding miR-574-5p, leading to elevated expression of SMAD4 in ESCC, ultimately inhibiting cell proliferation and promoting cell apoptosis. This axis of MTX2-6/miR-574-5p/SMAD4 clarifies its tumor suppressor role in ESCC progression and suggests potential therapeutic targets for ESCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Virology
Maximilian Ehrenfeld, Felicia Segeth, Klaus Mantwill, Corinna Brockhaus, Yuling Zhao, Christian Ploner, Andreas Kolk, Juergen E. Gschwend, Roman Nawroth, Per Sonne Holm
Summary: The two E2F-binding sites in the adenoviral E2-early promoter play a crucial role in the E1A-independent adenoviral DNA replication.
JOURNAL OF VIROLOGY
(2023)
Review
Cell Biology
Robert F. Brooks
Summary: Cell exit from quiescence following mitogenic stimulation is highly asynchronous and heterogeneous, with the RB-E2F and APC/C-CDH1 switches playing important roles in this dynamic process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Zhi-Guo Liu, Jing Su, Hao Liu, Xue-Jian Yang, Xue Yang, Ye Wei, Xin-Yao Zhu, Yong Song, Xian-Cheng Zhao, Hong-Lin Guo
Summary: This study identified the role of the E2F family in clear cell renal cell carcinoma (ccRCC) using RNA sequencing data and clinical data. The results showed that the expression levels of E2F1 to 4 and 6 to 8 were higher in ccRCC tissues, while E2F5 expression was lower. The expression of E2Fs was correlated with tumor stage, grade, and patient prognosis. Low expression of E2F1 to 5 and 7 to 8 was significantly associated with longer overall survival. The study also found correlations between E2F expression and DNA methylation and copy number, suggesting that E2F family genes could be potential targets for ccRCC molecular diagnosis and targeted therapy.
Article
Cell Biology
Zhongyi Zhou, Fengbo Tan, Qian Pei, Chenglong Li, Yuan Zhou, Yuqiang Li, Haiping Pei
Summary: In colorectal cancer, SNHG4 modulates cell cycle regulation through the miR-590-3p/CDK1 pathway to influence cell proliferation and transplanted tumor growth. Further validation using additional animal models and clinical investigations is required for the application of this axis.
Article
Entomology
Peng Chen, Ling Wang, Yan-Bi Long, Guang-Yan Liang, Xiu Yang, Zhan-Qi Dong, Xia Jiang, Yan Zhu, Min-Hui Pan, Cheng Lu
Summary: E2F4 plays a critical role in regulating the cell cycle in the silkworm, Bombyx mori. It can localize in the nucleus through interaction with the Bm14-3-3 zeta protein. These findings provide valuable insights into the function of E2F transcription factors and their involvement in cell cycle regulation.
Article
Biology
Bin Li, Lisi Zheng, Jiayi Ye, Chenmin Zhang, Jie Zhou, Qiaojuan Huang, Yanhua Guo, Luqin Wang, Peng Yu, Shurong Liu, Qiao Lin, Yuxia Luo, Hui Zhou, Jianhua Yang, Lianghu Qu
Summary: This study identifies previously unknown mechanisms of CREB1 in colorectal cancer cell plasticity, including the regulation of lncRNA CCAT1 and NF-kappa B pathways. Knocking out CREB1 triggers epithelial-mesenchymal transition (EMT), inhibits cell proliferation, and enhances cell motility.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kuriko Doi, Hiroto Takeuchi, Hiroshi Sakurai
Summary: The RB tumor suppressor protein, which is involved in cell proliferation and gene expression, is regulated by the phosphorylation state. This study reveals the role of protein phosphatase 2A (PP2A) adapter proteins IER2 and IER5 in RB dephosphorylation, which affects cell proliferation and gene expression. IER2 promotes the dephosphorylation of RB, while IER5 interacts with both RB and RB-like 1 (p107/RBL1) to enhance their dephosphorylation by PP2A.
Article
Multidisciplinary Sciences
Simon Gemble, Rene Wardenaar, Kristina Keuper, Nishit Srivastava, Maddalena Nano, Anne-Sophie Mace, Andrea E. Tijhuis, Sara Vanessa Bernhard, Diana C. J. Spierings, Anthony Simon, Oumou Goundiam, Helfrid Hochegger, Matthieu Piel, Floris Foijer, Zuzana Storchova, Renata Basto
Summary: This study reveals that human cells experience high levels of DNA damage during DNA replication in the first S phase following tetraploidy induction. These damages are caused by protein shortage during the G1/S transition, resulting in inaccurate DNA replication. These findings provide an explanation for the genetic instability landscape that favors tumorigenesis after tetraploidization.
Article
Oncology
Kangping Xiong, Gang Wang, Tianchen Peng, Fenfang Zhou, Siming Chen, Wei Liu, Lingao Ju, Yu Xiao, Kaiyu Qian, Xinghuan Wang
Summary: The study demonstrates that avasimibe can suppress tumor growth and migration through modulation of cell cycle-related proteins and EMT-related proteins via the E2F-1 signaling pathway, indicating its potential as a new effective drug for prostate cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Jin-Yu Liu, Ya-Jing Chen, Huan-Hui Feng, Zhan-Li Chen, Yun-Long Wang, Jin-E Yang, Shi-Mei Zhuang
Summary: The study reveals that SNHG17 interacts with LRPPRC to enhance c-Myc expression, accelerate G1/S transition and cell proliferation, promoting tumor growth. High levels of SNHG17 or LRPPRC are associated with lower survival rates in HCC patients.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Xinyu Wei, Shuang Tao, Huilan Mao, Haitao Zhu, Lingyu Mao, Wenhao Pei, Xiuru Shi, Yingxiang Shi, Shiwen Zhang, Yulun Wu, Ke Wei, Jing Wang, Siyan Pang, Wenrui Wang, Changjie Chen, Qingling Yang
Summary: This study found that lncRNA NEAT1 is highly expressed in BC cells and exosomes. NEAT1 promotes migration and paclitaxel resistance in BC cells, while downregulation of NEAT1 reduces drug resistance. In addition, downregulation of NEAT1 decreases migration and proliferation of BC cells by inhibiting CXCL12 expression and reducing miR-133b adsorption. This study reveals that exosomal lncRNA NEAT1 derived from SKBR3/PR cells in the tumor microenvironment can induce paclitaxel resistance, cell migration, and growth, and may serve as a new target for clinical treatment of BC.
Article
Multidisciplinary Sciences
Kyle Tretina, Malak Haidar, Sally A. Madsen-Bouterse, Takaya Sakura, Sara Mfarrej, Lindsay Fry, Marie Chaussepied, Arnab Pain, Donald P. Knowles, Vishvanath M. Nene, Doron Ginsberg, Claudia A. Daubenberger, Richard P. Bishop, Gordon Langsley, Joana C. Silva
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Rotem Ben-Hamo, Adi Jacob Berger, Nancy Gavert, Mendy Miller, Guy Pines, Roni Oren, Eli Pikarsky, Cyril H. Benes, Tzahi Neuman, Yaara Zwang, Sol Efroni, Gad Getz, Ravid Straussman
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Rivki Cashman, Alona Zilberberg, Avner Priel, Hagit Philip, Alexander Varvak, Avi Jacob, Irit Shoval, Sol Efroni
NPJ PRECISION ONCOLOGY
(2020)
Meeting Abstract
Oncology
D. E. Anderson, A. Zilberberg, H. Philip, M. Gordon, A-C. Fluckiger, S. Efroni, F. Diaz-Mitoma
ANNALS OF ONCOLOGY
(2020)
Article
Genetics & Heredity
Nili Tickotsky-Moskovitz, Yoram Louzoun, Shirit Dvorkin, Adi Rotkopf, Amir Asher Kuperman, Sol Efroni
Summary: This study found that the CDR3 sequence composition does not change during restoration post-allo-BMT and is dependent on HLA typing, while V-gene usage follows a time-dependent pattern, initially following the donor profile and then shifting back to the recipient profile. The differences in V-gene distribution between donors and recipients may serve as clinical biomarkers for monitoring immune recovery.
Article
Biochemical Research Methods
Miri Gordin, Hagit Philip, Alona Zilberberg, Moriah Gidoni, Raanan Margalit, Christopher Clouser, Kristofor Adams, Francois Vigneault, Irun R. Cohen, Gur Yaari, Sol Efroni
Summary: The study focused on the clonal behavior of T cells during mammary tumor development in mice, identifying specific T cell clones strongly associated with human breast cancer, leading to a better understanding of the immune system's role in cancer. By analyzing T cell receptor repertoires in mice and humans with breast cancer, the research identified shared TCR sequences across species as potential biomarkers for breast cancer development.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hagit Philip, Tom Snir, Miri Gordin, Mikhail Shugay, Alona Zilberberg, Sol Efroni
Summary: This study quantified the dynamics of the T cell receptor repertoire during treatment with anti-CTLA-4 in a mouse model for colorectal cancer, revealing that the response to treatment is closely connected to shared and public parts of the T cell repertoire, dominated by specific motifs and time-dependent behaviors of specific TCR sequences. The research also emphasizes the importance of temporal analyses of the immune response, showing that a specific time point might be useful in assessing the true response to treatment.
Article
Multidisciplinary Sciences
Adar Hacohen, Reuven Cohen, Sol Efroni, Ido Bachelet, Baruch Barzel
Summary: Efficient global distribution of a therapeutic for a global pandemic relies on considering the quantity and spreading patterns of the therapeutic, as well as the anticipated demand. Optimizing for supply volume alone can lead to inefficient mitigation, but prioritizing supply congruency with spreading patterns can significantly improve overall efficiency.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Dhiego Souto Andrade, Patrick Terrematte, Cesar Renno-Costa, Alona Zilberberg, Sol Efroni
Summary: This paper introduces GENTLE, an open-source and user-friendly web application tool for TCR repertoire researchers. It allows for the discovery of important features, creation and evaluation of classifier models, and quick generation of visualizations. A case study on TRegs and TConvs repertoire data showed the effectiveness of diversity features in distinguishing between healthy controls and breast cancer patients, and the accuracy of classifiers built with these features.
BMC BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Tom Snir, Hagit Philip, Miri Gordin, Alona Zilberberg, Sol Efroni
Summary: Immunotherapy plays a crucial role in cancer treatment, and the unique characteristics of an individual's T cell receptor repertoire are essential for its effectiveness. This study analyzed the repertoire through sequencing and generated a longitudinal dataset of T cell clones and their abundance after anti-CTLA-4 treatment in a mouse model for colorectal cancer. The dynamics of the repertoire over four weeks showed the ascending and descending clonal expansion of specific clones in response to treatment. The data can be used for treatment determination and prediction of its effect, as well as providing insights into the behavior of the immune system over time.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Dani Livne, Sol Efroni
Summary: Biochemical pathways analysis is an effective tool for understanding changes in gene expression data and associating such changes with cellular phenotypes. Pathway research aims to identify associated proteins within a cell using pathways and at building new pathways from a group of molecules of interest.
BIOINFORMATICS AND BIOMEDICAL ENGINEERING, PT II
(2022)
Article
Immunology
Irun R. Cohen, Sol Efroni, Henri Atlan
CRITICAL REVIEWS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Tom Snir, Sol Efroni
CURRENT OPINION IN SYSTEMS BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Orr Levy, Guy Amit, Dana Vaknin, Tom Snir, Sol Efroni, Peter Castaldi, Yang-Yu Liu, Haim Y. Cohen, Amir Bashan
Meeting Abstract
Oncology
Hagit Philip, Tom Snir, Miri Gordin, Yoav Wigelman, Alona Zilberberg, Sol Efroni
CANCER IMMUNOLOGY RESEARCH
(2020)