Article
Cell Biology
Mariela Artola-Boran, Angela Fallegger, Martina Priola, Rima Jeske, Tim Waterboer, Anders B. Dohlman, Xiling Shen, Sebastian Wild, Jiazhuo He, Mitchell P. Levesque, Shida Yousefi, Hans-Uwe Simon, Phil F. Cheng, Anne Mueller
Summary: The co-existence of Helicobacter pylori and Mycobacterium tuberculosis can affect each other's colonization and immune control in the human body, which should be taken into consideration in treatment decisions.
Article
Genetics & Heredity
Qi Liu, Danyan Li, Yunkai Dai, Yunzhan Zhang, Shaoyang Lan, Qi Luo, Jintong Ye, Xu Chen, Peiwu Li, Weijing Chen, Ruliu Li, Ling Hu
Summary: This study aimed to investigate the relationship between miR-146a, miR-196a2, miR-149, miR-499, and miR-27a gene single nucleotide polymorphisms (SNPs) and their expressions with pathological changes in gastric mucosa, and to further analyze the interactions between SNPs and Hp. The results showed that miR-196a2 rs11614913 and miR-27a rs895819 may affect the genetic susceptibility to gastric precancerous lesions (GPL) or gastric cancer (GC). The up-regulation of miR-499, miR-196a2, and miR-27a expression caused by Hp infection may be an important mechanism of gastric carcinogenesis.
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Serena Battista, Maria Raffaella Ambrosio, Francesco Limarzi, Graziana Gallo, Luca Saragoni
Summary: The article reviews the diagnostic and prognostic values of molecular markers in gastric cancer, focusing on the correlation between molecular alterations and prognosis in preinvasive neoplasia and early gastric cancer, as well as the (immuno)histochemical characterization of diffuse-type gastric cancer. The aim is to evaluate suitable biomarkers used in the pre-surgical phase for distinguishing patients with different prognoses and determining the best therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yoichi Akazawa, Hiroya Ueyama, Takuo Hayashi, Hisanori Utsunomiya, Ryota Uchida, Daiki Abe, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Noboru Yatagai, Hiroyuki Komori, Tsutomu Takeda, Kohei Matsumoto, Kumiko Ueda, Kenshi Matsumoto, Daisuke Asaoka, Mariko Hojo, Tsuyoshi Saito, Takashi Yao, Akihito Nagahara
Summary: This study investigates the clinicopathological and molecular features of HP-uninfected gastric adenocarcinoma and finds that it has distinct clinicopathologic and endoscopic characteristics. Moreover, HP-uninfected DGAs, especially those with a gastrointestinal phenotype, may be characterized by recurrent APC mutations.
JOURNAL OF GASTROENTEROLOGY
(2022)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Microbiology
Lei Peng, Yang Guo, Markus Gerhard, Juan-Juan Gao, Zong-Chao Liu, Raquel Mejias-Luque, Lian Zhang, Michael Vieth, Jun-Ling Ma, Wei-Dong Liu, Zhe-Xuan Li, Tong Zhou, Wen-Qing Li, Wei-Cheng You, Yang Zhang, Kai-Feng Pan
Summary: A panel including differential metabolites, genera, and their interactions was established in this study to discriminate high-risk subjects for progression from mild lesions to advanced precancerous lesions in short-term and long-term follow-up. Metabolites and their interactions with microbiota may be involved in Helicobacter pylori-associated gastric lesion development.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Rina Fujiwara-Tani, Tadataka Takagi, Shiori Mori, Shingo Kishi, Yukiko Nishiguchi, Takamitsu Sasaki, Masayuki Ikeda, Kenta Nagai, Ujjal Kumar Bhawal, Hitoshi Ohmori, Kiyomu Fujii, Hiroki Kuniyasu
Summary: Gastric cancers are closely associated with Helicobacter pylori infection and intestinal metaplasia. Telomere reduction and dysplastic metaplasia (DM) were found to be characteristics of high-risk intestinal metaplasia. A 10-year follow-up study revealed that high-grade DM cases have a high risk of progressing to gastric cancer, suggesting the importance of identifying and treating high-grade DM in H. pylori-positive patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Adriano Costa, Fernando Santa-Cruz, Raphael L. C. Araujo, Glauber Leitao, Jose-Luiz Figueiredo, Alvaro A. B. Ferraz
Summary: This study suggests that CTTS expression is higher in gastric adenocarcinoma samples, and there is a correlation between CTTS expression and gastritis caused by H. pylori.
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Oncology
Peipei Gao, Ning Cai, Xiaorong Yang, Ziyu Yuan, Tiejun Zhang, Ming Lu, Li Jin, Weimin Ye, Chen Suo, Xingdong Chen
Summary: The study found a positive association between Helicobacter pylori infection and gastric atrophy with the risk of adenocarcinoma of the esophagogastric junction (AEGJ). Specifically, the relationship between gastric atrophy and AEGJ risk may not be significantly modified by H. pylori infection.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Emily Taillieu, Chloe De Witte, Heiko De Schepper, Wouter Van Moerkercke, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Sven Francque, Frauke van Aert, Christophe George, Emma Callewaert, Tiene Callewaert, Glenn Vanneste, Erik Vanderstraeten, Nina Van Heddegem, Margaux Vansteelant, Koen Chiers, Freddy Haesebrouck, Christophe Van Steenkiste
Summary: This study reveals that gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals are linked with gastric disease in human patients. The findings suggest that routine PCR testing for zoonotic gastric NHPHs should be conducted on patients with gastric complaints to diagnose potential pathogens.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Microbiology
Ling Zhang, Ming Zhao, Xiangsheng Fu
Summary: Helicobacter pylori (H. pylori) infection is a common cause of gastric disease, but the increase in antibiotic resistance has made it challenging to eradicate. The stomach has a unique microecology that can have positive, negative, or neutral effects on microbial fitness and function. This article reviews the imbalance of gastric microecology and its relationship with H. pylori, as well as potential methods for modulating gastric microecology to facilitate H. pylori eradication, such as probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante, Davide Franceschini, Ciro Franzese, Marta Scorsetti, Andrea Marrari, Raffaele Cavina, Salvatore Marano, Carlo Castoro, Giuseppe Spriano
Summary: Definitive chemoradiotherapy is a valuable first-line treatment for cervical esophageal squamous cell carcinoma (CESCC) with favorable oncological outcomes. Further research is needed to identify survival predictors for stage-based clinical guidelines.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pathology
Gianluca Russo, Francesco Pepe, Pasquale Pisapia, Lucia Palumbo, Mariantonia Nacchio, Elena Vigliar, Pierlorenzo Pallante, Paola Parente, Matteo Fassan, Paolo Graziano, Claudio Bellevicine, Giancarlo Troncone, Umberto Malapelle, Antonino Iaccarino
Summary: This article reviews the results of microsatellite instability (MSI) evaluation using a customized workflow and microfluidic system in a diagnostic routine practice over a period of 4 years. The results showed that the majority of patients with metastatic colorectal cancer (mCRC) had microsatellite stability (MSS) profile, while a minority had microsatellite high (MSI-H) profile. Similarly, in patients without colorectal cancer, both MSS and MSI-H profiles were observed.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Valentina Mari, Valentina Angerilli, Giada Munari, Marco Scarpa, Quoc Riccardo Bao, Salvatore Pucciarelli, Matteo Fassan, Gaya Spolverato
Summary: This review outlines the molecular pathways involved in peritoneal metastatic dissemination in gastric cancer, highlighting the lack of comprehensive understanding of the complex molecular landscape of this disease. The integration of molecular profiling and histological evaluation is recommended for risk prediction assessment of peritoneal dissemination.
DIGESTIVE DISEASES
(2023)
Article
Pathology
Federica Grillo, Luca Carlin, Andrea Remo, Matteo Fassan, Claudia Mescoli, Michela Campora, Luigi Caserta, Fabrizio Mazza, Luca Mastracci
Summary: Dasatinib-induced colitis may present histological features similar to Crohn's disease, including microgranulomas and active inflammation, and complete remission can be achieved after treatment interruption.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Surgery
Gianluca Businello, Valentina Angerilli, Sara Lonardi, Francesca Bergamo, Michele Valmasoni, Fabio Farinati, Edoardo Savarino, Gaya Spolverato, Matteo Fassan
Summary: The comprehensive molecular characterization of gastric and gastroesophageal junction adenocarcinomas has improved targeted and effective treatments, introducing biomarkers into clinical practice. The evaluation mainly relies on limited biopsy material, making pathologists essential in patient selection for precision medicine approaches.
UPDATES IN SURGERY
(2023)
Article
Oncology
Alessandra A. Prete, Paolo Manca, Marco Messina, Vincenzo Formica, Giovanni L. Frassineti, Maria G. Zampino, Domenico C. Corsi, Corrado Orciuolo, Michele Prisciandaro, Francesca Bergamo, Valentina Angerilli, Mario Scartozzi, Mariaelena Casagrande, Gianluca Masi, Monica Ronzoni, Federica Morano, Valentina Vettore, Roberta Salmaso, Cosimo Rasola, Giulia Maddalena, Paola del Bianco, Massimo Milione, Chiara Cremolini, Matteo Fassan, Filippo Pietrantonio, Sara Lonardi
Summary: This study found that patients with high PD-L1 and high TMB had better survival outcomes when treated with immune checkpoint inhibitors for advanced squamous cell anal carcinoma.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Margherita Rimini, Carles Fabregat-Franco, Mara Persano, Valentina Burgio, Francesca Bergamo, Monica Niger, Mario Scartozzi, Ilario Giovanni Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Summary: This study investigated the prognostic impact of IDH1 mutations in patients with advanced iCCA after progression on first-line therapies. The presence of IDH1 mutations was associated with worse overall survival and worse objective response rate in second-line therapy. IDH1 mutations were confirmed as an independent negative prognostic factor.
Review
Health Care Sciences & Services
Alessandro Mangogna, Giada Munari, Francesco Pepe, Edoardo Maffii, Pierluigi Giampaolino, Giuseppe Ricci, Matteo Fassan, Umberto Malapelle, Stefania Biffi
Summary: Homologous recombination deficiency (HRD) refers to the inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway. It serves as a predictive biomarker for the clinical use of poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors and platinum-based chemotherapy in ovarian cancers. However, HRD is a complex genomic signature, and various methods of analysis have been developed for HRD testing in the clinical setting.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Grazia Vernaci, Edoardo Vincenzo Savarino, Ilaria Patuzzi, Sonia Facchin, Fabiana Zingone, Davide Massa, Giovanni Faggioni, Tommaso Giarratano, Federica Miglietta, Gaia Griguolo, Matteo Fassan, Marcello Lo Mele, Elisa Gasparini, Giancarlo Bisagni, Valentina Guarneri, Maria Vittoria Dieci
Summary: This article evaluates the feasibility of analyzing the gut microbiome in patients with early stage triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy, and explores its impact on treatment response and clinicopathologic factors. The study suggests that analyzing the gut microbiome may have potential significance in early TNBC, but further investigation is needed to understand its complex correlation with immunity and cancer.
Article
Pathology
Federica Zannier, Valentina Angerilli, Gaya Spolverato, Stefano Brignola, Daniele Sandona, Mariangela Balistreri, Marianna Sabbadin, Sara Lonardi, Francesca Bergamo, Claudia Mescoli, Marco Scarpa, Quoc Riccardo Bao, Angelo Paolo Dei Tos, Salvatore Pucciarelli, Emanuele L. D. Urso, Matteo Fassan
Summary: This study aimed to compare the pathological and clinical characteristics of MMR-deficient (MMRd) tumors and MMR proficient (MMRp) cases, with a particular focus on the relationship between these molecular subgroups and lymph node ratio (LNR). The study found significant differences between MMRd and MMRp tumors in terms of sex, age, size, growth pattern, inflammatory infiltrate, perineural invasion, stage, grade, and LNR. In conclusion, MMRd tumors are a distinct molecular subtype of colorectal cancer characterized by a significantly lower LNR, further supporting the prognostic impact of MMRd status in early-stage CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Valentina Angerilli, Paola Parente, Gianluca Businello, Alessandro Vanoli, Michele Paudice, Giovanni Perrone, Giada Munari, Ilaria Govoni, Giuseppe Neri, Elena Rebellato, Paola Parrella, Federica Grillo, Luca Mastracci, Matteo Fassan
Summary: Colorectal adenosquamous carcinoma (ASC) is a rare and aggressive disease with a higher metastatic rate and worse outcome than conventional colorectal adenocarcinoma. The molecular profile of this type of cancer needs further investigation.
Article
Oncology
Federica Miglietta, Moira Ragazzi, Bethania Fernandes, Gaia Griguolo, Davide Massa, Fabio Girardi, Michele Bottosso, Alessandra Bisagni, Giovanni Zarrilli, Francesca Porra, Daniela Iannaccone, Leocadia Dore, Mariangela Gaudio, Giacomo Santandrea, Matteo Fassan, Marcello Lo Mele, Rita De Sanctis, Alberto Zambelli, Giancarlo Bisagni, Valentina Guarneri, Maria Vittoria Dieci
Summary: The prognostic significance of tumor-infiltrating lymphocyte on residual disease (RD-TIL) in HER2+ patients with breast cancer who failed to achieve pathologic complete response (pCR) after anti-HER2+ chemotherapy (CT)-based neoadjuvant treatment (NAT) was evaluated. The study found that both RCB and RD-TIL were significantly associated with overall survival (OS) and could be used to predict patient prognosis. Additionally, a new composite prognostic score, RCB+TIL, was developed and found to be more informative than the isolated evaluation of RCB and RD-TILs.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Laura Bonanno, Martina Lorenzi, Davide Massa, Mattia De Nuzzo, Valentina Angerilli, Fabiana Zingone, Brigida Barberio, Alberto Russi, Fabio Girardi, Alessandra Ferro, Alessandro Dal Maso, Stefano Frega, Giulia Pasello, Angelo Paolo Dei Tos, Marina Coppola, Matteo Fassan, Edoardo Vincenzo Savarino, Valentina Guarneri
Summary: This study collected real-world data on the occurrence of immune-mediated diarrhea and colitis in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors, and assessed the clinical impact of a multidisciplinary approach on the management of this adverse event.
Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Article
Oncology
Daniela Brina, Adele Ponzoni, Martina Troiani, Bianca Cali, Emiliano Pasquini, Giuseppe Attanasio, Simone Mosole, Michela Mirenda, Mariantonietta D'Ambrosio, Manuel Colucci, Ilaria Guccini, Ajinkya Revandkar, Abdullah Alajati, Toma Tebaldi, Deborah Donzel, Fabio Lauria, Nahjme Parhizgari, Aurora Valdata, Martino Maddalena, Arianna Calcinotto, Marco Bolis, Andrea Rinaldi, Simon Barry, Jan Hendrik Rueschoff, Marianna Sabbadin, Semini Sumanasuriya, Mateus Crespo, Adam Sharp, Wei Yuan, Mathew Grinu, Alexandra Boyle, Cynthia Miller, Lloyd Trotman, Nicolas Delaleu, Matteo Fassan, Holger Moch, Gabriella Viero, Johann de Bono, Andrea Alimonti
Summary: In prostate cancer, the secretome is rewired at the translational level to recruit MDSCs, with Hgf, Spp1, and Bgn identified as key regulators. By inhibiting the MNK/eIF4E and AKT pathways, this study provides a therapeutic strategy that combines translation inhibition with immunotherapy to restore immune surveillance in prostate cancer.