Article
Pharmacology & Pharmacy
Woo-Yul Lee, Dong-Woo Chae, Choon-Ok Kim, Sang-Eun Lee, Yee-Gyung Kwak, Joon-Sup Yeom, Kyung-Soo Park
Summary: The study aimed to develop a population pharmacokinetic model of primaquine and its metabolite, and found that body weight and CYP2D6 activity significantly impact primaquine pharmacokinetics. The results showed that weight and enzyme activity play crucial roles in drug metabolism and can influence drug exposure levels.
Article
Emergency Medicine
Timothy Visclosky, William Schaeffer, Elaine Pomeranz, Daphne Morrison Ponce
Summary: Overdose of primaquine can lead to methemoglobinemia and hemolytic anemia in G6PD deficient patients, requiring cautious management. This article presents a case of a toddler with severe toxicity following an accidental overdose, whose condition improved after treatment.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jasmine M. Olvany, Scott M. Williams, Peter A. Zimmerman
Summary: Clinical trials and treatment outcomes have shown that genetic variation in the human cytochrome P450 gene, CYP2D6, is associated with effective primaquine treatment for malaria caused by Plasmodium vivax and P. ovale. Coordinated efforts between malaria and pharmacogenomics research communities are needed to optimize safe and effective PQ treatment for global malaria elimination.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Will Stone, Almahamoudou Mahamar, Merel J. Smit, Koualy Sanogo, Youssouf Sinaba, Sidi M. Niambele, Adama Sacko, Sekouba Keita, Oumar M. Dicko, Makonon Diallo, Seydina O. Maguiraga, Siaka Samake, Oumar Attaher, Kjerstin Lanke, Rob Ter Heine, John Bradley, Matthew B. B. McCall, Djibrilla Issiaka, Sekou F. Traore, Teun Bousema, Chris Drakeley, Alassane Dicko
Summary: By combining with dihydroartemisinin-piperaquine, three single low doses of tafenoquine can effectively reduce the infection and transmission rates of Plasmodium falciparum. Tafenoquine is well tolerated and can accelerate the clearance of gametocytes.
Article
Multidisciplinary Sciences
Soy Ty Kheang, Rosemarie Ridley, Eng Ngeth, Por Ir, Pengby Ngor, Siv Sovannaroth, Dysoley Lek, Somaly Phon, Neeraj Kak, Shunmay Yeung
Summary: Cambodia aims to eliminate malaria, but tackling P.v presents multiple challenges. The design, implementation, and evaluation of a new care pathway for radical cure treatment is crucial.
Article
Pharmacology & Pharmacy
Rajeev K. Mehlotra, Andrea Gaedigk, Rosalind E. Howes, Tovonahary A. Rakotomanga, Arsene C. Ratsimbasoa, Peter A. Zimmerman
Summary: The study found genetic variation in CYP2D6 in the population of Madagascar, where some individuals are predicted to be intermediate metabolizers, which is associated with therapeutic failure of PQ. The results also provide insights into the unique Asian-African admixed origin of Malagasy populations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Andreas Wangdahl, Klara Sonden, Katja Wyss, Christine Stenstrom, David Bjorklund, Jessica Zhang, Helena Hervius Askling, Christina Carlander, Urban Hellgren, Anna Farnert
Summary: The risk of relapse is lower in P. ovale compared to P. vivax and primaquine is effective in preventing P. vivax relapse. Few relapse episodes were observed in P. ovale and the evidence for primaquine remains limited in this species.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Wen Zeng, Ning Liu, Yuchun Li, Ai Gao, Mengyi Yuan, Rui Ma, Na Jiang, Dingwei Sun, Guangze Wang, Xinyu Feng
Summary: This study investigated the prevalence of G6PD deficiency in ancient malaria-endemic areas of Hainan. The results showed that the prevalence of G6PD deficiency was significantly higher in males, Li ethnic minority, and malaria patients compared to females, Han ethnic majority, and non-malarial patients. The spatial distribution of G6PD deficiency and malaria were different.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Microbiology
Pattaraporn Vanachayangkul, Darapiseth Sea, Mariusz Wojnarski, Somethy Sok, Chanikarn Kodchakorn, Winita Ta-Aksorn, Sohei Hom, Mali Ittiverakul, Worachet Kuntawunginn, Montri Arsanok, Nillawan Buathong, Thay Kheang Heng, Kong Nareth, Samon Nou, Sok Chandara, Sokna Ly, Pheaktra Oung, Brian Vesely, Jason Bennett, Gregory Reichard, Brandon Pybus, Charlotte Lanteri, David Saunders, Mark Fukuda, Philip Smith, Lek Dysoley, Huy Rekol, Norman C. Waters, Michele Spring
Summary: The active metabolites of primaquine, especially 5-hydroxyprimaquine, are produced through the hepatic CYP450 2D6 enzymatic pathway. This study found that the CYP2D6 *10 reduced activity allele was present in 57% of volunteers, and there were differences in primaquine metabolism between Normal Metabolizers and Intermediate Metabolizers. Future research may reveal the relationship between urine 5,6-orthoquinone levels and primaquine radical cure efficacy.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Public, Environmental & Occupational Health
G. Dennis Shanks
Summary: Since their first use in the 1920s, 8-aminoquinolines have been known to have important toxicities. However, when combined with other antimalarial drugs, particularly quinine or chloroquine, they can enhance efficacy and reduce toxicity.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Public, Environmental & Occupational Health
Yoon-A Park, Ki Hyun Park, Ha Young Yoon, Jeong Yee, Hye Sun Gwak
Summary: This meta-analysis confirms the association between CYP2D6 polymorphisms and Plasmodium vivax recurrence. The results can be used to predict P. vivax recurrence and suggest genotype-based primaquine dosing.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Chemistry, Medicinal
Caroline de Souza Pereira, Helenita Costa Quadros, Diogo Rodrigo Magalhaes Moreira, William Castro, Romulo Ivisson Santos De Deus Da Silva, Milena Botelho Pereira Soares, Diana Fontinha, Miguel Prudencio, Vinicius Schmitz, Helio F. Dos Santos, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Bruno Pradines, Maribel Navarro
Summary: The study presented a novel metallic hybrid antimalarial agent with potential dual efficacy in multiple erythrocytic stages of Plasmodium parasites. This hybrid compound showed promising in vitro and in vivo antimalarial activity against both blood and liver stages of the parasites, indicating its potential as a new chemotherapeutic agent for malaria treatment, prevention, and transmission.
Article
Microbiology
Marielle M. Macedo, Anne C. G. Almeida, Gabrielly S. Silva, Amanda C. Oliveira, Victor I. Mwangi, Ana C. Shuan, Laila R. A. Barbosa, Fernanda Rodrigues-Soares, Gisely C. Melo
Summary: Chloroquine plus primaquine is the recommended treatment for Plasmodium vivax in the Amazon. However, there are limitations due to the risk of hemolytic anemia in glucose-6-phosphate dehydrogenase (G6PD) deficiency. This study aimed to explore the influence of G6PD and cytochrome P450 enzymes on the treatment efficacy and adverse effects in malaria patients.
Article
Multidisciplinary Sciences
Yu Nandar Aung, Sai Thein Than Tun, Viengxay Vanisaveth, Keobouphaphone Chindavongsa, Lucy Kanya
Summary: This study examines the cost-effectiveness of different strategies for G6PD testing in Laos. The results show that while G6PD testing is more costly, it can improve the treatment outcomes. However, the effectiveness of G6PD testing in practice may be influenced by various factors.
Review
Infectious Diseases
Erni J. J. Nelwan, Sharifah Shakinah, Adeline Pasaribu
Summary: This study analyzed the association between glucose-6-phosphate-dehydrogenase deficiency (G6PDd) and anemia in malaria patients receiving anti-malarial drugs. The study found that single or daily standard doses of primaquine (0.25 mg/kg/day) and weekly primaquine (0.75 mg/kg/week) did not increase the risk of anemia in G6PDd patients.
Review
Cell Biology
Michelli Erica Souza Ferreira, Amanda Soares de Vasconcelos, Thyago da Costa Vilhena, Thiago Leite da Silva, Aline da Silva Barbosa, Antonio Rafael Quadros Gomes, Maria Fani Dolabela, Sandro Percario
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2015)
Review
Biochemistry & Molecular Biology
Sandro Percario, Danilo R. Moreira, Bruno A. Q. Gomes, Michelli E. S. Ferreira, Ana Carolina M. Goncalves, Paula S. O. C. Laurindo, Thyago C. Vilhena, Maria F. Dolabela, Michael D. Green
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2012)
Review
Cell Biology
Sandro Percario, Aline da Silva Barbosa, Everton Luiz Pompeu Varela, Antonio Rafael Quadros Gomes, Michelli Erica Souza Ferreira, Thayana de Nazare Araujo Moreira, Maria Fani Dolabela
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Multidisciplinary Sciences
Danilo Reymao Moreira, Ana Carolina Musa Goncalves Uberti, Antonio Rafael Quadros Gomes, Michelli Erica Souza Ferreira, Aline da Silva Barbosa, Everton Luiz Pompeu Varela, Maria Fani Dolabela, Sandro Percario
Summary: Inhibition of iNOS by dexamethasone increased the survival rate of Plasmodium berghei-infected mice, indicating a potential role of oxidative stress in the brain during plasmodial infection. Inhibiting brain iNOS also decreased parasitemia and improved the survival rate of infected animals.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Eduardo C. Nery, Aluisio M. S. Neto, Jorge S. Lyra, Michelli E. S. Ferreira
Summary: This study found that cervical cancer patients had lower antioxidant activity, indicating that changes in antioxidant defense may contribute to the pathophysiology of cervical cancer.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Public, Environmental & Occupational Health
Jose Luiz Vieira, Michelle E. S. Ferreira, Michelle V. D. Ferreira, Margarete M. Gomes
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2017)
