Article
Critical Care Medicine
Jason Akulian, Eihab O. Bedawi, Hawazin Abbas, Christine Argento, David T. Arnold, Akshu Balwan, Hitesh Batra, Juan Pablo Uribe Becerra, Adam Belanger, Kristin Berger, Allen Cole Burks, Jiwoon Chang, Ara A. Chrissian, David M. DiBardino, Xavier Fonseca Fuentes, Yaron B. Gesthalter, Christopher R. Gilbert, Kristen Glisinski, Mark Godfrey, Jed A. Gorden, Horiana Grosu, Mridul Gupta, Fayez Kheir, Kevin C. Ma, Adnan Majid, Fabien Maldonado, Nick A. Maskell, Hiren Mehta, Joshua Mercer, John Mullon, Darlene Nelson, Elaine Nguyen, Edward M. Pickering, Jonathan Puchalski, Chakravarthy Reddy, Alberto E. Revelo, Lance Roller, Ashutosh Sachdeva, Trinidad Sanchez, Priya Sathyanarayan, Roy Semaan, Michal Senitko, Samira Shojaee, Ryan Story, Jeffrey Thiboutot, Momen Wahidi, Candice L. Wilshire, Diana Yu, Aline Zouk, Najib M. Rahman, Lonny Yarmus
Summary: Combination intrapleural fibrinolytic and enzyme therapy (IET) carries a low overall bleeding risk in pleural infection. The concurrent use of therapeutic anticoagulation increases the bleeding rates, which can be mitigated by withholding anticoagulation before treatment. Parameters related to higher bleeding risk have been identified.
Article
Respiratory System
Alexandra Townsend, Harsha Raju, Krystina A. Serpa, Rachel Pruett, Syed S. Razi, Francisco A. Tarrazzi, Catherine M. Tami, Mark I. Block
Summary: This study retrospectively reviewed the use of low dose tPA with a 12-hour dwell time for the management of complex pleural effusions. The results suggest that this regimen may be as effective as the standard daily tPA and DNAse regimen.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
David T. Arnold, Emma Tucker, Anna Morley, Alice Milne, Louise Stadon, Sonia Patole, George W. Nava, Steven P. Walker, Nick A. Maskell
Summary: Therapeutic thoracentesis may reduce hospital stay in pleural infection.
BMC PULMONARY MEDICINE
(2022)
Article
Infectious Diseases
Yoshiki Shiraishi, Kirill Kryukov, Katsuyoshi Tomomatsu, Fumio Sakamaki, Shigeaki Inoue, So Nakagawa, Tadashi Imanishi, Koichiro Asano
Summary: This study aimed to identify probable causative bacteria in pleural empyema/parapneumonic effusions by combining 16S rRNA gene amplification and next-generation sequencing (NGS). NGS results were discordant with culture results in some patients who had been treated with antibiotics. Total and specific bacterial loads calculated using semi-quantitative PCR could efficiently distinguish infectious effusions from non-infectious effusions.
INFECTIOUS DISEASES
(2021)
Article
Immunology
Tadashi Hoshino, Daisuke Nishima, Mayumi Enseki, Naoki Umehara, Chie Fukasawa, Naruhiko Ishiwada
Summary: This nationwide survey on pediatric PPE/PE in Japan provides important insights into the clinical and bacteriologic features of the condition. The findings show a different trend in etiology compared to other countries and raise concerns about the underutilization of molecular methods for pathogenic diagnosis and the overuse of carbapenems. The establishment of clinical guidelines for PPE/PE in Japan is therefore imperative.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Jang Ho Lee, Chang-Min Choi, Namu Park, Hyung Jun Park
Summary: This study utilized deep learning models and contrastive-loss approach to classify the etiology of pleural effusion. The contrastive-loss model demonstrated the highest accuracy and provided visualization of typical and atypical effusion results. These findings offer valuable insights for clinicians in etiology diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Johannes Forster, Giuseppina Piazza, David Goettler, Daniel Kemmling, Christoph Schoen, Markus Rose, Andrea Streng, Johannes G. Liese
Summary: The study found that prehospital antibiotic therapy (PH-ABT) in children with PPE/PE shortened the hospital length of stay, reduced the rate of intensive care unit admission and infectious complications, but also decreased the overall rate of bacterial pathogen detection. However, PH-ABT did not affect the overall duration of the disease.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Respiratory System
Michele Mondoni, Laura Saderi, Federica Trogu, Silvia Terraneo, Paolo Carlucci, Filippo Ghelma, Stefano Centanni, Giovanni Sotgiu
Summary: Medical thoracoscopy is effective and safe in treating complicated parapneumonic effusions and empyema, with a high success rate. Bacteriological negativity of pleural effusion specimens and the use of intra-pleural fibrinolysis post-procedure are associated with an increased success rate.
BMC PULMONARY MEDICINE
(2021)
Article
Pediatrics
Luis Moral, Teresa Toral, Agustin Clavijo, Maria Caballero, Francisco Canals, Maria Jose Fornies, Jorge Moral, Raquel Revert, Raquel Lucas, Ana Maria Huertas, Maria Cristina Gonzalez, Belen Garcia-Aviles, Monica Belda, Nuria Marco
Summary: The size of parapneumonic effusion (PPE) is strongly correlated with its severity and length of hospital stay (LHS). Most patients can be treated with antibiotics alone, reducing the need for chest tube pleural drainage (CTPD).
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Zeng-hua Ren, Ling Xu
Summary: The study evaluated the accuracy of pfADA, pfLDH, and other parameters in the differential diagnosis of Neutrophil-predominant Tuberculous Pleural Effusion (NP-TPE) and Parapneumonic Pleural Effusion (PPE). The results showed that combining different parameters can improve diagnostic performance in different age groups.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Pediatrics
Matthieu Thimmesch, Andre Mulder, Frederic Lebrun, Frederic Pierart, Caroline Genin, Isabelle Loeckx, Pierre Demaret
Summary: This retrospective study examined the use of corticosteroids in the management of parapneumonic pleural effusion in children. The findings suggest that corticosteroids may be beneficial when conventional treatment fails, with a significant proportion of patients experiencing rapid resolution of fever after initiation of corticosteroid therapy. All patients were discharged from the hospital without the need for surgery.
PEDIATRIC PULMONOLOGY
(2022)
Article
Respiratory System
Chimaobi Ikechukwu Nwagboso, Chidiebere Peter Echieh, John Nkemakolam Eze, Stephen Omirigbe Ogbudu, Chibueze Haggai Njoku, Anietimfon Umoh Etiuma, Okokon Odonkwo Bassey
Summary: This study reveals that the development of empyema thoracis, a long duration of drainage, and a prolonged period of illness before presentation can predict the outcome of chest tube drainage.
Review
Medical Laboratory Technology
Xi-Shan Cao, Wen-Qi Zheng, Zhi-De Hu
Summary: Parapneumonic pleural effusion (PPE) is a common complication in patients with pneumonia. Current biomarkers lack adequate performance for diagnosing and stratifying PPE, highlighting the need for further research to identify and validate novel biomarkers and their combinations for PPE management.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Surgery
Yo Tsukamoto, Makoto Odaka, Takeo Nakada, Mitsuo Yabe, Eriko Harada, Tadashi Akiba, Naoki Toya, Takashi Ohtsuka
Summary: This study evaluated the feasibility of non-intubated video-assisted thoracoscopic surgery with local anesthesia for parapneumonic effusion and empyema resistant to conservative treatment. The study found some differences between patients who received local anesthesia and general anesthesia during surgery, but there were no significant differences in postoperative drainage duration, postoperative complication rate, and postoperative 30-day mortality rate.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Candice L. Wilshire, Anee S. Jackson, Eric Vallieres, Adam J. Bograd, Brian E. Louie, Ralph W. Aye, Alexander S. Farivar, Peter T. White, Christopher R. Gilbert, Jed A. Gorden
Summary: This study compared the feasibility, safety, and efficacy of tissue plasminogen activator plus deoxyribonuclease therapy with surgical decortication in patients with complicated pleural infections. The results showed that both treatments were feasible, safe, and efficacious in the treatment of complicated pleural infections.
Editorial Material
Respiratory System
Jose M. Porcel
EUROPEAN RESPIRATORY JOURNAL
(2020)
Editorial Material
Respiratory System
Jose M. Porcel
Editorial Material
Respiratory System
Srinivas R. Mummadi, Jose M. Porcel
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Medicine, General & Internal
Jose M. Porcel, Pyng Lee
Summary: Video-assisted thoracic surgery (VATS) is the preferred treatment for preventing recurrence in patients with spontaneous pneumothorax (SP). Advances in thoracoscopic technology have led to improved patient satisfaction and perioperative outcomes. In rare cases of ipsilateral recurrence, redo-VATS is a feasible therapeutic option, and further randomized controlled trials are needed to determine the best management of SP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Maria Alba Sorolla, Anabel Sorolla, Eva Parisi, Antonieta Salud, Jose M. Porcel
Summary: Malignant pleural effusion is a common complication in the natural progression of tumors, but current diagnostic methods are imperfect, necessitating more precise methods. Liquid biopsy, as a non-invasive strategy, is considered a promising tool for the diagnosis of malignant pleural effusion.
Article
Medicine, General & Internal
Maged Hassan, Shefaly Patel, Ahmed S. Sadaka, Eihab O. Bedawi, John P. Corcoran, Jose M. Porcel
Summary: Pleural infection in adults is a serious and life-threatening condition with increasing incidence especially in older adults. Anaerobic bacteria play a major role in the infection, requiring prolonged hospitalization. Surgical intervention or intrapleural fibrinolytic therapy are recommended for patients who fail standard medical therapy, but early intervention requires further evidence.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Respiratory System
Anabel Sorolla, Eva Parisi, Maria Alba Sorolla, Marta Marques, Jose M. Porcel
EUROPEAN RESPIRATORY JOURNAL
(2022)
Editorial Material
Respiratory System
Christopher R. Gilbert, Jose M. Porcel
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Agustin Ruiz-Gonzalez, Eduardo Saez-Huerta, Montserrat Martinez-Alonso, Albert Bernet-Sanchez, Jose M. Porcel
Summary: This study aimed to identify clinical parameters to differentiate between bacterial and viral infections in acute exacerbations of chronic obstructive pulmonary disease (AECOPD). A scoring system utilizing serum C-reactive protein level, duration of symptoms, and blood neutrophil count was found to be useful in distinguishing bacterial etiologies. The use of antibiotics was significantly associated with a higher probability of bacterial infection.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Oncology
Maria Mulet, Ruben Osuna-Gomez, Carlos Zamora, Jose M. Porcel, Juan C. Nieto, Lidia Perea, Virginia Pajares, Ana M. Munoz-Fernandez, Nuria Calvo, Maria Alba Sorolla, Silvia Vidal
Summary: This study provides novel information about the role of neutrophils in malignant pleural effusion (MPE) and their clinical relevance. Neutrophils contribute to tumor progression through the release of neutrophil extracellular traps (NETs) and are associated with worse outcomes in lung adenocarcinoma patients with MPE.
Editorial Material
Respiratory System
Srinivas R. Mummadi, Jose M. Porcel
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Joaquin L. Herraiz, Clara Freijo, Jorge Camacho, Mario Munoz, Ricardo Gonzalez, Rafael Alonso-Roca, Jorge Alvarez-Troncoso, Luis Matias Beltran-Romero, Maximo Bernabeu-Wittel, Rafael Blancas, Antonio Calvo-Cebrian, Ricardo Campo-Linares, Jaldun Chehayeb-Moran, Jose Chorda-Ribelles, Samuel Garcia-Rubio, Gonzalo Garcia-de-Casasola, Adriana Gil-Rodrigo, Cesar Henriquez-Camacho, Alba Hernandez-Piriz, Carlos Hernandez-Quiles, Rafael Llamas-Fuentes, Davide Luordo, Raquel Marin-Baselga, Maria Cristina Martinez-Diaz, Maria Mateos-Gonzalez, Manuel Mendez-Bailon, Francisco Miralles-Aguiar, Ramon Nogue, Marta Nogue, Borja Ortiz de Urbina-Antia, Alberto Angel Oviedo-Garcia, Jose M. Porcel, Santiago Rodriguez, Diego Anibal Rodriguez-Serrano, Talia Sainz, Ignacio Manuel Sanchez-Barrancos, Marta Torres-Arrese, Juan Torres-Macho, Angela Trueba Vicente, Tomas Villen-Villegas, Juan Jose Zafra-Sanchez, Yale Tung-Chen
Summary: This study aimed to investigate the inter-rater reliability (IRR) and performance of lung ultrasound (LUS) in detecting COVID-19 related signs in longitudinal or transverse orientation. Thirty-three physicians with advanced LUS experience independently evaluated ultrasound videos of 20 confirmed COVID-19 patients. The results showed substantial IRR for normal LUS, but only fair IRR for individual B-lines. No statistically significant differences were found between longitudinal and transverse scans. Standardized clinical protocols may improve the IRR of LUS in COVID-19 patients.
APPLIED SCIENCES-BASEL
(2023)
Review
Respiratory System
Jose M. Porcel, Rosa Cordovilla, Rachid Tazi-Mezalek, Deisy Barrios-Barreto, Javier Perez-Pallares, Helder Novais e Bastos, Raquel Martinez-Tomas, Javier Flandes-Aldeyturriaga, Enrique Cases-Viedma, Borja Recalde, Maribel Botana-Rial
Summary: Based on the analysis of multiple studies, the timing of systemic cancer therapy (SCT) does not significantly affect the efficacy and safety of indwelling pleural catheters (IPC) in patients with malignant pleural effusion (MPE). Using SCT while the IPC was in situ can reduce overall mortality, increase survival time, and improve quality-adjusted survival.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Respiratory System
Jose M. Porcel, Silvia Bielsa, Carmen Civit, Avinash Aujayeb, Julius Janssen, Uffe Bodtger, Katrine Fjaellegaard, Jesper Koefod Petersen, Hugh Welch, Jenny Symonds, Michael A. Mitchell, Elzbieta Magdalena Grabczak, Mohamed Ellayeh, Dinesh Addala, John M. Wrightson, Najib M. Rahman, Mohammed Munavvar, Coenraad F. N. Koegelenberg, Gonzalo Labarca, Federico Mei, Nick Maskell, Rahul Bhatnagar
Summary: This study retrospectively reviewed the medical records of 77 adult patients diagnosed with chylothorax in 12 medical centers across Europe, America, and South Africa from 2009 to 2021, aiming to better define and characterize the etiology, management, and outcomes of chylothorax.
Letter
Respiratory System
Jose M. Porcel, Anabel Sorolla, Eva Parisi, Silvia Bielsa, Antonieta Salud, M. Alba Sorolla
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)