Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders

Circadian rhythms and addiction: Mechanistic insights and future directions.

(2014) Ryan W. Logan et al.   BEHAVIORAL NEUROSCIENCE

Molecular network analysis enhances understanding of the biology of mental disorders

(2014) Kay S. Grennan et al.   BIOESSAYS

Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation

(2014) Sooyoung Chung et al.   CELL

Association between circadian genes, bipolar disorders and chronotypes

(2014) B. Etain et al.   CHRONOBIOLOGY INTERNATIONAL

Circadian rhythms have broad implications for understanding brain and behavior

(2014) Rae Silver et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Agomelatine in treating generalized anxiety disorder

(2014) Koen Demyttenaere   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres

(2014) Shawn L. Chavez et al.   HUMAN MOLECULAR GENETICS

The Relationship Between Bipolar Disorder and Biological Rhythms

(2014) Robert Gonzalez   JOURNAL OF CLINICAL PSYCHIATRY

Agomelatine in Generalized Anxiety Disorder

(2014) Dan J. Stein et al.   JOURNAL OF CLINICAL PSYCHIATRY

Circadian regulation of metabolism

(2014) Shannon M Bailey et al.   JOURNAL OF ENDOCRINOLOGY

Circadian behavior is light-reprogrammed by plastic DNA methylation

(2014) Abdelhalim Azzi et al.   NATURE NEUROSCIENCE

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

(2014) Nicole C. Gossan et al.   NUCLEIC ACIDS RESEARCH

Mistimed sleep disrupts circadian regulation of the human transcriptome

(2014) Simon N. Archer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders

(2014) Dominic Landgraf et al.   Current Psychiatry Reports

Machine Learning Helps Identify CHRONO as a Circadian Clock Component

(2014) Ron C. Anafi et al.   PLOS BIOLOGY

A Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock

(2014) Akihiro Goriki et al.   PLOS BIOLOGY

24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex

(2014) Andrew S. P. Lim et al.   PLoS Genetics

The genome-wide landscape of DNA methylation and hydroxymethylation in response to sleep deprivation impacts on synaptic plasticity genes

(2014) R Massart et al.   Translational Psychiatry

A genome-wide association study of sleep habits and insomnia

(2013) Enda M. Byrne et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The Dopamine Receptor D2 (DRD2) SNP rs1076560 is Associated with Opioid Addiction

(2013) Toni-Kim Clarke et al.   ANNALS OF HUMAN GENETICS

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

(2013) Smriti Murali Krishna et al.   ATHEROSCLEROSIS

Evolutionary conservation of long non-coding RNAs; sequence, structure, function

(2013) Per Johnsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

miRNAs Are Required for Generating a Time Delay Critical for the Circadian Oscillator

(2013) Rongmin Chen et al.   CURRENT BIOLOGY

A Prader–Willi locus lncRNA cloud modulates diurnal genes and energy expenditure

(2013) Weston T. Powell et al.   HUMAN MOLECULAR GENETICS

Insomnia

(2013) Daniel J. Buysse   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Odor Is a Time Cue for Circadian Behavior

(2013) U. Abraham et al.   JOURNAL OF BIOLOGICAL RHYTHMS

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(2013) Christos Savvidis et al.   MOLECULAR MEDICINE

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Association of PER2 Genotype and Stressful Life Events with Alcohol Drinking in Young Adults

(2013) Dorothea Blomeyer et al.   PLoS One

First Genome-Wide Association Study on Anxiety-Related Behaviours in Childhood

(2013) Maciej Trzaskowski et al.   PLoS One

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

(2013) J. Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome

(2013) C. S. Moller-Levet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment

(2013) Su-Xia Li et al.   PSYCHONEUROENDOCRINOLOGY

The genetics of insomnia – Evidence for epigenetic mechanisms?

(2013) Laura Palagini et al.   SLEEP MEDICINE REVIEWS

Genome-wide association study of co-occurring anxiety in major depression

(2013) Alexandra Schosser et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Recent Advances in Sleep-Wake Cycle and Biological Rhythms in Bipolar Disorder

(2013) Rébecca Robillard et al.   Current Psychiatry Reports

The Circadian Clock Coordinates Ribosome Biogenesis

(2013) Céline Jouffe et al.   PLOS BIOLOGY

Genetic and clinical factors predict lithium’s effects on PER2 gene expression rhythms in cells from bipolar disorder patients

(2013) M J McCarthy et al.   Translational Psychiatry

Convergence of Genome-Wide Association and Candidate Gene Studies for Alcoholism

(2012) Emily Olfson et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β

(2012) Sohan Punia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disrupted Circadian Rhythms in a Mouse Model of Schizophrenia

(2012) Peter L. Oliver et al.   CURRENT BIOLOGY

Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?

(2012) Cecilia Nagorny et al.   Current Diabetes Reports

Circadian genesPeriod 1andPeriod 2in the nucleus accumbens regulate anxiety-related behavior

(2012) Sade Spencer et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Timed high-fat diet resets circadian metabolism and prevents obesity

(2012) Hadas Sherman et al.   FASEB JOURNAL

Deep sequencing the circadian and diurnal transcriptome of Drosophila brain

(2012) M. E. Hughes et al.   GENOME RESEARCH

A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence

(2012) Fan Wang et al.   HUMAN GENETICS

Valproic Acid Phase Shifts the Rhythmic Expression of PERIOD2::LUCIFERASE

(2012) Anne-Sofie Johansson et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Integration of the circadian and stress systems: influence of neuropeptides and implications for alcohol consumption

(2012) Cybele C. P. Wong et al.   JOURNAL OF NEURAL TRANSMISSION

CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics

(2012) Vishal R Patel et al.   NATURE METHODS

Persistent Cell-Autonomous Circadian Oscillations in Fibroblasts Revealed by Six-Week Single-Cell Imaging of PER2::LUC Bioluminescence

(2012) Tanya L. Leise et al.   PLoS One

A Survey of Genomic Studies Supports Association of Circadian Clock Genes with Bipolar Disorder Spectrum Illnesses and Lithium Response

(2012) Michael J. McCarthy et al.   PLoS One

Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork

(2012) Johanna L. Barclay et al.   PLoS One

Circadian changes in long noncoding RNAs in the pineal gland

(2012) S. L. Coon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors

(2012) D. B. Rye et al.   Science Translational Medicine

Familial aggregation and heritability of insomnia in a community-based study

(2012) Y.K. Wing et al.   SLEEP MEDICINE

Brain-Specific Rescue of Clock Reveals System-Driven Transcriptional Rhythms in Peripheral Tissue

(2012) Michael E. Hughes et al.   PLoS Genetics

Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability

(2012) E Shumay et al.   Translational Psychiatry

Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking

(2011) Li Dong et al.   AMERICAN JOURNAL OF PSYCHIATRY

Circadian clock and cardiovascular disease

(2011) Norihiko Takeda et al.   Journal of Cardiology

Circadian rhythms, sleep, and metabolism

(2011) Wenyu Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila

(2011) K V Allebrandt et al.   MOLECULAR PSYCHIATRY

Circadian rhythms and depression: Human psychopathology and animal models

(2011) Noga Kronfeld-Schor et al.   NEUROPHARMACOLOGY

The Nuclear Transcription Factor PKNOX2 Is a Candidate Gene for Substance Dependence in European-Origin Women

(2011) Xiang Chen et al.   PLoS One

Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression

(2011) Marina M. Bellet et al.   PLoS One

Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock

(2011) L. DiTacchio et al.   SCIENCE

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

(2011) Juliane Winkelmann et al.   PLoS Genetics

Circadian Clock Gene Polymorphisms in Alcohol Use Disorders and Alcohol Consumption

(2010) L. Kovanen et al.   ALCOHOL AND ALCOHOLISM

Systems Biology of Mammalian Circadian Clocks

(2010) Hideki Ukai et al.   Annual Review of Physiology

An Association Analysis of Circadian Genes in Anxiety Disorders

(2010) Tessa Sipilä et al.   BIOLOGICAL PSYCHIATRY

EPIGENETIC EFFECTS OF SHIFTWORK ON BLOOD DNA METHYLATION

(2010) Valentina Bollati et al.   CHRONOBIOLOGY INTERNATIONAL

Circadian Rhythms and Metabolic Syndrome

(2010) Eleonore Maury et al.   CIRCULATION RESEARCH

Metabolism and Circadian Rhythms—Implications for Obesity

(2010) Oren Froy   ENDOCRINE REVIEWS

Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?

(2010) Garth R Swanson et al.   Expert Review of Clinical Immunology

Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates

(2010) Melissa Suter et al.   FASEB JOURNAL

miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock

(2010) Matías Alvarez-Saavedra et al.   HUMAN MOLECULAR GENETICS

Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia

(2010) Ester Saus et al.   HUMAN MOLECULAR GENETICS

Altered expression of circadian rhythm genes among individuals with a history of depression

(2010) Jean-Philippe Gouin et al.   JOURNAL OF AFFECTIVE DISORDERS

Efficacy of the Novel Antidepressant Agomelatine on the Circadian Rest-Activity Cycle and Depressive and Anxiety Symptoms in Patients With Major Depressive Disorder

(2010) Siegfried Kasper et al.   JOURNAL OF CLINICAL PSYCHIATRY

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells

(2010) Teresa M Osland et al.   JOURNAL OF PSYCHOPHARMACOLOGY

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Perinatal photoperiod imprints the circadian clock

(2010) Christopher M Ciarleglio et al.   NATURE NEUROSCIENCE

Clocks not winding down: unravelling circadian networks

(2010) Eric E. Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease

(2010) Katharina Wulff et al.   NATURE REVIEWS NEUROSCIENCE

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

(2010) Virginia Soria et al.   NEUROPSYCHOPHARMACOLOGY

Systematic Analysis of Circadian Genes in a Population-Based Sample Reveals Association of TIMELESS with Depression and Sleep Disturbance

(2010) Siddheshwar J. Utge et al.   PLoS One

Behavioral circadian regularity at age 1 month predicts anxiety levels during school-age years

(2010) Timothy H. Monk et al.   PSYCHIATRY RESEARCH

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents

(2010) Erika Comasco et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia

(2009) Hader A Mansour et al.   BIPOLAR DISORDERS

A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

(2009) Eric E. Zhang et al.   CELL

The SCN-independent clocks, methamphetamine and food restriction

(2009) Ken-ichi Honma et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The effect of food intake on gene expression in human peripheral blood

(2009) Amy S. Leonardson et al.   HUMAN MOLECULAR GENETICS

Narcolepsy is strongly associated with the T-cell receptor alpha locus

(2009) Joachim Hallmayer et al.   NATURE GENETICS

Regulation of Clock-Controlled Genes in Mammals

(2009) Katarzyna Bozek et al.   PLoS One

Replicable differences in preferred circadian phase between bipolar disorder patients and control individuals

(2009) Joel Wood et al.   PSYCHIATRY RESEARCH

Circadian misalignment in major depressive disorder

(2009) Jonathan Emens et al.   PSYCHIATRY RESEARCH

Post-translational modifications in circadian rhythms

(2009) Arun Mehra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm

(2008) Jiajun Shi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Sleep Disturbance in Bipolar Disorder: Therapeutic Implications

(2008) David T. Plante et al.   AMERICAN JOURNAL OF PSYCHIATRY

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Genetic susceptibility to heroin addiction: a candidate gene association study

(2008) O. Levran et al.   GENES BRAIN AND BEHAVIOR

Adolescents with Insomnia and Substance Abuse: Consequences and Comorbidities

(2008) HEATHER L. SHIBLEY et al.   Journal of Psychiatric Practice

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

(2008) Theresa Alenghat et al.   NATURE

Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

(2008) Trilochan Sahoo et al.   NATURE GENETICS

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

(2008) Barbara Schormair et al.   NATURE GENETICS

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON

Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock

(2008) Y. Kumaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Autonomous Circadian Clock in the Inner Mouse Retina Regulated by Dopamine and GABA

(2008) Guo-Xiang Ruan et al.   PLOS BIOLOGY

Analysis of Gene Regulatory Networks in the Mammalian Circadian Rhythm

(2008) Jun Yan et al.   PLoS Computational Biology

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

(2007) Molly S. Bray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY