Journal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
Volume 24, Issue 2, Pages 215-224Publisher
SPRINGERNATURE
DOI: 10.1016/j.bjp.2014.04.004
Keywords
Ethnopharmacology; Giardia lamblia; Giardicidal activity; In vitro; Medicinal plants
Categories
Funding
- CNPq
- FAPEMA
- FAPEMAT
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The aim of this study was to compile the traditional knowledge about plants used for the treatment of giardiasis, and also to carry out experimental research to evaluate the anti-Giardia activity of five species. To reach this objective, 398 interviews were performed using a previously prepared questionnaire, followed by an in vitro evaluation of giardicidal potential of hydroalcoholic leaf extracts of Anacardium occidentale L., Chenopodium ambrosioides L., Passiflora edulis Sims, Psidium guajava L., and Stachytarpheta cayennensis (Rich.) Vahl. Among the interviewed people, 55.53% reported the use of plants to treat diarrhea, the most severe symptom of giardiasis. The results indicated 36 species used by this population for these problems. The use of leaves (72.50%) of a single plant (64.25%) collected from backyards and gardens (44.34%) and prepared by decoction were predominant. The majority of the interviewees (85.52%) attributed their cure to the use of plants. In the experimental tests, all extracts inhibited the growth of Giardia lamblia trophozoites in different intensities: A. occidentale and P. guajava extracts elicited a moderate activity (250 <= IC50 <= 500 mu g/ml), C. ambrosioides and S. cayennensis extracts evoked a high activity (100 <= IC50 <= 250 mu g/ml), and P. edulis extract showed very high activity (IC50 <= 100 mu g/ml). This study shows that an ethnopharmacological approach is useful in the selection of plant materials with potential giardicidal activity. (C) 2014 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.
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