Journal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
Volume 21, Issue 4, Pages 587-593Publisher
SOC BRASILEIRA FARMACOGNOSIA
DOI: 10.1590/S0102-695X2011005000110
Keywords
antimicrobial activity; cytotoxic activity; essential oil; extracts; Guatemala; Piper
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Funding
- General Directorate of Research (DIGI) at USAC, Guatemala
- Organization of American States (OAS) [SEDI/AICD/106/01]
- RIBIOFAR Network of the Ibero-American Program of Science and Technology for Development (CYTED) [Red 0284]
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The essential oils from two native species from Guatemala were studied for their chemical composition and the dichloromethane and methanol extracts for their biological activity. A GC-MS analysis of the essential oil from Piper jacquemontianum Kunth, Piperaceae, showed 34 constituents, consisting mainly of linalool (69.4%), while Piper variabile C. DC. essential oil had 36 constituents, camphor (28.4%), camphene (16.6%) and limonene (13.9%) being the major components. Dichloromethane extracts of both species were cytotoxic against MCF-7, H-460 and SF-268 cell lines (<7 mu g/mL). Dichloromethane extract of P. jacquemontianum was slightly active against bacteria (0.5 mg/mL), was active against promastigotes of Leishmania (20.4-61.0 mu g/mL), and epimastigotes of Trypanosoma cruzi (51.9 mu g/mL). The methanol extract of P. variabile showed antimalarial activity against Plasmodium falciparum F32 (4.5 mu g/mL), and the dichloromethane extract against Leishmania (55.8-76.3 mu g/mL) and T. cruzi (45.8 mu g/mL). None of the extracts from the two species was active against Aedes aegypti larvae and Artemia salina nauplii.
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