Article
Multidisciplinary Sciences
Evan Mercier, Xiaolin Wang, Manisankar Maiti, Wolfgang Wintermeyer, Marina Rodnina
Summary: The study reveals that during the synthesis of membrane proteins, the lateral gate fluctuations are highly dynamic, continuously sampling between open and closed states even without ligands. Ribosome binding and transmembrane segment insertion do not stop the gate fluctuations but tend to increase sampling of the open state. Binding of YidC facilitates substantial opening of the gate, aiding in the folding of YidC-dependent polytopic membrane proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Astronomy & Astrophysics
Christopher D. Matzner, Stephen Ro
Summary: This study focuses on shocks from acoustic pulses and wave trains in one-dimensional flows, particularly in the context of super-Eddington outbursts in massive stars. By using approximate adiabatic invariants and generalizing the classical equal-area technique, the authors were able to predict shock evolution and improve expressions for shock-heating rate. Additionally, the study demonstrates the importance of waveform for shock dynamics and provides analysis to predict when shocks will become strong.
ASTROPHYSICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Anais M. E. Cassaignau, Tomasz Wlodarski, Sammy H. S. Chan, Lauren F. Woodburn, Ivana V. Bukvin, Julian O. Streit, Lisa D. Cabrita, Christopher A. Waudby, John Christodoulou
Summary: The study characterizes interactions between the ribosome surface and unfolded nascent chains, with the strongest interactions found in the C-terminal segment essential for folding. Quantitative agreement is demonstrated between these interactions and the energetics of co-translational folding. Competition between folding and binding provides a simple, dynamic mechanism for the modulation of co-translational folding by the ribosome.
Review
Biochemistry & Molecular Biology
Julia Oswald, Robert Njenga, Ana Natriashvili, Pinku Sarmah, Hans-Georg Koch
Summary: The spatial and temporal coordination of protein transport is crucial for bacterial adaptation to different environmental conditions. The SecYEG translocon plays a key role in bacterial protein transport, with its ability to interact with multiple targeting factors, chaperones, and accessory proteins influencing its ability to transport a variety of substrates.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michal Mayer, Lulu Winer, Amihai Karniel, Elhanan Pinner, Eliane H. Yardeni, David Morgenstern, Eitan Bibi
Summary: Many integral membrane proteins are produced by translocon-associated ribosomes. Our studies reveal the co-translational targeting of FtsY and its interactions with cytosolic chaperones and the translocon, providing insights into the mechanism of membrane targeting.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Physics, Multidisciplinary
Marko D. Petrovic, Priyanka Mondal, Adrian E. Feiguin, Branislav K. Nikolic
Summary: The standard model of spin-transfer torque in antiferromagnetic spintronics does not capture the ground state entanglement of quantum spins, requiring a fully quantum treatment to understand the exchange of spin angular momentum. This new approach predicts a nonzero expectation value of localized spins in antiferromagnetic Mott insulators when subjected to spin-polarized current pulses, leading to a spatially inhomogeneous ferromagnetic phase with a zigzag profile. The total spin absorbed by AFMI increases with electron-electron repulsion, as well as when there is no charge exchange between layers.
PHYSICAL REVIEW LETTERS
(2021)
Article
Neurosciences
Jean-Francois Daneault, Brandon Oubre, Jose Garcia Vivas Miranda, Sunghoon Ivan Lee
Summary: In this study, a novel approach of decomposing movements into movement elements was proposed, providing insights into how the brain generates movements. By applying an unsupervised clustering algorithm, researchers were able to group movement elements based on their morphological characteristics and observed that most movement elements aligned with the expected velocity profile of goal-directed movements. However, deviations from this theoretical shape revealed distinct patterns in shape. Additionally, the body axis from which movement elements were extracted affected the proportion of elements that matched the theoretical model, indicating the potential role of movement element variability in exploring the environment.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Tobias Eul, Eva Prinz, Michael Hartelt, Benjamin Frisch, Martin Aeschlimann, Benjamin Stadtmueller
Summary: The authors observe anisotropic light-matter interaction on a noble metal surface, contrary to the expectation of isotropic interaction in free-electron-like materials. This can be explained by the existence of optical transition dipoles with fixed orientations. The findings challenge the notion of isotropic light-matter interaction in free electron-like metals.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
William J. Allen, Ian Collinson
Summary: Encapsulation and compartmentalization in cellular life require specialized machines called translocons to partition proteins across impermeable barriers. Recent technical innovations in structural biology, biophysics, and biochemistry have led to a largely complete understanding of the bacterial version of the core Sec machinery. This knowledge will have immense value for studying other translocons in biological membranes and potentially altering their functions for pharmaceutical or biotechnological purposes.
Article
Chemistry, Multidisciplinary
Mathias Pont, Anne-Laurence Phaneuf-L'Heureux, Regis Andre, Sebastien Francoeur
Summary: Motional narrowing is a phenomenon where a quantum state can be entangled with a noisy environment and retain coherence. Accelerating spectral diffusion into the THz regime can approach the optimal coherence limit set by the radiative rate.
Article
Biology
William J. Allen, Robin A. Corey, Daniel W. Watkins, A. Sofia F. Oliveira, Kiel Hards, Gregory M. Cook, Ian Collinson
Summary: Transport of proteins across and into membranes is a fundamental process in biology. Recent studies have shown that the diffusion of arginine residues limits pre-protein transport, while lysine can be transported across membranes in its neutral form. These findings have implications for understanding the mechanism of protein secretion and suggest a potential role of proton-motive force in aiding transport.
Article
Multidisciplinary Sciences
Lance T. Denes, Chase P. Kelley, Eric T. Wang
Summary: The study highlights the importance of RNA localization in skeletal muscle and the critical role of directed transport of RNPs in achieving this localization pattern. It also suggests that global active RNP transport may be essential for distributing RNAs in highly differentiated cells, offering insights into fundamental mechanisms of gene regulation with implications for myopathies.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jayanta Dana, Omer S. Haggag, Joanna Dehnel, Morin Mor, Efrat Lifshitz, Sanford Ruhman
Summary: Numerous studies have shown that core CdSe nanocrystals do not exhibit state filling in 1S(h), which has significant implications in light-emitting applications. By conducting spectroscopy experiments on CdSe crystals with organic ligands, it was observed that there is no rapid filling effects of hole states in transient absorption measurements.
Article
Biology
Valeria Guzman-Luna, Andrew M. Fuchs, Anna J. Allen, Alexios Staikos, Silvia Cavagnero
Summary: Guzman-Luna et al. present a study on the interaction between unstructured nascent chains and specific ribosomal proteins near the nascent polypeptide exit tunnel, showing that these interactions are dependent on the peptide length, surface charge, and Mg+2 concentration, providing insights into co-translational protein folding and misfolding/aggregation.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ruth Steinberg, Hans-Georg Koch
Summary: Small proteins, typically consisting of less than 50 amino acids in prokaryotes and less than 100 amino acids in eukaryotes, play important roles in cell physiology by stabilizing protein assemblies and modifying the activity of larger proteins. They are often produced under stress conditions and serve as intracellular modifiers for adjusting cell metabolism.
Article
Biophysics
Martin Linden, Johan Elf
BIOPHYSICAL JOURNAL
(2018)
Article
Chemistry, Physical
Federico Elias-Wolff, Martin Linden, Alexander P. Lyubartsev, Erik G. Brandt
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2018)
Article
Biochemistry & Molecular Biology
Patricia Lara, Asa Tellgren-Roth, Hourinaz Behesti, Zachi Horn, Nina Schiller, Karl Enquist, Malin Cammenberg, Amanda Liljenstrom, Mary E. Hatten, Gunnar von Heijne, IngMarie Nilsson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biology
Vivekanandan Shanmuganathan, Nina Schiller, Anastasia Magoulopoulou, Jingdong Cheng, Katharina Braunger, Florian Cymer, Otto Berninghausen, Birgitta Beatrix, Kenji Kohno, Gunnar von Heijne, Roland Beckmann
Article
Biochemistry & Molecular Biology
Maximilian Seurig, Moira Ek, Gunnar von Heijne, Nir Fluman
NATURE CHEMICAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Grant Kemp, Ola B. Nilsson, Pengfei Tian, Robert B. Best, Gunnar von Heijne
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Rageia Elfageih, Alexandros Karyolaimos, Grant Kemp, Jan-Willem de Gier, Gunnar von Heijne, Renuka Kudva
Article
Biology
Felix Nicolaus, Ane Metola, Daphne Mermans, Amanda Liljenstrom, Ajda Krc, Salmo Mohammed Abdullahi, Matthew Zimmer, Thomas F. Miller, Gunnar von Heijne
Summary: The study investigates the cotranslational biosynthesis of E. coli inner membrane proteins and reveals the complexities in membrane integration process, including protein folding in the ribosome exit tunnel and interactions between charged residues and the membrane. The results also suggest residue-specific interactions between transmembrane helices during the integration process, supporting the 'sliding' model of translocon-mediated membrane protein integration.
Editorial Material
Multidisciplinary Sciences
Gunnar von Heijne
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Felix Nicolaus, Fatima Ibrahimi, Anne den Besten, Gunnar von Heijne
Summary: During the cotranslational insertion of membrane proteins mediated by SecYEG, both electrostatic and hydrophobic interactions involving sequence elements can impact the behavior of transmembrane helices, leading to delayed contact with the membrane.
Article
Biotechnology & Applied Microbiology
Felix Teufel, Jose Juan Almagro Armenteros, Alexander Rosenberg Johansen, Magnus Halldor Gislason, Silas Irby Pihl, Konstantinos D. Tsirigos, Ole Winther, Soren Brunak, Gunnar von Heijne, Henrik Nielsen
Summary: Signal peptides are short amino acid sequences that regulate protein secretion and translocation. SignalP 6.0, a machine learning model, is introduced to detect all types of signal peptides, including those applicable to metagenomic data.
NATURE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Daphne Mermans, Felix Nicolaus, Klara Fleisch, Gunnar von Heijne
Summary: In recent years, it has been discovered that many cytoplasmic proteins can dimerize while being translated. However, it was unclear whether this phenomenon also applies to integral membrane proteins. This study demonstrates that the inner membrane protein EmrE in Escherichia coli can indeed undergo cotranslational interactions, suggesting that membrane proteins can start to fold and dimerize during the membrane insertion process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Daphne Mermans, Felix Nicolaus, Aysel Baygin, Gunnar von Heijne
Summary: Human growth hormone (hGH) is a protein with four helix bundles and has pharmacological interest. This study investigates the folding of hGH during expression in Escherichia coli, both in vitro translation with or without the chaperone trigger factor (TF) and in E. coli. The findings suggest that hGH begins folding before it is fully released from the ribosome and may interact with TF and other chaperones.
Article
Biology
Jose Juan Almagro Armenteros, Marco Salvatore, Olof Emanuelsson, Ole Winther, Gunnar von Heijne, Arne Elofsson, Henrik Nielsen
LIFE SCIENCE ALLIANCE
(2019)
Article
Chemistry, Physical
Federico Elias-Wolff, Martin Linden, Alexander P. Lyubartsev, Erik G. Brandt
