Silencing of CDK5 as potential therapy for Alzheimer’s disease

RNAi therapeutics for CNS disorders

(2010) Ryan L. Boudreau et al.   BRAIN RESEARCH

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

(2010) Jesús Avila et al.   Expert Review of Neurotherapeutics

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

(2010) D. Piedrahita et al.   JOURNAL OF NEUROSCIENCE

No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

(2010) D. W. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

GSK-3: A key player in neurodegeneration and memory

(2009) Karl Peter Giese   IUBMB LIFE

Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

(2009) Ryan L Boudreau et al.   MOLECULAR THERAPY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Roscovitine Reduces Neuronal Loss, Glial Activation, and Neurologic Deficits after Brain Trauma

(2008) Genell D Hilton et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

(2008) Shuxin Hu et al.   NEUROBIOLOGY OF DISEASE

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

Allele-Specific RNA Silencing of Mutant Ataxin-3 Mediates Neuroprotection in a Rat Model of Machado-Joseph Disease

(2008) Sandro Alves et al.   PLoS One

Cdk5 is essential for adult hippocampal neurogenesis

(2008) D. C. Lagace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA