Insulin and glucagon signaling in the central nervous system

Reversal of Diet-Induced Obesity Increases Insulin Transport into Cerebrospinal Fluid and Restores Sensitivity to the Anorexic Action of Central Insulin in Male Rats

(2013) Denovan P. Begg et al.   ENDOCRINOLOGY

Lipid Sensing and Insulin Resistance in the Brain

(2012) Jessica T.Y. Yue et al.   Cell Metabolism

Brainstem Nutrient Sensing in the Nucleus of the Solitary Tract Inhibits Feeding

(2012) Clemence Blouet et al.   Cell Metabolism

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

(2012) Beatrice M. Filippi et al.   Cell Metabolism

Glycine Normalizes Hepatic Triglyceride-Rich VLDL Secretion by Triggering the CNS in High-Fat Fed Rats

(2012) Jessica T.Y. Yue et al.   CIRCULATION RESEARCH

The mechanism underlying the central glucagon-induced hyperglycemia and anorexia in chicks

(2012) Kazuhisa Honda et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Is Insulin Action in the Brain Clinically Relevant?

(2012) B. M. Filippi et al.   DIABETES

Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women

(2012) M. Hallschmid et al.   DIABETES

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

(2012) Danna M Breen et al.   NATURE MEDICINE

The Evil Axis of Obesity, Inflammation and Type-2 Diabetes

(2012) Arghya Das et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Food reward, hyperphagia, and obesity

(2011) Hans-Rudolf Berthoud et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

Role for Insulin Signaling in Catecholaminergic Neurons in Control of Energy Homeostasis

(2011) A. Christine Könner et al.   Cell Metabolism

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

Activation of KATP channels suppresses glucose production in humans

(2011) Preeti Kishore et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs

(2011) Christopher J. Ramnanan et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparisons of insulin related parameters in commercial-type chicks: Evidence for insulin resistance in broiler chicks

(2011) Jun-ichi Shiraishi et al.   PHYSIOLOGY & BEHAVIOR

PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure

(2011) Yongheng Cao et al.   PLoS One

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake

(2010) Kristy Iskandar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

Brainstem Hap1-Ahi1 is involved in insulin-mediated feeding control

(2010) Shao-Na Niu et al.   FEBS LETTERS

Neuronal regulation of homeostasis by nutrient sensing

(2010) Tony K T Lam   NATURE MEDICINE

Melanocortin signaling in the CNS directly regulates circulating cholesterol

(2010) Diego Perez-Tilve et al.   NATURE NEUROSCIENCE

Expanding the definition of hypothalamic obesity

(2010) I. Hochberg et al.   Obesity Reviews

High-fat diets induce a rapid loss of the insulin anorectic response in the amygdala

(2009) Stéphane Boghossian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effects of central administration of glucagon on feed intake and endocrine responses in sheep

(2009) Yohei KUROSE et al.   ANIMAL SCIENCE JOURNAL

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

(2009) H. V. Lin et al.   DIABETES

Hypothalamic Leptin Signaling Regulates Hepatic Insulin Sensitivity via a Neurocircuit Involving the Vagus Nerve

(2009) Jonathan German et al.   ENDOCRINOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Long-Term Intracerebroventricular Infusion of Insulin, but Not Glucose, Modulates Body Weight and Hepatic Insulin Sensitivity by Modifying the Hypothalamic Insulin Signaling Pathway in Type 2 Diabetic Rats

(2009) Sunmin Park et al.   NEUROENDOCRINOLOGY

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Central Nervous System Neuropeptide Y Signaling Modulates VLDL Triglyceride Secretion

(2008) J. M. Stafford et al.   DIABETES

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

(2008) D. A. Sandoval et al.   DIABETES

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE