The role of adiponectin signaling in metabolic syndrome and cancer

Integral Role of PTP1B in Adiponectin-Mediated Inhibition of Oncogenic Actions of Leptin in Breast Carcinogenesis

(2015) LaTonia Taliaferro-Smith et al.   NEOPLASIA

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

(2013) Madhumita Dandapani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

LKB1 and AMPK and the cancer-metabolism link - ten years after

(2013) D Hardie et al.   BMC BIOLOGY

Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

(2013) Toshimasa Yamauchi et al.   Cell Metabolism

Molecular Pathways: Adiponectin and Leptin Signaling in Cancer

(2013) M. N. VanSaun   CLINICAL CANCER RESEARCH

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Obesity and cancer risk: evidence, mechanisms, and recommendations

(2012) Ivana Vucenik et al.   Annals of the New York Academy of Sciences

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Body Fat Distribution and Risk of Cardiovascular Disease

(2012) Jean-Pierre Després   CIRCULATION

Adipose Tissue Inflammation and Adiponectin Resistance in Patients With Advanced Heart Failure

(2012) Raffay S. Khan et al.   Circulation-Heart Failure

Adiponectin Increases Skeletal Muscle Mitochondrial Biogenesis by Suppressing Mitogen-Activated Protein Kinase Phosphatase-1

(2012) L. Qiao et al.   DIABETES

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

The Role of Adiponectin in Cancer: A Review of Current Evidence

(2012) Maria Dalamaga et al.   ENDOCRINE REVIEWS

Overexpression of the Adiponectin Receptor AdipoR1 in Rat Skeletal Muscle Amplifies Local Insulin Sensitivity

(2012) S. A. Patel et al.   ENDOCRINOLOGY

Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice

(2012) JM Farias et al.   Lipids in Health and Disease

Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice

(2011) Yanzhuo Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pathophysiology of the Metabolic Syndrome: Implications for the Cardiometabolic Risks Associated With Type 2 Diabetes

(2011) Derek Leroith   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Adiponectin and cardiovascular health: an update

(2011) Xiaoyan Hui et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adiponectin: Sometimes Good, Sometimes Bad?

(2011) Thomas Ebert et al.   CARDIOLOGY

Insulin decreases myocardial adiponectin receptor 1 expression via PI3K/Akt and FoxO1 pathway

(2011) Xiao-Bing Cui et al.   CARDIOVASCULAR RESEARCH

The Obesity Paradox in Heart Failure: Accepting Reality and Making Rational Decisions

(2011) S D Anker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Metabolic Syndrome and Heart Failure—The Risk, Paradox, and Treatment

(2011) Krishna K. Gaddam et al.   CURRENT HYPERTENSION REPORTS

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

(2011) Yi Wang et al.   DIABETES

The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reflects Lipid Metabolism of the Human Donors

(2011) Anna-Maria Ordelheide et al.   Experimental Diabetes Research

Adiponectin Ameliorates Doxorubicin-induced Cardiotoxicity through Akt Protein-dependent Mechanism

(2011) Sonomi Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss

(2011) R. Marinho et al.   JOURNAL OF CELLULAR PHYSIOLOGY

APPL1 Mediates Adiponectin-Induced LKB1 Cytosolic Localization Through the PP2A-PKCζ Signaling Pathway

(2011) Sathyaseelan S. Deepa et al.   MOLECULAR ENDOCRINOLOGY

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis

(2011) H. James Harwood   NEUROPHARMACOLOGY

Globular Adiponectin, Acting via AdipoR1/APPL1, Protects H9c2 Cells from Hypoxia/Reoxygenation-Induced Apoptosis

(2011) Min Park et al.   PLoS One

N-Acetylcysteine and Allopurinol Synergistically Enhance Cardiac Adiponectin Content and Reduce Myocardial Reperfusion Injury in Diabetic Rats

(2011) Tingting Wang et al.   PLoS One

Globular and Full-Length Adiponectin Induce NO-Dependent Vasodilation in Resistance Arteries of Zucker Lean but Not Zucker Diabetic Fatty Rats

(2010) P. M. Schmid et al.   AMERICAN JOURNAL OF HYPERTENSION

An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart

(2010) Xiangping Fang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduced Cardioprotective Action of Adiponectin in High-Fat Diet–Induced Type II Diabetic Mice and Its Underlying Mechanisms

(2010) Wei Yi et al.   ANTIOXIDANTS & REDOX SIGNALING

Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion

(2010) Nadeeja Wijesekara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Associations of Insulin Resistance and Adiponectin With Mortality in Women With Breast Cancer

(2010) Catherine Duggan et al.   JOURNAL OF CLINICAL ONCOLOGY

Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response

(2010) Masayuki Shimano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment

(2009) Ying Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications

(2009) Yu Wang et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation

(2009) K.-y. Kim et al.   CANCER RESEARCH

APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

(2009) Kenneth K.Y. Cheng et al.   Cell Metabolism

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

Adiponectin Deficiency, Diastolic Dysfunction, and Diastolic Heart Failure

(2009) Flora Sam et al.   ENDOCRINOLOGY

Appl1Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts

(2009) Yinfei Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

(2009) Lijun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

(2009) Changhua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Globular adiponectin inhibits angiotensin II-induced nuclear factor κB activation through AMP-activated protein kinase in cardiac hypertrophy

(2009) Cheng Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis

(2009) Z. Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Energy Homoeostasis: The Roles of Adipose Tissue-Derived Hormones, Peptide YY and Ghrelin

(2009) Jocelin Hall et al.   Obesity Facts

LKB1 is required for adiponectin-mediated modulation of AMPK–S6K axis and inhibition of migration and invasion of breast cancer cells

(2009) L Taliaferro-Smith et al.   ONCOGENE

Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities

(2009) Janice B. B. Lam et al.   PLoS One

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The concept of cardiometabolic risk: Bridging the fields of diabetology and cardiology

(2008) Jean-Pierre Després et al.   ANNALS OF MEDICINE

Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-α

(2008) Koichi Fujita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of adiponectin on breast cancer cell growth and signaling

(2008) M E Grossmann et al.   BRITISH JOURNAL OF CANCER

Dietary Energy Balance Modulates Signaling through the Akt/Mammalian Target of Rapamycin Pathways in Multiple Epithelial Tissues

(2008) Tricia Moore et al.   Cancer Prevention Research

Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1

(2008) Jing Liu et al.   CARCINOGENESIS

Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy

(2008) C. Skurk et al.   EUROPEAN HEART JOURNAL

Cardiac Remodeling in Obesity

(2008) E. Dale Abel et al.   PHYSIOLOGICAL REVIEWS