Review
Cell Biology
Kyu Hwan Kwack, Hyeon-Woo Lee
Summary: Dental caries is a common disease that causes damage to teeth and pulp tissue. Dental pulp stem cells have multipotency, high proliferation rate, and immunosuppressive properties, making them ideal for regenerating damaged pulp tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Liwen Zheng, Yaxian Liu, Lin Jiang, Xiaoping Wang, Yuqin Chen, Lan Li, Mingyu Song, Hongmei Zhang, Yu Shrike Zhang, Ximu Zhang
Summary: This study proposes a new strategy for pulp regeneration by using hydrogel microspheres incorporated with decellularized dental pulp matrix-derived bioactive factors to simulate a pulp-specific three-dimensional microenvironment. The constructed microspheres exhibit favorable plasticity, biocompatibility, and biological performances, and hDPSCs cultured on the microspheres demonstrate enhanced pulp-formation ability. In vivo experiments show that the microspheres facilitate the regeneration of pulp-like tissue and new dentin. The decellularized pulp matrix-derived bioactive factors mediate the multi-directional differentiation of hDPSCs to regenerate the pulp tissue.
ACTA BIOMATERIALIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zafer C. Cehreli, Gizem Erbas Unverdi, Elif Ballikaya
Summary: This case series demonstrates the clinical and radiographic outcomes of regenerative endodontic treatment (RET) using deciduous pulp autotransplantation in traumatized, necrotic young permanent incisors. Follow-up observations at 12 and 24 months showed radiographic evidence of complete periapical healing, slight increase in dentinal wall thickness, and continued apical closure in all patients.
JOURNAL OF ENDODONTICS
(2022)
Review
Biochemistry & Molecular Biology
Zhuo Xie, Zongshan Shen, Peimeng Zhan, Jiayu Yang, Qiting Huang, Shuheng Huang, Lingling Chen, Zhengmei Lin
Summary: Treatment of pulpal and periapical diseases faces challenges, but significant progress has been made in achieving true pulp tissue regeneration through technologies such as stem cells, biomaterials, and growth factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Francesca Diomede, Luigia Fonticoli, Guya Diletta Marconi, Ylenia Della Rocca, Thangavelu Soundara Rajan, Oriana Trubiani, Giovanna Murmura, Jacopo Pizzicannella
Summary: The study aimed to develop an in vitro culture system using decellularized dental pulp (DDP) matrix, 5-Aza-2'-deoxycytidine (5-Aza), and extracellular vesicles (EVs) derived from human dental pulp stem cells (hDPSCs) to facilitate dental pulp regeneration.
Article
Dentistry, Oral Surgery & Medicine
Pedram Iranmanesh, Mahmoud Torabinejad, Masoud Saatchi, Davood Toghraie, Sayed Mohammad Razavi, Abbasali Khademi
Summary: This study aimed to evaluate the effect of the duration of root canal infection on the ability of dentin-pulp complex regeneration. The results showed that long-term root canal infection decreased the ability of the body to regenerate the dentin-pulp complex.
JOURNAL OF ENDODONTICS
(2022)
Article
Engineering, Biomedical
Mauricio Goncalves da Costa Sousa, Gabriela Conceicao de Almeida, Danilo Cesar Martins Mota, Rosiane Andrade da Costa, Simoni Campos Dias, Samuel Nunes Limberger, Frank Ko, Li Ting Lin, Evan F. Haney, Hashem Etayash, Beverlie Baquir, Michael J. Trimble, Ya Shen, Zheng Su, Markus Haapasalo, Daniel Pletzer, Leticia Chaves de Souza, Glaucia Schuindt Teixeira, Renato M. Silva, Robert E. W. Hancock, Octavio Luiz Franco, Taia Maria Berto Rezende
Summary: This article introduces a multifunctional scaffold material for dental pulp regeneration, which has antibacterial and immunomodulatory activities, and achieves pulp-like tissue formation in vivo.
BIOACTIVE MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alina Wikstrom, Malin Brundin, Nelly Romani Vestman, Olena Rakhimova, Georgios Tsilingaridis
Summary: This study evaluates the clinical and radiographical outcomes of pulp revitalization treatment for traumatized necrotic incisors. The results suggest that pulp revitalization provides satisfactory outcomes, but improvements are needed to enhance the predictability of the treatment.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mostafa Ezeldeen, Mariano N. Simon Pedano De Piero, Lianyi Xu, Ronald B. Driesen, Jan Wyatt, Gertrude Van Gorp, Nastaran Meschi, Bart Van Meerbeek, Ivo Lambrichts, Reinhilde Jacobs
Summary: This study aimed to characterize the pattern of dental pulp healing in human teeth that underwent tooth autotransplantation (TAT) and regenerative endodontic treatment (RET) using state-of-the-art imaging techniques. The results revealed different patterns of dental pulp healing after TAT and RET.
JOURNAL OF ENDODONTICS
(2023)
Article
Engineering, Chemical
Mengdi Xu, Jinxue Cheng, Xiongfei Du, Qiang Guo, Yan Huang, Qinglin Huang
Summary: This study developed an amphiphobic PTFE nanofibrous membrane with enhanced anti-wetting and anti-fouling properties, showing stable flux and excellent salt rejection in MD process. The membrane exhibited strong water and oil repellency and demonstrated good stability and reusability, suggesting promising application prospects, especially in harsh environments.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Biomedical
Ruiyi Dong, Siyu Tian, Jiangbo Bai, Kunlun Yu, Chunjie Liu, Lei Liu, Dehu Tian
Summary: This study found that the use of electrospun polycaprolactone-amnion nanofibrous membranes effectively prevents peripheral nerve adhesion after neurolysis and promotes nerve repair and regeneration, showing promising clinical application prospects.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Jiahui Fu, Jianfeng Chen, Wenjun Li, Xiaomin Yang, Jingyan Yang, Huixin Quan, Haitao Huang, Gang Chen
Summary: The supplementation of laminins to DPEM enhances odontogenic differentiation of cells and contributes to the formation of the odontoblast layer in dental pulp regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Qian Li, Zhiai Hu, Yongxi Liang, Cancan Xu, Yi Hong, Xiaohua Liu
Summary: The study developed a multifunctional peptide-conjugated, pH-sensitive non-viral gene vector for fast revascularization and pulp regeneration in a full-length human tooth root. This vector significantly increased gene transfection efficiency, reduced cytotoxicity, upregulated VEGF expression in dental pulp stem cells, and accelerated new blood vessel formation and pulp tissue regeneration. The approach proves to be safe and effective for regenerative endodontics.
ACTA BIOMATERIALIA
(2021)
Review
Cell & Tissue Engineering
Pedram Iranmanesh, Amirhossein Vedaei, Sadra Salehi-Mazandarani, Parvaneh Nikpour, Saber Khazaei, Abbasali Khademi, Kerstin M. M. Galler, Mohammad-Hossein Nekoofar, Paul M. H. Dummer
Summary: This systematic review investigated the mechanisms regulating the differentiation of hDP-MSCs and identified several miRNAs involved in this process. Bioinformatic analysis revealed target genes, signaling pathways, and gene ontologies associated with these miRNAs. The findings support the potential application of these specific miRNAs in regulating the directed differentiation of hDP-MSCs in regenerative therapies.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hengameh Bakhtiar, Azin Ashoori, Sarah Rajabi, Mohamad Pezeshki-Modaress, Alireza Ayati, Mohammad Reza Mousavi, Mohammad Reza Ellini, Amir Kamali, Amir Azarpazhooh, Anil Kishen
Summary: The 30 mg/ml HAM ECM scaffold exhibited optimal physical properties and enhanced hDPSC migration. The HAM ECM scaffold did not hinder the formation of pulp-like tissue and revascularization within the root canal when used as both cell-free and cell-loaded scaffold. These findings underscore the potential of HAM ECM membrane for further exploration in regenerative endodontics.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Rene Elkaim, Isaac Maximiliano Bugueno-Valdebenito, Nadia Benkirane-Jessel, Henri Tenenbaum
Article
Pathology
Isaac M. Bugueno, Fareeha Batool, Linda Korah, Nadia Benkirane-Jessel, Olivier Huck
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Xavier Van Bellinghen, Ysia Idoux-Gillet, Marion Pugliano, Marion Strub, Fabien Bornert, Francois Clauss, Pascale Schwinte, Laetitia Keller, Nadia Benkirane-Jessel, Sabine Kuchler-Bopp, Jean Christophe Lutz, Florence Fioretti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Dentistry, Oral Surgery & Medicine
M. Strub, L. Keller, Y. Idoux-Gillet, H. Lesot, F. Clauss, N. Benkirane-Jessel, S. Kuchler-Bopp
JOURNAL OF DENTAL RESEARCH
(2018)
Article
Cell & Tissue Engineering
Sabine Kuchler-Bopp, Dominique Bagnard, Michael Van-Der-Heyden, Ysia Idoux-Gillet, Marion Strub, Herve Gegout, Herve Lesot, Nadia Benkirane-Jessel, Laetitia Keller
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Chemistry, Physical
Fareeha Batool, David-Nicolas Morand, Lionel Thomas, Isaac Maximiliano Bugueno, Javier Aragon, Silvia Irusta, Laetitia Keller, Nadia Benkirane-Jessel, Henri Tenenbaum, Olivier Huck
Article
Biotechnology & Applied Microbiology
Marion Strub, Xavier Van Bellinghen, Florence Fioretti, Fabien Bornert, Nadia Benkirane-Jessel, Ysia Idoux-Gillet, Sabine Kuchler-Bopp, Francois Clauss
BIOMED RESEARCH INTERNATIONAL
(2018)
Review
Chemistry, Multidisciplinary
Fareeha Batool, Marion Strub, Catherine Petit, Isaac Maximiliano Bugueno, Fabien Bornert, Francois Clauss, Olivier Huck, Sabine Kuchler-Bopp, Nadia Benkirane-Jessel
Review
Cell & Tissue Engineering
Gabriel Fernandez de Grado, Laetitia Keller, Ysia Idoux-Gillet, Quentin Wagner, Anne-Marie Musset, Nadia Benkirane-Jessel, Fabien Bornert, Damien Offner
JOURNAL OF TISSUE ENGINEERING
(2018)
Article
Chemistry, Physical
Rana Smaida, Luc Pijnenburg, Silvia Irusta, Erico Himawan, Gracia Mendoza, Ezeddine Harmouch, Ysia Idoux-Gillet, Sabine Kuchler-Bopp, Nadia Benkirane-Jessel, Guoqiang Hua
Article
Chemistry, Multidisciplinary
Celine Stutz, Marion Strub, Francois Clauss, Olivier Huck, Georg Schulz, Herve Gegout, Nadia Benkirane-Jessel, Fabien Bornert, Sabine Kuchler-Bopp
Article
Chemistry, Multidisciplinary
Celine Stutz, Francois Clauss, Olivier Huck, Georg Schulz, Nadia Benkirane-Jessel, Fabien Bornert, Sabine Kuchler-Bopp, Marion Strub
Summary: The use of a PCL membrane can prevent ankylosis when implanting bioengineered teeth and promote spontaneous eruption. This study describes a new method that improves the success rate of bioengineered teeth in the jawbone of adult mice.
Article
Cell & Tissue Engineering
Jessica Schiavi, Loic Reppel, Naceur Charif, Natalia de Isla, Didier Mainard, Nadia Benkirane-Jessel, Jean-Francois Stoltz, Rachid Rahouadj, Celine Huselstein
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)