Article
Pharmacology & Pharmacy
Mingchao Wang, Alessio Malfanti, Chiara Bastiancich, Veronique Preat
Summary: The study found that tocopherol succinate (TOS) and D-a-tocopherol polyethylene2000 succinate (TPGS2000) micelles could enhance the anti-cancer efficacy for the treatment of glioblastoma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Chemistry, Multidisciplinary
Ozlem Gokce Kocabay, Osman Ismail
Summary: In this study, doxorubicin (DOX) loaded polymeric micelles (PMs) with high drug-loading encapsulation efficiency and pH-dependent drug release were successfully synthesized. The co-encapsulation of two agents led to enhanced solubility compared to DOX loaded formulations (DOX-PMs).
Article
Pharmacology & Pharmacy
Xinran Wang, Jieyi Pan, Haohui Shi, Na Liang, Shaoping Sun
Summary: This study aimed to develop tumor-targeting and acid-responsive micelles as carriers for paclitaxel (PTX). An amphipathic polymer TOS-Ace-PEG-Bio was designed and synthesized and proved to self-assemble into nanosized micelles capable of encapsulating PTX. The PTX-loaded micelles showed pH-dependent drug release behavior and were selectively internalized by MCF-7 cells. In vivo studies confirmed their excellent antitumor activity and reduced side effects, making the TOS-Ace-PEG-Bio micelles promising carriers for PTX delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Songjin Cai, Xin Xie, Qinglan Yuan, Jian Ding, Lijia Meng, Junzhi Li, Ming He, Weidong Li, Jingmou Yu
Summary: The reduction-responsive CST micelles can enhance the efficacy of DOX at the tumor site and control drug release. These micelles can form self-assembled micelles, with DOX-containing CST micelles showing reduction-triggered drug release in the presence of reducing agents. Furthermore, D-CST exhibited stronger cytotoxicity against A549 and AGS cells.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Aditya R. Darade, Maria Lapteva, Vincent Ling, Yogeshvar N. Kalia
Summary: This study developed a micelle-based formulation of TAK-441 using TPGS, which significantly increased the aqueous solubility of TAK-441. Experimental results showed that this formulation resulted in greater cutaneous deposition of TAK-441 compared to a non-micelle control formulation, with negligible transdermal permeation, thereby reducing the risk of systemic side effects in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Sushrut Marathe, Gauri Shadambikar, Tabish Mehraj, Suresh P. Sulochana, Narendar Dudhipala, Soumyajit Majumdar
Summary: This study aimed to develop PTX-loaded NLCs to improve ocular bioavailability, with formulations demonstrating desirable physicochemical properties and stability under refrigerated conditions.
Article
Pharmacology & Pharmacy
Lyubomira Radeva, Yordan Yordanov, Ivanka Spassova, Daniela Kovacheva, Virginia Tzankova, Krassimira Yoncheva
Summary: This study aimed to improve the safety of the anticancer drug doxorubicin by encapsulating it with the cardioprotective agent resveratrol in Pluronic micelles. The micelles were successfully prepared and characterized by small size and narrow size distribution. In vitro studies showed that the dual-loaded micelles reduced the cytotoxicity of doxorubicin in cardiac cells while enhancing its cytotoxic effect in lymphoma cells.
Article
Pharmacology & Pharmacy
Renata S. Fernandes, Raquel Gregorio Arribada, Juliana O. Silva, Armando Silva-Cunha, Danyelle M. Townsend, Lucas A. M. Ferreira, Andre L. B. Barros
Summary: This study developed a novel hybrid nanoparticle for the treatment of breast cancer by combining the advantages of liposomes and polymeric nanoparticles. The nanoparticles demonstrated significant reductions in cell viability and migration, as well as enhanced cellular uptake, leading to effective inhibition of tumor growth. The increased accumulation of drugs in the tumor area, along with the synergic combination with TS, further improved the antitumor efficacy.
Article
Pharmacology & Pharmacy
Mohamad Mahani, Maral Bahmanpouri, Faeze Khakbaz, Faten Divsar
Summary: A pH-tunable on-off module polymeric micelles were synthesized for the delivery and controlled release of drug DOX. Nitrogen-doped carbon quantum dots were used to form micelles with robust fluorescence characteristics, and their properties were verified through various analyses. In vitro experiments showed that the developed nanocarrier exhibited good cytotoxicity against tumor cells, making it a promising approach for drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qianli Sheng, Min Yuan, Dan Wang, Yuanqi Kou, Lei Liu, Yan Chen, Shiyong Song
Summary: An injectable hydrogel based on self-assembled micelles of a Vitamin E derivative α-TOS was developed for combined chemotherapy. The hydrogel sustained released the loaded drug over 7 days and demonstrated synergistic antitumor effects with minimal toxic side effects.
Article
Chemistry, Multidisciplinary
Peng Liu, Ping Huang, En-Tang Kang
Summary: This study introduces a novel dextran-based drug delivery system that exhibits pH sensitivity during cancer chemotherapy. Experimental results show that the system has good biocompatibility and anti-tumor effects in vitro, while in vivo studies demonstrate its effectiveness in inhibiting tumor growth with minimal weight loss.
Article
Materials Science, Biomaterials
Heng Mei, Jing Li, Shengsheng Cai, Xuequan Zhang, Wenqiang Shi, Hai Zhu, Jun Cao, Bin He
Summary: This study developed a carrier-free nanoplatform assembled by dual-drug conjugates, which demonstrated good stability, efficient cellular uptake, and highly effective anti-tumor outcomes by disrupting intratumoral DNA activity and inhibiting mitochondria function simultaneously. The design principles of targeting different intracellular organelles for facilitating ROS production and DNA disruption in carrier-free nanodrugs construction can be extended to other therapeutic systems.
REGENERATIVE BIOMATERIALS
(2021)
Article
Engineering, Biomedical
Lipeng Qiu, Jiamin Xu, Kamel S. S. Ahmed, Mengqin Zhu, Yan Zhang, Miaomiao Long, Weijun Chen, Wenjie Fang, Huijie Zhang, Jinghua Chen
Summary: A dual-functional pH-sensitive drug delivery system was developed for breast cancer therapy. The system showed higher cytotoxicity and cell uptake efficiency compared to other drug-loaded micelles, indicating its potential for reversing multidrug resistance. In vivo experiments demonstrated that the system effectively inhibited tumor growth without significant changes in body weight. The results suggest that the dual gain DNVM can enhance the efficacy of chemotherapy for doxorubicin-resistant tumor cells and has the potential to overcome multiple drug resistance.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Irina Negut, Bogdan Bita
Summary: Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The advancement in the field of material science and nanomedicine has led to improved drug delivery systems with proven efficacy and fewer side effects. Various intelligent nanomedicines are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Thorough knowledge of these nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are simple to make and have high solubilization characteristics, making them a promising alternative in nanosystems for cancer treatment.
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Computer Science, Artificial Intelligence
Chao Wang, Yunchu Zhang, Yanfei Zhou, Shaohan Sun, Hanyuan Zhang, Yepeng Wang
Summary: This paper proposes a novel algorithm DFV-YOLOv5 for occupancy detection, which tackles the problems of slow model convergence and poor detection performance for densely occluded targets. The proposed algorithm uses the anchor-free mechanism and decoupled detection heads to improve the detection accuracy and robustness. Experimental results show the practicality and superiority of the algorithm in occupancy detection compared to mainstream target detection models.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Chemistry, Medicinal
Haiyu Zhang, Xinmei Xie, Junzhuo Shi, Qian Zhao, Dongmei Luo, Jiaojiao Hao, Yunfeng Zhou, Guang Han, Xiaobin Pang
Summary: The present study confirmed the cognition-enhancing effect of 3, 14, 19-Triacetyl andrographolide (ADA) on learning and memory deficits in 3 x Tg-AD mice. ADA improves synaptic plasticity and cognitive function mainly through inducing autophagy and promoting the degradation process.
PHYTOTHERAPY RESEARCH
(2023)
Article
Engineering, Geological
Chao Zhang, Chao Ding, Yun Zhou, Guangyu Wang, Fei Shi, Weiyuan Huang
Summary: A novel stair system is proposed in this study, which is a prefabricated reinforced concrete staircase isolated by high damping rubber (HDR) bearings that can alleviate the detrimental diagonal bracing effect of traditional staircases under lateral inputs. The remarkable properties of HDR bearings are verified through material tests, and a parametric study is conducted to understand the behavior of the developed system. The results confirm that the proposed system can mitigate the detrimental effect and improve the seismic performance, with the rubber thickness of the HDR bearings playing a significant role.
BULLETIN OF EARTHQUAKE ENGINEERING
(2023)
Article
Cell Biology
Rilei Jiang, Bing Lu, Fanchao Feng, Qian Li, Xiaolei Chen, Shibing Cao, Zhaoxia Pan, Zhengming Deng, Yufei Zhou, Ping Liu, Jiatuo Xu
Summary: The study indicated that a derivative of Houttuynia cordata (SNH) promoted pyroptosis in non-small cell lung cancer (NSCLC) cells by up-regulating a novel lncRNA (TCONS-14036) and activating the TCONS-14036/miR-1228-5p/PRKCDBP pathway. This finding offers a potential therapeutic target for NSCLC.
CELL PROLIFERATION
(2023)
Article
Biochemical Research Methods
Wenxian Wang, Dan Yang, Yufei Zhou, Yuding Zhang, Lijiao Guan, Xianfen Zhang, Weiming Xue, Saipeng Huang
Summary: This study successfully constructed highly sensitive and functional carbon quantum dots for the detection of tyrosinase activity. These carbon quantum dots showed excellent linear relationship and broad linear range with high accuracy and recovery in human serum samples. Furthermore, they demonstrated good cellular imaging capability and biocompatibility, making them suitable for intracellular tyrosinase detection. This research holds potential biomedical applications in early diagnosis of melanoma and other tyrosinase-related diseases.
JOURNAL OF FLUORESCENCE
(2023)
Article
Chemistry, Medicinal
Chengliang Sun, Mingxiao Yin, Yao Cheng, Zean Kuang, Xiaojia Liu, Gefei Wang, Xiao Wang, Kai Yuan, Wenjian Min, Jingwen Dong, Yi Hou, Lingrong Hu, Guoyu Zhang, Wenli Pei, Liping Wang, Yanze Sun, Xinmiao Yu, Yibei Xiao, Hongbin Deng, Peng Yang
Summary: S4-1 is an innovative small-molecule inhibitor of PD-L1 that effectively alters the PD-L1/PD-1 interaction, enhances cytotoxicity of immune cells towards tumor cells, and shows significant tumor growth inhibition in vivo. It also activates T-cells and reverses the inhibitory tumor microenvironment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Surgery
Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Chio-Hou Chong, Yang-Dan Liu, Yu-Xin Liu, Dan-Ning Zheng, Yi-Fan Zhang, Li Yu
Summary: Sal-B could improve the effect of fat transplantation by inhibiting the polarization of M1 macrophages through NF-kappa B signaling. The results showed that Sal-B significantly improved fat graft survival and attenuated adipose tissue fibrosis and inflammation. In addition, Sal-B had an inhibitory effect on NF-kappa B signaling.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Chemistry, Physical
Xiaojia Luo, Xiao Liang, Yang Wei, Ligan Hou, Ru Li, Dandan Liu, Mo Li, Shuyu Zhou
Summary: With the shrinking size of electronic devices, it is important to develop new wire materials with higher current carrying capacity. Super-aligned carbon nanotubes (SACNTs) introduced into copper thin films offer a solution for atom chips, exhibiting an ultra-high current carrying capacity beyond traditional wires. The composite structures have potential in high-power electronic devices, high-performance on-chip interconnecting, and other applications with long-term high-current demands.
Article
Computer Science, Information Systems
Yujie Zhou, Ruyan Wang, Xingyue Mo, Zhidu Li, Tong Tang
Summary: This study proposes a robust hierarchical federated learning (R-HFL) framework that utilizes cloud-edge cooperation to enhance communication efficiency and system resistance to abnormal behaviors in distributed machine learning training.
Article
Agronomy
Yong-Kang Liu, Cai-Di Xu, Xu-Song Zheng, Lei Chao, Yan-Fei Zhou, Guo-Yong Li, Yan Wu, Xue-Lian Bai, Ting Zhou, Bin Tang, Hong-Xing Xu
Summary: Excessive zinc is toxic to plants and its effect on the herbivorous insect Nilaparvata lugens is still unclear. This study assessed the impact of zinc-stressed rice plants on N. lugens. The results showed that zinc treatment altered sugar content in rice, reduced fecundity and trehalose content in N. lugens, and impacted trehalose metabolism. These findings suggest that zinc-stressed plants may have negative effects on herbivorous insects.
Article
Environmental Sciences
Nan Yang, Xing Hou, Yi Li, Huanjun Zhang, Jun Wang, Xiaodong Hu, Wenlong Zhang
Summary: This study investigates the effects of water diversion on microbial communities in different habitats. It finds that increased connectivity between aquatic habitats due to water diversion can homogenize microbial communities and reduce heterogeneity. Stochastic processes play an important role in shaping microbial community assembly, with dispersal limitation and variable selection being the dominant mechanisms in isolated lakes. The study provides important insights for water resource allocation and project management.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Xin Ma, Yi Li, Lihua Niu, Jiahui Shang, Nan Yang
Summary: Low-head dams are common hydraulic facilities that fragment rivers and contribute to river eutrophication. This study examined the effects of low-head dams on microbial community structure and ecosystem function in an urban river. The findings showed significant differences in microbial communities among cascade impoundments, which may be due to environmental heterogeneity caused by the dams. The study also revealed that the flow velocity is a key factor controlling river eutrophication. Therefore, careful consideration should be given to the location, type, and water storage capacity of low-head dams in river construction projects to optimize hydrodynamic conditions.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Kexin Li, Yufeng Jiang, Yiyao Zeng, Yafeng Zhou
Summary: Arrhythmogenic cardiomyopathy (ACM) is a heterogeneous disorder characterized by the replacement of cardiac myocytes with fibro-fatty tissues, leading to abnormal excitation-contraction (EC) coupling and a range of malignant events. The pathogenesis of ACM involves mutation variants in desmosomal or non-desmosomal gene loci, as well as various external factors. Ion channel alterations, autophagy and non-desmosomal variants are also important components in the development of ACM. Reviewing recent studies on these topics is crucial for better diagnosing and treating the molecular phase of ACM.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Environmental Sciences
Aiping Cheng, Yafeng Zhou, Guoju Chen, Shibing Huang, Zuyang Ye
Summary: Cemented tailings backfill (CTB) is a cost-effective and environmentally friendly method for recycling tailings in mining. This study investigates the fracture mechanism of CTB through an acoustic emission (AE) test under uniaxial compression. The results reveal the periodic characteristics of CTB in different stages, the significance of ultra-high frequency AE signals as precursor information, and the differentiation of AE signals between shear and tension cracks. The study also classifies the fracture types of AE sources in CTB. These findings provide a basis for stability monitoring and fracture prediction in CTB.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Chunjiang Liu, Liming Tang, Yue Zhou, Xiaoqi Tang, Gang Zhang, Qin Zhu, Yufei Zhou
Summary: This study systematically identified three candidate hub genes (FGR, LCP1, and C5AR1) and established a nomogram to assist in diagnosing unstable carotid plaques (USCP) with uremia using various bioinformatic analyses and machine learning algorithms. The findings provide a foothold for future studies on potential diagnostic candidate genes for USCP in uremic patients. Additionally, immune cell infiltration analysis revealed that dysregulated immune cell proportions were identified, and macrophages could have a critical role in USCP pathogenesis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
