Journal
RETROVIROLOGY
Volume 7, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1742-4690-7-99
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Funding
- French Foundation Cent pour sang la Vie
- Institut National du cancer (INCA)
- Association de lutte contre le cancer
- ligue nationale contre le cancer
- canceropole d'ile de France
- foundation pour la recherche medicale
- foundation de France
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The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection.
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