Article
Medicine, General & Internal
Huanhuan Cheng, Kenneth J. Ciuffreda, Huilu Jiang, Kun Zhou, Sigeng Lin, Jingwei Zheng, Xinping Yu, Balamurali Vasudevan, Yuanbo Liang
Summary: The study investigated the relationship between cone parameters and visual resolution in eyes with different levels of best corrected visual acuity. Eyes with better BCVA had greater cone density and smaller cone spacing compared to eyes with lower BCVA. This information may be useful for different clinical scenarios.
Article
Endocrinology & Metabolism
Jianchen Hao, Jiantong Du, Xiaopeng Gu, Yadi Zhang, Liu Yang, Shijie Zhang
Summary: This study found that there is a correlation between intraretinal blood flow perfusion and nerve changes in diabetic patients without diabetic retinopathy. Optical coherence tomography (OCT) and OCT angiography were performed on 86 diabetic patients, and it was found that the thickness of the ganglion cell-inner plexiform layer (GCIPL) in the macular area of affected eyes was lower compared to the control group. The study also found a positive correlation between the mean vessel length density and GCIPL thickness in the macular area, but no correlation between blood flow perfusion parameters and retinal nerve fibre layer (RNFL) thickness.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yong Zeng, Miao Liu, Mengyu Li, Dinyang Wei, Mingzhu Mao, Xinyue Liu, Sizhu Chen, Yang Liu, Bo Chen, Lei Yang, Sanmei Liu, Lifeng Qiao, Ruifan Zhang, Jie Li, Wentao Dong, Jie Zhong
Summary: This study investigated retinal vascular changes in patients with diabetic retinopathy (DR) using a newly developed ultrawide rapid scanning swept-source optical coherence tomography angiography (SS-OCTA) device. The results showed that the average vascular density (VD) of the superficial vascular complex (SVC) was significantly lower in the DR group, while the average VD of the deep vascular complex (DVC) was significantly higher. The VD of SVC had better predictive ability for DR, and the VD of DVC could also predict DR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wojciech Matuszewski, Katarzyna Gontarz-Nowak, Joanna M. Harazny, Elzbieta Bandurska-Stankiewicz
Summary: The study aims to evaluate the morphological parameters of retinal arterioles in patients with type 1 diabetes mellitus (DM1). The results showed significant morphological changes in retinal vessels in DM1 patients without previously diagnosed diabetic retinopathy. These changes may be early indicators of cardiovascular risk.
Article
Biology
Katarzyna Samelska, Jacek Pawel Szaflik, Barbara Smigielska, Anna Zaleska-Zmijewska
Summary: This study utilized adaptive optics to examine inherited retinal dystrophies affecting the macula and analyze the changes in cone parameters. The results showed significant changes in cone density and spacing over time, as well as deterioration in best corrected visual acuity.
Review
Ophthalmology
Vivian Schreur, Morten B. Larsen, Lucia Sobrin, Abdhish R. Bhavsar, Anneke den Hollander, B. Jeroen Klevering, Carel B. Hoyng, Eiko K. de Jong, Jakob Grauslund, Tunde Peto
Summary: Diabetic retinopathy (DR) is a significant complication of diabetes mellitus (DM) globally. The development of imaging modalities and emerging treatment options have improved prevention of vision loss through large-scale screening programs. Combining information from various imaging techniques can help design more personalized care for DR patients.
ACTA OPHTHALMOLOGICA
(2022)
Article
Endocrinology & Metabolism
Selina L. Liu, John R. Gonder, Ehsan Owrangi, Neil S. Klar, Irene M. Hramiak, Artem Uvarov, Jeffrey L. Mahon
Summary: This study examined whether nonmydriatic ultra-widefield screening on the day of a diabetes clinic visit improved detection of clinically important eye disease. The results showed that more eye diseases were detected in the on-site screening group compared to the usual screening group, demonstrating the effectiveness of nonmydriatic ultra-widefield screening in improving screening quality.
Article
Ophthalmology
Danial Roshandel, Danuta M. Sampson, David A. Mackey, Fred K. Chen
Summary: This study investigates the discordance between the adaptive optics (AO) montage center (AMC) and the foveal pit center (FPC) and its implications for cone mosaic analysis. The results show a marked mismatch between the AMC and FPC, which may be modified by diseases such as rod-cone dystrophy. The distance between AMC and FPC is a significant determinant of cone density and inter-cone distance.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Enrico Borrelli, Costanza Barresi, Alessandro Feo, Giorgio Lari, Domenico Grosso, Lea Querques, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques
Summary: The study aimed to assess the relationship between clinical characteristics and the rate of retinal thinning in eyes with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (VEGF) therapy. The findings showed a significant longitudinal thinning in the inner and outer retina in all analyzed regions. Type 2 diabetes, subfoveal neuroretinal detachment, gender, and diabetic retinopathy stage were associated with different rates of retinal thinning.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Fuhua Yang, Hui Zhang, Xinyue Yu, Qingqin Tao, Chuan Zhao, Jinying An, Xiaomin Zhang, Xiaorong Li
Summary: Our previous research has found that TNFAIP8 is increased in the plasma extracellular vesicles and vitreous humor in patients with diabetic retinopathy (DR). In this study, we investigated the effect of TNFAIP8 on DR development using an animal model and found that TNFAIP8 exacerbated pathological abnormalities, increased avascular area, leukostasis, and expression of inflammatory factors in the retina of diabetic mice. These results support the role of TNFAIP8 in the pathogenesis of DR and may provide novel therapeutic strategies.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Guisela Fernandez-Espinosa, Elvira Orduna-Hospital, Ana Boned-Murillo, Maria Dolores Diaz-Barreda, Ana Sanchez-Cano, Maria Sopena-Pinilla, Isabel Pinilla
Summary: This study aimed to investigate the choroidal thickness in patients with moderate diabetic retinopathy and its correlation with retinal thickness compared to healthy subjects. The results showed that retinal thickness was higher in certain areas in the diabetic group, but choroidal thickness did not differ between the groups. Additionally, age was found to have an impact on retinal thickness and choroidal thickness.
Article
Neurosciences
Ruyi Han, Mengmeng Jin, Gezhi Xu, Jie He
Summary: Historically, diabetic retinopathy was considered a vascular disease. However, recent evidence suggests that it is initiated by neuropathy. This study provides a new zebrafish model for studying progressive diabetic retinopathy defects and reveals cone morphologic defects as an early neuropathy in diabetic retinopathy.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Helia Ashourizadeh, Maryam Fakhri, Kiana Hassanpour, Ali Masoudi, Sattar Jalali, Danial Roshandel, Fred K. Chen
Summary: Adaptive optics (AO) retinal imaging allows for the visualization of individual photoreceptors in a clinical setting, which is crucial for studying photoreceptor degeneration. AO imaging is a powerful clinical tool that can detect cellular-level degeneration that may be missed by traditional methods. It is also useful for early-stage diagnosis and monitoring disease progression. However, caution should be exercised when interpreting AO imaging results due to various factors that can affect image quality and normal values.
Review
Medicine, General & Internal
Warren W. Pan, Thomas W. Gardner, Jennifer L. Harder
Summary: DRD remains a common cause of vision loss in working-age adults, with limited progress on new therapies due to the complexity of the human eye. Utilizing systems biology approaches that have been successful in DKD research may help clarify the molecular basis and progression of DRD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jacque L. Duncan, Joseph Carroll
Summary: The human retina can be visualized using various imaging modalities in a direct and noninvasive manner. Over the past 140 years, there has been continuous evolution in retinal imaging technology. Advances in image acquisition and processing speed now allow real-time visualization of retinal structure, revolutionizing the diagnosis and management of eye diseases. High-resolution imaging, such as adaptive optics-based systems, enables retina imaging with single-cell resolution. Functional imaging techniques provide the ability to assess function with exquisite spatial and temporal resolution. These imaging advances have had a profound impact on inherited retinal disease research. In this article, we will review the advances and applications of adaptive optics retinal imaging in patients with inherited retinal diseases.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2023)
Article
Ophthalmology
Pierluigi Iacono, Stefano Da Pozzo, Alberto Bedendo, Alessandro Arrigo, Mariacristina Parravano, Monica Varano, Maurizio Battaglia Parodi
Summary: OCTA evaluation in treatment-naive RA patients showed a significant reduction in the VD of SCP, indicating vascular remodeling in the retinal microcirculation. However, there was no difference in the VD of DCP and FAZ area between RA patients and healthy controls.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Sebastiano Serrao, Giuseppe Lombardo, Marco Lombardo
Summary: The most frequent adverse events after CXL were corneal haze and corneal edema, which were mild and transient. The clinical benefits of CXL highly outweighed the risks for the treatment of keratoconus and corneal ectasia.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Veterinary Sciences
Andrea Marchegiani, Rodolfo Gialletti, Maria Paola Cassarani, Matteo Cerquetella, Anna Rita Attili, Giuseppe Lombardo, Marco Lombardo, Andrea Spaterna, Rolando Arcelli
Summary: The study found that riboflavin/UV-A corneal phototherapy can effectively promote the healing of corneal ulcers in dogs and is faster than traditional medical therapy.
VETERINARNI MEDICINA
(2022)
Article
Pharmacology & Pharmacy
Mariacristina Parravano, Davide Allegrini, Adriano Carnevali, Eliana Costanzo, Giuseppe Giannaccare, Paola Giorno, Vincenzo Scorcia, Giorgio Alfredo Spedicato, Monica Varano, Mario R. Romano
Summary: This study evaluates the addition of a curcumin formulation with a polyvinylpyrrolidone-hydrophilic carrier to intravitreal injections of dexamethasone and its effects on the morphological retinal characteristics and re-treatment period in patients with diabetic macular edema. The results show significant differences in central retinal thickness, best-corrected visual acuity, and retinal layer thickness between the combined therapy group and the control group. This suggests that the combination of curcumin formulation with dexamethasone could be a promising therapeutic option for DME patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Giuseppe Lombardo, Sebastiano Serrao, Marco Lombardo
Summary: The purpose of this study was to investigate keratoconus progression using zonal average analysis of corneal tomography. The study analyzed corneal tomographies of patients at baseline and follow-up visits up to 4 years. The study found that single-point tomography indexes were not effective in capturing the overall structure and shape changes of the cornea, suggesting the need to update criteria for keratoconus management.
Review
Medicine, General & Internal
Gianni Virgili, Mariacristina Parravano, Davide Petri, Erica Maurutto, Francesca Menchini, Paolo Lanzetta, Monica Varano, Silvio Paolo Mariotti, Antonio Cherubini, Ersilia Lucenteforte
Summary: This study conducted a systematic review and meta-analysis to investigate the association between depression and vision impairment (VI) in adults. The results showed a direct association between depression and VI, particularly in the older adult population. Therefore, it is important to actively seek both morbidities when one is identified.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Marco Lombardo, Sebastiano Serrao, Giuseppe Lombardo
Summary: Age-related macular degeneration (AMD) is the leading cause of vision loss in individuals aged 60 and above. The disease's etiology is still uncertain, but multiple risk factors contribute to its onset and progression. Prevention and early detection are crucial in reducing the social and economic burden of AMD. Nutritional and lifestyle changes have been shown to protect against AMD progression.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Giuseppe Lombardo, Giuseppe Massimo Bernava, Sebastiano Serrao, Marco Lombardo
Summary: Theranostics is a personalized medicine approach that combines therapy and diagnostics. This study used theranostic-guided corneal cross-linking to treat human sclero-corneal tissues. The theranostic device provided real-time measurement of corneal riboflavin concentration and a theranostic score to estimate treatment efficacy. The study found a significant correlation between the theranostic score and the increase in mean corneal stiffness, with an accuracy and precision of 90% in predicting the induced corneal tissue stiffening.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Biochemical Research Methods
Giuseppe Lombardo, Giuseppe Massimo Bernava, Sebastiano Serrao, Marco Lombardo
Summary: The picture illustrates a dehydrative glycosylation mediated by 2-aryl-1,3-dithiane 1-oxides, with the activation of sulfoxide in the reagent leading to the installation of a temporary leaving group on the 1-OH sugar, facilitating the glycosylation reaction.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Ophthalmology
Marco Lombardo, Giuseppe Massimo Bernava, Sebastiano Serrao, Anna Maria Roszkowska, Giuseppe Lombardo
Summary: This study assessed the predictability of tissue biomechanical stiffening induced by corneal crosslinking (CXL) through real-time assessment of riboflavin concentration. The results showed that the measurement of riboflavin concentration and treatment efficacy during CXL can accurately predict and improve corneal tissue strength.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Anna Maria Roszkowska, Giuseppe Lombardo, Rita Mencucci, Vincenzo Scorcia, Giuseppe Giannaccare, Annarita Vestri, Danilo Alunni Fegatelli, Giuseppe Massimo Bernava, Sebastiano Serrao, Marco Lombardo
Summary: The ARGO clinical trial aims to test the efficacy of theranostic-guided riboflavin/UV-A corneal cross-linking for the treatment of keratoconus. The trial will validate the theranostic software module of a novel UV-A medical device and assess its real-time accuracy in estimating corneal cross-linking efficacy. 50 participants aged between 18 and 40 years with progressive keratoconus will be randomly allocated to two treatment protocols and monitored for 12 months to evaluate the change in maximum keratometry point value.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Fabio Scarinci, Monica Varano, Mariacristina Parravano
Summary: This study aimed to analyze the morphological and functional findings in patients with APMPPE using microperimetry and OCTA. The results showed improved retinal sensitivity in most eyes after treatment and OCTA revealed choriocapillaris flow deficit associated with reduced retinal sensitivity in the resolution phase.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)