Article
Medicine, General & Internal
Rita Serra, Antonio Pinna, Francine Behar-Cohen, Florence Coscas
Summary: This study investigated the incidence and features of choroidal neovascularization (CNV) in central serous chorioretinopathy (CSCR) patients using optical coherence tomography angiography (OCT-A). Complex CSCR is often complicated by type 1 CNV and polypoidal choroidal vasculopathy (PCV) with similar neovascular architecture, suggesting they may be different stages of the same neovascular process. Future studies incorporating demographic data, imaging morphology, and treatment response are needed for definitive conclusions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Takahiko Izumi, Hideki Koizumi, Ichiro Maruko, Taiji Hasegawa, Tomohiro Iida
Summary: This study aimed to evaluate the flow signals in subretinal hyperreflective material (SHRM) that represent classic choroidal neovascularization (CNV) using OCT angiography (OCTA) in eyes with polypoidal choroidal vasculopathy. The study successfully differentiated true Type 2 macular neovascularization from pseudo classic CNV.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Medicine, General & Internal
Figen Batioglu, Ozge Yanik, Ferhad Ozer, Sibel Demirel, Emin Ozmert
Summary: The study compares the choroidal characteristics of typical polypoidal choroidal vasculopathy (T-PCV) and polypoidal choroidal neovascularization (P-CNV) cases, and investigates the presence of intervortex venous anastomoses in these PCV subtypes using en face optical coherence tomography angiography (OCTA). Results show that T-PCV cases have significantly higher mean choroidal vascularity index (CVI) values and more dilated anastomotic vessels compared to P-CNV cases.
Article
Biochemistry & Molecular Biology
Young Ho Kim, Yoo-Ri Chung, Chungwoon Kim, Kihwang Lee, Won Ki Lee
Summary: This study investigated the relationship between pachydrusen and choroidal thickness and age in eyes with polypoidal choroidal vasculopathy (PCV) and eyes with central serous chorioretinopathy (CSC). The presence of pachydrusen was more frequent in PCV eyes compared to CSC eyes, and subfoveal choroidal thickness was associated with pachydrusen in PCV eyes while age was associated with pachydrusen in CSC eyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Timothy Y. Y. Lai, Ziqi Tang, Adrian C. W. Lai, Simon K. H. Szeto, Ricky Y. K. Lai, Carol Y. Cheung
Summary: The specific form of drusen, known as pachydrusen, is associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). This study found that pachydrusen are more prevalent in PCV than CSC and may be linked to age and more extensive abnormalities in fundus autofluorescence (FAF).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Stefano Da Pozzo, Pierluigi Iacono, Alessandro Arrigo, Maurizio Battaglia Parodi
Summary: Central serous chorioretinopathy (CSC) is a contentious disease involving various eye structures, with multiple therapeutic options available. Imaging plays a crucial role in evaluating and guiding treatment, while biomarkers serve as diagnostic and prognostic reference points.
Article
Ophthalmology
Yu-Yeh Tsai, Wei-Yang Lin, Shih-Jen Chen, Paisan Ruamviboonsuk, Cheng-Ho King, Chia-Ling Tsai
Summary: This study developed attention-based deep learning networks for the accurate diagnosis and segmentation of polypoidal choroidal vasculopathy (PCV) using fluorescein angiography (FA). The developed system achieved high classification and segmentation performance, providing a promising tool for early diagnosis and treatment of PCV.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Alessandro Arrigo, Emanuela Aragona, Alessandro Bordato, Alessandro Calamuneri, Alessio Grazioli Moretti, Stefano Mercuri, Francesco Bandello, Maurizio Battaglia Parodi
Summary: The study aimed to differentiate acute central serous chorioretinopathy (CSC) subtypes by using multimodal imaging. Two main subtypes, retinal pigment epithelium-related CSC (RPE-CSC) and choroidal-related CSC (choroidal-CSC), were identified based on quantitative pachychoroid cutoff values, showing differing responses to treatment and development of macular neovascularization (MNV).
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hooshang Faghihi, Alireza Mahmoudi, Elias Khalili Pour, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi, Ahmad Mirshahi, Alireza Khodabande, Hassan Khojasteh, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hamid Riazi-Esfahani
Summary: This study investigated differences in choroidal biomarkers between avascular (aFIPED) and vascularized (vFIPED) flat irregular pigment epithelial detachments in eyes with chronic CSC. The results showed that vFIPED patients had lower SFCT and higher CVI compared to aFIPED patients. Measurement of CVI along with SFCT may help differentiate aFIPED from vFIPED in CSC patients.
Article
Medicine, General & Internal
Ari Shinojima, Yoko Ozawa, Atsuro Uchida, Norihiro Nagai, Hajime Shinoda, Toshihide Kurihara, Misa Suzuki, Sakiko Minami, Kazuno Negishi, Kazuo Tsubota
Summary: This study assessed the HFF in CSC using different imaging techniques and found that NIR-AF was the easiest method to detect HFF on late-phase ICGA, which may indicate melanin abnormalities in the retinal pigment epithelium.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Ryo Mukai, Kanako Itagaki, Jyunichiro Honjyo, Hidetaka Matsumoto, Tetsuju Sekiryu
Summary: This study aimed to determine the relationship between posterior vortex vein pulsation, choroidal thickness, and choroidal vascular hyperpermeability (CVH) in polypoidal choroidal vasculopathy (PCV). The study found that pulsation was associated with a thin choroid, but not with CVH.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Joon Seo Lim, Cheolwon Moon, Junyeop Lee
Summary: The presence of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC) is associated with disturbances in retinal blood flow, including reduced venous blood flow velocity and rate, as well as changes in venous diameter. SRF thickness is correlated with a decrease in venous blood flow rate, suggesting that SRF plays a role in altering retinal blood flow dynamics.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Huajui Wu, Yukinori Sugano, Kanako Itagaki, Akihito Kasai, Hiroaki Shintake, Tetsuju Sekiryu
Summary: The study found that the number of flow voids (FVs) in fellow eyes of unilateral polypoidal choroidal vasculopathy (PCV) was significantly lower compared to the control group, indicating a higher prevalence rate of choroidal vascular hyperpermeability (CVH) in PCVF.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Voraporn Chaikitmongkol, Thanaphat Chaovisitsaree, Direk Patikulsila, Paradee Kunavisarut, Nopasak Phasukkijwatana, Nawat Watanachai, Janejit Choovuthayakorn, Sirawit Isipradit, Pawinee Boonyot, Apisara Sangkaew, Thammasin Ingviya, Susan B. Bressler, Neil M. Bressler
Summary: The purpose of this study was to determine the accuracy and relative risk (RR) of posttreatment optical coherence tomography (OCT) features in identifying complete or incomplete polypoidal regression in polypoidal choroidal vasculopathy (PCV). The results showed that OCT features could provide high accuracy in identifying posttreatment complete or incomplete polypoidal regression in PCV, even without indocyanine green angiography (ICGA).
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Qiyu Bo, Min Zhang, Jieqiong Chen, Huixun Jia, Mengxi Shen, Mengsha Sun, Mengqiao Xu, Jingyang Feng, Quan Yan, Yang Yu, Peirong Huang, Tong Li, Fenghua Wang, Philip J. Rosenfeld, Xiaodong Sun
Summary: The purpose of this study was to investigate the characteristics of the branching vascular network (BVN) and polypoidal lesions in polypoidal choroidal vasculopathy (PCV) and determine near-term indicators that may predict exudative recurrence. The findings suggest that the growth of nonexudative BVN and progression of polypoidal lesions are associated with exudative recurrences, and the progression of polypoidal lesions may serve as an indicator for the near-term onset of exudation.
Article
Multidisciplinary Sciences
Ari Shinojima, Miki Sawa, Ryusaburo Mori, Tetsuju Sekiryu, Yuji Oshima, Aki Kato, Chikako Hara, Masaaki Saito, Yukinori Sugano, Masayuki Ashikari, Yoshio Hirano, Hitomi Asato, Mayumi Nakamure, Kiyoshi Matsune, Noriyuki Kuno, Erika Kimure, Takeshi Nishiyama, Mitsuko Yuzawa, Tatsuro Ishibashi, Yuichiro Ogura, Tomohiro Lida, Fumi Gomi, Tsutomu Yasukawa
Article
Ophthalmology
Adrian T. Fung, Raymond Guan, Veronica Forlani, Yi-Chiao Li, Jay Chhablani, Dmitrii S. Maltsev, Dinah Zur, Matias Iglicki, Aude Couturier, Ari Shinojima, Ana C. Almeida, Catharina Busch, Marco Lupidi, Carlo Cagini, Pukhraj Rishi, Pierre-Henry Gabrielle, Samantha Fraser-Bell, Atchara Amphornphruet, Peranut Chotcomwongse, Yan Hong Chen, Marco Pellegrini, Patricio J. Rodriguez-Valdez, Zafer Cebeci, Ermete Giancipoli, Voraporn Chaikitmongkol, Mali Okada, Ines Lains, Anna Sala-Puigdollers, Malgorzata Ozimek, Matus Rehak, Anat Loewenstein
Summary: This study found that 11.7% of choroidal naevi not visible with subretinal fluid on clinical examination demonstrated subretinal fluid on OCT scans. These naevi more commonly exhibited features known to be associated with growth and transformation to melanoma. The presence of subclinical OCT-detectable fluid over choroidal naevi may assist in their risk stratification.
Article
Neurosciences
Ken-ichi Iwasaki, Yojiro Ogawa, Takuya Kurazumi, Syed M. Imaduddin, Chiaki Mukai, Satoshi Furukawa, Ryo Yanagida, Tomokazu Kato, Toru Konishi, Ari Shinojima, Benjamin D. Levine, Thomas Heldt
Summary: The study found that in the majority of astronauts (>90%), long-duration spaceflight did not lead to an increase in postflight intracranial pressure, suggesting that the fluid shift during spaceflight does not systematically elevate ICP. For astronauts with ocular alterations, both increases and decreases in intracranial pressure were observed post-flight, indicating a lack of primary causal relationship between elevated ICP and spaceflight associated optical changes. Independently of ICP and ocular alterations, the results suggest that long-duration spaceflight may increase cerebral blood flow, possibly due to reduced haemoglobin concentration.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Ophthalmology
Sumihiro Kawano, Takumi Imai, Taiji Sakamoto
Summary: A retrospective cohort study of patients with uncomplicated phakic macula-on retinal detachment was conducted to compare outcomes of pars plana vitrectomy (PPV) versus scleral buckling (SB). The study showed a higher proportion of anatomical failures in the PPV group compared to the SB group, but no significant difference in change in best-corrected visual acuity between the two groups.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Ari Shinojima, Yoko Ozawa, Atsuro Uchida, Norihiro Nagai, Hajime Shinoda, Toshihide Kurihara, Misa Suzuki, Sakiko Minami, Kazuno Negishi, Kazuo Tsubota
Summary: This study assessed the HFF in CSC using different imaging techniques and found that NIR-AF was the easiest method to detect HFF on late-phase ICGA, which may indicate melanin abnormalities in the retinal pigment epithelium.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Toshihide Kurihara, Deokho Lee, Ari Shinojima, Taku Kinoshita, Saori Nishizaki, Yoko Arita, Yuki Hidaka, Yasuyo Nishi, Yoshinori Shirakawa, Sho Kimura, Yukari Tsuneyoshi, Hidemasa Torii, Kazuo Tsubota, Kazuno Negishi
Summary: Study found a correlation between glucose levels in the anterior chamber of the eye and blood glucose levels, with the strength of the correlation depending on blood glucose dynamics. Establishing noninvasive blood glucose monitoring from measuring glucose levels in the anterior chamber more accurately based on this correlation would be helpful for proper and prompt management of glucose-mediated complications.
Article
Multidisciplinary Sciences
Deokho Lee, Heonuk Jeong, Yukihiro Miwa, Ari Shinojima, Yusaku Katada, Kazuo Tsubota, Toshihide Kurihara
Summary: The study established a murine model of chronic hypoperfusion retinal injuries by permanent unilateral common carotid artery occlusion (UCCAO) to investigate pathological mechanisms of retinal ischemia, with results showing functional, morphological, and molecular changes in the retina after UCCAO.
Article
Multidisciplinary Sciences
Ryoh Funatsu, Hiroto Terasaki, Taiji Sakamoto
Summary: This study found regional and sex differences in the treatment of rhegmatogenous retinal detachment in Japan, with men in certain regions more likely to undergo early surgical intervention, while women are less likely to receive it.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Ari Shinojima, Deokho Lee, Kazuo Tsubota, Kazuno Negishi, Toshihide Kurihara
Summary: The number of patients with age-related macular degeneration (AMD) is increasing worldwide with increased life expectancy, and the standard treatment for wet-AMD is intravitreal injection of anti-VEGF drugs. HIF is considered a promising therapeutic target in ocular ischemic diseases, and abnormal hypofluorescent areas detected in late-phase indocyanine green angiography are thought to be related to AMD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yukihiro Miwa, Hiroyuki Komatsu, Ari Shinojima, Ayako Oda, Mao Inagaki, Kensuke Usami, Minori Akasaka, Yoshitaka Kobayashi
Summary: A 7.5-year-old male Japanese macaque with intact eyes underwent evaluation for vision loss and was diagnosed with hypermature cataract in both eyes. Following cataract surgery, the patient was able to find food and walk in a straight line.
CLINICAL CASE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara
Summary: The study suggests that NMN administration offers protection against retinal ischemia/reperfusion injury by suppressing inflammation, protecting retinal neuronal cells, and activating the antioxidant pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Heonuk Jeong, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara
Summary: This study demonstrated for the first time the protective effect of NMN in cardiovascular disease-induced retinal ischemia in a mouse model, suppressing retinal dysfunction and pathological gliosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Public, Environmental & Occupational Health
Ari Shinojima, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Summary: The myopia epidemic is a global public health problem, and the COVID-19 outbreak has accelerated its progression. Current treatments for humans include eye drops, optical treatment, and orthokeratology, while animal experiments have revealed new mechanisms of myopia suppression.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Yuji Oshima, Ari Shinojima, Miki Sawa, Ryusaburo Mori, Tetsuju Sekiryu, Aki Kato, Chikako Hara, Masaaki Saito, Yukinori Sugano, Yoshio Hirano, Hitomi Asato, Mayumi Nakamura, Erika Kimura, Mitsuko Yuzawa, Tatsuro Ishibashi, Yuichiro Ogura, Tomohiro Iida, Fumi Gomi, Tsutomu Yasukawa
Summary: This study aimed to evaluate the progression of early age-related macular degeneration (AMD) to neovascular AMD (nAMD) and identify the abnormal fundus autofluorescence (FAF) patterns and markers of choroidal neovascularization (CNV) in the fellow eyes of patients with unilateral nAMD. The study found that fellow eyes with abnormal FAF in patients with unilateral nAMD may progress from early to advanced nAMD, but no FAF pattern was found that predicted progression in nAMD.
Article
Biology
Ari Shinojima, Toshihide Kurihara, Kiwako Mori, Yujiro Iwai, Akiko Hanyuda, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota
Summary: The study aims to identify new factors predicting myopia and explore gender differences in high myopia. Results indicate a potential relationship between body height and foot length with axial length, differing by gender.
BMC RESEARCH NOTES
(2021)
