Article
Ophthalmology
Dun Jack Fu, Daren Hanumunthadu, Tiarnan D. L. Keenan, Siegfried Wagner, Konstantinos Balsakas, Pearse A. Keane, Praveen J. Patel
Summary: This study aims to evaluate the proportion of AMD patients achieving a 12-week dosing interval of aflibercept. The study found that 68% of eyes were able to achieve a q12 injection dose within the first 2 years of treatment. Eyes achieving a q12 injection had similar visual acuity outcomes at both 1 and 2-year follow-up to those unable to do so, with fewer total injections.
Article
Ophthalmology
Tiarnan D. L. Keenan, Traci E. Clemons, Amitha Domalpally, Michael J. Elman, Moshe Havilio, Elvira Agron, Gidi Benyamini, Emily Y. Chew
Summary: This study evaluated the performance of retinal specialists in detecting retinal fluid presence in eyes with age-related macular degeneration, and found that an artificial intelligence algorithm achieved higher accuracy compared to human specialists. The AI algorithm outperformed human specialists in detecting both intraretinal and subretinal fluid presence.
Article
Ophthalmology
Emilie Dobler, Bashar Raouf Mohammed, Randhir Chavan, Peck Lin Lip, Arijit Mitra, Bushra Mushtaq
Summary: This study reports the 5-year real-world efficacy and safety of the 0.19 mg fluocinolone acetonide implant (ILUVIEN) for the treatment of chronic diabetic macular oedema (DMO) in a tertiary centre in Birmingham, UK. The results show significant improvement in visual acuity after 1 year of ILUVIEN treatment, with a gradual recovery to baseline levels over 5 years. Central retinal thickness was consistently reduced throughout the 5-year period. Although the proportion of eyes on IOP-lowering medication was higher, the rates of incisional IOP-lowering surgery and other complications remained low.
Article
Ophthalmology
Sanjeeb Bhandari, David Squirrell, Vuong Nguyen, Nancy Wang, Jane M. Wells, Terence Tan, Rachel Barnes, Richard Barry, Daniel Barthelmes, Mark Gillies
Summary: In routine clinical practice, bevacizumab was shown to be an effective treatment for diabetic macular oedema (DMO) in unselected populations. Eyes with better vision tended to maintain their vision, while eyes with worse vision showed improvement over the observation period.
Article
Multidisciplinary Sciences
D. Palanker, Y. Le Mer, S. Mohand-Said, J. A. Sahel
Summary: In this study, researchers conducted a clinical trial using a wireless photovoltaic subretinal implant on patients with atrophic age-related macular degeneration. The results showed that patients exhibited prosthetic visual perception closely matching the pixel size during the 18-24 month follow-up period.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Simrat K. Sodhi, Austin Pereira, Jonathan D. Oakley, John Golding, Carmelina Trimboli, Daniel B. Russakoff, Netan Choudhry
Summary: This study evaluated the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity outcomes in neovascular age-related macular degeneration patients. The results showed that the total retinal fluid volume at baseline had the strongest correlation with improvement in BCVA. Additionally, combining OCT-A information improved the correlation.
Article
Ophthalmology
Yi Guo, Jinye Wu, Xueying Zheng, Chang Yin, Zhenyu Wu
Summary: This study examines the association between early-stage variation in central retinal thickness (CRT) and long-term visual outcomes in patients with neovascular age-related macular degeneration (nAMD). The results show that high early-stage CRT variability is significantly associated with an increased risk of legal blindness.
OPHTHALMIC RESEARCH
(2022)
Article
Ophthalmology
Conceicao Lobo, Torcato Santos, Ines P. Marques, Maria H. Madeira, Ana Rita Santos, Joao Figueira, Jose Cunha-Vaz
Summary: This study characterizes the prevalence and progression of centre-involving diabetic macular oedema (CI-DMO) in minimal to moderate non-proliferative diabetic retinopathy using optical coherence tomography (OCT) and optical reflectivity ratios (OCT-Leakage) measurements of retinal fluid. The results show that subclinical CI-DMO and CI-DMO occur independently of the severity grading of retinopathy and exhibit a progressive increase in retinal extracellular fluid, which is associated with vision loss.
Article
Ophthalmology
David R. Lally, Anat Loewenstein, Jennifer J. Arnold, Yit C. Yang, Kinfemichael Gedif, Catherine Best, Hersh Patel, Ramin Tadayoni, Jeffrey S. Heier
Summary: This analysis shows that brolucizumab has better anatomical and visual outcomes compared to aflibercept, and may achieve greater disease control in nAMD patients with early persistent retinal fluid.
Article
Ophthalmology
Onnisa Nanegrungsunk, Sophie Z. Gu, Susan B. Bressler, Weiming DU, Fouad Amer, Hadi Moini, Neil M. Bressler
Summary: This study aimed to determine the correlation between changes in central subfield thickness (CST) and changes in best-corrected visual acuity (BCVA) in patients with neovascular age-related macular degeneration. The results showed weak or no correlation between CST and BCVA, regardless of the type of drug or treatment regimen. This suggests that changes in CST should not be used as a surrogate marker for visual acuity outcomes in this condition.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Shruti Chandra, Sarega Gurudas, Benjamin J. L. Burton, Geeta Menon, Ian Pearce, Martin Mckibbin, Ajay Kotagiri, James Talks, Anna Grabowska, Faruque Ghanchi, Richard Gale, Andrea Giani, Victor Chong, Taffeta Ching Ning Yamaguchi, Bishwanath Pal, Sridevi Thottarath, Raheeba Muhamed Pakeer, Swati Chandak, Andrea Montesel, Sobha Sivaprasad
Summary: The associations of optical coherence tomography (OCT) features with visual acuity (VA) in treatment naive neovascular age-related macular degeneration (nAMD) were studied. The presence of fovea-involving atrophy, intraretinal fluid, subretinal hyperreflective material, fibrosis, loss of integrity of the foveal ellipsoid zone/external limiting membrane, and increased central subfield thickness were found to determine poor presenting VA.
Article
Ophthalmology
Nishaant Bhambra, Aman P. Sayal, Marko M. Popovic, Rajeev H. Muni, Peter J. Kertes
Summary: In patients with macular edema secondary to RVO, there were no significant differences between combination MLP-IVI or peripheral LPC-IVI relative to IVI monotherapy for final BCVA or OCT parameters.
Article
Ophthalmology
Justus G. Garweg, Christin Gerhardt
Summary: The study assessed disease stability and treatment interval extension in exudative AMD. Results showed varying rates of disease stability and treatment interval extension among different drugs, with most eyes achieving stability at 12 weeks and some extending treatment to over 12 weeks. This highlights the challenges in balancing treatment intensity in AMD management.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Prasad Apsangikar, Pravin Ghadge, Manoj Naik, Santosh Nair, Ravikiran Payghan
Summary: The study found no significant difference in clinical efficacy, safety, and immunogenicity between the biosimilar ranibizumab and the reference product, based on evaluations of visual acuity, central macular thickness, adverse events, and immunogenicity in patients with neovascular age-related macular degeneration.
CLINICAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Mali Okada, Tien Yin Wong, Paul Mitchell, Bora Eldem, S. James Talks, Tariq Aslam, Vincent Daien, Francisco J. Rodriguez, Richard Gale, Jane Barratt, Robert P. Finger, Anat Loewenstein
Summary: This study developed and validated terminology on patient nonadherence and nonpersistence to anti-vascular endothelial growth factor therapy for nAMD, aiming to provide a framework for assessing treatment nonadherence and nonpersistence over time and across different health settings.
JAMA OPHTHALMOLOGY
(2021)
Article
Endocrinology & Metabolism
Julie A. Lovshin, Yuliya Lytvyn, Leif E. Lovblom, Alexandra Katz, Genevieve Boulet, Petter Bjornstad, Vesta Lai, Leslie Cham, Josephine Tse, Andrej Orszag, Hillary A. Keenan, Narinder Paul, Vera Bril, David T. Wong, Kylen D. McReelis, Michael H. Brent, Bruce A. Perkins, David Z. I. Cherney
Article
Ophthalmology
Gerardo Gonzalez-Saldivar, Alan Berger, David Wong, Verena Juncal, David R. Chow
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Letter
Ophthalmology
Shicheng Jin, Carolina L. M. Francisconi, David T. Wong
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2020)
Review
Ophthalmology
Wai-Ching Lam, Netan Choudhry, David Wong
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2020)
Article
Ophthalmology
M. C. Boucher, J. Qian, M. H. Brent, D. T. Wong, T. Sheidow, R. Duval, A. Kherani, R. Dookeran, D. Maberley, A. Samad, V Chaudhary
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2020)
Article
Ophthalmology
Daniel Q. Li, Adam K. Rudkin, Filiberto Altomare, Louis Giavedoni, David T. Wong
Correction
Endocrinology & Metabolism
Paolo Lanzetta, Valentina Sarao, Peter H. Scanlon, Jane Barratt, Massimo Porta, Francesco Bandello, Anat Loewenstein
ACTA DIABETOLOGICA
(2020)
Article
Endocrinology & Metabolism
Paolo Lanzetta, Valentina Sarao, Peter H. Scanlon, Jane Barratt, Massimo Porta, Francesco Bandello, Anat Loewenstein, Bora Eldem, Alex Hunyor, Antonia Joussen, Adrian Koh, Jean-Francois Korobelnik, Monica Lovestam-Adrian, Rafael Navarro, Annabelle A. Okada, Ian Pearce, Francisco J. Rodriguez, Giovanni Staurenghi, Sebastian Wolf, David T. Wong
ACTA DIABETOLOGICA
(2020)
Review
Ophthalmology
Jean-Francois Korobelnik, Anat Loewenstein, Bora Eldem, Antonia M. Joussen, Adrian Koh, George N. Lambrou, Paolo Lanzetta, Xiaoxin Li, Monica Lovestam-Adrian, Rafael Navarro, Annabelle A. Okada, Ian Pearce, Francisco J. Rodriguez, David T. Wong, Lihteh Wu
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Koby Brosh, Carolina L. M. Francisconi, Jenny Qian, Francesco Sabatino, Verena R. Juncal, Roxane J. Hillier, Varun Chaudhary, Alan R. Berger, Louis R. Giavedoni, David T. Wong, Filiberto Altomare, Mustafa R. Kadhim, Richard B. Newsom, Samara B. Marafon, Rajeev H. Muni
JAMA OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Rajeev H. Muni, Carolina L. M. Francisconi, Tina Felfeli, Michael Y. K. Mak, Alan R. Berger, David T. Wong, Filiberto Altomare, Louis R. Giavedoni, Radha P. Kohly, Peter J. Kertes, Natalia Figueiredo, Fei Zuo, Kevin E. Thorpe, Roxane J. Hillier
JAMA OPHTHALMOLOGY
(2020)
Letter
Ophthalmology
Bryon R. McKay, David Ta Kim, David T. Wong
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2020)
Review
Ophthalmology
Parsa Mehraban Far, Felicia Tai, Adeteju Ogunbameru, Petros Pechlivanoglou, Beate Sander, David T. Wong, Michael H. Brent, Tina Felfeli
Summary: Teleretinal screening is highly accurate for detecting any DR and DR warranting referral. Data for AMD screening is promising but warrants further investigation.
BMJ OPEN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jeff Park, Tina Felfeli, Imaan Z. Kherani, Filiberto Altomare, David R. Chow, David T. Wong
Summary: This retrospective study aimed to evaluate the baseline prevalence of subretinal fluid (SRF) in patients with diabetic macular edema (DME) and retinal vein occlusion (RVO) and its effects on anatomical and visual outcomes following anti-vascular endothelial growth factor (VEGF) therapy. The study found that eyes with SRF in the DME subgroup showed significant improvement in visual acuity (VA) and greater reduction in central subfield thickness (CST), while no significant association between SRF and VA improvement was observed in the RVO subgroup.
BMJ OPEN OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Marion R. Munk, Amir H. Kashani, Ramin Tadayoni, Jean-Francois Korobelnik, Sebastian Wolf, Francesco Pichi, Adrian Koh, Akihiro Ishibazawa, Alain Gaudric, Anat Loewenstein, Bruno Lumbroso, Daniela Ferrara, David Sarraf, David T. Wong, Dimitra Skondra, Francisco J. Rodriguez, Giovanni Staurenghi, Ian Pearce, Judy E. Kim, K. Bailey Freund, Maurizio Battaglia Parodi, Nadia K. Waheed, Richard Rosen, Richard F. Spaide, Shintaro Nakao, SriniVas Sadda, Stela Vujosevic, Tien Yin Wong, Toshinori Murata, Usha Chakravarthy, Yuichiro Ogura, Wolfgang Huf, Meng Tian
Summary: This study provides international consensus recommendations for reporting OCTA findings in retinal vascular disease, which may help to improve the interpretability and description in clinic and clinical trials.
OPHTHALMOLOGY RETINA
(2022)