Article
Medicine, General & Internal
Timothy Y. Y. Lai, Ziqi Tang, Adrian C. W. Lai, Simon K. H. Szeto, Ricky Y. K. Lai, Carol Y. Cheung
Summary: The specific form of drusen, known as pachydrusen, is associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). This study found that pachydrusen are more prevalent in PCV than CSC and may be linked to age and more extensive abnormalities in fundus autofluorescence (FAF).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Keiko Azuma, Ryo Obata, Rei Arasaki, Shouko Ikeda, Arisa Ito, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: Cigarette smoking is associated with increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may play an important role in modulating the disease. Age, SE, and past smoking history are key factors influencing SFCT.
Article
Biochemistry & Molecular Biology
Young Ho Kim, Yoo-Ri Chung, Chungwoon Kim, Kihwang Lee, Won Ki Lee
Summary: This study investigated the relationship between pachydrusen and choroidal thickness and age in eyes with polypoidal choroidal vasculopathy (PCV) and eyes with central serous chorioretinopathy (CSC). The presence of pachydrusen was more frequent in PCV eyes compared to CSC eyes, and subfoveal choroidal thickness was associated with pachydrusen in PCV eyes while age was associated with pachydrusen in CSC eyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yihao Xia, Xiaodong Li, Jiaqi Zhang, Xuejun Xie
Summary: This study evaluated the choroidal vascularity index (CVI) in central serous chorioretinopathy (CSC) and found that CVI is increased in acute CSC eyes and fellow eyes. There was no significant difference in CVI between acute and chronic CSC eyes. The area selected for CVI calculation may influence the outcomes of the study and requires further research.
Article
Medicine, General & Internal
Rita Serra, Antonio Pinna, Francine Behar-Cohen, Florence Coscas
Summary: This study investigated the incidence and features of choroidal neovascularization (CNV) in central serous chorioretinopathy (CSCR) patients using optical coherence tomography angiography (OCT-A). Complex CSCR is often complicated by type 1 CNV and polypoidal choroidal vasculopathy (PCV) with similar neovascular architecture, suggesting they may be different stages of the same neovascular process. Future studies incorporating demographic data, imaging morphology, and treatment response are needed for definitive conclusions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Filippo Tatti, Claudio Iovino, Giuseppe Demarinis, Emanuele Siotto Pintor, Marco Pellegrini, Oliver Beale, Kiran Kumar Vupparaboina, Mohammed Abdul Rasheed, Giuseppe Giannaccare, Jay Chhablani, Enrico Peiretti
Summary: The aim of this study was to evaluate choroidal vascularity in unilateral central serous chorioretinopathy (CSC) using en face optical coherence tomography (OCT) images. The study included 40 eyes of 20 CSC patients and 20 eyes of 10 healthy individuals. The results showed no significant differences in choroidal vascularity index (CVI) between different layers of the choroid in CSC-affected eyes and fellow eyes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Richard F. Spaide, Wei Kiong Ngo, Irene Barbazetto, John A. Sorenson
Summary: Variations in venous caliber are common in central serous chorioretinopathy and are associated with increased pressure and remodeling of larger choroidal veins.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Enrico Borrelli, Marco Battista, Costanza Barresi, Domenico Grosso, Maria Cristina Gabela, Alberto Quarta, Andrea Saladino, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
Summary: The purpose of this study was to quantitatively evaluate the inner and outer choroidal changes in the fellow eyes of patients with unilateral central serous chorioretinopathy (CSC). The results showed that both the choriocapillaris and stromal areas were increased in the unaffected eyes of unilateral CSC patients, along with a higher choroidal vascularity index. Additionally, the percentage and number of choriocapillaris flow deficits were also increased in these patients.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Etsuyo Horiguchi, Jun Takeuchi, Ryo Tomita, Keiko Asai, Yuyako Nakano, Hikaru Ota, Yosuke Taki, Yasuki Ito, Hiroko Terasaki, Koji M. Nishiguchi, Keiko Kataoka
Summary: This retrospective study evaluated choroidal hemodynamics after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) using laser speckle flowgraphy. The study found that half-dose PDT reduced choroidal blood flow in the treated area, with current smoking status blunting this effect.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Young Ho Kim, Boram Lee, Edward Kang, Jaeryung Oh
Summary: Subfoveal choroidal thickness was greater in acute CSC group compared to other groups while peripapillary choroidal thickness was significantly higher in acute and chronic CSC groups than in controls. Choroidal vascularity index outside the macula was increased in all eyes with both current and past history of CSC, suggesting potential implications for choroidal characteristics.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Physiology
Fabao Xu, Cheng Wan, Lanqin Zhao, Qijing You, Yifan Xiang, Lijun Zhou, Zhongwen Li, Songjian Gong, Yi Zhu, Chuan Chen, Cong Li, Li Zhang, Chong Guo, Longhui Li, Yajun Gong, Xiayin Zhang, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Daniel Ting, Chenjin Jin, Haotian Lin
Summary: The study aimed to predict the recurrence of central serous chorioretinopathy (CSC) patients using machine learning. The ensemble model performed the best among six different algorithms, demonstrating high accuracy in predicting recurrence at both 3 and 6 months. The simplified model showed comparable predictive power to the ensemble model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hooshang Faghihi, Alireza Mahmoudi, Elias Khalili Pour, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi, Ahmad Mirshahi, Alireza Khodabande, Hassan Khojasteh, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hamid Riazi-Esfahani
Summary: This study investigated differences in choroidal biomarkers between avascular (aFIPED) and vascularized (vFIPED) flat irregular pigment epithelial detachments in eyes with chronic CSC. The results showed that vFIPED patients had lower SFCT and higher CVI compared to aFIPED patients. Measurement of CVI along with SFCT may help differentiate aFIPED from vFIPED in CSC patients.
Article
Multidisciplinary Sciences
Aya Kamimura, Akiko Miki, Maya Kishi, Mina Okuda, Mayuka Hayashida-Hirano, Mari Sakamoto, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
Summary: The purpose of this study was to compare the two-year outcome of half-time photodynamic therapy in chronic central serous chorioretinopathy patients with and without choroidal neovascularization. The study found that htPDT was less effective in eyes with CNV regarding the recurrence and persistence of subretinal fluid.
Article
Ophthalmology
Kentaro Kawai, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Ayako Takahashi, Akihito Uji, Yuki Muraoka, Masahiro Miyake, Kenji Yamashiro, Akitaka Tsujikawa
Summary: This study found that a thin subfoveal choroid at baseline and multiple anti-VEGF injections in a PRN regimen increase the risk of developing macular atrophy (MA) involving the fovea after photodynamic therapy (PDT) and PRN treatment.
Review
Allergy
Ken Fukuda, Tatsuma Kishimoto, Tamaki Sumi, Kenji Yamashiro, Nobuyuki Ebihara
Summary: The use of biologics targeting specific antibodies and receptors has significantly improved the treatment outcomes in allergic diseases. However, these drugs have not been approved for ocular allergic diseases. While some studies have reported beneficial effects, adverse ocular symptoms have also been observed. Different biologics may have specific effects on different ocular allergies, and allergists must fully understand the effects of each drug on the eye. This review outlines the potential therapeutic and adverse effects of various biologics on allergic diseases of the eye.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Ophthalmology
Yuki Hama, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Yuki Muraoka, Masahiro Miyake, Ayako Takahashi, Tomotaka Wakazono, Akihito Uji, Kenji Yamashiro, Akitaka Tsujikawa
Summary: The study aimed to investigate the 7-year best-corrected visual acuity (BCVA) course of neovascular age-related macular degeneration (nAMD) patients after a 1-year fixed regimen of intravitreal aflibercept injection (IVA). The results showed that the BCVA in nAMD patients could be maintained for 7 years after the 1-year fixed regimen of IVA, emphasizing the importance of early diagnosis and treatment for long-term good visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Masato Akiyama, Masahiro Miyake, Yukihide Momozawa, Satoshi Arakawa, Maiko Maruyama-Inoue, Mikiko Endo, Yusuke Iwasaki, Kazuyoshi Ishigaki, Nana Matoba, Yukinori Okada, Miho Yasuda, Yuji Oshima, Shigeo Yoshida, Shin-ya Nakao, Kazuya Morino, Yuki Mori, Ai Kido, Aki Kato, Tsutomu Yasukawa, Ryo Obata, Yoshimi Nagai, Kanji Takahashi, Kimihiko Fujisawa, Akiko Miki, Makoto Nakamura, Shigeru Honda, Hiroaki Ushida, Tetsuhiro Yasuma, Koji M. Nishiguchi, Ryusaburo Mori, Koji Tanaka, Yu Wakatsuki, Kenji Yamashiro, Kazuaki Kadonosono, Chikashi Terao, Tatsuro Ishibashi, Akitaka Tsujikawa, Koh-Hei Sonoda, Michiaki Kubo, Yoichiro Kamatani
Summary: The genetic architecture of age-related macular degeneration (AMD) in a Japanese population was investigated through a genome-wide association study (GWAS). A meta-analysis of two GWASs identified six loci significantly associated with AMD, including four known loci and two novel loci. These associations were confirmed in a replication study and showed significant associations with central serous chorioretinopathy (CSC) as well. Genetic correlation analysis indicated shared polygenic architecture between AMD and smoking cessation.
Article
Biology
Anthony M. Musolf, Annechien E. G. Haarman, Robert N. Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D. Lewis, Milly S. Tedja, Adriana I. Iglesias, Hengtong Li, Cameron S. Cowan, Ginevra Biino, Alison P. Klein, Priya Duggal, David A. Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Parssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G. Hysi, Anthony P. Khawaja, Veronique Vitart, Christopher J. Hammond, Cornelia M. van Duijn, Virginie J. M. Verhoeven, Caroline C. W. Klaver, Joan E. Bailey-Wilson
Summary: Refractive error is a complex eye condition caused by genetic and environmental factors. Genome-wide association studies have identified common genetic risk factors, but a significant portion of the heritability is still unexplained. By conducting gene-based association tests, we identified 129 unique genes associated with refractive error in a large dataset. Some of the novel candidates, such as PDCD6IP, PER3, and P4HTM, show promise for future functional studies and validation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Ophthalmology
Masahiro Miyake, Shin-ya Nakao, Kazuya Morino, Shota Yasukura, Yuki Mori, Kenji Ishihara, Yuki Muraoka, Manabu Miyata, Hiroshi Tamura, Taiji Sakamoto, Akitaka Tsujikawa
Summary: This study aimed to evaluate the association between the duration of macular detachment (DMD) and visual prognosis in patients with macula-off rhegmatogenous retinal detachment (RD). The results showed that surgical treatment within 3 days from the onset of macular detachment significantly improved visual prognosis.
OPHTHALMOLOGY RETINA
(2023)
Article
Medicine, General & Internal
Rosie Clark, Samantha Sze-Yee Lee, Ran Du, Yining Wang, Sander C. M. Kneepkens, Jason Charng, Yu Huang, Michael L. Hunter, Chen Jiang, J. Willem L. Tideman, Ronald B. Melles, Caroline C. W. Klaver, David A. Mackey, Cathy Williams, Helene Choquet, Kyoko Ohno-Matsui, Jeremy A. Guggenheim
Summary: This study aimed to predict the risk of high myopia (HM) through an improved polygenic score (PGS) and test if the PGS is predictive of myopic macular degeneration (MMD) after considering refractive error. The study found that PGS can predict the risk of HM in Europeans, but its predictive ability is weaker in other populations.
Article
Ophthalmology
Ayako Takahashi, Yuki Muraoka, Sho Koyasu, Yoshiki Arakawa, Eijiro Nakamura, Akitaka Tsujikawa
Summary: The purpose of this study was to investigate the clinical characteristics of atypical retinal vascular proliferation in patients with von Hippel-Lindau (VHL) disease using OCT angiography (OCTA). Among 57 patients with VHL disease, 12.1% showed atypical flat retinal hemangioblastomas (RHs). These flat RHs appeared as retinal hemorrhages or faint abnormal retinal vessels and displayed abundant blood flow in the lesions on OCTA. During a mean follow-up period of 20.4 months, no significant changes or complications were observed in flat RHs.
Article
Multidisciplinary Sciences
Masaharu Ishikura, Yuki Muraoka, Naomi Nishigori, Shin Kadomoto, Shogo Numa, Tomoaki Murakami, Masayuki Hata, Akitaka Tsujikawa
Summary: Extended interscan time (IST) on OCTA can detect slow retinal blood flow that is undetectable on default IST. The shape of the foveal avascular zone (FAZ) varies with different ISTs.
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Takahiro Kogo, Yuki Muraoka, Masaharu Ishikura, Naomi Nishigori, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: The purpose of this study was to investigate choroidal angiographic features associated with the resolution or persistency of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC). The study found that vertically asymmetric dilation of choroidal vessels in the posterior pole may be a good predictor of future SRF status.
Article
Ophthalmology
Yuta Doi, Yuki Muraoka, Akitaka Tsujikawa
Summary: The purpose of this study was to evaluate the efficiency and safety of a 27G 20,000 cpm vitreous cutter in clinical settings. The study included 40 patients with idiopathic epiretinal membrane, and the results showed that the 20,000 cpm group had shorter duration of vitrectomy and no complications compared to the 10,000 cpm group.
CLINICAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yutaro Yamagata, Kenji Suda, Tadamichi Akagi, Hanako Ohashi Ikeda, Takanori Kameda, Tomoko Hasegawa, Masahiro Miyake, Akitaka Tsujikawa
Summary: This study aimed to evaluate the effect of trabeculectomy on visual field progression in eyes with glaucoma and high myopia. The results showed that trabeculectomy reduced intraocular pressure and slowed down visual field deterioration, but the effect was weaker and nonsignificant in the highly myopic group.
CLINICAL OPHTHALMOLOGY
(2023)