Article
Computer Science, Theory & Methods
Wei Feng, Meihan Duan, Bingjie Wang, Yu Du, Yiran Zhao, Bin Wang, Lin Zhao, Zongyuan Ge, Yuntao Hu
Summary: Optical coherence tomography angiography (OCTA) is a non-invasive diagnostic method commonly used in neovascular age-related macular degeneration (nAMD) to provide a comprehensive view of choroidal neovascularization (CNV). In this study, a deep learning model was developed for automatic segmentation of CNV regions from OCTA images. The model demonstrated satisfactory performance in accurately extracting CNV regions from OCTA images of nAMD patients.
JOURNAL OF BIG DATA
(2023)
Article
Medicine, Research & Experimental
Angelo Maria Minnella, Chiara Centini, Gloria Gambini, Maria Cristina Savastano, Valeria Pagliei, Benedetto Falsini, Stanislao Rizzo, Gabriele Ciasca, Martina Maceroni
Summary: This study investigated the choroidal thickness (CT) changes after intravitreal aflibercept injections in treatment-naive patients with neovascular age-related macular degeneration (nAMD). The results showed a significant reduction in CT at days 15, 90, and 365 compared to baseline, with the major reduction observed at day 15 and in eyes with thicker choroid at baseline. There was no significant correlation between CT variation and the number of injections performed. These findings contribute to understanding the role of aflibercept injections in choroidal vasculature and suggest that CT can serve as a potential biomarker.
ADVANCES IN THERAPY
(2022)
Article
Ophthalmology
Lauriana Solecki, Prisca Loganadane, Anne-Sophie Gauthier, Manon Simonin, Marc Puyraveau, Bernard Delbosc, Maher Saleh
Summary: In this study, it was found that the presence of qCNV increased the risk of exudation in the fellow eyes of eyes treated for neovascular AMD. Specific factors such as increase in central macular thickness, pigment epithelial detachment height and width, neovessels' surface on OCT-A, branching pattern, and appearance of a hypointense halo were identified as predictors for exudation. These biomarkers can help in detecting the activation of qCNV for timely antiangiogenic therapy.
Article
Ophthalmology
Nicholas T. Rinella, Hao Zhou, Jessica Wong, Qinqin Zhang, Khashayar Nattagh, Travis C. Porco, Ruikang K. Wang, Daniel M. Schwartz, Jacque L. Duncan
Summary: This study found that choriocapillaris flow deficit significantly increased in patients with geographic atrophy, while retinal sensitivity significantly decreased. An inverse correlation was observed between choriocapillaris flow deficit and sensitivity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Marco Pellegrini, Federico Bernabei, Andrea Mercanti, Stefano Sebastiani, Enrico Peiretti, Claudio Iovino, Giamberto Casini, Pasquale Loiudice, Vincenzo Scorcia, Giuseppe Giannaccare
Summary: This study evaluated choroidal vascular changes in nAMD patients treated with aflibercept injections, showing significant decreases in choroidal thickness and vascularity after treatment, which were significantly correlated with baseline choroidal vascularity index.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Chemistry, Medicinal
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang, Qing Peng
Summary: The study investigated cytokine and chemokines profiling in the aqueous humor of nAMD patients, finding lower levels of basic fibroblast growth factor and RANTES, and higher levels of VEGF-A compared to the control group. After IVR treatment, levels of Eotaxin increased while VEGF-A decreased in nAMD patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Ophthalmology
Enrico Borrelli, Francesco Bandello, Eric H. Souied, Costanza Barresi, Alexandra Miere, Lea Querques, Riccardo Sacconi, Giuseppe Querques
Summary: New imaging technologies have provided a remarkable opportunity to bridge the gap between histology and clinical findings in neovascular AMD, enhancing our understanding of the disease.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Rudolf Muth, Mario Damiano Toro, Anahita Bajka, Kamil Jonak, Roman Rieder, Myrtha Magdalena Kohler, Jeanne Martine Gunzinger, Eric H. Souied, Michael Engelbert, K. Bailey Freund, Sandrine Anne Zweifel
Summary: This study investigated the associations and predictive factors between different types of macular neovascularization (MNV) lesion variants and drusen types in patients with treatment-naive neovascular age-related macular degeneration (AMD). The findings suggest that subretinal drusenoid deposits (SDDs) are a common characteristic in AMD eyes with treatment-naive MNV, and the predominant drusen type may help predict the type of MNV that will develop.
Article
Ophthalmology
Enrico Borrelli, Costanza Barresi, Giorgio Lari, Alessandro Berni, Marco Battista, Michele Reibaldi, Maria Lucia Cascavilla, Francesco Bandello
Summary: The purpose of this study was to evaluate the impact of the transition from intermediate to exudative neovascular age-related macular degeneration (AMD) on the inner retina and to assess the relationship between clinical characteristics, optical coherence tomography (OCT) findings, and inner retinal changes. The study found that the development of exudative neovascularization is associated with significant neuronal loss, which can be detected after the exudation is resolved through OCT analysis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biology
Oluchukwu Onwuka, Jackson L. Saddemi, Fatma Sema Akkan Aydogmus, Claudia C. Lasalle, David J. Ramsey
Summary: This study examined the relationship between the interval of monitoring the at-risk eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) and the severity of the disease at diagnosis. The study compared the visual acuity and central macular thickness of patients who were actively receiving anti-VEGF treatment at the time of second eye diagnosis with patients who had discontinued treatment in their first eye. The results showed that the at-risk eyes of patients who had stopped treatment prior to fellow eye conversion were monitored less frequently than those who continued treatment. However, the visual acuity and central macular thickness were similar at the time of fellow eye diagnosis for both groups.
Article
Ophthalmology
Huixun Jia, Bing Lu, Zhi Zhao, Yang Yu, Fenghua Wang, Minwen Zhou, Xiaodong Sun
Summary: The characteristics of choroidal neovascularization (CNV) measured by optical coherence tomography angiography (OCTA) can predict the prognosis of neovascular age-related macular degeneration (nAMD) after anti-vascular endothelial growth factor (anti-VEGF) therapy. Type 2 and mixed-type neovascularization are associated with a better response to anti-VEGF therapy.
Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim
Summary: This study investigated the incidence, risk factors, and impact on visual outcomes of SRH in patients with nAMD and PCV who discontinued treatment. SRH development led to poor visual prognosis in those who stopped treatment, and type 3 MNV had a relatively high risk of SRH occurrence.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Gili Kredi, Matias Iglicki, Nir Gomel, Assaf Hilely, Anat Loewenstein, Zohar Habot-Wilner, Dinah Zur
Summary: This study investigated the prevalence, risk factors, and clinical significance of prechoroidal cleft (PC) in Caucasian neovascular age-related macular degeneration (nAMD) patients. The results showed that PC was found in 15% of the patients and was associated with greater retinal and pigment epithelial detachment (PED) height, as well as the presence of multi-layered PED. Eyes with PC required more anti-VEGF injections. The presence of PC correlated with disease activity, and intensive anti-VEGF suppression can preserve vision.
ACTA OPHTHALMOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
I-Chia Liang, Wen-Chin Ko, Yu-Jou Hsu, Yi-Ru Lin, Yun-Hsiang Chang, Xv-Hui Zong, Pei-Chen Lai, Der-Chen Chang, Chi-Feng Hung
Summary: The experiment demonstrated that H-2 inhalation could significantly alleviate CNV leakage in a mouse model of CNV, possibly through suppression of the inflammatory process and VEGF-driven CNV formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lisa Toto, Maria Ludovica Ruggeri, Federica Evangelista, Chiara Trivigno, Rossella D'Aloisio, Chiara De Nicola, Pasquale Viggiano, Emanuele Doronzo, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua
Summary: This study investigates the parameters of optical coherence tomography (OCT) and OCT angiography (OCTA) in patients with neovascular age-related macular degeneration (nAMD) and macular neovascularization (MNV) types 1, 2, and 3. The results showed significant differences in CVI, CMT, and ORCCFA between MNV 1 and the other two groups. CVI was significantly different between MNV 1 and healthy controls and between MNV 1 and MNV 2. ORCCFA and CMT were significantly different between MNV 1 and MNV 2. There was no statistically significant difference in subfoveal choroidal thickness (SFCT) among the three groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Rupalatha Maddala, Leona T. Y. Ho, Shruthi Karnam, Iris Navarro, Anja Osterwald, Sandra S. Stinnett, Christoph Ullmer, Robin R. Vann, Pratap Challa, Ponugoti V. Rao
Summary: This study found that GDF15 levels were significantly elevated in the aqueous humor and serum of POAG patients, potentially indicating an association with the pathology of POAG.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Wajiha J. Kheir, Sandra S. Stinnett, Sheridan Meltsner, Ekaterina Semenova, Yvonne M. Mowery, Oana Craciunescu, David G. Kirsch, Miguel A. Materin
Summary: This study reviewed the preliminary outcomes of patients with uveal melanoma treated with iodine-125 plaques using a novel treatment planning approach. The results showed that the treatment plan was effective in disease control and led to favorable visual outcomes.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Article
Ophthalmology
Weiliang Wang, Gloria J. Hong, Sandra S. Stinnett, Sharon F. Freedman, David K. Wallace, S. Grace Prakalapakorn
Summary: Current therapies for treatment-indicated retinopathy of prematurity mainly include laser photocoagulation and bevacizumab injection. Quantitative analysis showed that vascular dilation and tortuosity decreased significantly following both treatments, but bevacizumab had a faster effect on tortuosity reduction.
Article
Ophthalmology
Amal Al-Lozi, Allison C. Umfress, Sandra S. Stinnett, Sharon F. Freedman
Summary: This retrospective study evaluated the indications and postoperative outcomes of inferonasal Ahmed and Baerveldt glaucoma drainage devices (GDDs) in pediatric glaucoma. The results showed modest success with this treatment approach and frequent complications, although vision-threatening complications were rare.
Article
Obstetrics & Gynecology
Lavanya Vasudevan, Sandra S. S. Stinnett, Lauren Hart, Pedro Gomez Altamirano, Angel Gonzalez, Kristin Weaver, Beverly Gray, John Bartlett
Summary: This study aimed to assess the intention of pregnant individuals to accept routine and COVID-19 vaccines for their baby after birth and to identify demographic and nondemographic characteristics associated with vaccination intention. The results showed that only 67% of pregnant individuals planned to vaccinate their baby with routine vaccines, and 35% would vaccinate their baby with a COVID-19 vaccine as soon as possible. Younger pregnant individuals and those identifying as Black or African American had lower vaccination intention. Routine vaccination intention was associated with familiarity with vaccination schedule, trimester of pregnancy, ethnicity, history of prior birth, and computer access.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Ophthalmology
Tika Zbornik Thompson, Joshua L. Jones, Rick Pittman, Sandra S. Stinnett, Noelle E. Younge, Michael Cotten, Sharon F. Freedman, S. Grace Prakalapakorn
Summary: This retrospective study investigated the possible differences between male and female mixed-sex multiple gestation infants in terms of the stage of retinopathy of prematurity (ROP) developed and the need for ROP treatment. The study found that there was no statistically significant difference between sexes in the most severe stage of ROP developed or the need for ROP treatment among mixed-sex twin infants. However, males received treatment at an earlier post-menstrual age (PMA) than females, despite females having a lower mean birthweight and slower mean growth velocity compared to males.
Article
Ophthalmology
Ailin Song, Jay B. Lusk, Anthony N. Kuo, Kelly W. Muir, Sandra S. Stinnett, Durga S. Borkar
Summary: This systematic analysis assessed the levels of evidence (LOE) behind American Academy of Ophthalmology (AAO) Preferred Practice Pattern (PPP) guidelines and found an increasing emphasis on evidence from randomized controlled trials from 2012 to 2021. However, the number of recommendations with reported LOE has decreased, indicating a need for improvement in future guidelines.
Article
Ophthalmology
Praruj Pant, Anita Kundu, Jay K. Rathinavelu, Xin Wei, Rupesh Agrawal, Sandra S. Stinnett, Jane S. Kim, Akshay S. Thomas, Sharon Fekrat
Summary: This study aimed to characterize choroidal vascular changes in BRVO eyes with CME by comparing the CVI, SFCT, and CST. The results showed differences in CVI between BRVO eyes and fellow eyes at presentation, but these differences resolved over time. The study provides important insights for predicting visual outcomes and treatment patterns for patients with BRVO-related CME.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Grace E. Nipp, Ahmad A. Aref, Sandra S. Stinnett, Kelly W. Muir
Summary: The number of microinvasive glaucoma surgeries (MIGS) has increased significantly in recent years, with no substantial decline in trabeculectomies or aqueous shunt surgeries. This has resulted in an increase in the total number of procedures performed per fellow each year.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Dennis Y. Akrobetu, Cason B. Robbins, Justin P. Ma, Snnath Soundararajan, Michael S. Quist, Sandra S. Stinnett, Kathryn P. L. Moore, Kim G. Johnson, Andy J. Liu, Dilraj S. Grewal, Sharon Fekrat
Summary: The purpose of this study was to assess the intrasession repeatability of macular OCTA parameters in AD, MCI, PD, and NC patients. The results showed that the repeatability of macular OCTA metrics was similar and moderate to good in both NC and neurodegenerative disease groups.
OPHTHALMOLOGY SCIENCE
(2023)
Editorial Material
Medicine, General & Internal
Cynthia A. Toth
Summary: The 2023 Lasker-DeBakey Clinical Medical Research Award recognizes the impact of optical coherence tomography, inventeda by Drs. Fujimoto, Huang, and Swanson.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Ophthalmology
Eleonora M. Lad, Vivienne Fang, Michel Tessier, Anna Rautanen, Javier Gayan, Sandra S. Stinnett, Ulrich F. O. Luhmann
Summary: The study aimed to evaluate visual function changes in early and intermediate AMD patients over 24 months. The results showed that in iAMD stage, microperimetry, cone contrast tests, and dark adaptation revealed slow and nonlinear functional decline. Furthermore, genetic risk factors may modify the structural and functional features of iAMD.
OPHTHALMOLOGY SCIENCE
(2022)
Article
Ophthalmology
Alexander M. Warwick, Howard M. Bomze, Luyu Wang, Mikael Klingeborn, Ying Hao, Sandra S. Stinnett, Sidney M. Gospe
Summary: Continuous hypoxia was found to have a significant neuroprotective effect on early retinal ganglion cell degeneration in mice with severe mitochondrial dysfunction. However, the complete rescue effect was not durable after a certain period of time. Hypoxia prevented gliosis but had limited effect on the accumulation of mononuclear phagocytic cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Jason Q. Core, Maxwell Pistilli, Peiying Hua, Ebenezer Daniel, Juan E. Grunwald, Cynthia A. Toth, Glenn J. Jaffe, Daniel F. Martin, Maureen G. Maguire, Gui-Shuang Ying
Summary: The study aims to describe the association between predominantly persistent intraretinal fluid (PP-IRF) and visual acuity (VA) and retinal anatomic findings at long-term follow-up. The results show that PP-IRF is associated with worse VA and a higher risk of scar development.
OPHTHALMOLOGY RETINA
(2022)
Article
Ophthalmology
Justin P. Ma, Cason B. Robbins, Jia Min Lee, Srinath Soundararajan, Sandra S. Stinnett, Rupesh Agrawal, Brenda L. Plassman, Eleonora M. Lad, Heather Whitson, Dilraj S. Grewal, Sharon Fekrat
Summary: The purpose of this study was to assess the baseline differences and longitudinal rate of change in retinal and choroidal imaging parameters between APOE 64 carriers and noncarriers with normal cognition. The results showed that there were differences in certain parameters between the APOE 64 carriers and noncarriers, but no significant differences in the rates of change between the groups during the follow-up. These findings provide preliminary evidence for further investigating the prognostic value of these parameters.
OPHTHALMOLOGY RETINA
(2022)