Article
Physiology
Tan Wang, Erqian Wang, Huan Chen, Ningning Li, Hanyi Min
Summary: This study investigated the different tamponade effects of intravitreal silicone oil (SO) and perfluoropropane gas on the retinal structure and vasculature in patients with proliferative diabetic retinopathy (PDR). The results showed that, compared to gas tamponade, SO tamponade resulted in a significantly greater decrease in peripapillary retinal nerve fiber layer (pRNFL) thickness over 90 days. Additionally, the change in pRNFL thickness was significantly correlated with changes in full retina thickness and superficial vascular complex (SVC) vessel density (VD) after the operation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Chunyan Lei, Yun Zhang, Meixia Zhang
Summary: The study shows a significant association between insulin treatment and reduced risks of postoperative DME in Japanese PDR patients with PPV surgery compared with oral medications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhikun Yang, Yu Di, Junjie Ye, Weihong Yu, Zijian Guo
Summary: The purpose of this study was to evaluate the optimal timing of intravitreal conbercept (IVC) treatment before pars plana vitrectomy (PPV) in patients with severe proliferative diabetic retinopathy (PDR). The study found that IVC treatment administered 7 days prior to surgery had better effectiveness and lower vitreous VEGF concentration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Infectious Diseases
Magdalene Yin Lin Ting, Soyang Ella Kim, Rodrigo Anguita
Summary: This literature review investigated the incidence, protective and predisposing factors, causative pathogens, management options, and prognosis of infectious endophthalmitis in silicone oil-filled eyes. The studies found that this condition is rare and has a guarded visual prognosis. Existing research is limited in design and sample size, but observational studies still play a crucial role in rare conditions. The aim of this comprehensive review is to summarize the available literature, provide answers for ophthalmologists, and suggest future research directions.
Article
Health Care Sciences & Services
Yuzhi Ding, Na Su, Jie Luan, Yan Ni, Zilin Sun
Summary: The effect of intravitreal conbercept (IVC) on surgical complications in patients with proliferative diabetic retinopathy (PDR) was observed. The results showed that the content of VEGF in the vitreous of the IVC group was significantly lower than that in the No-IVC group, and the IVC group had lower bleeding rate and complication rate after surgery compared to the No-IVC group.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Fabrizio Sinisi, Marco Della Santina, Pasquale Loiudice, Michele Figus, Giamberto Casini
Summary: This study reviewed the literature on the use of silicone oil tamponade in patients with postoperative endophthalmitis treated with pars plana vitrectomy. It found that silicone oil tamponade can reduce the risk of retinal detachment, improve visual acuity, and decrease the need for additional surgery, while also exhibiting antimicrobial activity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sungsoon Hwang, Se Woong Kang, Kyung Tae Kim, Hoon Noh, Sang Jin Kim
Summary: This study found that vitrectomy combined with intraoperative dexamethasone implantation provides satisfactory long-term clinical outcomes for non-tractional refractory DME, reducing the number of intraocular injections required for treatment. Postoperative improvements were seen in both BCVA and CMT, with a decrease in the need for additional non-surgical treatments. Temporary ocular hypertension was a common complication but was managed effectively with antihypertensive eye drops.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Daiki Hira, Tomoya Kitagawa, Taku Imamura, Masashi Kakinoki, Satoshi Ueshima, Tomonobu Okano, Masahito Ohji, Mikio Kakumoto, Tomohiro Terada
Summary: This study investigated the quantitative impact of silicone oil tamponades on intraocular vancomycin pharmacokinetics using cynomolgus monkey eyes. The results showed that silicone oil tamponades significantly decreased the volume of distribution of vancomycin, while pars plana vitrectomy increased the clearance and diffusion rate constants.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Machiko Shimmura-Tomita, Hiroko Takano, Yoshiaki Tanaka, Rina Takagi, Toshikatsu Kaburaki, Akihiro Kakehashi
Summary: This study investigated the impact of silicone oil presence in the anterior chamber on corneal endothelium damage following pars plana vitrectomy. The results showed a high correlation between the retention period of silicone oil tamponade and the decrease rate of corneal endothelial cell density. However, there was no correlation between the presence of anterior chamber silicone oil, area of silicone oil attachment, lens status, and the decrease rate of corneal endothelial cell density.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Maria H. Berrocal, Luis Acaba-Berrocal, Alexandra M. Acaba
Summary: The long-term outcomes of pars plana vitrectomy (PPV) for complications of proliferative diabetic retinopathy were evaluated. The results showed that eyes that underwent PPV had better visual outcomes than eyes that received conventional treatment, regardless of age group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
San-Ni Chen, Shih-Jen Chen, Tsung-Tien Wu, Wei-Chi Wu, Chang-Hao Yang, Chung-May Yang
Summary: Pars plana vitrectomy (PPV) has been widely used in the treatment of severe diabetic retinopathy, and new technologies have expanded its applications. This article reviews the applications of new technologies for PPV in eyes with diabetic retinopathy, based on the experiences with Asian patients, and highlights important procedures and entities not commonly mentioned in the literature.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Kei Takayama, Hideaki Someya, Hiroshi Yokoyama, Takeshi Kimura, Yoshihiro Takamura, Masakazu Morioka, Hiroto Terasaki, Tetsuo Ueda, Nahoko Ogata, Shigehiko Kitano, Maki Tashiro, Taiji Sakamoto, Masaru Takeuchi
Summary: In this study, younger age and the presence of neovascular glaucoma and tractional retinal detachment were identified as potential biases in using IVI before vitrectomy for PDR complications. Eyes that received preoperative IVI had a higher frequency of intraoperative retinal breaks requiring tamponade, but there were no significant differences in postoperative outcomes compared to eyes that did not receive IVI.
Article
Ophthalmology
Mengyang Li, Jiyang Tang, Zhongxu Jia, Yuou Yao, Enzhong Jin, Zongyi Wang, Jie Hu, Guosheng Sun, Hong Yin, Jianhong Liang, Xiaoxin Li, Yanrong Jiang, Jinfeng Qu, Mingwei Zhao
Summary: In high myopic eyes with macular hole retinal detachment, complete macular atrophy is a significant risk factor for retinal re-detachment after silicon oil removal, while internal limiting membrane peeling and duration of silicon oil tamponade are protective factors.
Article
Medicine, General & Internal
Yu-Hong Nie, Yu Zhang, Fan Li, Qiong Wang, A-Min Xu, Zhen Chen
Summary: The development of postoperative hyphema after PPV for PDR patients without neovascularization of the iris or angles and NVG is not uncommon, with membrane removal identified as a risk factor. Timely management ensures that hyphema does not affect visual recovery or final anatomical success.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, General & Internal
Stefano Ranno, Stela Vujosevic, Manuela Mambretti, Cristian Metrangolo, Micol Alkabes, Giovanni Rabbiolo, Andrea Govetto, Elisa Carini, Paolo Nucci, Paolo Radice
Summary: This study evaluates the role of vitrectomy with or without internal limiting membrane (ILM) peeling in nontractional refractory diabetic macular edema (DME). The results show significant improvements in central macular thickness and visual acuity after vitrectomy. Better outcomes are observed in patients with subfoveal serous retinal detachment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Zhuyun Qian, Xu Chen, Yong Tao, Wensheng Li, Wei Gu
Summary: In HIV-negative patients receiving multiple intravitreal injections of ganciclovir for CMV retinitis, there is a positive correlation between initial and final visual acuity.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Medicine, Research & Experimental
Li Chen, Zhuo Zai Xu, Yong Tao
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Ophthalmology
Yewei Wang, Hua Fan, Ke Gao, Wei He, Yong Tao
Article
Ophthalmology
Hui Wang, Yong Tao
Summary: The study compared the levels of intraocular cytokines between Fuchs uveitis syndrome (FUS) eyes and senile cataract eyes, finding higher inflammatory cytokine levels in FUS eyes and a significant positive correlation between severity of posterior subcapsular cataract and levels of IL-6 and IL-8 in the aqueous humor.
Article
Ophthalmology
Hao Kang, Yunbo Wei, Ming Liu, Di Yu, Yong Tao
Summary: The study found that patients with ARN caused by VZV had different intraocular T lymphocyte subsets and cytokines profiles compared to non-infectious patients. High percentages of CD8+ T lymphocytes and low CD4/CD8 T cell ratios may be a potential biomarker for the diagnosis of viral-infectious uveitis. Examination of T lymphocytes at inflammatory sites has the potential to become a useful research tool for differentiating viral and non-viral uveitis.
Article
Engineering, Biomedical
Ying Tian, Fan Zhang, Yefeng Qiu, Shuang Wang, Feng Li, Jiawei Zhao, Chao Pan, Yong Tao, Di Yu, Wei Wei
Summary: Injecting exosomes derived from regulatory T cells and conjugated with an anti-VEGF antibody into the eye significantly suppressed ocular neovascularization in mouse and non-human primate models, showing potential for use in other combination therapies.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
Tianwei Liang, Zhuyun Qian, Yong Tao, Yaguang Peng, Yanhui Cui, Chengyue Zhang, Chunxia Peng, Lili Liu, Man Hu, Li Li, Ningdong Li
Summary: This study analyzed the relationship between the severity of type 1 retinopathy of prematurity (ROP) and the level of vascular endothelial growth factor (VEGF) in aqueous fluid. The results showed that the aqueous VEGF level was highest in patients with severe ROP and was correlated with the location and venous tortuosity of ROP lesions, indicating the severity of ROP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jing Feng, Weiqiang Yang, Fuxiao Luan, Fang Ma, Yingjie Wang, Yiquan Zhang, Xuhui Liu, Li Chen, Xiaofeng Hu, Yong Tao
Summary: Diabetic retinopathy is a common and serious complication of diabetes, and there is currently no effective treatment for early stage. However, apelin has been found to potentially reduce vascular leakage by protecting pericytes, which suggests a promising new direction for early treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Jian Ji, Yong Tao, Yan Pang
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Xiaojun Wang, Fuxiao Luan, Hua Yue, Cui Song, Shuang Wang, Jing Feng, Xiao Zhang, Wei Yang, Yuxin Li, Wei Wei, Yong Tao
Summary: Due to the complexity of ocular diseases and the natural ocular barriers, drug therapy for these diseases has limitations. With the development of biotechnology, smart materials have been widely tested to treat ocular diseases. This review analyzes recent developments in smart materials and discusses future directions for clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Ying Tian, Yiquan Zhang, Jiawei Zhao, Fuxiao Luan, Yingjie Wang, Fan Lai, Defang Ouyang, Yong Tao
Summary: Dry eye syndrome (DES) is a common ocular disorder characterized by inflammation and increased reactive oxygen species (ROS). Researchers have developed a novel treatment approach by growing cerium oxide nanocrystals on mesenchymal stem cell-derived exosomes (MSCExos). This approach promotes corneal cell growth, scavenges ROS, and effectively suppresses inflammation. The findings highlight the potential of MSCExo-Ce as a promising therapeutic candidate for DES.
Article
Biochemistry & Molecular Biology
Fuxiao Luan, Rui Liu, Jing Li, Xin Ge, Nan Wang, Qihan Guo, Yong Tao, Jianmin Ma
Summary: This study retrospectively analyzed the immune and inflammatory indices of patients with lacrimal-gland benign lymphoepithelial lesion (LGBLEL) and identified independent risk factors, including IgG4, IgG, and C3, for predicting LGBLEL occurrence. The combined diagnostic efficacy of IgG4+IgG+C3 was higher than any single factor. These findings provide valuable reference indices for the diagnosis of LGBLEL.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Immunology
Hao Kang, Hongjian Sun, Yang Yang, Zewen K. Tuong, Minglei Shu, Yunbo Wei, Yu Zhang, Di Yu, Yong Tao
Summary: Single-cell analysis reveals differences in immune cell infiltration and T-cell clonal expansions between Behcet's disease and Vogt-Koyanagi-Harada disease uveitis, providing guidance for precision disease management.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Article
Ophthalmology
Hui Wang, Yong Tao
Summary: The initial best-corrected visual acuity and anterior inflammation grade were related. Treatment significantly improved visual acuity and anterior inflammation. Ocular toxocariasis eyes had higher aqueous humor cytokine levels.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Clinical Neurology
Hao Kang, Hongyang Li, Nanping Ai, Hongjuan Liu, Quangang Xu, Yong Tao, Shihui Wei
FRONTIERS IN NEUROLOGY
(2020)