Article
Ophthalmology
Qiyu Bo, Min Zhang, Jieqiong Chen, Huixun Jia, Mengxi Shen, Mengsha Sun, Mengqiao Xu, Jingyang Feng, Quan Yan, Yang Yu, Peirong Huang, Tong Li, Fenghua Wang, Philip J. Rosenfeld, Xiaodong Sun
Summary: The purpose of this study was to investigate the characteristics of the branching vascular network (BVN) and polypoidal lesions in polypoidal choroidal vasculopathy (PCV) and determine near-term indicators that may predict exudative recurrence. The findings suggest that the growth of nonexudative BVN and progression of polypoidal lesions are associated with exudative recurrences, and the progression of polypoidal lesions may serve as an indicator for the near-term onset of exudation.
Article
Ophthalmology
Wen-Yi Wang, Chang-Hao Yang, Ta-Ching Chen, Yi-Ting Hsieh, Tzyy-Chang Ho, Chung-May Yang, Fang-Yu Liu, Tso-Ting Lai
Summary: The study investigated the changes in branching neovascular networks (BNN) in patients with polypoidal choroidal vasculopathy (PCV) who received combined photodynamic therapy (PDT) and anti-vascular endothelial growth factor (anti-VEGF) therapy using optical coherence tomography angiography (OCTA). The results showed that BNN initially regressed but enlarged at 6 months after therapy. Patients with continuous BNN regression had thicker choroid at baseline. OCTA can be used for follow-up evaluations of PCV patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Areum Jeong, Jinam Lim, Min Sagong
Summary: Using ultra-widefield ICGA, this study found that patients with PCV exhibit vortex vein engorgement and an increased choroidal hyperpermeability area. These results offer valuable insights into the pathogenesis and prognosis of PCV patients.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Lulu Chen, Mingzhen Yuan, Lu Sun, Youxin Chen
Summary: The purpose of this study was to evaluate the classification system of branching neovascular network (BNN) morphology in polypoidal choroidal vasculopathy (PCV) patients based on SS-OCT and SS-OCTA, and analyze the morphological features as potential prognostic features. Results showed that the current classification system based on BNN morphology on SS-OCTA was highly applicable and revealed distinct characteristics in each group. The BNN type was not correlated with BCVA at 12 months after treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Junwoo Lee, Kiyoung Kim, Eung Suk Kim, Seung-Young Yu, Min Seok Kang
Summary: In patients with polypoidal choroidal vasculopathy (PCV), the regression of polypoidal lesion one year after anti-VEGF combined with verteporfin PDT treatment is associated with favorable long-term visual prognosis and the maintenance of good visual acuity.
Article
Ophthalmology
Federico Corvi, Shruti Chandra, Alessandro Invernizzi, Lucia Pace, Francesco Viola, Sobha Sivaprasad, Giovanni Staurenghi, Chui Ming Gemmy Cheung, Kelvin Yi Chong Teo
Summary: The study compared the multimodal imaging features of Asian and Caucasian eyes with PCV, finding that Asian eyes had more severe disease characteristics such as lower visual acuity, more hemorrhage, and wider lesion areas, while Caucasian eyes showed more drusen. Ethnic differences in disease characteristics of PCV were revealed through multimodal imaging analysis, suggesting varying pathophysiologic mechanisms based on ethnicity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Yukinori Sakaeda, Aki Kato, Soichiro Kuwayama, Shuichiro Hirahara, Norihiro Suzuki, Yuichiro Ogura, Yoko Nakazawa, Tsutomu Yasukawa
Summary: We assessed the long-term prognosis of PCV patients treated with PDT in real-world settings. In total, 60 eyes of 57 patients were retrospectively reviewed. Initial PDT showed effectiveness in 30% of cases, with good BCVA and no need for additional treatment. However, rescue PDT required additional treatment in most cases and vision decreased in many cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Zuhua Sun, Yuanyuan Gong, Yating Yang, Ying Huang, Suqin Yu, Junqing Pei, Bing Lin, Rong Zhou, Yingzi Li, Yumin Li, Junyan Zhang, Xiaoling Liu
Summary: The study compared the efficacy of initial versus delayed photodynamic therapy in combination with intravitreal injection of conbercept for polypoidal choroidal vasculopathy, and found that both treatment groups were effective in improving visual acuity and polyp regression, with the initial therapy group showing more efficient reduction in central retinal thickness and polyp regression, along with fewer injections. However, the initial therapy group was non-inferior to the delayed therapy group in terms of improvement in best-corrected visual acuity.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Anna C. S. Tan, Janice Marie Jordan-Yu, Chinmayi Himanshuroy Vyas, Alfred Tau Liang Gan, Kelvin Yi Chong Teo, Choi Mun Chan, Ranjana Mathur, Tien Yin Wong, Usha Chakravarthy, Gemmy Chui Ming
Summary: The purpose of this study was to evaluate whether optical coherence tomography (OCT) can determine the perfusion of polypoidal lesions (PL) in eyes with polypoidal choroidal vasculopathy after 12 months of aflibercept monotherapy. The results showed that specific OCT features can accurately detect the closure of polypoidal lesions, which is an important anatomical treatment outcome typically defined by indocyanine green angiography.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Medicine, General & Internal
Figen Batioglu, Ozge Yanik, Ferhad Ozer, Sibel Demirel, Emin Ozmert
Summary: The study compares the choroidal characteristics of typical polypoidal choroidal vasculopathy (T-PCV) and polypoidal choroidal neovascularization (P-CNV) cases, and investigates the presence of intervortex venous anastomoses in these PCV subtypes using en face optical coherence tomography angiography (OCTA). Results show that T-PCV cases have significantly higher mean choroidal vascularity index (CVI) values and more dilated anastomotic vessels compared to P-CNV cases.
Article
Ophthalmology
Voraporn Chaikitmongkol, Malgorzata Ozimek, Titipol Srisomboon, Direk Patikulsila, Samantha Fraser-bell, Jay Chhablani, Janejit Choovuthayakorn, Nawat Watanachai, Paradee Kunavisarut, Patricio J. Rodriguez-Valdes, David Lozano-Rechy, Marco Lupidi, Mayss Al-Sheikh, Adrian T. Fung, Catharian Busch, Hemal Mehta, Pierre-Henry Gabrielle, Dinah Zur, Dan Ramon, Apisara Sangkaew, Thammasin Ingviya, Atchara Amphornprut, Zafer Cebeci, Aude Couturier, Thais Sousa Mendes, Ermete Giancipoli, Matias Iglicki, Alessandro Invernizzi, Ines Lains, Matus Rehak, Anna Sala-Puigdollers, Mali Okada, Anat Loewenstein, Neil M. Bressler
Summary: The study aimed to determine the prevalence of probable polypoidal choroidal vasculopathy (PCV) among white patients with neovascular age-related macular degeneration (nAMD) using non-indocyanine green angiography (ICGA) criteria. The results showed that the prevalence of probable PCV was 23.4% in white individuals with nAMD, and it was more commonly found in non-Hispanic white individuals.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Kelvin Yi Chong Teo, Janice Marie Jordan-Yu, Anna C. S. Tan, Ian Y. S. Yeo, Ranjana Mathur, Choi Mun Chan, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung
Summary: The personalised regimen was non-inferior to the fixed regimen in terms of BCVA improvement, and showed numerically higher closure of PL. Further results also demonstrated that the personalised group had a greater reduction in CSFT compared to the fixed group.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ryo Mukai, Kanako Itagaki, Jyunichiro Honjyo, Hidetaka Matsumoto, Tetsuju Sekiryu
Summary: This study aimed to determine the relationship between posterior vortex vein pulsation, choroidal thickness, and choroidal vascular hyperpermeability (CVH) in polypoidal choroidal vasculopathy (PCV). The study found that pulsation was associated with a thin choroid, but not with CVH.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Jinzhi Zhao, Priya R. Chandrasekaran, Kai Xiong Cheong, Mark Wong, Kelvin Teo
Summary: This review summarizes the utilization of multimodal imaging modalities in differentiating PCV from nAMD and predicting disease activity and prognosis. OCT shows great potential in diagnosing PCV.
Article
Ophthalmology
Ryo Mukai, Hidetaka Matsumoto, Tomoko Miyakubo, Hideo Akiyama
Summary: The study found that PDT combined with intravitreal aflibercept treatment can significantly decrease vascular density in the choriocapillaris and middle layer of the choroid in patients with polypoidal choroidal vasculopathy, as well as lead to a significant reduction in the diameter of the largest vessels.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)