Biographical-Item
Surgery
Konstantinos Karamouzis, Miltiadis Perdikakis, Spyros N. Michaleas, Marianna Karamanou
Summary: Baron Dominique Jean Larrey was a military surgeon in the French army who made significant contributions to medical innovation, particularly his invention of the "flying ambulance" and the "triage" method, which radically transformed medical ideas of his time.
ACTA CHIRURGICA BELGICA
(2023)
Article
Art
Maxime Blin, Veronique Boidard
Summary: This passage describes the process of creating the monument commemorating military doctor Dominique-Jean Larrey, as well as the archival sources and preparatory works related to the project.
REVUE DES MUSEES DE FRANCE-REVUE DU LOUVRE
(2022)
Review
Pediatrics
Mohamed El-Dib, Eniko Szakmar, Ela Chakkarapani, Hany Aly
Summary: Neonatal encephalopathy is a serious condition that can have devastating neurological outcomes, and therapeutic hypothermia is currently recommended for treatment. However, TH may have respiratory implications, so respiratory management should aim to minimize exposure to hypocapnia or hyperoxia. It is important to heat and humidify inspiratory gas, correct blood gas values to core temperature, and use caution with sedatives and paralytic agents.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2021)
Article
Respiratory System
Ulrich Koehler, Regina Conradt
Summary: Larrey is known as the father of modern military surgery for his innovative first-aid measures and quick rescue of wounded soldiers on the battlefield.
Article
Critical Care Medicine
Andrew W. Moulton, Steven G. Schauer, Matthew A. Borgman
Summary: This study retrospectively analyzed data from pediatric patients in deployed US military medical facilities in Iraq and Afghanistan to identify risk factors associated with prolonged mechanical ventilation (PMV). The findings will inform resource planning and potential resuscitation strategies for future studies.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Josefine Baekgaard, Volkert Siersma, Rasmus Ejlersgaard Christensen, Camilla Ikast Ottosen, Katrine Bennett Gyldenkaerne, Jasmin Garoussian, Emilie S. Baekgaard, Jacob Steinmetz, Lars S. Rasmussen
Summary: This study investigated the association between fraction of inspired oxygen (FiO(2)) and one-year all-cause mortality in intubated trauma patients. The results showed that a FiO(2) above 60% for more than 2 hours during the first 24 hours of admission was associated with increased mortality in a duration-dependent manner.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Emergency Medicine
Gerie J. Glas, Janneke Horn, Markus W. Hollmann, Benedikt Preckel, Kirsten Colpaert, Manu Malbrain, Ary Serpa Neto, Karim Asehnoune, Marcello Gamma de Abreu, Ignacio Martin-Loeches, Paolo Pelosi, Folke Sjoberg, Jan M. Binnekade, Berry Cleffken, Nicole P. Juffermans, Paul Knape, Bert G. Loef, David P. Mackie, Perenlei Enkhbaatar, Nadia Depetris, Anders Perner, Eva Herrero, Lucia Cachafeiro, Marc Jeschke, Jeffrey Lipman, Matthieu Legrand, Johannes Horter, Athina Lavrentieva, Alex Kazemi, Anne Berit Guttormsen, Frederik Huss, Mark Kol, Helen Wong, Therese Starr, Luc De Crop, Wilson de Oliveira Filho, Joao Manoel Silva Junior, Cintia M. C. Grion, Marjorie Burnett, Frederik Mondrup, Francois Ravat, Mathieu Fontaine, Renan Le Floch, Mathieu Jeanne, Morgane Bacus, Maite Chaussard, Marcus Lehnhardt, Bassem Daniel Mikhail, Jochen Gille, Aidan Sharkey, Nicole Trommel, Auke C. Reidinga, Nadine Vieleers, Anna Tilsley, Henning Onarheim, Maria Teresa Bouza, Alexander Agrifoglio, Filip Freden, Tina Palmieri, Lynda E. Painting, Marcus J. Schultz
Summary: The study found that lung-protective ventilation was used in the majority of burn patients in the ICU, regardless of the presence of inhalation trauma. The use of low V-T ventilation was not associated with a reduction in VFD-28.
Article
Medicine, General & Internal
Jiyeon Kwon, Eunsu Kang, Sunghyun Shin, Byeongcheol Lee, Myoungjin Ko, Sehun Kim, Soojee Lee
Summary: A heated, humidified breathing circuit equipped with a fluid-warming unit has been developed for perioperative hypothermia prevention. We report a case of ventilation difficulty caused by an obstructed heated breathing circuit. The irregularly thicker cotton surrounding the hot wire, temperature sensor, and fluid tubing in the distal inspiratory limb nearly blocked the lumen. Routine flow testing and meticulous examination of the heated breathing circuit before every procedure is emphasized in this case.
MEDICINA-LITHUANIA
(2023)
Article
Anesthesiology
Harendra Arora, John A. Encarnacion, Quefeng Li, Yutong Liu, Priya A. Kumar, Alan M. Smeltz
Summary: This retrospective cohort study aimed to investigate the incidence of perioperative hypothermia and its association with time from procedure end to extubation in patients recovering from endovascular aortic surgery. The results showed that hypothermia was associated with prolonged extubation time, along with age, diabetes, history of carotid disease, and crystalloid volume. However, the extent to which prolonged mechanical ventilation was influenced by low temperature could not be determined due to the nature of the analysis.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Review
Critical Care Medicine
David M. Maslove, Stephanie Sibley, J. Gordon Boyd, Ewan C. Goligher, Laveena Munshi, Isaac I. Bogoch, Bram Rochwerg
Summary: Patients admitted to the ICU with critical COVID-19 often require prolonged mechanical ventilation, which may result in ventilator-induced lung and diaphragmatic injuries. Difficult weaning, slow progress, and clinical deterioration are commonly encountered in these patients during the recovery process.
Article
Medicine, General & Internal
Manuel Florian Struck, Christian Kleber, Sebastian Ewens, Sebastian Ebel, Holger Kirsten, Sebastian Kraemer, Stefan Schob, Georg Osterhoff, Felix Girrbach, Peter Hilbert-Carius, Benjamin Ondruschka, Gunther Hempel
Summary: This study aims to investigate the rate of occult pneumothorax in trauma patients before initial computed tomography (CT) and analyze the role of chest CT in assessing thoracic pathology and injury severity. The results show that clinical decisions for chest tube placement (CTP) before CT are associated with significant false-negative and false-positive cases, indicating that a combination of clinical assessment and CT imaging is important for CTP decisions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Giulia Regiroli, Barbara Loi, Feriel Fortas, Roberta Centorrino, Fabio Mosca, Daniele De Luca
Summary: The study showed that decreasing the inspired gas temperature from 37 degrees Celsius to 32 degrees Celsius for 3 hours did not affect lung mechanics and gas exchange in intubated patients undergoing whole body hypothermia treatment, regardless of the presence of respiratory failure or the treatment in normothermia or hypothermia.
Article
Medicine, General & Internal
Liliana Mirea, Cristian Cobilinschi, Raluca Ungureanu, Ana-Maria Cotae, Raluca Darie, Radu Tincu, Oana Avram, Sorin Constantinescu, Costin Minoiu, Alexandru Baetu, Ioana Marina Grintescu
Summary: Considering the importance of prioritizing life-threatening injuries in trauma care, the secondary dysfunction of ventilator-induced diaphragmatic dysfunction (VIDD) is often neglected. A study was conducted to assess the occurrence of VIDD in polytrauma patients, which included 24 patients who were mechanically ventilated for at least 48 hours. The study found a significant decrease in diaphragmatic thickness on both sides and a positive correlation between the duration of mechanical ventilation and the difference in diaphragmatic thickness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Stefan Andrei, Sebastian Isac, Maricica Carstea, Cristina Martac, Lucian Mihalcea, Cristina Buzatu, Dorin Ionescu, Dragos Eugen Georgescu, Gabriela Droc
Summary: The objective of this study was to analyze the expertise of a non-emergency center for liver surgery from Romania after initial stabilization in county hospitals. Our results revealed that intubation status at admission, norepinephrine infusion during surgery, hyperfibrinogenemia, and duration of mechanical ventilation in patients with isolated liver trauma were correlated with prolonged ICU length of stay.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Surgery
David Ray Velez
Summary: In the past, abdominal trauma was treated nonoperatively. However, French surgeon Jean Baptiste Lucien Baudens performed the first two trauma laparotomies, with the first patient dying but the second surviving. Since then, laparotomy in trauma has evolved into a life-saving intervention and fundamental tool. Baudens documented these cases in his 1836 work, which has been largely overlooked in English literature. This manuscript serves as the first translation of Baudens' contributions.
Article
Emergency Medicine
Emmanuel Urquieta, Alexa Bello, Daryelle Samantha Varon, Joseph Varon
Summary: Medical transport of prisoner patients via helicopter presents unique challenges and risks. A retrospective analysis on air medical transport of felons in Mexico City revealed that factors like heart rate, systolic blood pressure, GCS score, age, and need for CPR were significantly associated with mortality. Despite the dangers, air medical transport of prisoners by a police crew physician was found to be safe and reliable.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
Luz Ramirez, Jose Diaz, Abbas Alshami, Daryelle S. Varon, Sharon Einav, Salim Surani, Joseph Varon
Summary: The portrayal of CPR in television medical dramas (TVMDs) is often inaccurate, with recommended CPR techniques not being fully depicted. Male patients were shown to have a higher survival rate than female patients, and paramedics outperformed physicians and nurses in CPR performance. The outcomes shown on screen were more favorable than in real life, highlighting missed opportunities for improving CPR performance and communication in TVMDs.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Infectious Diseases
Paul E. Marik, Pierre Kory, Joseph Varon, Jose Iglesias, G. Umberto Meduri
Summary: The pulmonary phase of COVID-19 is characterized by organizing pneumonia with immune dysregulation, clotting activation, and microvascular injury leading to severe hypoxemia. The MATH+ protocol combines methylprednisolone, ascorbic acid, thiamine, and heparin to manage this phase. While there is no single cure for COVID-19, the MATH+ protocol is believed to effectively treat respiratory failure and prevent complications and death.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Critical Care Medicine
Alan Araiza, Melanie Duran, Cesar Patino, Paul E. Marik, Joseph Varon
Summary: This study investigated the relationship between CT scores and prognosis of patients with COVID-19 pneumonia, finding that the Ichikado CT score is an independent predictor of all-cause mortality during hospitalization. Age and Ichikado CT score were identified as independent predictors for in-hospital mortality.
JOURNAL OF INTENSIVE CARE
(2021)
Editorial Material
Medicine, General & Internal
Alan Araiza, Melanie Duran, Joseph Varon
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2022)
Article
Multidisciplinary Sciences
Kadhim Al-Banaa, Abbas Alshami, Eiman Elhouderi, Sally Hannoodee, Maryam Hannoodee, Alsadiq Al-Hillan, Hussam Alhasson, Faisal Musa, Joseph Varon, Sharon Einav
Summary: A multicenter retrospective cohort study found that high dose anticoagulation at the time of ICU/SDU admission was associated with decreased mortality among critically ill adult patients with COVID-19.
Editorial Material
Respiratory System
Joseph Varon, Najia Hussaini
CURRENT RESPIRATORY MEDICINE REVIEWS
(2022)
Editorial Material
Respiratory System
Najia Hussaini, Joseph Varon
CURRENT RESPIRATORY MEDICINE REVIEWS
(2022)
Editorial Material
Respiratory System
Joseph Varon, Sushen Bhalla, Daniel Martini
CURRENT RESPIRATORY MEDICINE REVIEWS
(2022)
Article
Microbiology
Fatih M. Uckun, Muhammad Saeed, Mustafa Awili, Ibrahim H. Ozercan, Sanjive Qazi, Cynthia Lee, Adeel Shibli, Alan W. Skolnick, Alonso Prusmack, Joseph Varon, Cesar I. P. Barrera, Cemal Orhan, Michael Volk, Kazim Sahin
Summary: This study compared the effects of Rejuveinix, dexamethasone, and their combination on fatal sepsis in an animal model and COVID-19 patients. The results showed that RJX exhibited potent anti-inflammatory activity, reducing cytokine responses and organ damage in mice, and improving survival outcome. The clinical study also demonstrated that RJX plus DEX was well tolerated by COVID-19 patients.
FUTURE MICROBIOLOGY
(2022)
Editorial Material
Respiratory System
Claudia M. Ramirez, Joseph Varon
CURRENT RESPIRATORY MEDICINE REVIEWS
(2022)
Editorial Material
Respiratory System
Moises Rodriguez, Joseph Varon
CURRENT RESPIRATORY MEDICINE REVIEWS
(2023)
Article
Emergency Medicine
W. Frank Peacock, Karina M. Soto-Ruiz, Stacey L. House, Chad M. Cannon, Gary Headden, Brian Tiffany, Sergey Motov, Kian Merchant-Borna, Anna Marie Chang, Claire Pearson, Brian W. Patterson, Alan E. Jones, Joseph Miller, Joseph Varon, Aveh Bastani, Carol Clark, Zubaid Rafique, Bory Kea, John Eppensteiner, James M. Williams, Simon A. Mahler, Brian E. Driver, Phyllis Hendry, Eugenia Quackenbush, David Robinson, Jon W. Schrock, James P. D'Etienne, Christopher J. Hogan, Anwar Osborne, Ralph Riviello, Stephen Young
Summary: The BinaxNOW point-of-care test has good sensitivity and excellent specificity for the detection of COVID-19. We recommend using the BinaxNOW test for patients with symptoms up to 2 weeks.
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2022)
Review
Immunology
Paul E. Marik, Jose Iglesias, Joseph Varon, Pierre Kory
Summary: COVID-19 is a highly complex medical disorder, with severe cases involving multiple pathological processes such as inflammation, endothelial inflammation, and thrombosis. The presence of auto-antibodies exacerbates the severity of the disease.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Abdulrahman S. Museedi, Abbas Alshami, Steven Douedi, Firas Ajam, Joseph Varon
Summary: This study stratified HF patients based on ejection fraction and different predictors, finding that admissions for HFrEF had higher mortality rate compared to HFpEF. Variables significantly associated with in-hospital mortality in univariate analyses included age, race, hypertension, diabetes mellitus, etc.
CARDIOLOGY RESEARCH
(2021)
Article
Critical Care Medicine
Veerle Heesters, Janneke Dekker, Timothy J. R. Panneflek, Kristel L. A. M. Kuypers, Stuart B. Hooper, Remco Visser, Arjan B. te Pas
Summary: This study visualized the closure of vocal cords during apnea, in between breaths, and during breath holds in preterm infants using ultrasonography. The closure of vocal cords impaired the effect of respiratory support.
