Review
Critical Care Medicine
Simon Parlow, Melissa Fay Lepage-Ratte, Richard G. Jung, Shannon M. Fernando, Sarah Visintini, Lee H. Sterling, Pietro Di Santo, Trevor Simard, Juan J. Russo, Marino Labinaz, Benjamin Hibbert, Jerry P. Nolan, Bram Rochwerg, Rebecca Mathew
Summary: A systematic review and meta-analysis compared the use of volatile anaesthetics to conventional sedation in patients admitted with ROSC after OHCA. The results suggested that volatile anaesthetics may be associated with a decreased duration of mechanical ventilation, but the certainty of evidence was low.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanneke M. Keijzer, Marco Duering, Ofer Pasternak, Frederick J. A. Meijer, Marlous M. L. H. Verhulst, Bart A. R. Tonino, Michiel J. Blans, Cornelia W. E. Hoedemaekers, Catharina J. M. Klijn, Jeannette Hofmeijer
Summary: This study evaluates the potential value of free water corrected mean diffusivity (MD) and fractional anisotropy (FA) based on diffusion tensor imaging (DTI), for predicting the neurological recovery of comatose patients after cardiac arrest. The results show that MD and FA can discriminate between patients with good and poor outcomes, indicating their potential in multimodal outcome prediction.
EUROPEAN RADIOLOGY
(2023)
Article
Anesthesiology
Jeong-Rim Lee, Bernadin Joseph, Rylon D. Hofacer, Brian Upton, Samuel Y. Lee, Loren Ewing, Bingqing Zhang, Steve C. Danzer, Andreas W. Loepke
Summary: The study found that combining dexmedetomidine with 1% sevoflurane can increase anesthesia depth and reduce responses to pain. However, this combination did not reliably reduce neuronal apoptosis compared to an equianaesthetic dose of 2.5% sevoflurane.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Critical Care Medicine
Kate F. Kernan, Rachel P. Berger, Robert S. B. Clark, R. Scott Watson, Derek C. Angus, Ashok Panigrahy, Clifton W. Callaway, Michael J. Bell, Patrick M. Kochanek, Ericka L. Fink, Dennis W. Simon
Summary: This study investigated the association between serum biomarkers of inflammation and neurological outcomes in children following cardiac arrest. Elevated levels of CNTF and IL-17 were found to be independently associated with unfavorable 6-month neurological outcomes, suggesting a potential role in post-cardiac arrest syndrome pathophysiology.
Review
Pharmacology & Pharmacy
Laura Paz-Artigas, Pilar Montero-Calle, Olalla Iglesias-Garcia, Manuel M. Mazo, Ignacio Ochoa, Jesus Ciriza
Summary: Myocardial ischaemia is a major cause of death worldwide. Animal models, although informative, lack the characteristics of human patients with ischemia and are time-consuming and expensive. In vitro models that mimic the human cardiac microenvironment during an ischaemic event can help develop new drugs, understand molecular events, and optimize therapeutic approaches. Current in vitro cardiac culture systems, from organoids to heart-on-chip platforms, can recreate ischaemic hallmarks, but still have limitations in fully recapitulating the complexity of clinical situations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Medicine, General & Internal
Mihai Stefan, Cornelia Predoi, Raluca Goicea, Daniela Filipescu
Summary: This article summarizes the mechanisms of myocardial ischemia/reperfusion injury and cardioprotection in cardiac surgery, and provides a comprehensive analysis of outcomes in patients undergoing cardiac surgery with volatile or intravenous anesthesia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Katarina Varnas, Sjoerd J. Finnema, Peter Johnstrom, Ryosuke Arakawa, Christer Halldin, Lars Eriksson, Lars Farde
Summary: The study found that sevoflurane anesthesia significantly reduces the binding of MAO-B in the primate brain, suggesting potential implications for the regulation of systemic blood pressure during anesthesia.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Cardiac & Cardiovascular Systems
Dylan Chase, Thomas R. Eykyn, Michael J. Shattock, Yu Jin Chung
Summary: This study aims to test whether EMPA directly alters cardiac ketone metabolism independent of supply.
CARDIOVASCULAR RESEARCH
(2023)
Review
Agriculture, Dairy & Animal Science
Ana Vidal Pinheiro, Goncalo N. Petrucci, Amandio Dourado, Isabel Pires
Summary: Anaesthetic drugs may increase the risk of tumor dissemination during the perioperative period by suppressing the immune system, making it important to study anaesthetics and techniques that have immunoprotective and anti-tumor effects for developing novel veterinary anaesthetic strategies.
Article
Critical Care Medicine
Norbert A. Foudraine, Adam Algargoush, Frits H. van Osch, Alex T. Bos
Summary: The study revealed that using sevoflurane combined with higher targeted temperature management significantly reduced the incidence of delirium in out-of-hospital cardiac arrest patients compared to intravenous sedation combined with traditional cooling protocols. Additionally, this approach also resulted in shorter mechanical ventilation times and ICU stays for patients.
Article
Cell Biology
Qingtong Zhang, Jiangwen Yin, Feng Xu, Jingwen Zhai, Jieting Yin, Mingyue Ge, Wenyi Zhou, Nian Li, Xinlei Qin, Yan Li, Sheng Wang
Summary: MEF2D is involved in neuroprotection after cerebral ischaemia/reperfusion injury, and post-conditioning with ISO promotes ERK5 phosphorylation, enhances MEF2D transcriptional activity, inhibits caspase-3 expression, and plays a role in brain protection.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Maike Krenz
Summary: Regulation of protein tyrosine phosphorylation is crucial for cellular processes in the heart. Understanding the roles and mechanisms of protein tyrosine phosphatases in cardiac pathology can provide insights for future research and potential therapeutic targets.
CELLULAR SIGNALLING
(2022)
Article
Physiology
Neerav Patel, Joseph Edwards, Hossam Abdou, David P. Stonko, Rebecca N. Treffalls, Noha N. Elansary, Thomas Ptak, Jonathan J. Morrison
Summary: This study quantitated cerebral perfusion during open cardiac massage (OCM) using computed tomography perfusion (CTP) imaging in a swine model of normo- and hypovolemia. The results showed that OCM in normovolemia generates superior coronary hemodynamics compared to hypovolemia, but neither generates adequate cerebral blood flow (CBF) compared to baseline values. Therefore, further research is needed to develop resuscitative techniques that specifically target cerebral perfusion.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Arianna Scalco, Nicola Moro, Marco Mongillo, Tania Zaglia
Summary: The cardiac autonomic nervous system plays a crucial role in regulating heart function, with the parasympathetic branch dominant during rest and the sympathetic activation enhancing heart performance. Studies have revealed the presence of an intracardiac neuron system and communication between the heart and the central nervous system. Optogenetics has been instrumental in uncovering the cellular mechanisms of neurogenic heart control, providing valuable insights in both physiology and pathology.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Oncology
Mats Enlund
Summary: The choice of anaesthetic may impact long-term survival, with propofol potentially being more beneficial for cancer survival than volatile anaesthetics. Retrospective studies suggest a potential link between anaesthetic technique and cancer survival, but this has not been proven in randomized clinical trials yet.
Article
Cell Biology
Priyanka Tripathi, Haihong Guo, Alice Dreser, Alfred Yamoah, Antonio Sechi, Christopher Marvin Jesse, Istvan Katona, Panagiotis Doukas, Stefan Nikolin, Sabrina Ernst, Eleonora Aronica, Hannes Glass, Andreas Hermann, Harry Steinbusch, Alfred C. Feller, Markus Bergmann, Dick Jaarsma, Joachim Weis, Anand Goswami
Summary: Mutations in RNA binding proteins and genes regulating autophagy can cause familial amyotrophic lateral sclerosis. The P56S mutation in VAPB affects the autophagy pathway and RBP homeostasis.
CELL DEATH & DISEASE
(2021)
Review
Pediatrics
Rudolf Korinthenberg, Regina Trollmann, Barbara Plecko, Georg M. Stettner, Markus Blankenburg, Joachim Weis, Benedikt Schoser, Wolfgang Mueller-Felber, Nina Lochbuehler, Gabriele Hahn, Sabine Rudnik-Schoeneborn
Summary: This article provides information on differential diagnostic workup for peripheral nerve disorders, developed through a formal consensus process involving experts from 10 German societies dedicated to neuroscience. The guidelines emphasize the importance of patient history and clinical findings in determining further diagnostic steps, including nerve sonography, MRI, and genetic testing for hereditary neuropathies.
Article
Medicine, General & Internal
Claudia Neumann, Grigorij Schleifer, Nadine Strassberger-Nerschbach, Johannes Kamp, Gregor Massoth, Alexandra Gortzen-Patin, Dishalen Cudian, Markus Velten, Mark Coburn, Ehrenfried Schindler, Maria Wittmann
Summary: The use of digital online pre-operative patient information or evaluation in Europe varies widely and is not currently implemented as standard practice, particularly in the pediatric population. However, telemedicine may provide benefits in terms of reduced contact and exposure to health risks for high-risk patients in the future.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Haktan Altinova, Pascal Achenbach, Moniek Palm, Istvan Katona, Emmanuel Hermans, Hans Clusmann, Joachim Weis, Gary Anthony Brook
Summary: Research on using bioengineered scaffolds for spinal cord injury repair showed the formation of scar cells with characteristics of perineurial cells in the spinal cord tissue after scaffold implantation. This change in cellular composition highlights the complexity of scar formation in response to injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pathology
Danny Jonigk, Christopher Werlein, Till Acker, Martin Aepfelbacher, Kerstin U. Amann, Gustavo Baretton, Peter Barth, Rainer M. Bohle, Andreas Buettner, Reinhard Buettner, Reinhard Dettmeyer, Philip Eichhorn, Sefer Elezkurtaj, Irene Esposito, Katja Evert, Matthias Evert, Falko Fend, Nikolaus Gassler, Stefan Gattenloehner, Markus Glatzel, Heike Goebel, Elise Gradhand, Torsten Hansen, Arndt Hartmann, Axel Heinemann, Frank L. Heppner, Julia Hilsenbeck, David Horst, Jan C. Kamp, Gita Mall, Bruno Maerkl, Benjamin Ondruschka, Jessica Pablik, Susanne Pfefferle, Alexander Quaas, Helena Radbruch, Christoph Roecken, Andreas Rosenwald, Wilfried Roth, Martina Rudelius, Peter Schirmacher, Julia Slotta-Huspenina, Kevin Smith, Linna Sommer, Konrad Stock, Philipp Stroebel, Stephanie Strobl, Ulf Titze, Gregor Weirich, Joachim Weis, Martin Werner, Claudia Wickenhauser, Thorsten Wiech, Peter Wild, Tobias Welte, Saskia von Stillfried, Peter Boor
Summary: This article discusses the importance of autopsies in the context of the COVID-19 pandemic and presents findings from autopsies conducted in German autopsy centers. The study reveals the distribution of SARS-CoV-2 in various organs and tissues, and provides insights into the pathological features and mechanisms of COVID-19. However, the pathological changes in non-respiratory organs remain unclear.
Article
Endocrinology & Metabolism
Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, Kristian Handler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Summary: Mitochondrial retrograde signaling can stimulate organelle biogenesis as a compensatory adaptation to abnormal activity of the oxidative phosphorylation (OXPHOS) system. In this study, the researchers investigated the molecular mechanisms promoting mitochondrial maintenance in energy-deprived cells and identified the sphingosine phosphate lyase SPL-1/SGPL1 and the ATFS-1-target HOPS complex subunit VPS-39/VPS39 as critical lifespan modulators. They also found that VPS39 recruitment to the mitochondria may be a common signature associated with altered OXPHOS system in mouse-derived muscles.
MOLECULAR METABOLISM
(2022)
Article
Clinical Neurology
Andrea Maier, Romina Kapfenberger, Istvan Katona, Joachim Weis, Jorg B. Schulz, Roman Rolke
Summary: In this retrospective analysis of autoimmune autonomic neuropathy (AAN) patients, it was found that neuropathic pain was not as common as sensory loss. Sensory loss was widely distributed, mainly affecting cold and warm detection thresholds and the thermal sensory limen. Serostatus was not a significant predictor of small fiber deficit in AAN.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Deniz Yilmazer-Hanke, Najwa Ouali Alami, Lubin Fang, Sigried Klotz, Gabor G. Kovacs, Helmut Pankratz, Joachim Weis, Istvan Katona, Angelika Scheuerle, Wolfgang J. Streit, Kelly Del Tredici
Summary: The expression of glial markers CHIT1 and CHI3L1 in the human striate cortex and cerebellum after hypoxic-ischemic brain injury was studied. Different expression patterns were found between the two brain regions. CHIT1 and CHI3L1 could be valuable biomarkers for monitoring the outcome of brain injury.
Letter
Neurosciences
Juliane Bremer, Johannes Friemann, Saskia von Stillfried, Peter Boor, Joachim Weis
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Patricia Franzka, Svenja Caren Schueler, Takfarinas Kentache, Robert Storm, Andrea Bock, Istvan Katona, Joachim Weis, Katrin Buder, Christoph Kaether, Christian A. Hubner
Summary: Proteins of the secretory pathway undergo glycosylation in the ER and Golgi apparatus. Mutations in GMPPA can cause AAMR syndrome with various symptoms. Loss of GMPPA leads to Golgi fragmentation, altered protein abundance, reduced furin activity, and increased retention of alpha-DG.
Article
Health Care Sciences & Services
Saskia von Stillfried, Roman David Buelow, Rainer Roehrig, Peter Boor
Summary: The German COVID-19 Autopsy Registry (DeRegCOVID) serves as a central hub for multicenter autopsy-based studies and provides support for researchers and data analysis. The registry shows that COVID-19 is the underlying cause of death in most autopsy cases, with diffuse alveolar damage and multi-organ failure being the most common immediate causes of death. The registry is of great importance for medical research, policy-making, and public discussion.
LANCET REGIONAL HEALTH-EUROPE
(2022)
Correction
Clinical Neurology
Nelson Ferreira, Mette Richner, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Christian B. Vaegter, Jens R. Nyengaard, Glenda M. Halliday, Joachim Weis, Benoit I. Giasson, Ian R. Mackenzie, Poul H. Jensen, Asad Jan
BRAIN COMMUNICATIONS
(2022)
Article
Critical Care Medicine
Saskia von Stillfried, Roman David Buelow, Rainer Roehrig, Patrick Meybohm, Peter Boor
Summary: This study analyzed data from the German COVID-19 autopsy registry and found that bleeding events were more frequent in ECMO cases, with a higher proportion of intracranial bleeding. The study suggests the potential value of autopsies and a joint interdisciplinary multicenter approach in addressing fatal complications in COVID-19.
Article
Medicine, Research & Experimental
Eva Lausberg, Sebastian Giesselmann, Joseph P. Dewulf, Elsa Wiame, Anja Holz, Ramona Salvarinova, Clara D. van Karnebeek, Patricia Klemm, Kim Ohl, Michael Mull, Till Braunschweig, Joachim Weis, Clemens J. Sommer, Stephanie Demuth, Claudia Haase, Claudia Stollbrink-Peschgens, Francois-Guillaume Debray, Cecile Libioulle, Daniela Choukair, Prasad T. Oommen, Arndt Borkhardt, Harald Surowy, Dagmar Wieczorek, Norbert Wagner, Robert Meyer, Thomas Eggermann, Matthias Begemann, Emile Van Schaftingen, Martin Hausler, Klaus Tenbrock, Lambert van den Heuvel, Miriam Elbracht, Ingo Kurth, Florian Kraft
Summary: Our study reveals that C2orf69 is associated with brain abnormalities, liver dysfunction, and recurrent autoinflammation, as well as influencing mitochondrial function and glycogen metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Patricia Franzka, Henriette Henze, M. Juliane Jung, Svenja Caren Schueler, Sonnhild Mittag, Karina Biskup, Lutz Liebmann, Takfarinas Kentache, Jose Morales, Braulio Martinez, Istvan Katona, Tanja Herrmann, Antje-Kathrin Huebner, J. Christopher Hennings, Susann Groth, Lennart Gresing, Rudiger Horstkorte, Thorsten Marquardt, Joachim Weis, Christoph Kaether, Osvaldo M. Mutchinick, Alessandro Ori, Otmar Huber, Veronique Blanchard, Julia von Maltzahn, Christian A. Huebner
Summary: GMPPB facilitates the generation of GDP-mannose and its defects can cause muscle disease; Mutations of catalytically inactive homolog GMPPA may cause AAMR syndrome, which includes muscle weakness.
JOURNAL OF CLINICAL INVESTIGATION
(2021)