Article
Critical Care Medicine
Jean Bourbeau, Dany Doiron, Sharmistha Biswas, Benjamin M. Smith, Andrea Benedetti, Jeffrey R. Brook, Shawn D. Aaron, Kenneth R. Chapman, Paul Hernandez, Francois Maltais, Darcy D. Marciniuk, Denis O'Donnell, Don D. Sin, Brandie Walker, Liesel Dsilva, Gilbert Nadeau, Valerie Coats, Chris Compton, Bruce E. Miller, Wan C. Tan
Summary: Outdoor air pollution is associated with lower lung function and COPD, with possible interactions with dysanapsis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taohu Zhou, Wenting Tu, Peng Dong, Shaofeng Duan, Xiuxiu Zhou, Yanqing Ma, Yun Wang, Tian Liu, Hanxiao Zhang, Yan Feng, Wenjun Huang, Yanming Ge, Shiyuan Liu, Zhaobin Li, Li Fan
Summary: This study developed a model for predicting chronic obstructive pulmonary disease (COPD) in patients with lung cancer based on computed tomography (CT) radiomic signatures and clinical and imaging features. The radiomic signature was significantly related to COPD and served as an independent predictor in the multivariate regression analysis. The model, incorporating radiomic signatures, clinical and radiological features, can be used to predict the risk of COPD in patients with lung cancer using one-stop chest CT scanning.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Armin Frille, Michael Rullmann, Georg-Alexander Becker, Marianne Patt, Julia Luthardt, Solveig Tiepolt, Hubert Wirtz, Osama Sabri, Swen Hesse, Hans-Juergen Seyfarth
Summary: This study investigated the in vivo availability of serotonin transporter in the lungs of patients with COPD and PH for the first time. The findings suggest that pulmonary SERT may be involved in the development of PH in COPD patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Medicine, General & Internal
Tao Li, Hao-Peng Zhou, Zhi-Jun Zhou, Li-Quan Guo, Linfu Zhou
Summary: This review highlights the role and importance of CT in identifying different phenotypes of COPD, emphasizing the accuracy of small airway CT phenotypes in reflecting disease severity and aiding in improving prognosis. Additionally, it discusses the application of CT in clinical, epidemiologic, and genetic investigations related to COPD.
CHINESE MEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Allan Felipe Fattori Alves, Jose Ricardo Arruda Miranda, Fabiano Reis, Abner Alves Oliveira, Sergio Augusto Santana Souza, Carlos Magno Castelo Branco Fortaleza, Suzana Erico Tanni, Jose Thiago Souza Castro, Diana Rodrigues Pina
Summary: This study developed an automatic algorithm for quantifying total volume and lung impairments in different diseases, which showed good agreement with a semi-automatic algorithm. The algorithm is capable of measuring volume and differentiating various pulmonary involvements, providing reliable quantification for physicians in important lung diseases.
Article
Respiratory System
Sang Won Park, Myoung-Nam Lim, Woo Jin Kim, So Hyeon Bak
Summary: This study analyzed the correlation between longitudinal changes in pulmonary vascular parameters and clinical parameters in COPD patients, and found that quantitative computed tomography features can accurately reflect pulmonary vascular alterations.
RESPIRATORY RESEARCH
(2022)
Article
Medicine, General & Internal
Andrzej Obojski, Mateusz Patyk, Urszula Zaleska-Dorobisz
Summary: This study found that the thickness of the bronchial wall was greater in the SA-PAL group than in the COPD group, with the lowest lung density observed in the SA-PAL group and a higher percentage of low-attenuation volume compared to the healthy volunteer group. Severe asthma with persistent airflow limitation and COPD become similar in terms of functional and morphological dimensions over time, both showing emphysema qualities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Hoon Cho, Joon Beom Seo, Sang Min Lee, Namkug Kim, Jihye Yun, Jeong Eun Hwang, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee, Li-Cher Loh, Choo-Khoom Ong
Summary: Radiomics analysis was applied for overall survival prediction in COPD patients, with the radiomics signature effectively identifying those at increased risk of mortality. The constructed radiomics model demonstrated acceptable performance in survival prediction and risk stratification for COPD patients.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Michael G. Milligan, Inga T. Lennes, Saif Hawari, Melin J. Khandekar, Yolonda Colson, Jo-Anne O. Shepard, Angela Frank, Lecia Sequist, Henning Willers, Florence K. Keane
Summary: This study conducted in a lung nodule and lung cancer screening clinic aimed to evaluate the role of stereotactic body radiation therapy among patients enrolled in a lung cancer screening program. The findings revealed that one in four patients with screen-detected pulmonary nodules requiring intervention were treated with stereotactic body radiation therapy, highlighting the importance of radiation oncologists in the multidisciplinary management of pulmonary nodules.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia K. A. L. Kwee, Bart Luijk, Pim A. de Jong, Harry J. M. Groen, Joachim G. J. V. Aerts, Jean-Paul Charbonnier, Rozemarijn Vliegenthart, Firdaus A. A. Mohamed Hoesein
Summary: Bronchiectasis has a prevalence of 5.4% in lung cancer screening participants and is associated with more respiratory symptoms and, in those with COPD, lower lung function and more emphysema. However, incidental findings of mild bronchiectasis are not very relevant in a lung cancer screening population unless COPD is also present.
EUROPEAN RADIOLOGY
(2023)
Article
Environmental Sciences
Yacong Bo, Ly-yun Chang, Cui Guo, Changqing Lin, Alexis K. H. Lau, Tony Tam, Xiang Qian Lao
Summary: Reduced exposure to PM2.5 pollution was associated with improvements in lung function parameters and a decreased risk of COPD development. Strategies aimed at reducing air pollution may effectively combat the risk of developing COPD.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Respiratory System
Adamo A. Donovan, Gregory Johnston, Michelle Moore, Dennis Jensen, Andrea Benedetti, Harvey O. Coxson, Stewart B. Gottfried, Basil J. Petrof, Jean Bourbeau, Benjamin M. Smith
Summary: The study found that CT-assessed diaphragm morphology was associated with COPD severity, exacerbations, impaired health status, and exercise intolerance.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Review
Medicine, General & Internal
Xiaoyan Gai, Brian Allwood, Yongchang Sun
Summary: The burden of chronic airway diseases, including chronic obstructive pulmonary disease (COPD), continues to increase, especially in low- and middle-income countries. Post-tuberculosis lung disease (PTLD), characterized by chronic lung changes after the cure of pulmonary tuberculosis (TB), may be associated with the pathogenesis of COPD. However, data on PTLD's prevalence, clinical manifestations, computed tomography features, lung function impairment patterns, and influencing factors are limited. More research is needed to elucidate the pathogenesis of PTLD.
CHINESE MEDICAL JOURNAL
(2023)
Article
Critical Care Medicine
Steven Booth, Aileen Hsieh, Leila Mostaco-Guidolin, Hyun-Kyoung Koo, Keith Wu, Fatemeh Aminazadeh, Chen Xi Yang, Daniela Quail, Yuhong Wei, Joel D. Cooper, Peter D. Pare, James C. Hogg, Dragos M. Vasilescu, Tillie-Louise Hackett
Summary: This study has developed a comprehensive single-cell atlas of terminal bronchiole loss in COPD, revealing the cellular and gene alterations associated with this pathology. The findings suggest that the narrowing of the lumen area of terminal bronchioles occurs before microscopic tissue destruction in the early stages of COPD, and that various immune cells and genes are involved in the pathobiology of this disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Siddharth S. Madapoosi, Charmion Cruickshank-Quinn, Kristopher Opron, John R. Erb-Downward, Lesa A. Begley, Gen Li, Igor Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, David J. Couper, Christopher B. Cooper, Christine M. Freeman, MeiLan K. Han, Robert J. Kaner, Wassim Labaki, Fernando J. Martinez, Victor E. Ortega, Stephen P. Peters, Robert Paine, Prescott Woodruff, Jeffrey L. Curtis, Gary B. Huffnagle, Kathleen A. Stringer, Russell P. Bowler, Charles R. Esther, Nichole Reisdorph, Yvonne J. Huang
Summary: The study found that lung microbiota and metabolites are associated with clinical markers in patients with milder COPD, suggesting their potential collaborative roles in disease pathogenesis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)