Review
Endocrinology & Metabolism
Qi Lu, Yang Xu, Zeng Zhang, Shanshan Li, Zhenlin Zhang
Summary: Primary hypertrophic osteoarthropathy (PHO) is a genetic disorder with clubbing fingers, pachydermia, and periostosis as its main characteristics. Mutations in the HPGD or SLCO2A1 gene lead to elevated levels of prostaglandin E2 (PGE2) due to impaired PGE2 degradation. The identification of causative genes has improved our understanding of the underlying mechanisms. This review outlines the synthesis and signaling pathways of PGE2 and discusses current treatment options and potential future treatments for PHO based on clinical research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cristina Chimenti, Maria Alfarano, Viviana Maestrini, Nicola Galea, Giuseppe De Vincentis, Romina Verardo, Francesco Fedele, Andrea Frustaci
Summary: A case study of an 85-year-old man with positive bone scintigraphy but diagnosed with sarcomeric hypertrophic cardiomyopathy through endomyocardial biopsy. Genetic study did not show mutations in TTR gene but suggested involvement of sarcomeric genes. In hypertrophic cardiomyopathy, factors such as cell necrosis related to oxygen mismatch or small vessels disease could lead to false-positive bone scintigraphy for transthyretin amyloidosis, highlighting the importance of endomyocardial biopsy for accurate diagnosis.
Article
Oncology
Hang Li, Ting Ye, Nan Li, Guozhan Xia, Bin Li, Yang Zhang, Hong Hu, Yihua Sun, Yawei Zhang, Jiaqing Xiang, Dongchun Ma, Yuan Weng, Shilei Liu, Chunyi Jia, Bin Qian, Yajia Gu, Yuan Li, Shaoli Song, Haiquan Chen
Summary: In this study involving 691 patients with cT1N0 subsolid lung cancer, it was found that bone scintigraphy is unnecessary as part of the preoperative workup for these patients. The study suggests that physicians should consider skipping bone scans from the preoperative evaluation for cT1 subsolid lung cancer patients.
Article
Oncology
Ryuta Tagawa, Hiroshi Soda, Yosuke Dotsu, Hiroaki Senju, Satoshi Irifune, Masataka Yoshida, Shota Nakashima, Asuka Umemura, Keisuke Iwasaki, Hirokazu Taniguchi, Shinnosuke Takemoto, Yuichi Fukuda, Hiroshi Mukae
Summary: This article presents the case of a 69-year-old man who developed intractably painful hypertrophic osteoarthropathy (HOA) secondary to lung cancer. Treatment with carboplatin, paclitaxel, and bevacizumab reduced tumor size and plasma vascular endothelial growth factor (VEGF) levels, relieving the patient's leg pain. The immunohistochemical examination showed that lung cancer cells were positive for VEGF, suggesting a potential role of hypoxia-inducible factor-1a in VEGF production. The findings of this study may lead to the development of novel management strategies for painful HOA.
Article
Oncology
Jun Hanaoka, Makoto Yoden, Kazuki Hayashi, Takuya Shiratori, Keigo Okamoto, Ryosuke Kaku, Yo Kawaguchi, Yasuhiko Ohshio, Akinaga Sonoda
Summary: The study confirmed that dynamic perfusion digital radiography can be a suitable alternative to pulmonary perfusion scintigraphy for predicting postoperative values and the risk for postoperative respiratory complications. It is a convenient, cost-effective modality that provides comprehensive respiratory functional information.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Teng Ma, Yu Tang, Taolin Wang, Yang Yang, Yige Zhang, Ruihuan Wang, Yongxin Zhang, Yi Li, Mingbo Wu, Miao Tang, Xueli Hu, Chaoyu Zou, Yuan Ren, Huan Liu, Qianhua Zhang, Heyue Li, Min Wu, Jing Li, Xikun Zhou
Summary: Chronic bacterial infection in the lungs promotes breast cancer metastasis by recruiting a specific type of neutrophils that enhance tumor metastasis. CCL2 from lung tissues plays a crucial role in the recruitment and maintenance of these neutrophils. This study links bacterial-immune crosstalk to breast cancer lung metastasis and identifies MHCIIhi neutrophils as the key mediator between chronic infection and tumor metastasis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Health Care Sciences & Services
Maoyuan Zhao, Yanru Du, Qing Peng, Zhouguang Hui
Summary: This article describes a 48-year-old Chinese male patient with advanced sarcomatoid carcinoma diagnosed while examining symptoms of HPOA. The patient's condition was effectively controlled by chemotherapy and radiotherapy, with stable disease and no remission or exacerbation of clubbing. The purpose of this report is to present the feature and treatment of primary esophageal sarcomatoid carcinoma with HPOA, helpful for understanding the disease and clinical decision making.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yang Xu, Zeng Zhang, Hua Yue, Shanshan Li, Zhenlin Zhang
Summary: The study identified SLCO2A1 monoallelic mutations as the cause of PHOAD, with milder symptoms compared to PHOAR2, as well as a positive response to oral etoricoxib treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierre-Yves Le Roux, Pierre-Benoit Bonnefoy, Achraf Bahloul, Benoit Denizot, Bertrand Barres, Caroline Moreau-Triby, Astrid Girma, Amandine Pallardy, Quentin Ceyrat, Laure Sarda-Mantel, Micheline Razzouk-Cadet, Reka Zsigmond, Cachin Florent, Gilles Karcher, Pierre-Yves Salaun
Summary: This study assessed the role of ventilation imaging in COVID-19 patients undergoing lung scintigraphy for suspected pulmonary embolism (PE). The findings showed that in this population, only 57% of patients could confidently exclude PE without ventilation imaging, while 31% of patients required ventilation imaging to rule out PE. The study also revealed a low prevalence of PE (12%).
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Medicine, General & Internal
Romain Le Pennec, Cecile Tromeur, Charles Orione, Philippe Robin, Raphael Le Mao, Claire De Moreuil, Mitja Jevnikar, Clement Hoffman, Laurent Savale, Francis Couturaud, Olivier Sitbon, David Montani, Xavier Jais, Gregoire Le Gal, Pierre Yves Salauen, Marc Humbert, Pierre Yves Le Roux
Summary: The aim of this study was to assess the accuracy of various interpretation criteria of planar V/Q scintigraphy for the screening of CTEPH. The optimal diagnostic cut-off for interpretation was found to be 2.5 segmental mismatched perfusion defects, providing a sensitivity of 100% and a specificity of 94.7%. An interpretation based solely on perfusion defects had similar sensitivity but lower specificity.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Qi Lu, Yang Xu, Shanshan Li, Zeng Zhang, Jiagen Sheng, Zhenlin Zhang
Summary: This study analyzed the clinical and biochemical characteristics and HPGD gene mutations in 12 Chinese patients with PHOAR1. The most common features observed were digital clubbing and periostosis, and the recurrent mutation c.310_311delCT was identified as a hotspot mutation. Patients with PHOAR1 had elevated urinary PGE2 levels and decreased urinary PGE-M levels compared to healthy controls, with a lower PGE2/PGE-M ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Editorial Material
Medicine, General & Internal
Marie-Claude Eberle, Cyril Fersing, Sophie Guillemard, Diana Ilonca, Severine Guiu, Emmanuel Deshayes
Summary: A 48-year-old woman with breast cancer underwent a bone scan and two hot spots were found in the left lung. CT slices showed no abnormalities and other possible causes were ruled out. Radiotracer microembolism seems to be the most likely hypothesis in this case.
Article
Critical Care Medicine
Paul Pinsky, Eric Miller, Nick Faris, Raymond Osarogiagbon
Summary: This study explores the relationship between pulmonary nodules and lung cancer, assessing the commonness of nodules in the Medicare population and the rate of lung cancer after their detection. The study finds that pulmonary nodules are relatively common and are associated with a higher occurrence of lung cancer. It also suggests that a larger proportion of early-stage lung cancer is diagnosed through reporting of nodules compared to low-dose CT scan screening.
Review
Immunology
Xing-Xing Fan, Qiang Wu
Summary: Lung cancer is highly heterogeneous, and single-cell analysis can help us understand its molecular characteristics and cell types better. Recent findings may provide new directions for the treatment strategies of lung cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Areej Albawa'neh, Mariam Ghareeb Al Mansoori, Sehriban Diab, Fatma Al Jasmi, Nadia Akawi
Summary: A 22-year-old Emirati male with autosomal recessive primary hypertrophic osteoarthropathy was reported, and a possibly pathogenic homozygous non-synonymous variant in the SLCO2A1 gene was identified. The patient showed significant clinical improvement with etoricoxib treatment, making it an important first-line therapy recommendation for primary hypertrophic osteoarthropathy.
FRONTIERS IN GENETICS
(2022)