Article
Virology
Erwan Sallard, Frank Schult, Carolin Baehren, Eleni Buedding, Olivier Mboma, Parviz Ahmad-Nejad, Beniam Ghebremedhin, Anja Ehrhardt, Stefan Wirth, Malik Aydin
Summary: Respiratory viruses play a significant role in exacerbating asthma, and human rhinovirus (HRV) infection is a strong biomarker for exacerbation.
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Yu Kawakami, Ikuo Takazawa, Merritt L. Fajt, Kazumi Kasakura, Joseph Lin, Julienne Ferrer, David B. Kantor, Wanda Phipatanakul, Peter W. Heymann, Chris A. Benedict, Yuko Kawakami, Toshiaki Kawakami
Summary: This study investigates the role of histamine-releasing factor (HRF) in asthma severity and virus-induced asthma exacerbations. The results show that HRF-reactive IgE is higher in severe asthmatic patients and that respiratory epithelial cells secrete HRF in response to RV infection. This suggests that HRF may contribute to the pathogenesis of asthma and RV-induced asthma exacerbation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pediatrics
Julie Magnier, Valerie Julian, Aurelien Mulliez, Alexandra Usclade, Emmanuelle Rochette, Bertrand Evrard, Flore Amat, Carole Egron
Summary: The study revealed that male infants with a family history of allergies may be at higher risk for asthma at school age following their first episode of acute bronchiolitis. Additionally, rhinovirus infection and specific gene may have significant associations with asthma at age seven.
Article
Public, Environmental & Occupational Health
Hortense Petat, Matthieu Schuers, Christophe Marguet, Xavier Humbert, Francois Le Bas, Andry Rabiaza, Sandrine Corbet, Bryce Leterrier, Astrid Vabret, Meriadeg Ar Gouilh
Summary: This study provides additional information on the relationships between respiratory viruses, which remains limited in primary care.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Immunology
Heidi Makrinioti, Andrew Bush, James Gern, Sebastian Lennox Johnston, Nikolaos Papadopoulos, Wojciech Feleszko, Carlos A. Camargo, Kohei Hasegawa, Tuomas Jartti
Summary: Bronchiolitis is a common cause of hospitalization in infants and is associated with a higher risk of childhood asthma development. The mechanisms underlying asthma development following bronchiolitis hospitalization are complex and involve immune responses to respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Allergy
Niek B. Achten, Annemarie M. C. van Rossum, Leonard B. Bacharier, Anne M. Fitzpatrick, Tina Hartert
Summary: This article examines the impact of early-life viral infections on the lung and immune systems and focuses on the causal relationship between early-life viral infections and asthma. The article calls for a shift in research focus towards improving patient outcomes in the spectrum of respiratory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Immunology
Ben Nicholas, Hyun-Hee Lee, Jane Guo, Milenko Cicmil, Cornelia Blume, Rene De Waal Malefyt, Ratko Djukanovic
Summary: Asthmatics are more susceptible to viral infections and have impaired immune response. The expression of immune-modulatory regulators (IMRs), such as PD-1, is elevated in lung tissues of asthmatics following influenza infection. PD-1 inhibition treatment is ineffective in asthmatics and may increase infection rates in healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Yuki Furuse, Raita Tamaki, Akira Suzuki, Taro Kamigaki, Michiko Okamoto, Mariko Saito-Obata, Emiko Nakagawa, Mayuko Saito, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani
Summary: This study examined the prevalence of respiratory viruses among children with acute respiratory infections in the Philippines. The research found that the prevalence of respiratory viruses in healthcare facilities was significantly higher than in households, with respiratory syncytial virus and rhinovirus being the most common.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Critical Care Medicine
Joe G. Zein, Chao-Ping Wu, Amy H. Attaway, Peng Zhang, Aziz Nazha
Summary: Machine learning models built with outpatient data accurately predicted asthma exacerbations and severity, enhancing the quality of outpatient care and preventing adverse outcomes.
Article
Medicine, General & Internal
Ahmad R. Alsayed, Anas Abed, Mahmoud Abu-Samak, Farhan Alshammari, Bushra Alshammari
Summary: This research aimed to identify the causative virus(es) of acute bronchiolitis and establish a practical protocol for classifying Human Rhinovirus (HRV) species. Nasopharyngeal samples from children aged 1-24 months with acute bronchiolitis were analyzed using a quantitative polymerase chain reaction (qPCR) and high-throughput assay to confirm HRV species. The study identified 7 HRV-A, 1 HRV-B, and 7 HRV-C types based on VP4/VP2 and VP3/VP1 sequences, with the VP4/VP2 region showing lower nucleotide divergence than the VP3/VP1 region. The results highlighted the potential utility of VP4/VP2 and VP3/VP1 regions in differentiating HRV genotypes, and confirmed the practicality of nested and semi-nested PCR for HRV sequencing and genotyping.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Kazuyuki Nakagome, Makoto Nagata
Summary: Viral infection, especially with rhinovirus, is a major cause of asthma exacerbation. The production of anti-viral cytokines is lower in asthma patients, which can contribute to the worsening of viral-induced diseases. rhinovirus species C induces more severe diseases compared to other rhinoviruses. Neutrophils activated by viral infection and virus-related proteins can induce airway inflammation through different mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Andres Pizzorno, Blandine Padey, Victoria Duliere, William Mouton, Justine Oliva, Emilie Laurent, Cedrine Milesi, Bruno Lina, Aurelien Traversier, Thomas Julien, Sophie Trouillet-Assant, Manuel Rosa-Calatrava, Olivier Terrier
Summary: This study investigates the interactions between SARS-CoV-2 and other respiratory viruses, revealing that virus type and sequence of infections play a crucial role in determining virus-virus interactions, with the primary infection having a determinant role in the immune response to the secondary infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Allergy
Mauro Tutino, Raquel Granell, John A. Curtin, Sadia Haider, Sara Fontanella, Clare S. Murray, Graham Roberts, S. Hasan Arshad, Stephen Turner, Andrew P. Morris, Adnan Custovic, Angela Simpson
Summary: This study found that the asthma-risk variant rs2305480 in the 17q12-21 locus is no longer associated with an increased risk of persistent wheeze when there is an interaction with early-life dog ownership, but no such interaction was observed with cat ownership.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Letter
Critical Care Medicine
Adnan Custovic, Sara Fontanella, Sadia Haider
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Adnan Custovic, Sara Fontanella
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Allergy
Jiakai Wu, Rajia Bahri, Marina Tsoumani, Aida Semic-Jusufagic, Clare S. Murray, Adnan Custovic, George Guibas, Miriam Bennett, Ran Wang, Gail Gauvreau, Ruth Cusack, Clare Mills, Silvia Bulfone-Paus, Angela Simpson
Summary: This study developed a high-throughput basophil activation test based on human progenitor cell-derived basophils (PCB). The PCB activation test (PCBAT) was found to correlate with clinical allergy and may serve as a powerful alternative tool in allergy testing.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Pediatrics
Carlyle McCready, Sadia Haider, Francesca Little, Mark P. Nicol, Lesley Workman, Diane M. Gray, Raquel Granell, Dan J. Stein, Adnan Custovic, Heather J. Zar
Summary: This study aimed to describe the developmental trajectories of childhood wheezing in South Africa and the UK. Four wheeze phenotypes were identified in the South African cohort: never, early transient, late onset, and recurrent. All-cause lower respiratory tract infection and respiratory syncytial virus infection were associated with recurrent wheeze.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Allergy
Mohamed H. Shamji, Markus Ollert, Ian M. Adcock, Oscar Bennett, Alberto Favaro, Roudin Sarama, Carmen Riggioni, Isabella Annesi-Maesano, Adnan Custovic, Sara Fontanella, Claudia Traidl-Hoffmann, Kari Nadeau, Lorenzo Cecchi, Magdalena Zemelka-Wiacek, Cezmi A. Akdis, Marek Jutel, Ioana Agache
Summary: Allergic diseases and asthma are closely connected to our living environment and patterns of exposure. The utilization of artificial intelligence and machine-learning methods can help unlock the potential of complex environmental data sets for understanding causality models of exposure and intervention. This article discusses the progress and future prospects of applying these approaches, as well as examples of machine learning in allergic disease research and its integration with representative exposome data. The promise of artificial intelligence in personalized medicine and improving public health is also explored.
Article
Respiratory System
Nicholas A. Scott, Laurence Pearmain, Sean B. Knight, Oliver Brand, David J. Morgan, Christopher Jagger, Sarah Harbach, Saba Khan, Halima A. Shuwa, Miriam Franklin, Verena Kaestele, Thomas Williams, Ian Prise, Flora A. McClure, Pamela Hackney, Lara Smith, Madhvi Menon, Joanne E. Konkel, Criag Lawless, James Wilson, Alexander G. Mathioudakis, Stefan C. Stanel, Andrew Ustianowski, Gabriella Lindergard, Seema Brij, Nawar Diar Bakerly, Paul Dark, Christopher Brighting, Pilar Rivera-Ortega, Graham M. Lord, Alex Horsley, L. CIRCO, Karen Piper Hanley, Timothy Felton, Angela Simpson, John R. Grainger, Tracy Hussell, Elizabeth R. Mann
Summary: COVID-19 is associated with immune dysfunction, which may contribute to the chronic symptoms in long COVID patients. Phenotypical and functional changes in monocytes were assessed in COVID-19 patients during hospitalization and convalescence. Specific monocyte alterations were found in long COVID patients with unresolved lung injury and ongoing fatigue. These findings offer potential therapeutic opportunities for COVID-19 patients with persistent morbidity.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Allergy
Adnan Custovic, Angela Pinot de Moira, Clare S. S. Murray, Angela Simpson
Summary: Exposure to allergens is related to the development of allergen-specific sensitization, but this relationship is influenced by other exposures and genetic predisposition of the host. The effectiveness of allergen avoidance in preventing sensitization and asthma in pregnancy and early life is inconsistent. However, there is consistent evidence that high exposure to sensitizing allergens worsens clinical outcomes in children with asthma. The use of allergen-impermeable bed encasings and targeted environmental control can reduce hospital attendance with asthma attacks and improve asthma control in children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Otorhinolaryngology
Sarah K. Wise, Cecelia Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Elina Toskala, Jennifer Villwock, Baharudin Abdullah, Cezmi Akdis, Jeremiah A. Alt, Ignacio J. Ansotegui, Antoine Azar, Fuad Baroody, Michael S. Benninger, Jonathan Bernstein, Christopher Brook, Raewyn Campbell, Thomas Casale, Mohamad Chaaban, Fook Tim Chew, Jeffrey Chambliss, Antonella Cianferoni, Adnan Custovic, Elizabeth Mahoney Davis, John M. DelGaudiomd, Anne K. Ellis, Carrie Flanagan, Wytske J. Fokkens, Christine Franzese, Matthew Greenhawt, Amarbir Gill, Ashleigh Halderman, Jens M. Hohlfeld, Cristoforo Incorvaia, Stephanie A. Joe, Shyam Joshi, Merin Elizabeth Kuruvilla, Jean Kim, Adam M. Klein, Helene J. Krouse, Edward C. Kuan, David Lang, Desiree Larenas-Linnemann, Adrienne M. Laury, Matt Lechner, Stella E. Lee, Victoria S. Lee, Patricia Loftus, Sonya Marcus, Haidy Marzouk, Jose Mattos, Edward McCoul, Erik Melen, James W. Mims, Joaquim Mullol, Jayakar V. Nayak, John Oppenheimer, Richard R. Orlandi, Katie Phillips, Michael Platt, Murugappan Ramanathan, Mallory Raymond, Chae-Seo Rhee, Sietze Reitsma, Matthew Ryan, Joaquin Sastre, Rodney J. Schlosser, Theodore A. Schuman, Marcus S. Shaker, Aziz Sheikh, Kristine A. Smith, Michael B. Soyka, Masayoshi Takashima, Monica Tang, Pongsakorn Tantilipikorn, Malcolm B. Taw, Jody Tversky, Matthew A. Tyler, Maria C. Veling, Dana Wallace, De Yun Wang, Andrew White, Luo Zhang
Summary: The ICAR-Allergic Rhinitis 2023 update expands on the 2018 International Consensus Statement on Allergy and Rhinology, including 144 topics on allergic rhinitis. The update employed evidence-based review methodology and peer consensus for each topic. It provides comprehensive evaluation, evidence, and recommendations for patient evaluation and treatment of allergic rhinitis.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Allergy
Nandinee Patel, Wayne G. Shreffler, Adnan Custovic, Alexandra F. Santos
Summary: Oral food challenges (OFCs) are the definitive diagnostic procedure in food allergy, but they carry a risk for severe allergic reactions. This review explores the various roles OFC plays in clinical and research settings, discusses progress in developing alternative diagnostic tools, and emphasizes the ongoing importance of research OFC to improve diagnostic capabilities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Respiratory System
Sormeh Salehian, Louise Fleming, Sejal Saglani, Adnan Custovic
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Allergy
Mariana Farraia, Francisca Castro Mendes, Oksana Sokhatska, Tiago Rama, Milton Severo, Adnan Custovic, Joao Cavaleiro Rufo, Henrique Barros, Andre Moreira
Summary: This study aims to develop and evaluate a personalized predictive algorithm for asthma that combines component-resolved diagnosis (CRD) with clinical data, and uses information on allergic sensitization to improve the accuracy of asthma prediction models.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Torsten Zuberbier, Amir Abdul Latiff, Xenofon Aggelidis, Matthias Augustin, Radu-Gheorghe Balan, Christine Bangert, Lisa Beck, Thomas Bieber, Jonathan A. Bernstein, Marta Bertolin Colilla, Alejandro Berardi, Anna Bedbrook, Carsten Bindslev-Jensen, Jean Bousquet, Marjolein de Bruin-Weller, Dayanne Bruscky, Betul Buyuktiryaki, Giorgio Walter Canonica, Carla Castro, Natia Chanturidze, Herberto Jose Chong-Neto, Chia-Yu Chu, Leena Chularojanamontri, Michael Cork, Roberta F. J. Criado, Laia Curto Barredo, Adnan Custovic, Ulf Darsow, Arben Emurlai, Ana de Pablo, Stefano Del Giacco, Giampiero Girolomoni, Tanja Deleva Jovanova, Mette Deleuran, Nikolaos Douladiris, Bruno Duarte, Ruta Dubakiene, Esben Eller, Batya Engel-Yeger, Luis Felipe Ensina, Nelson Rosario Filho, Carsten Flohr, Daria Fomina, Wojciech Francuzik, Maria Laura Galimberti, Ana M. Gimenez-Arnau, Kiran Godse, Charlotte Gotthard Mortz, Maia Gotua, Michihiro Hide, Wolfram Hoetzenecker, Nicolas Hunzelmann, Alan Irvine, Carolyn Jack, Ioanna Kanavarou, Norito Katoh, Tamar Kinaciyan, Emek Kocatuerk, Kanokvalai Kulthanan, Hilde Lapeere, Susanne Lau, Mariana Machado Forti Nastri, Michael Makris, Eli Mansour, Alexander Marsland, Mara Morelo Rocha Felix, Ana Paula Moschione Castro, Eustachio Nettis, J. F. Nicolas, Audrey Nosbaum, Mikaela Odemyr, Niki Papapostolou, Claudio A. S. Parisi, Sushil Paudel, Jonny Peter, Prakash Pokharel, Luis Puig, Tamara Quint, German Dario Ramon, Frederico Regateiro, Giampaolo Ricci, Cristine Rosario, Cansin Sackesen, Peter Schmid-Grendelmeier, Esther Serra-Baldrich, Kristina Siemens, Cathrine Smith, Petra Staubach, Katarina Stevanovic, Ozlem Su-Kucuk, Gordon Sussman, Simona Tavecchio, Natasa Teovska Mitrevska, Diamant Thaci, Elias Toubi, Claudia Traidl-Hoffmann, Regina Treudler, Zahava Vadasz, Ingrid van Hofman, Maria Teresa Ventura, Zhao Wang, Thomas Werfel, Andreas Wollenberg, Ariana Yang, Yik Weng Yew, Zuotao Zhao, Ricardo Zwiener, Margitta Worm
Summary: AD-ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
