Article
Infectious Diseases
Lizhen Cao, Lin He, Siyuan Wang, Lianjie Xu, Shifang Zhuang
Summary: This article reports the first case of human infection with C. pecorum. The patient, a 51-year-old man, presented with high fever and dry cough and was diagnosed with severe community-acquired pneumonia and respiratory failure. C. pecorum was identified as the causative agent through metagenomic next-generation sequencing and further confirmed using other diagnostic methods. The patient's condition improved rapidly after targeted treatment. The patient, a farmer with diabetes mellitus, had a history of close contact with sheep, which may have resulted in the C. pecorum infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Saeed Shoar, Fernando H. Centeno, Daniel M. Musher
Summary: This study provides a detailed comparison between Haemophilus influenzae and Streptococcus pneumoniae infections, showing that Haemophilus infection is less severe than pneumonia caused by Streptococcus. Additionally, viral coinfection greatly increases the severity of Haemophilus pneumonia.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Letter
Medicine, General & Internal
Jan O. Friedrich, Elisa Gouvea Bogossian
Summary: In a trial evaluating the efficacy of hydrocortisone in treating community-acquired pneumonia, researchers found a nearly 50% lower 28-day mortality rate in the hydrocortisone group compared to the placebo group. They also observed a higher incidence of septic shock in the placebo group. The trial did not allow the use of open-label glucocorticoids, which may have contributed to the higher mortality rate in the placebo group.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Infectious Diseases
Monika Fliss, Charlotte H. S. B. van den Berg, Ed Kuijper, Daan W. Notermans, Antoni P. A. Hendrickx, Mirthe H. Schoots, Erik Bathoorn
Summary: Two severe community-acquired pulmonary infections caused by hypervirulent Klebsiella pneumoniae were reported in patients without recent travel history in the Netherlands. The bacterial isolates were closely related to a typical archetype ST23 hvKp reference strain. Surveillance programs may consider including isolates from community-acquired pneumonia caused by K. pneumoniae.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Immunology
Xin-Cheng Qin, Jinwei Huang, Zhangnv Yang, Xiangrong Sun, Wen Wang, Enhui Gong, Zhuo Cao, Jianfeng Lin, Yanai Qiu, Bohai Wen, Biao Kan, Jianguo Xu, Tian Qin
Summary: This study describes a case of C. psittaci infection in Lishui city, Zhejiang province, China, and identifies a potential link with local geese. The findings highlight the importance of strengthening surveillance for C. psittaci in both poultry and humans.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Carlos G. Grijalva, Wesley H. Self, Seema Jain, Krow Ampofo, Andrew T. Pavia, Sandra R. Arnold, Jonathan A. McCullers, Evan J. Anderson, Richard G. Wunderink, Derek J. Williams
Summary: Clinical features did not reliably distinguish HMPV-associated pneumonia from other pathogens. HMPV-associated pneumonia was less severe than bacterial and adult RSV pneumonia, but was otherwise as or more severe than other common pathogens.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Critical Care Medicine
Vicente F. Corrales-Medina, Robert A. deKemp, Julio A. Chirinos, Wanzhen Zeng, Jerry Wang, Grant Waterer, Rob S. B. Beanlands, Girish Dwivedi
Summary: CAP survivors show evidence of persistent pulmonary inflammation activity even after treatment, which may contribute to the increased risk of cardiovascular disease, cognitive decline, functional impairment, and mortality observed in this population.
Article
Respiratory System
Hannah Lawrence, Tricia M. McKeever, Wei Shen Lim, British Thoracic Soc
Summary: The readmission rates for community-acquired pneumonia (CAP) in the UK have increased over the past decade. This study aimed to describe the cohort of patients who were readmitted within 30 days after hospitalisation for CAP in England and explore the reasons for this. A retrospective analysis was performed using data from the British Thoracic Society audit, and it was found that pneumonia was the most common condition treated on readmission and had a higher mortality rate than other diagnoses.
Article
Immunology
Zheng Liu, Qian Wang, Hui Wang, Jing Li, Ying Yuan, Guo-zhen Yi
Summary: This study examines the differences and similarities in albumin and lipid metabolism in non-severe COVID-19 infection, non-severe community-acquired pneumonia, and severe community pneumonia with underlying diseases, as well as the relationship between albumin and lipid metabolism and inflammatory mediators. The results indicate that hypoalbuminemia and abnormal lipid metabolism are important indicators of bacterial infection, especially severe bacterial pneumonia.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Microbiology
Marco Falcone, Giusy Tiseo, Alessandro Leonildi, Leonardo Della Sala, Alessandra Vecchione, Simona Barnini, Alessio Farcomeni, Francesco Menichetti
Summary: Cefiderocol appears to be a promising therapeutic option for carbapenem-resistant Acinetobacter baumannii (CRAB) infections, with a potential protective effect on 30-day mortality. However, further studies are needed to address the issue of microbiological failure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Susanne Paukner, David Mariano, Anita F. Das, Gregory J. Moran, Christian Sandrock, Ken B. Waites, Thomas M. File
Summary: Lefamulin, the first pleuromutilin antibiotic approved for systemic use in adult community-acquired bacterial pneumonia, showed high efficacy and safety against atypical pathogens in both intravenous and oral formulations.
Review
Infectious Diseases
Catia Cilloniz, Juan Manuel Pericas, Walter H. Curioso
Summary: This article reviews the factors related to CAP-associated outcomes, including host, microorganism, therapeutic approach, and health system organization. The aim is to discuss controversial points and provide recommendations for further research and patient management to improve CAP outcomes, beyond mortality.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Infectious Diseases
Catia Cilloniz, Cristina Dominedo, Albert Gabarrus, Carolina Garcia-Vidal, Jose Becerril, Diego Tovar, Estela Moreno, Juan M. Pericas, Carmen Rosa Vargas, Antoni Torres
Summary: This study aimed to describe the prevalence, risk factors, and outcomes of MSSA community-acquired pneumonia and found that MSSA CAP patients had higher 30-day mortality than pneumococcal CAP patients, with MSSA being an independent factor of mortality.
JOURNAL OF INFECTION
(2021)
Article
Medicine, General & Internal
Kang Chang, Haibo Wang, Jianping Zhao, Xianghong Yang, Bo Wu, Wenkui Sun, Man Huang, Zhenshun Cheng, Hong Chen, Yuanlin Song, Ping Chen, Xiangqi Chen, Xin Gan, Wanli Ma, Lihua Xing, Yimin Wang, Xiaoying Gu, Xiaohui Zou, Bin Cao
Summary: This study suggests that the appropriate polymyxin B/tigecycline combination therapy is not superior to appropriate polymyxin B therapy in terms of 28-day mortality in the treatment of hospital-acquired pneumonia caused by carbapenem-resistant organisms.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Qiu-Hong Bao, Li Yu, Jian-Jun Ding, Ying-Jun Chen, Jun-Wei Wang, Jian-Ming Pang, Qi Jin
Summary: This case report highlights the importance of next generation sequencing in diagnosing infections with unknown causes, particularly focusing on a severe pneumonia case caused by Leptospira. Early diagnosis and treatment were crucial for successful recovery in this patient.
WORLD JOURNAL OF CLINICAL CASES
(2021)
