Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 189, Issue 3, Pages 646-648Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2013.08.016
Keywords
Obstructive sleep apnea; Intermittent hypoxia; Bone metabolism; Animal model; Bone mineral density; Osteoporosis
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Funding
- Spanish Ministry of Economy and Competitiveness [SAF2009-02991, PI081908, PI080277]
- CDTI under the CENIT Program (AMIT Project)
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Very recent clinical research has investigated whether obstructive sleep apnea (OSA) may modulate bone homeostasis but the few data available are conflicting. Here we report novel data obtained in a mouse study specifically designed to determine whether chronic intermittent hypoxia realistically mimicking USA modifies bone mineral density (BMD). Normal male and female mice and orchidectomized mice (N=10 each group) were subjected to a pattern of high-frequency intermittent hypoxia (20 s at 5% and 40s at 21%, 60 cycles/h) for 6 h/day. Identical groups breathing room air (normoxia) were the controls. After 32 days of intermittent hypoxia/normoxia the trabecular bone mineral density (BMD) in the peripheral femora were measured by micro-CT scanning. When compared with normoxia (two-way ANOVA), intermittent hypoxia did not significantly modify BMD in the three animal groups tested. Data in this study suggest that the type of intermittent hypoxia characterizing USA, applied as a single challenge, preserves bone homeostasis. (C) 2013 Elsevier B.V. All rights reserved.
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