CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients

Differential Reduction in Monocyte Activation and Vascular Inflammation With Integrase Inhibitor–Based Initial Antiretroviral Therapy Among HIV-Infected Individuals

(2015) Corrilynn O. Hileman et al.   JOURNAL OF INFECTIOUS DISEASES

Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection

(2015) Mohammad-Ali Jenabian et al.   JOURNAL OF INFECTIOUS DISEASES

HIV and the Gut Microbiota, Partners in Crime: Breaking the Vicious Cycle to Unearth New Therapeutic Targets

(2015) Kishanda Vyboh et al.   Journal of Immunology Research

CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study

(2015) Cristina Mussini et al.   Lancet HIV

Chronic Inflammation in a Long-Term Cohort of HIV-Infected Patients According to the Normalization of the CD4:CD8 Ratio

(2014) Annalisa Saracino et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Aging of the human innate immune system in HIV infection

(2014) Heidi J Zapata et al.   CURRENT OPINION IN IMMUNOLOGY

Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy

(2014) J-P Routy et al.   HIV MEDICINE

Multiparametric Bioinformatics Distinguish the CD4/CD8 Ratio as a Suitable Laboratory Predictor of Combined T Cell Pathogenesis in HIV Infection

(2014) M. Buggert et al.   JOURNAL OF IMMUNOLOGY

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease

(2014) Brinda Emu et al.   PLoS One

Increased Risk of Serious Non-AIDS-Related Events in HIV-Infected Subjects on Antiretroviral Therapy Associated with a Low CD4/CD8 Ratio

(2014) Sergio Serrano-Villar et al.   PLoS One

Clinical, Immunological and Treatment-Related Factors Associated with Normalised CD4+/CD8+ T-Cell Ratio: Effect of Naïve and Memory T-Cell Subsets

(2014) Willard Tinago et al.   PLoS One

Delay in cART Initiation Results in Persistent Immune Dysregulation and Poor Recovery of T-Cell Phenotype Despite a Decade of Successful HIV Suppression

(2014) Patricia Ndumbi et al.   PLoS One

CD4+ and CD8+ T Cell Activation Are Associated with HIV DNA in Resting CD4+ T Cells

(2014) Leslie R. Cockerham et al.   PLoS One

Immunologic strategies for HIV-1 remission and eradication

(2014) D. H. Barouch et al.   SCIENCE

CD8 T cell persistence in treated HIV infection

(2014) Joseph C. Mudd et al.   Current Opinion in HIV and AIDS

Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infection

(2014) John Thornhill et al.   Journal of the International AIDS Society

The CD4:CD8 ratio is associated with IMT progression in HIV-infected patients on antiretroviral treatment

(2014) Enrique Bernal et al.   Journal of the International AIDS Society

Decreases in Colonic and Systemic Inflammation in Chronic HIV Infection after IL-7 Administration

(2014) Irini Sereti et al.   PLoS Pathogens

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

(2014) Sergio Serrano-Villar et al.   PLoS Pathogens

The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

(2013) Talía Sainz et al.   AIDS

Long-term antiretroviral therapy initiated during primary HIV-1 infection is key to achieving both low HIV reservoirs and normal T cell counts

(2013) Laurent Hocqueloux et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The end of AIDS: HIV infection as a chronic disease

(2013) Steven G Deeks et al.   LANCET

Predictors of CD4:CD8 Ratio Normalization and Its Effect on Health Outcomes in the Era of Combination Antiretroviral Therapy

(2013) Victor Leung et al.   PLoS One

Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

(2013) Mohammad-Ali Jenabian et al.   PLoS One

Immune control of HIV-1 reservoirs

(2013) Brigitte Autran et al.   Current Opinion in HIV and AIDS

Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions

(2012) Julie C. Gaardbo et al.   Clinical & Developmental Immunology

The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression

(2012) Sergio Serrano-Villar et al.   JOURNAL OF INFECTION

Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection

(2011) P. Corbeau et al.   BLOOD

Factors influencing the normalization of CD4+ T-cell count, percentage and CD4+/CD8+ T-cell ratio in HIV-infected patients on long-term suppressive antiretroviral therapy

(2011) C. Torti et al.   CLINICAL MICROBIOLOGY AND INFECTION

CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy

(2011) Mohamed-Rachid Boulassel et al.   JOURNAL OF CLINICAL VIROLOGY

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Impact of Individual Antiretroviral Drugs on the Risk of Myocardial Infarction in Human Immunodeficiency Virus–Infected PatientsA Case-Control Study Nested Within the French Hospital Database on HIV ANRS Cohort CO4Antiretroviral Drugs, Risk of MI, and HIV

(2010) Sylvie Lang   ARCHIVES OF INTERNAL MEDICINE

Low CD4/CD8 T lymphocyte ratio in acute myocardial infarction

(2010) H. SYRJÄLÄ et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A challenge for the future: aging and HIV infection

(2010) Tammy M. Rickabaugh et al.   IMMUNOLOGIC RESEARCH

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

(2010) Andrej Košmrlj et al.   NATURE

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Hodgkin lymphoma in the Swiss HIV Cohort Study

(2009) G. M. Clifford et al.   BLOOD

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival

(2009) Mari M. Kitahata et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune activation and inflammation in HIV-1 infection: causes and consequences

(2007) V Appay et al.   JOURNAL OF PATHOLOGY