Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 178, Issue 2, Pages 304-314Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2011.06.029
Keywords
Cell therapy; Growth factors; Cytokines; Apoptosis; Sepsis
Categories
Funding
- Centres of Excellence Program (PRONEX-FAPERJ)
- Brazilian Council for Scientific and Technological Development (MCT/CNPq)
- Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation (FAPERJ)
- Sao Paulo State Research Support Foundation (FAPESP)
- National Institute of Science and Technology of Drugs and Medicine (INCT-INOFAR)
- Coordination for the Improvement of Higher Level Personnel (CAPES)
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We tested the hypothesis that bone marrow-derived mononuclear cells (BMDMCs) at an early phase of cecal ligation and puncture (CLP)-induced sepsis may have lasting effects on: (1) lung mechanics and histology, (2) the structural remodelling of lung parenchyma, (3) lung, kidney, and liver cell apoptosis, and (4) pro- and anti-inflammatory cytokines and growth factors. At day 1, BMDMC significantly reduced mortality, as well as caspase-3, interleukin (IL)-6 and IL-1 beta vascular endothelial growth factor, platelet-derived growth factor, hepatocyte growth factor, and transforming growth factor-beta, but increased IL-10 mRNA expression in lung tissue in septic mice contributing to endothelium and epithelium alveolar repair and improvement of lung mechanics. BMDMC also prevented the increase of apoptotic cells in lung, liver, and kidney. At day 7, these early functional and morphological effects were preserved or further improved. In conclusion, in the present model of sepsis, the beneficial effects of early administration of BMDMCs on lung and distal organs were preserved, possibly by paracrine mechanisms. (C) 2011 Elsevier B.V. All rights reserved.
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