Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 173, Issue -, Pages S55-S64Publisher
ELSEVIER
DOI: 10.1016/j.resp.2010.02.014
Keywords
Pulmonary surfactant; X-ray diffraction; Fluorescence microscopy; Mass spectroscopy; Phospholipid metabolism; Acute respiratory distress
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Funding
- Austrian Science Fund (FWF) [P 20472] Funding Source: researchfish
- Lundbeck Foundation [R7-2006-712] Funding Source: researchfish
- NHLBI NIH HHS [R01 HL060914, R01 HL054209] Funding Source: Medline
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This article examines the manner in which some new methodologies and novel concepts have contributed to our under standing of how pulmonary surfactant reduces alveolar surface tension Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary Ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and electrospray mass spectroscopy are highlighted and a new model of ventilation-Induced acute lung injury described This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface (C) 2010 Elsevier B V All rights reserved
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