Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 168, Issue 1-2, Pages 86-91Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2009.06.013
Keywords
Respiratory rhythm generator (RRG); Development; Respiratory oscillators
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- ANR
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Breathing is vital for life ex utero and therefore requires that the respiratory rhythm generator (RRG), the central neural network generating the continuous rhythmic motor command, be functional at birth. The RRG, located in the brainstem, appears to comprise two interacting respiratory oscillators: the parafacial respiratory group (pFRG), and the preBotzinger complex (preBotC). Data on the establishment of these respiratory oscillators during embryonic and foetal periods are beginning to be produced. The present paper provides a short review of the current knowledge regarding: (i) the emergence of activity in the two respiratory oscillators and (ii) their functional coupling during prenatal development in rodents. (C) 2009 Elsevier B.V. All rights reserved.
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