Pulmonary outcome and its correlates in school-aged children born with a gestational age ≤ 32 weeks

Background: There is limited data regarding factors influencing the respiratory outcome at school age of ex-preterms born since the introduction of antenatal steroids, surfactant replacement together with less aggressive ventilation. Objectives: To establish the main antenatal, neonatal and early childhood respiratory correlates of respiratory status in school-aged children born at <= 32weeks of gestation. Methods: Ex-preterm children born at <= 32weeks of gestation between 1997 and 2001 at Bordeaux University Hospital were evaluated at school age, using a respiratory questionnaire and lung function tests (spirometry, plethysmography, exercise challenge test and CO lung diffusing capacity DLCO measurements). Factors associated with lung function were investigated using polynomial regression analyses. Results: Of the 151 included children [mean age: 8.6 +/- 0.8 years; mean gestational age, 30.1 +/- 1.7 weeks; mean birth weight = 1310 +/- 380 g; 68.2% ventilated at birth; 46.4% treated with surfactant; 36.4% with prior bronchopulmonary dysplasia (BPD)], 47% presented obstructive lung abnormalities, 11% restrictive or mixed lung abnormalities, 41% exercise-induced bronchoconstriction, and 15.5% reduced DLCO. Surfactant therapy was independently associated with a lower risk of lung abnormalities (p < 0.05). The association between BPD and lung abnormalities at school age was not significant, but prior BPD increased the risk of restrictive or mixed abnormalities (odds ratio: 6.11, confidence interval [1.1; 33.99]). Early childhood respiratory events were not associated with the occurrence of lung abnormalities. Conclusion: Children born at <= 32 weeks of gestation remain at risk for impaired lung function at school age in particular when they did not receive surfactant. Restrictive or mixed lung defects are mainly associated with prior BPD. (C) 2013 Elsevier Ltd. All rights reserved.