Article
Medicine, General & Internal
Oh-Beom Kwon, Chang-Dong Yeo, Hwa-Young Lee, Hye-Seon Kang, Sung-Kyoung Kim, Ju-Sang Kim, Chan-Kwon Park, Sang-Haak Lee, Seung-Joon Kim, Jin-Woo Kim
Summary: Chronic obstructive pulmonary disease (COPD) is frequently seen in patients with non-small cell lung cancer (NSCLC), and lung hyperinflation is associated with postoperative lung function. This study found that a preoperative residual volume/total lung capacity of >= 40% is an independent predictor of preserved lung function after lung cancer surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Chihiro Konoeda, Masaaki Sato, Kazuhiro Nagayama, Jun Nakajima
Summary: Lung transplantation and lung volume reduction surgery are established therapies for end-stage chronic obstructive pulmonary disease. Despite the known risk of native lung hyperinflation, unilateral lung transplantation continues due to severe shortages of cadaveric donors. Therefore, all possible protection should be provided to prevent adverse effects on the graft.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Respiratory System
Romane Fumat, Marion Dupuis, Siham Mallah, Valentin Heluain, Florent Favard, Yannick Simonneau, Matthieu Dusselier, Romain Barthes, Sandrine Pontier, Samia Collot, Gavin Plat, Thomas Egenod, Nicolas Guibert
Summary: In this study, researchers hypothesized that bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) can decrease dynamic hyperinflation (DH) and improve exertional dyspnea in severe emphysema patients. The results showed that after 3 months of treatment, inspiratory capacity (IC) and end-expiratory lung volume (EELV) at isotime significantly improved. Patients who had bigger changes in residual volume (RV) and forced expiratory volume in one-second (FEV1) showed better improvements.
Article
Critical Care Medicine
Marieke C. van der Molen, Jorine E. Hartman, Lowie E. G. W. Vanfleteren, Huib A. M. Kerstjens, Joost P. van Melle, Tineke P. Willems, Dirk-Jan Slebos
Summary: Bronchoscopic lung volume reduction (BLVR) with endobronchial valves significantly improves pulmonary hyperinflation and cardiac preload, myocardial contractility, and cardiac output without changes in pulmonary artery pressures.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Eugenio Pompeo, Ahmed Elkhouly, Paola Rogliani, Mario Dauri, Michael Peer, Gianluigi Sergiacomi, Roberto Sorge
Summary: The study evaluated the outcomes and costs of QLM-LVR surgical method for lung volume reduction in patients with severe emphysema. QLM-LVR group had better pain score, shorter hospital stay, lower costs, and lower morbidity rate compared to control groups. Overall, QLM-LVR proved to be safer with better perioperative outcomes and lower costs.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Pediatrics
Dimitrios Moutafidis, Maria Gavra, Sotirios Golfinopoulos, Antonios Kattamis, George Chrousos, Christina Kanaka-Gantenbein, Athanasios G. Kaditis
Summary: This study investigated age effects on lung attenuation and low- and high-attenuation thresholds in pediatric quantitative chest CT scans. It found that age was inversely associated with mean lung attenuation, and there were correlations between low- and high-attenuation percentages with age and total lung capacity. The findings suggest that quantitative analysis of chest CT scans in children without lung disease can help define age-specific thresholds for evaluating pediatric lung disease severity.
Article
Respiratory System
Massimo Pifferi, Andrew Bush, Giuseppe Mule, Serena Gracci, Rossella Fonnesu, Angela Michelucci, Angela Cangiotti, Maria Adelaide Caligo, Mario Miccoli, Attilio L. Boner, Diego Peroni
Summary: This study investigated the evolution of static lung volumes in patients with PCD over a 10-year period, and found that patients with absent inner dynein arms and certain gene mutations had significantly worse lung function at baseline. The trend of lung volume increase over time was influenced by ultrastructural defects and genetic mutations.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Physiology
Janis Schierbauer, Sandra Ficher, Paul Zimmermann, Nadine B. Wachsmuth, Walter F. J. Schmidt
Summary: The study aimed to evaluate the individual stroke volume (SV) and blood volume (BV) during exercise and to examine their correlation at different exercise intensities. The results showed that there was a significant correlation between SV and BV. Additionally, a higher BV was associated with a higher SV, particularly at high-intensity exercise. The arterial oxygen content also had an effect on SV.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Engineering, Biomedical
Jorrit B. A. Welling, T. David Koster, Dirk-Jan Slebos
Summary: One-way endobronchial valve treatment is effective for improving lung function, exercise capacity, and quality of life in patients with severe emphysema and hyperinflation. It can also be used for the treatment of persistent air leak, giant emphysematous bullae, native lung hyperinflation, hemoptysis, and tuberculosis.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Article
Respiratory System
Anastasiya Kornyeva, Axel Semmelmann, Ecem Deniz Ogutur, Wolfgang Jungraithmayr, Torsten Loop, Isabelle Moneke
Summary: eLVR as a bridge to LTx does not increase the risk of PPCs, surgical complications, or reduced survival in patients with emphysematous lung disease.
Article
Cardiac & Cardiovascular Systems
Emanuele Accalai, Carlo Vignati, Elisabetta Salvioni, Beatrice Pezzuto, Mauro Contini, Christian Cadeddu, Luigi Meloni, Piergiuseppe Agostoni
Summary: In heart failure patients, oxygen uptake and cardiac output measurements during exercise are important for defining severity and prognosis. The relationship between oxygen pulse and measured stroke volume is strong during exercise, but varies at rest. Stroke volume estimation during exercise can represent stroke volume for population studies, but direct measurement may be needed for individual subjects.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Oncology
Jeannette Jansen, Elke Beyreuther, Daniel Garcia-Calderon, Leonhard Karsch, Jan Knoll, Joerg Pawelke, Michael Schuerer, Joao Seco
Summary: The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O2 content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Respiratory System
Danial Ahmad, Brandon E. Ferrell, Abhiraj Saxena, Diana C. Jimenez, Thomas J. O'Malley, Marco A. Dispagna, Tyler Grenda, Vakhtang Tchantchaleishvili
Summary: A comparative study was conducted on lung volume reduction (LVR) and lung transplantation (LTx) for chronic obstructive pulmonary disease (COPD) patients. The results showed that LTx achieved better FEV1 than LVR, but the outcomes in other aspects were comparable.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Critical Care Medicine
Majid Shafiq, Emily Polhemus, Ryan Perkins, Victoria Forth, M. Blair Marshall
Summary: This article describes two novel management approaches for lung volume reduction, including bilateral bronchoscopic lung volume reduction and a combined thoracic surgical and interventional pulmonary procedure. Both methods have proven to be safe and effective in reducing lung volume of both lungs with excellent patient outcomes.
Article
Engineering, Biomedical
Ali Akil, Stephan Ziegeler, Stephanie Rehers, Mahyar Lavae-Mokhtari, Lars Richter, Nicolas Johannes Dickgreber, Erik Christian Ernst, Stefan Fischer
Summary: This study aimed to assess the changes in pulmonary arterial pressure (PAP) after LVRS and compare them with preoperative measures. The results showed a significant reduction in pulmonary arterial systolic pressure (PASP) after surgery, with normal levels maintained at 3 months postoperatively. This study suggests that LVRS can improve pulmonary arterial hypertension and protect right ventricular function.
Article
Critical Care Medicine
Auyon J. Ghosh, Brian D. Hobbs, Matthew Moll, Aabida Saferali, Adel Boueiz, Jeong H. Yun, Frank Sciurba, Lucas Barwick, Andrew H. Limper, Kevin Flaherty, Gerard Criner, Kevin K. Brown, Robert Wise, Fernando J. Martinez, David Lomas, Peter J. Castaldi, Vincent J. Carey, Dawn L. DeMeo, Michael H. Cho, Edwin K. Silverman, Craig P. Hersh
Summary: This study found that carriers of the AAT Z allele (MZ heterozygotes) with COPD had lower lung function and more emphysema compared to MM subjects with COPD. In addition, there were subtle differences in gene expression between the two groups, suggesting that MZ subjects may represent a subtype of COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Raul San Jose Estepar
Summary: This review discusses the application of artificial intelligence in lung functional imaging, including high-resolution image reconstruction, prediction, and quantification of functional responses. Artificial intelligence has great potential in clinical lung function assessment, but also faces challenges.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Critical Care Medicine
Stefanie E. Mason, Rafael Moreta-Martinez, Wassim W. Labaki, Matthew J. Strand, Elizabeth A. Regan, Jessica Bon, Ruben San Jose Estepar, Richard Casaburi, Merry-Lynn McDonald, Harry B. Rossiter, Barry Make, Mark T. Dransfield, MeiLan K. Han, Kendra Young, Jeffrey L. Curtis, Kathleen Stringer, Greg Kinney, John E. Hokanson, Raul San Jose Estepar, George R. Washko
Summary: The longitudinal loss of fat-free mass (FFM) is associated with increased all-cause mortality, regardless of initial body composition metrics, including BMI or muscle mass. This finding may improve risk stratification and identify novel therapeutic targets for patients with chronic obstructive pulmonary disease.
Article
Respiratory System
Jenna McNeill, Ariel Chernofsky, Matthew Nayor, Farbod N. Rahaghi, Raul San Jose Estepar, George Washko, Andrew Synn, Ramachandran S. Vasan, George O'Connor, Martin G. Larson, Jennifer E. Ho, Gregory D. Lewis
Summary: This study found an association between lower lung function and exercise capacity, as well as other parameters such as oxygen uptake efficiency and ventilatory efficiency. Additionally, lower pulmonary blood vessel volume was also associated with lower exercise capacity. These findings highlight the significance of lung function and blood vessel volume in overall exercise capacity.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Critical Care Medicine
Emily S. Wan, John E. Hokanson, Elizabeth A. Regan, Kendra A. Young, Barry J. Make, Dawn L. DeMeo, Stefanie E. Mason, Raul San Jose Estepar, James D. Crapo, Edwin K. Silverman
Summary: The study found that individuals with preserved ratio impaired spirometry (PRISm) often experience transitions in lung function, which are associated with both obstructive and normal spirometry.
Review
Respiratory System
Sharyn A. Roodenburg, Jorine E. Hartman, Gaetan Deslee, Felix J. F. Herth, Karin Klooster, Frank C. Sciurba, Pallav L. Shah, Arschang Valipour, Zaid Zoumot, Dirk-Jan Slebos
Summary: LVR-coil treatment has significant effects on pulmonary function, quality of life, and exercise capacity, with shorter-lived improvements in exercise capacity.
Article
Cardiac & Cardiovascular Systems
Anne Bjerg Nielsen, Kristoffer Grundtvig Skaarup, Kasper Djernaes, Raphael Hauser, Raul San Jose Estepar, Samuel Kiil Sorensen, Martin Huth Ruwald, Morten Lock Hansen, Rene Husted Worck, Arne Johannessen, Jim Hansen, Tor Biering-Sorensen
Summary: This study found that left atrial deformation analysis by echocardiography may be useful in predicting the risk of ATA recurrence in patients undergoing CA for AF, even in those with a normal-sized LA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Letter
Critical Care Medicine
Gabrielle Y. Liu, Laura A. Colangelo, Raul San Jose Estepar, Anthony J. Esposito, Samuel Y. Ash, Bina Choi, David R. Jacobs, Mercedes R. Carnethon, George R. Washko, Ravi Kalhan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Bina Choi, Raul San Jose Estepar, Suneeta Godbole, Jeffrey L. Curtis, Jennifer M. Wang, Ruben San Jose Estepar, Ivan O. Rosas, Jared R. Mayers, Brian D. Hobbs, Craig P. Hersh, Samuel Y. Ash, MeiLan K. Han, Russell P. Bowler, Kathleen A. Stringer, George R. Washko, Wassim W. Labaki
Summary: This study identified 85 metabolites significantly associated with QIA, involving pathways related to nicotinate and nicotinamide, histidine, starch and sucrose, pyrimidine, phosphatidylcholine, lysophospholipid, and sphingomyelin. Additionally, 75 metabolites were significantly different between QIA-predominant and emphysema-predominant phenotypes, including pathways related to phosphatidylethanolamine, nicotinate and nicotinamide, aminoacyl-tRNA, arginine, proline, alanine, aspartate, and glutamate. Metabolomic correlates may provide insights into the biological perturbations underlying clinically meaningful quantitative CT measurements like QIA in smokers.
RESPIRATORY RESEARCH
(2023)
Meeting Abstract
Rheumatology
Gregory McDermott, Keigo Hayashi, Kazuki Yoshida, Matthew Moll, Michael Cho, Tracy Doyle, Paul Dellaripa, Rachel Putman, Raul San Jose Estepar, George Washko, Elizabeth Regan, Hiroto Hatabu, Gary M. Hunninghake, Edwin Silverman, Jeffrey Sparks
ARTHRITIS & RHEUMATOLOGY
(2022)
Proceedings Paper
Engineering, Biomedical
D. Bermejo-Pelaez, R. San Jose Estepar, M. Fernandez-Velilla, C. Palacios Miras, G. Gallardo Madueno, M. Benegas, M. A. Luengo Oroz, J. Sellares, M. Sanchez, G. Peces Barba, L. M. Seijo, M. J. Ledesma-Carbayo
Summary: This work presents artificial intelligence algorithms based on CNN to automatically identify and quantify COVID-19 pneumonia patterns, as well as to automatically segment different lesion subtypes.
MEDICAL IMAGING 2022: COMPUTER-AIDED DIAGNOSIS
(2022)
Article
Respiratory System
Auyon J. Ghosh, Brian D. Hobbs, Jeong H. Yun, Aabida Saferali, Matthew Moll, Zhonghui Xu, Robert P. Chase, Jarrett Morrow, John Ziniti, Frank Sciurba, Lucas Barwick, Andrew H. Limper, Kevin Flaherty, Gerard Criner, Kevin K. Brown, Robert Wise, Fernando J. Martinez, Daniel McGoldrick, Michael H. Cho, Dawn L. DeMeo, Edwin K. Silverman, Peter J. Castaldi, Craig P. Hersh
Summary: This study identified divergent gene expression signatures between COPD and IPF, with increased expression in COPD and decreased expression in IPF. These signatures were associated with worse lung function in both diseases.
RESPIRATORY RESEARCH
(2022)
Letter
Respiratory System
Anand S. Iyer, Trisha M. Parekh, Jacqueline O'Toole, Surya P. Bhatt, Michelle N. Eakin, Jerry A. Krishnan, Abebaw M. Yohannes, Prescott G. Woodruff, Christopher B. Cooper, Richard E. Kanner, Nicola A. Hanania, Mark T. Dransfield, Elizabeth A. Regan, Karin F. Hoth, Victor Kim
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
