Article
Respiratory System
Brian Garnet, Rodrigo Diaz-Lankenau, Elie Jean, Michael Campos
Summary: This study evaluated the performance of SpO(2) compared to arterial blood gas analysis in detecting severe resting hypoxemia in patients with COPD. The results showed that using only SpO(2) as a measure of oxygenation had a high false negative rate, and it is recommended to use ABG analysis to evaluate oxygenation in these patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Palm, Magnus Ekstrom
Summary: The study found that transplant-free survival was lower in patients with ILD compared to COPD, despite LTOT treatment. In COPD patients, worse hypoxemia was associated with a slightly increased risk of death/lung transplantation, while in ILD patients, this association was not observed.
RESPIRATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Francois Alexandre, Virginie Molinier, Maurice Hayot, Guillaume Chevance, Gregory Moullec, Alain Varray, Nelly Heraud
Summary: This study aims to evaluate the impact of LTOT prescription outside the guidelines on the survival of COPD patients through a systematic review and individual patient data meta-analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Eun Lee, Kum Ju Chae, Young Ju Suh, Won Gi Jeong, Taebum Lee, Yun-Hyeon Kim, Gong Yong Jin, Yeon Joo Jeong
Summary: This study investigated the prevalence of interstitial lung abnormalities (ILAs) in an Asian health screening cohort and found that fibrotic ILA was associated with increased risks of ILA progression, lung cancer development, and mortality over a 10-year follow-up period.
Article
Multidisciplinary Sciences
Brian Garnet, Elie Jean, Rodrigo Diaz Lankenau, Michael Campos
Summary: Several studies have shown increased exercise capacity with supplemental oxygen therapy in COPD patients with exertional hypoxemia, but a large trial failed to show a survival benefit. This retrospective study found that male COPD patients with exertional hypoxemia who had a clinically meaningful improvement in exercise capacity while using supplemental oxygen had lower mortality rates compared to non-responders. Assessing the immediate effects of oxygen on exercise capacity may be important for identifying individuals who may benefit from ambulatory oxygen in the long-term.
Article
Veterinary Sciences
Maria Rosa de Jaureguizar Tesas, Hannah Matson, Simon Tappin, Emily Thomas
Summary: High-Flow Nasal Oxygen Therapy is a safe and effective method for delivering oxygen to dogs during bronchoscopy. It reduces the incidence of hypoxemia and improves oxygen saturation. However, further studies are needed to confirm these findings and compare the efficacy of this therapy with other oxygen delivery systems.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Critical Care Medicine
Amelia C. A. Harrison, Julien F. Robinson, Laura Tu, Christine F. McDonald, Yet Hong Khor
Summary: This study found that patients receiving LTOT had poor transplant-free survival after initiation, which was even worse for those with ILD compared to those with COPD. Despite their poor overall survival, only a minority of patients were referred for palliative care. Referrals to pulmonary rehabilitation were also suboptimal. Improving appropriate and early referrals to palliative care and care coordination is crucial for this complex patient population.
Article
Respiratory System
Matthias Roetting, Katharina Kriegsmann, Markus Polke, Nilab Polke, Konstantina Kontogianni, Ralf Eberhardt, Felix J. F. Herth, Daniela Gompelmann
Summary: This retrospective analysis examined the efficacy of endoscopic valve treatment in COPD patients with hypercapnia. The results showed significant improvements in lung function and 6-minute walk test, as well as a significant reduction in pCO(2) levels at 3 and 6 months following valve implantation. 40% of the patients achieved normal pCO(2) values after the intervention. These findings suggest that valve treatment can be effective in improving respiratory outcomes in COPD patients with hypercapnia.
Article
Respiratory System
Ferhan Saleem, Christopher J. Ryerson, Nandini Sarma, Kerri Johannson, Veronica Marcoux, Jolene Fisher, Deborah Assayag, Helene Manganas, Nasreen Khalil, Julie Morisset, Ian N. Glaspole, Nicole Goh, Justin M. Oldham, Gerard Cox, Charlene Fell, Andrea S. Gershon, Andrew Halayko, Nathan Hambly, Stacey D. Lok, Shane Shapera, Teresa To, Pearce G. Wilcox, Alyson W. Wong, Martin Kolb, Yet H. Khor
Summary: This study developed a risk prediction tool for predicting new-onset exertional and resting hypoxemia in fibrotic interstitial lung disease. The tool showed good performance in both derivation and validation cohorts, aiding in appropriate patient discussion and consideration of home oxygen.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Daniel Sebastian Majorski, Saba Gul Khan, Sarah Bettina Stanzel, Maximilian Wollsching-Strobel, Doreen Kroppen, Tim Mathes, Maximilian Zimmermann, Wolfram Windisch, Friederike Sophie Magnet
Summary: This study investigated the effect of two different portable oxygen conservation devices on dyspnea, oxygenation, and 6-minute walking test (6MWT) distance in COPD GOLD IV patients. The results showed that the constant-bolus device required a significantly lower operating level to achieve the success criteria for mobile oxygen therapy, and there were no significant differences in secondary endpoints.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Guillermo A. Keller, Ivana Colaianni, Javier Coria, Guillermo Di Girolamo, Silvia Miranda
Summary: COVID-19 patients who received hyperbaric oxygen therapy showed faster improvement in oxygen saturation, increased white blood cell count, lymphocytes count, and platelet count, decreased D-dimer and lactate dehydrogenase concentration, as well as reduced levels of inflammatory markers.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Jingzhou Zhang, Dawn L. DeMeo, Edwin K. Silverman, Barry J. Make, R. Chad Wade, J. Michael Wells, Michael H. Cho, Brian D. Hobbs
Summary: The study found that in COPD patients, factors associated with increased risk of secondary polycythemia included male sex, current smoking, severe hypoxemia, impaired DLCO, and enrollment at the Denver clinical center. Continuous or nocturnal supplemental oxygen use was associated with decreased risk of polycythemia.
BMC PULMONARY MEDICINE
(2021)
Review
Critical Care Medicine
Marilyn K. Glassberg, Isabelle Csete, Emmanuelle Simonet, Sharon J. Elliot
Summary: COPD is a chronic inflammatory and destructive disease with no cure. Mesenchymal stem cells (MSCs) have shown potential as a therapeutic option, but there is currently a lack of evidence supporting their ability to restore lung function in patients with COPD.
Article
Critical Care Medicine
Yet H. Khor, Lawrence Gutman, Nebal Abu Hussein, Kerri A. Johannson, Ian N. Glaspole, Sabina A. Guler, Manuela Funke-Chambour, Thomas Geiser, Nicole S. L. Goh, Christopher J. Ryerson
Summary: Patients with idiopathic pulmonary fibrosis (IPF) have higher cumulative incidence of exertional and resting hypoxemia compared with patients without IPF. The extended ILD-GAP-O-2 model provides additional risk stratification for 1-year prognosis in patients with fibrotic ILD.
Article
Respiratory System
Zhongshang Dai, Xiangming Liu, Huihui Zeng, Yan Chen
Summary: In COPD patients, HOTAIR expression is up-regulated, promoting HPVEC apoptosis through DNMT1-mediated hypermethylation of the Bcl-2 promoter, and silencing HOTAIR can alleviate cell apoptosis and emphysema. In vitro experiments showed that HOTAIR can exacerbate apoptosis in CSE-exposed HPVEC.
RESPIRATORY RESEARCH
(2022)