Article
Medicine, General & Internal
Jae Hyuk Choi, Eunkyu Lee, Sang Duk Hong, Seung Kyu Chung, Yong Gi Jung, Hyo Yeol Kim
Summary: A retrospective analysis of OSA patients undergoing CPAP therapy showed significant improvements in laryngopharyngeal reflux symptoms and examination findings, independent of body mass index or OSA severity.CPAP treatment has the potential to reduce laryngeal reflux symptoms and improve laryngeal examination results in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yoko Fujino, Yasunori Oka, Tomoko Wakamura
Summary: This study found that seasonal differences can impact the CPAP adherence of patients with obstructive sleep apnea. Patients in the adherent group had lower CPAP use rate and shorter duration in summer, while the non-adherent group showed significant differences between winter and summer.
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Article
Medicine, General & Internal
Baixin Chen, Miaolan Guo, Yueksel Peker, Neus Salord, Luciano F. Drager, Geraldo Lorenzi-Filho, Xiangdong Tang, Yun Li
Summary: CPAP treatment leads to a significant decrease in total cholesterol but has no effect on other lipid profiles in patients with obstructive sleep apnea. Factors such as age, gender, body mass index, daytime sleepiness, OSA severity, follow-up duration, CPAP compliance, and presence of cardiometabolic disease do not moderate the effects of CPAP treatment on lipid profiles.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Janna R. Raphelson, Kimberly Y. Kreitinger, Atul Malhotra
Summary: Obstructive sleep apnea (OSA) is a common condition with significant neurocognitive and cardiovascular effects. Positive airway pressure (PAP) therapy can help prevent airway collapse and improve oxygen levels, carbon dioxide levels, and sleep quality. While adherence to PAP therapy was once seen as a barrier, in reality, adherence rates are likely higher than commonly believed, with various strategies available to help improve patient adherence.
Article
Clinical Neurology
Wojciech Trzepizur, Peter A. Cistulli, Martin Glos, Bruno Vielle, Kate Sutherland, Peter J. Wijkstra, Aarnoud Hoekema, Frederic Gagnadoux
Summary: This study compared the treatment effects of CPAP and MAD in patients with severe OSA. Results showed that MAD had similar impact to CPAP on sleepiness and quality of life, while CPAP was more effective in reducing AHI and ODI. Both treatments had similar impact on sleep structure, but patients preferred MAD for treatment adherence and preference.
Article
Pediatrics
Sarah Benke, Caroline U. A. Okorie, MaryAnne A. Tablizo
Summary: The study aimed to assess the safety and efficacy of autoCPAP in pediatric patients with obesity and OSAS, finding that autoCPAP use was effective and safe, potentially reducing treatment delays. Further research is needed to verify the long-term effectiveness of autoCPAP in this population.
Article
Critical Care Medicine
Susanna S. S. Ng, Vincent W. S. Wong, Grace L. H. Wong, Winnie C. W. Chu, Tat-On Chan, Kin-Wang To, Fanny W. S. Ko, Ka-Pang Chan, David S. Hui
Summary: This study aimed to investigate the effects of autoadjusting CPAP versus subtherapeutic CPAP on NAFLD in patients with concomitant OSA, showing no significant differences in primary and secondary endpoints between the two treatment groups. Weight change correlated with changes in intrahepatic triglyceride and CAP, suggesting weight reduction through lifestyle modification may be beneficial for improving NAFLD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Xinyao Li, Xinbin Zhou, Xiaoming Xu, Jin Dai, Chen Chen, Lan Ma, Jiaying Li, Wei Mao, Min Zhu
Summary: The study found that CPAP therapy can significantly reduce the risk of AF recurrence or progression, especially for patients with OSA. Compared to patients without OSA, CPAP nonusers had a higher rate of AF recurrence or progression.
Article
Health Care Sciences & Services
Angela Fidler Pfammatter, Bonnie Olivia Hughes, Becky Tucker, Harry Whitmore, Bonnie Spring, Esra Tasali
Summary: This study developed a mobile health tool that integrated weight loss features with novel CPAP adherence tracking for patients with OSA. The tool tracked CPAP wear time relative to time spent in bed and included push notifications to foster adherence. Future research is needed to evaluate the effectiveness of this tool in improving OSA treatment adherence.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Medicine, General & Internal
Hyunjin Jo, Sujung Choi, Dongyeop Kim, Eunyeon Joo
Summary: Patients with epilepsy have milder characteristics of obstructive sleep apnea (OSA), but because of the high coexistence of OSA and epilepsy, continuous positive airway pressure (CPAP) therapy can reduce the frequency of seizures. Therefore, it is important to evaluate the presence of OSA in patients with epilepsy and provide concurrent treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Kelly K. Hady, Caroline U. A. Okorie
Summary: Pediatric obstructive sleep apnea syndrome is a disorder characterized by breathing difficulties during sleep, affecting 2-4% of children worldwide. Surgical intervention is the primary treatment, but positive airway pressure therapy is often used for those not suitable for surgery or with residual symptoms. This therapy is effective, but additional considerations exist for pediatric patients.
Article
Clinical Neurology
Anne Walker, Matthew T. Naughton, Lachlan Shaw, Andrew T. Jeklin, Catherine Martin, Eli Dabscheck
Summary: The study aimed to evaluate changes in Hospital Anxiety and Depression Scale (HADS) scores after CPAP treatment in patients with obstructive sleep apnea. Results showed that CPAP therapy reduced depression scores, especially with high CPAP adherence. Anxiety scores also decreased, but there was no significant difference between high and low CPAP adherence groups.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Review
Medicine, General & Internal
Yinghua Xu, Haiyan Wu, Xiaoling Lu
Summary: This meta-analysis investigated the influence of continuous positive airway pressure (CPAP) on lipid profiles of patients with obstructive sleep apnea (OSA). The results showed that CPAP treatment did not affect the lipid profiles, including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL), of OSA patients, regardless of the duration of CPAP treatment.
Editorial Material
Clinical Neurology
Martino F. Pengo, David Gozal, Miguel Angel Martinez-Garcia
Summary: The majority of current international OSA guidelines recommend CPAP treatment based on symptoms, but controversy exists for non-sleepy patients. A proposed algorithm attempts to phenotype non-sleepy OSA patients and consider clinically relevant elements before deciding on CPAP treatment. Extensive validation is needed before implementing this algorithm in clinical settings.
Letter
Peripheral Vascular Disease
Kazuki Shiina, Hirofumi Tomiyama, Chisa Matsumoto, Syunsuke Komatsu, Midori Natsume, Chisato Oba, Yukio Ohshiba, Taketo Yamaji, Taishiro Chikamori, Akira Yamashina
HYPERTENSION RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Koichi Nagashima, Takafumi Hiro, Daisuke Fukamachi, Yasuo Okumura, Ichiro Watanabe, Atsushi Hirayama, Masashi Tanaka, Tomofumi Tanaka, Itaru Takamisawa, Isao Taguchi, Akira Sato, Kazutaka Aonuma, Seiji Fukamizu, Akihiro Nakada, Atsuyuki Watanabe, Naofumi Amioka, Yasuyuki Suzuki, Naoya Matsumoto, Junichi Koizumi, Kazuya Kumagai, Masanao Naya, Yoshiharu Higuchi, Yoshiro Naito, Tohru Masuyama, Mitsuharu Kawamura, Ryusuke Tsunoda, Susumu Suzuki, Hideki Ishii, Toyoaki Murohara, Takeshi Shimizu, Yasuchika Takeishi, Kazuki Shiina, Jun Yamashita, Tomohiko Imamura, Naokata Sumitomo, Teruo Noguchi, Toshihide Aso, Kojiro Furukawa, Yasuteru Yamauchi, Kaoru Okishige, Kenji Sakata, Masakazu Yamagishi, Shigeo Shimizu, Masakazu Ohno, Teruyasu Sugano, Koichiro Matsumura, Kensuke Matsumoto, Kazuyuki Ozaki, Shunji Hayashidani, Hiroshi Meno, Atsushi Iwata, Takumi Higuma, Hirofumi Tomita, Hideaki Yoshino, Seiichi Taniai, Koki Shishido, Masato Murakami, Koji Negishi, Masaki Nii, Daisuke Wakatsuki, Hiroshi Suzuki, Yuji Motoike, Yukio Ozaki, Jun Nakazato, Hidemori Hayashi, Satoshi Higuchi, Morio Shoda
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2020)
Article
Multidisciplinary Sciences
Masato Kajikawa, Tatsuya Maruhashi, Takayuki Hidaka, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Yukiko Nakano, Satoshi Kurisu, Yasuki Kihara, Farina Mohamad Yusoff, Shinji Kishimoto, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Takafumi Hiro, Atsushi Hirayama, Kazuki Shiina, Hirofumi Tomiyama, Shusuke Yagi, Rie Amano, Hirotsugu Yamada, Masataka Sata, Yukihito Higashi
SCIENTIFIC REPORTS
(2019)
Letter
Endocrinology & Metabolism
Atsushi Tanaka, Michio Shimabukuro, Noritaka Machii, Hiroki Teragawa, Yosuke Okada, Kosuke R. Shima, Toshinari Takamura, Isao Taguchi, Itaru Hisauchi, Shigeru Toyoda, Yasushi Matsuzawa, Hirofumi Tomiyama, Minako Yamaoka-Tojo, Hisako Yoshida, Yasunori Sato, Yumi Ikehara, Shinichiro Ueda, Yukihito Higashi, Koichi Node
Letter
Peripheral Vascular Disease
Chisa Matsumoto, Hirofumi Tomiyama, Kazutaka Kimura, Kazuki Shiina, Masanori Kamei, Hiroyuki Inagaki, Taishirou Chikamori, Akira Yamshina
HYPERTENSION RESEARCH
(2020)
Article
Peripheral Vascular Disease
Hirofumi Tomiyama, Charalambos Vlachopoulos, Panagiotis Xaplanteris, Hiroki Nakano, Kazuki Shiina, Tomoko Ishizu, Takahide Kohro, Yukihito Higashi, Bonpei Takase, Toru Suzuki, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Atsushi Tanaka, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Toshiaki Ohkuma, Toshiharu Ninomiya, Taishiro Chikamori, Akira Yamashina, Shin-ichiro Ueda
HYPERTENSION RESEARCH
(2020)
Editorial Material
Peripheral Vascular Disease
Kazuki Shiina, Hirofumi Tomiyama, Yoshifumi Takata, Taishiro Chikamori
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2020)
Article
Peripheral Vascular Disease
Masatsune Fujii, Hirofumi Tomiyama, Hiroki Nakano, Yoichi Iwasaki, Chisa Matsumoto, Kazuki Shiina, Akira Yamashina, Taishiro Chikamori
Summary: This prospective observational study examined the longitudinal associations of conventional cardiovascular disease risk factors with arterial stiffness and abnormal pressure wave reflection. High blood pressure was independently associated with both arterial stiffness and abnormal pressure wave reflection, suggesting a link between blood pressure and microvascular damage. Abnormal glucose metabolism and dyslipidemia were only independently associated with arterial stiffness, indicating a connection to macrovascular damage.
HYPERTENSION RESEARCH
(2021)
Review
Peripheral Vascular Disease
Hirofumi Tomiyama, Kazuki Shiina
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2020)
Article
Peripheral Vascular Disease
Hirofumi Tomiyama, Kazuki Shiina, Hiroki Nakano, Yoichi Iwasaki, Chisa Matsumoto, Masatsune Fujii, Taishiro Chikamori, Akira Yamashina
JOURNAL OF HYPERTENSION
(2020)
Article
Cardiac & Cardiovascular Systems
Takamichi Takahashi, Hirofumi Tomiyama, Victor Aboyans, Kento Kumai, Hiroki Nakano, Masatsune Fujii, Kazuki Shiina, Chisa Matsumoto, Akira Yamashina, Taishiro Chikamori
Summary: The study found that arterial stiffness may impact ABI directly and through pressure wave reflection in middle-aged Japanese men without PAD. Pressure wave reflection may directly affect ABI and, at least in part, through attenuation of peripheral pulse pressure amplification.
Review
Biochemistry & Molecular Biology
Hiroki Nakano, Kazuki Shiina, Hirofumi Tomiyama
Summary: The global COVID-19 pandemic has seen over 100 million cases and 2.5 million deaths. Studies have shown that SARS-CoV-2 can lead to fatal non-respiratory conditions like cardiovascular events. One of the known mechanisms behind multi-organ damage during the acute phase of COVID-19 is vascular dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Yoichi Iwasaki, Kazuki Shiina, Chisa Matsumoto, Hiroki Nakano, Masatsune Fujii, Akira Yamashina, Taishiro Chikamori, Hirofumi Tomiyama
Summary: FLI is correlated with baPWV, FIB-4 score is correlated with serum NT-pro-BNP level. Changes in FLI are correlated with changes in baPWV, changes in FIB-4 score are correlated with changes in serum NT-pro-BNP level. FLI may serve as a marker of arterial stiffness, while FIB-4 score may serve as a marker of the risk of heart failure development in Japanese men without a history of CVD.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Editorial Material
Peripheral Vascular Disease
Hirofumi Tomiyama, Kazuki Shiina
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Nutrition & Dietetics
Kazuki Shiina, Yoshifumi Takata, Takamichi Takahashi, Junya Kani, Hiroki Nakano, Yasuyuki Takada, Yoshinao Yazaki, Kazuhiro Satomi, Hirofumi Tomiyama
Summary: The prevalence of atrial fibrillation (AF) is higher in patients with obstructive sleep apnea (OSA) compared to those without AF. This study aimed to determine the prevalence and factors associated with AF in OSA patients from a large Japanese sleep cohort. The results showed that age, a history of alcohol consumption, undernutrition, and reduced sleep quality were independent risk factors for AF presence in OSA patients.