Journal
RESPIRATORY CARE
Volume 58, Issue 9, Pages 1489-1494Publisher
DAEDALUS ENTERPRISES INC
DOI: 10.4187/respcare.02191
Keywords
drug resistance; inhaled corticosteroids; pneumonia; severity of illness index
Categories
Funding
- Howard Hughes Medical Institute [00378-001]
- Department of Veteran Affairs Veterans Integrated Service Network 17
- Instituto de Salud Carlos III [BAE11/00102]
- Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR)
- Societat Catalana de Pneumologia
- Fundacio Catalana de Pneumologia
- National Heart, Lung, and Blood Institute [K23HL096054]
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BACKGROUND: Limited information is available regarding the impact of prior use of inhaled corticosteroids (ICS) in patients subsequently developing community-acquired pneumonia (CAP). We assessed the effects of prior ICS use on severity of illness and microbiology in CAP hospitalized patients. METHODS: A retrospective cohort study of subjects with CAP (by the International Classification of Diseases, 9th Revision, Clinical Modification) was conducted over a 4-year period at 2 tertiary teaching hospitals. Subjects were considered to be ICS users if they received ICS prior to admission. Primary outcomes were severity of illness and microbiology at admission. RESULTS: Data were abstracted on 664 subjects: 89 prior ICS users (13.4%) and 575 non-users (86.6%). Prior ICS users had higher severity of illness at admission: mean +/- SD Pneumonia Severity Index 100.8 +/- 31.4 vs 68.8 +/- 33.4, P = .001, and CURB-65 (confusion, urea nitrogen, respiratory rate, blood pressure, >= 65 years of age) score 1.56 +/- 1.02 vs 1.19 +/- 1.02, P = .002. Prior ICS use was independently associated with antimicrobial-resistant pathogens: 11.2% vs 5.9%, odds ratio 2.6, 95% CI 1.1-6.1, P = .04. CONCLUSIONS: Prior ICS use was associated with higher severity of illness at admission and higher incidence of antimicrobial-resistant pathogens in CAP hospitalized patients.
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