Review
Biochemistry & Molecular Biology
Annamaria Venanzi, Paola Di Filippo, Chiara Santagata, Sabrina Di Pillo, Francesco Chiarelli, Marina Attanasi
Summary: High-flow nasal cannula (HFNC) therapy has gained interest as a valid alternative to nasal continuous positive airway pressure (nCPAP) in children with respiratory failure. Despite its wide use in clinical practice, there is a lack of guidelines to standardize the use of HFNC. This review aims to summarize the current knowledge about HFNC in children and propose a clinical practices algorithm for respiratory failure.
Review
Medicine, General & Internal
Santi Nolasco, Sara Manti, Salvatore Leonardi, Carlo Vancheri, Lucia Spicuzza
Summary: High-flow nasal cannula (HFNC) oxygen therapy is widely used in pediatric care due to its ease of use and safety, allowing for regulation of gas flow and temperature. HFNC have various physiological effects, including delivery of oxygen, positive end-expiratory pressure, reduction of work of breathing and clearance of dead space.
FRONTIERS IN MEDICINE
(2022)
Review
Multidisciplinary Sciences
Ruvistay Gutierrez-Arias, Pamela INTRehab Res Grp, Gabriel Salgado-Maldonado, Paola Letelier Valdivia, Francisco Salinas-Barahona, Carmen Echeverria-Valdebenito, Pamela Seron
Summary: This review aims to summarize the evidence on the frequency and methods of assessment of swallowing disorders in adult HFNC users, in order to promote routine swallowing assessment in this population and guide new studies in less researched areas.
Article
Emergency Medicine
Muhammad Khidir Mohd Kamil, Khadijah Poh Yuen Yoong, Abdul Muhaimin Noor Azhar, Aida Bustam, Ahmad Hariz Abdullah, Mohd Hafyzuddin Md Yusuf, Aliyah Zambri, Ahmad Zulkarnain Ahmad Zahedi, Hidayah Shafie
Summary: This study compared the effectiveness of non-rebreather mask combined with low-flow nasal cannula (NRB + NC) versus high-flow nasal cannula (HFNC) in improving oxygenation in patients with COVID-19-related hypoxemic respiratory failure (HRF). The results showed that HFNC may be beneficial for COVID-19 HRF, while NRB + NC is a viable alternative. Further randomized controlled trials are needed to evaluate the effectiveness of NRB + NC.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Emergency Medicine
Muhammad Khidir Mohd Kamil, Khadijah Poh Yuen Yoong, Abdul Muhaimin Noor Azhar, Aida Bustam, Ahmad Hariz Abdullah, Mohd Hafyzuddin Md Yusuf, Aliyah Zambri, Ahmad Zulkarnain Ahmad Zahedi, Hidayah Shafie
Summary: This study retrospectively analyzed the effectiveness of non-rebreather mask combined with low-flow nasal cannula (NRB + NC) compared to high-flow nasal cannula (HFNC) in improving oxygenation in patients with COVID-19-related hypoxemic respiratory failure (HRF). The results showed significant improvements in oxygenation in both NRB + NC and HFNC groups. There were no significant differences in long-term outcomes between the two groups.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Federico Lionello, Francesco Lapia, Beatrice Molena, Andrea Padoan, Sara Lococo, Giovanna Arcaro, Gabriella Guarnieri, Andrea Vianello
Summary: The study aimed to investigate the safety profile of High-Flow Nasal Cannula (HFNC) in Neuromuscular Disease (NMD) patients intolerant to Non-Invasive Ventilation (NIV) for Acute Respiratory Failure (ARF). The results showed that HFNC used during the daytime alongside nocturnal NIV appeared to be a safe therapeutic approach for ARF patients with NMD. However, continuous use of HFNC was associated with an increased risk of treatment failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Mathematics, Interdisciplinary Applications
Jingen Xia, Jiaqi Chang, Jixiang Liang, Yixuan Wang, Na Wang
Summary: This paper used finite element simulation to analyze the impact of HFNC machine on upper respiratory tract under different flow and oxygen concentration, guiding professionals to adjust parameters appropriately. The study explored the complex environment of human respiratory tract and ventilation airflow, explaining some clinical phenomena using mathematical tools.
Article
Critical Care Medicine
Virginie Lemiale, Guillaume Dumas, Alexandre Demoule, Frederic Pene, Achille Kouatchet, Magali Bisbal, Saad Nseir, Laurent Argaud, Loay Kontar, Kada Klouche, Francois Barbier, Amelie Seguin, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet, Vincent Peigne, Christophe Girault, Johanna Oziel, Martine Nyunga, Nicolas Terzi, Lila Bouadma, Alexandre Lautrette, Naike Bige, Jean-Herle Raphalen, Laurent Papazian, Fabrice Bruneel, Christine Lebert, Dominique Benoit, Anne-Pascale Meert, Samir Jaber, Djamel Mokart, Michael Darmon, Elie Azoulay
Summary: A ROX index greater than 4.88 appears to have a poor ability to predict intubation in immunocompromised patients with acute respiratory failure, although it remains highly associated with the risk of intubation and may be useful to stratify such risk in future studies.
ANNALS OF INTENSIVE CARE
(2021)
Article
Critical Care Medicine
Kazuma Nagata, Takeo Horie, Naohiko Chohnabayashi, Torahiko Jinta, Ryosuke Tsugitomi, Akira Shiraki, Fumiaki Tokioka, Toru Kadowaki, Akira Watanabe, Motonari Fukui, Takamasa Kitajima, Susumu Sato, Toru Tsuda, Nobuhito Kishimoto, Hideo Kita, Yoshihiro Mori, Masayuki Nakayama, Kenichi Takahashi, Tomomasa Tsuboi, Makoto Yoshida, Osamu Hataji, Satoshi Fuke, Michiko Kagajo, Hiroki Nishine, Hiroyasu Kobayashi, Hiroyuki Nakamura, Miyuki Okuda, Sayaka Tachibana, Shohei Takata, Hisayuki Osoreda, Kenichi Minami, Takashi Nishimura, Tadashi Ishida, Jiro Terada, Naoko Takeuchi, Yasuo Kohashi, Hiromasa Inoue, Yoko Nakagawa, Takashi Kikuchi, Keisuke Tomii
Summary: The study found that long-term use of high-flow nasal cannula can reduce the number of exacerbations in patients with chronic obstructive pulmonary disease, improving physiological parameters and quality of life.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Robert P. Carroll, Ravind Balasubramaniam, Michael Sawyer, Khoa Tran
Summary: The FOx index can efficiently predict the outcome of high-flow nasal prongs therapy in acute respiratory failure, providing clinicians with a valuable tool in managing this condition.
INTERNAL MEDICINE JOURNAL
(2022)
Review
Medicine, Research & Experimental
Zhiping Xu, Lingxia Zhu, Jingye Zhan, Lijun Liu
Summary: High-flow nasal cannula (HFNC) therapy is more advantageous over noninvasive ventilation (NIV) in treating COPD and type II respiratory failure patients, as it can significantly lower PaCO2 levels and reduce the length of hospital stay. There were no significant differences in oxygenation levels, incidence of tracheal intubation, and mortality between HFNC and NIV therapy. Further studies with larger sample sizes and rigorous designs are needed to clarify the role of HFNC in COPD and respiratory failure.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Hematology
Simon Tetlow, Rathai Anandanadesan, Leila Taheri, Eirini Pagkalidou, Hugues De Lavallade, Victoria Metaxa
Summary: Patients with haematological malignancies receiving ward-based high-flow nasal cannula oxygen therapy have a higher rate of ICU admission. However, their hospital mortality is comparable to patients who require critical care outreach service evaluation without respiratory support.
ANNALS OF HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Amy H. Attaway, Jihane Faress, Frank Jacono, Srinivasan Dasarathy
Summary: The study revealed that increasing oxygen fraction without adjusting flow rate may exacerbate hypercapnia in COPD patients. Therefore, careful titration of oxygen therapy is essential, especially in COPD patients with baseline hypercapnia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Dusanka Obradovic, Aleksandra Milovancev, Aleksandra Plecas Duric, Stanislava Sovilj-Gmizic, Vladimir Durovic, Jovica Sovic, Milos Durdevic, Stevan Tubic, Jelena Bulajic, Milena Misic, Jovana Jojic, Miroslava Pusara, Ivana Lazic, Mladen Durkovic, Renata Bek Pupovac, Aleksandra Vulic, Marija Jozing
Summary: This study examines outcomes in COVID-19 patients with pneumonia and severe AHRF treated with HFNC. The study finds that HFNC oxygen therapy is a safe and effective respiratory support for COVID-19 patients with AHRF, with a success rate of 52%. The ICU group has a higher mortality rate and a higher incidence of complications, but there is no significant difference in the length of hospital stay between the two groups.
FRONTIERS IN MEDICINE
(2023)
Article
Respiratory System
Kazuma Nagata, Toshiki Yokoyama, Ryosuke Tsugitomi, Harunori Nakashima, Hiroshi Kuraishi, Shinichiro Ohshimo, Yoshihiro Mori, Masaaki Sakuraya, Ryogo Kagami, Motoaki Tanigawa, Kazunori Tobino, Tetsuro Kamo, Toru Kadowaki, Yasutaka Koga, Yoshitaka Ogata, Naoki Nishimura, Yasuhiro Kondoh, Satsuki Taniuchi, Ayumi Shintani, Keisuke Tomii, JaNP Hi Study Investigators
Summary: This multicenter randomized controlled trial compared the efficacy of CPAP and HFNC in patients with acute hypoxemic respiratory failure. CPAP was found to be more effective than HFNC in reducing the risk of meeting intubation criteria. However, there were no significant differences between the two groups in terms of intubation rates, mortality rates, duration of respiratory support, and duration of hospitalization for respiratory illness.
