Article
Acoustics
Nicole M. Duggan, Andrew J. Goldsmith, Ahad Alhassan AL Saud, Irene W. Y. Ma, Hamid Shokoohi, Andrew s. Liteplo
Summary: In this prospective study, optimal parameters for visualizing ultrasonographic B-lines were investigated, with results showing that using a curvilinear transducer, gain of at least 50%, and focal position at the pleural line can improve B-line visualization and image quality. Increasing gain above 50% and placing the focal point at the pleural line were associated with better B-line visualization, while maintaining image quality.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Review
Acoustics
Andrea Smargiassi, Alessandro Zanforlin, Tiziano Perrone, Danilo Buonsenso, Elena Torri, Giuseppe Limoli, Elisa E. Mossolani, Francesco Tursi, Gino Soldati, Riccardo Inchingolo
Summary: Although there have been significant advancements in lung ultrasound (LUS) technique in recent years, the physical phenomena behind artifacts observed in clinical practice, especially vertical artifacts known as B-lines, still require further explanation. A better understanding of these artifactual phenomena will improve classification, nomenclature, and correlation between anatomo-pathological data and clinical scenarios. This review aims to collect and document different signs and artifacts in chest ultrasound history, with a focus on B-lines and sonographic interstitial syndrome (SIS), providing an interpretation and presenting the viewpoint of the Accademia di Ecografia Toracica (AdET) in terms of nomenclature and clinical approach to SIS.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Rheumatology
Luna Gargani, Chiara Romei, Cosimo Bruni, Gemma Lepri, Khadija El-Aoufy, Martina Orlandi, Luigia D'Errico, Giulia Bandini, Gennaro D'Angelo, Serena Guiducci, Lorenzo Dagna, Fabio Falaschi, Marco Matucci-Cerinic, Alberto Moggi-Pignone
Summary: Lung ultrasound (LUS) can accurately detect SSc-related ILD by evaluating B-lines and pleural line alterations. A cut-off value of >10 B-lines on the whole chest or >1 B-line on the postero-basal chest can be used for screening SSc-ILD. Assessing only the postero-basal chest seems to be the most effective approach, combining high sensitivity with less time consumption.
Article
Medicine, General & Internal
Yukai Wang, Xuezhen Xie, Shaoyu Zheng, Guangzhou Du, Shaoqi Chen, Weijin Zhang, Jinghua Zhuang, Jianqun Lin, Shijian Hu, Kedi Zheng, Angelina Mikish, Zhuangyong Xu, Guohong Zhang, Luna Gargani, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Marco Matucci-Cerinic, Daniel E. E. Furst
Summary: This study investigated the role of serum B-cell activating factor (BAFF) and lung ultrasound (LUS) B-lines in connective tissue disease related interstitial lung disease (CTD-ILD). The results showed that serum BAFF levels were correlated with B-lines number, KL-6 level, and Warrick score in ILD patients. Patients with fibrotic ILD had higher BAFF concentrations and B-lines numbers. ROC curve analysis determined the optimal cut-off values to distinguish fibrotic ILD from non-fibrotic ILD.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Cosimo Bruni, Lavinia Mattolini, Lorenzo Tofani, Luna Gargani, Nicholas Landini, Nicola Roma, Gemma Lepri, Martina Orlandi, Serena Guiducci, Silvia Bellando-Randone, Chiara Romei, Yukai Wang, Marco Matucci-Cerinic
Summary: The study found that lung ultrasound (LUS) can be used as a tool to evaluate systemic sclerosis-related interstitial lung disease (SSc-ILD) and can be correlated with different methods of ILD evaluation.
Article
Rheumatology
Dina S. Fotoh, Asrar Helal, Mohamed S. Rizk, Heba A. Esaily
Summary: RA-associated interstitial lung disease (RA-ILD) is a serious manifestation with high mortality, necessitating accurate evaluation tools. This study found that serum KL-6 levels and lung ultrasound B lines (LUS B lines) score are correlated with the severity of ILD in RA-ILD. The study suggests that the cut-off values for KL-6 and LUS (277.5 U/ml and < 5.5) can be used as prognostic tools for RA-ILD.
CLINICAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Peter Korsten, Jan-Gerd Rademacher, Linn Riedel, Eva-Maria Schnitzler, Ulrike Olgemoller, Cornelia Sabine Seitz, Jens Schmidt, Jorg Larsen, Radovan Vasko
Summary: The study found that immunosuppressive therapy in ASyS patients can improve radiological alterations in ILD, with stable lung function observed in pulmonary function tests. Although myositis and relapsing disease were more common in the RTX treatment group, there were no significant differences in clinical and radiographic outcomes compared to the non-RTX-treated group.
FRONTIERS IN MEDICINE
(2021)
Article
Emergency Medicine
Ankit Kumar Sahu, Roshan Mathew, Sanjeev Bhoi, Tej Prakash Sinha, Jamshed Nayer, Praveen Aggarwal
Summary: The objective of this study was to describe the lung sonographic findings of COVID-19 patients prospectively and investigate its association with disease severity. The study included 106 laboratory confirmed COVID-19 patients and found common sonographic findings like pleural line irregularity or shredding, B - profile, pleural line thickening, etc. Specific sonographic characteristics like bilateral lung involvement, B - profile, spared areas and confluent B - lines or waterfall sign were significantly associated with clinical severity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Kuntharee Traisrisilp, Wisit Chankhunaphas, Rekwan Sittiwangkul, Chureerat Phokaew, Vorasuk Shotelersuk, Theera Tongsong
Summary: CHARGE syndrome is a rare autosomal dominant disorder characterized by a combination of specific anomalies, including heart defects, ear abnormalities, and renal malrotation. This case report identified a novel genetic variant in the CHD7 gene, expanding the mutational spectrum of CHARGE syndrome. Prenatal sonographers should be aware of minor abnormalities as genetic sonomarkers for early detection.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Han, Lu Chen, Yanqing Fan, Osamah Alwalid, Xi Jia, Yuting Zheng, Jie Liu, Yumin Li, Yukun Cao, Jin Gu, Jia Liu, Chuansheng Zheng, Qing Ye, Heshui Shi
Summary: This prospective study longitudinally assessed changes in chest CT abnormalities and pulmonary function in individuals after recovery from SARS-CoV-2 infection. The study found that more than one-third of the participants had persistent interstitial lung abnormalities 2 years after infection, which were associated with respiratory symptoms and decreased diffusion pulmonary function.
Article
Medicine, General & Internal
Jun-Hong Yan, Lei Pan, Yan-Bing Gao, Guang-He Cui, Yue-Heng Wang
Summary: The study compared the diagnostic value of LUS and HRCT in patients with ILD, showing that both methods are important in diagnosing ILD, but with differing advantages and disadvantages.
Article
Medicine, General & Internal
Xin Dong, Yanli Gao, Man Li, Dong Wang, Jifeng Li, Yongfeng Zhang
Summary: The characteristics of elderly-onset primary Sjogren syndrome (pSS) were investigated using chest high-resolution computed tomography and pulmonary function tests (PFTs). The data of 102 patients with pSS with interstitial lung disease were retrospectively analyzed. Among them, 34 were in the elderly-onset pSS (EopSS) group (>= 65 years) and 68 were in the adult-onset pSS (AopSS) group (<65 years). EopSS patients showed a higher incidence of usual interstitial pneumonia and a lower incidence of nonspecific interstitial pneumonia compared to AopSS patients. The EopSS group had its own characteristics in terms of lung involvement and pulmonary function.
Article
Medicine, General & Internal
Alberto Raiteri, Margherita Alvisi, Ilaria Serio, Federico Stefanini, Francesco Tovoli, Fabio Piscaglia
Summary: This study aimed to determine the likelihood of finding LU abnormalities in COVID-19 negative healthy individuals, and found that a slightly altered LU can be quite frequent in healthy COVID-19 negative subjects. Age and COVID-19 positivity are independent predictors of total LUS, and a total LUS ≥ 2 has reasonable sensitivity and specificity in detecting COVID-19 positivity, but LU may not be effective in screening poorly symptomatic cases.
Article
Obstetrics & Gynecology
Pawel Krawczyk, Agnieszka Jastrzebska, Wojciech Szczeklik, Janusz Andres
Summary: The study evaluated LUS patterns in a group of women undergoing gynecological surgery with uneventful anesthesia. The results showed that there were no significant changes in A-line appearance in patients at different assessment times, but an increase in B-lines at 30 and 60 minutes after induction, indicating that uneventful anesthesia may predispose to abnormal LUS findings.
GINEKOLOGIA POLSKA
(2021)
Article
Medicine, General & Internal
Guangke Cao, Yu Wu, Yuliang Zhao, Ling Wang, Yang Zhang
Summary: The study of 76 MODS patients undergoing CBP treatment showed that the change in the number of pulmonary ultrasound B-lines accurately reflects the changes in EVLW, and is positively correlated with improvements in 24-hour negative lung fluid balance, EVLW decrease, oxygenation index improvement, and decreased BNP content.
Letter
Critical Care Medicine
Elena Torri, Alessandro Zanforlin, Gino Soldati, Danilo Buonsenso, Andrea Smargiassi, Gian Luca Trobia, Giuseppe Francesco Sferrazza Papa, Elisa Eleonora Mossolani, Riccardo Inchingolo, Francesco Tursi, Tiziano Perrone
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Review
Acoustics
Libertario Demi, Frank Wolfram, Catherine Klersy, Annalisa De Silvestri, Virginia Valeria Ferretti, Marie Muller, Douglas Miller, Francesco Feletti, Marcin Welnicki, Natalia Buda, Agnieszka Skoczylas, Andrzej Pomiecko, Domagoj Damjanovic, Robert Olszewski, Andrew W. Kirkpatrick, Raoul Breitkreutz, Gebhart Mathis, Gino Soldati, Andrea Smargiassi, Riccardo Inchingolo, Tiziano Perrone
Summary: A multidisciplinary panel of international LUS experts reviewed and updated the international consensus for point-of-care LUS, resulting in 20 statements with guidelines and future development proposals in the areas of technical, clinical, educational, and safety aspects.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Review
Acoustics
Andrea Smargiassi, Alessandro Zanforlin, Tiziano Perrone, Danilo Buonsenso, Elena Torri, Giuseppe Limoli, Elisa E. Mossolani, Francesco Tursi, Gino Soldati, Riccardo Inchingolo
Summary: Although there have been significant advancements in lung ultrasound (LUS) technique in recent years, the physical phenomena behind artifacts observed in clinical practice, especially vertical artifacts known as B-lines, still require further explanation. A better understanding of these artifactual phenomena will improve classification, nomenclature, and correlation between anatomo-pathological data and clinical scenarios. This review aims to collect and document different signs and artifacts in chest ultrasound history, with a focus on B-lines and sonographic interstitial syndrome (SIS), providing an interpretation and presenting the viewpoint of the Accademia di Ecografia Toracica (AdET) in terms of nomenclature and clinical approach to SIS.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Medicine, General & Internal
Angela Rizzi, Raffaella Chini, Serena Porcari, Carlo Romano Settanni, Eleonora Persichetti, Vincenzina Mora, Caterina Fanali, Alessia Leonetti, Giuseppe Parrinello, Franziska Michaela Lohmeyer, Riccardo Inchingolo, Maria Cristina Mele, Antonio Gasbarrini, Eleonora Nucera
Summary: This study compared the effects of hydroponic agriculture and conventional cultivation on tomato puree, and found that hydroponic tomato puree can improve SNAS symptoms and enhance quality of life.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Danilo Buonsenso, Rosa Morello, Valentina Ferro, Anna Maria Musolino, Cristina De Rose, Riccardo Inchingolo, Piero Valentini
Summary: The study found that bronchiolitis during the COVID-19 pandemic was not more severe than before, despite certain factors being increased during the pandemic period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Emanuele Giovanni Conte, Andrea Smargiassi, Filippo Lococo, Giampietro Marchetti, Riccardo Inchingolo
Summary: The study evaluated the application of lung ultrasound in diagnosing pleural malignancies, finding that LUS was more efficient and accurate in detecting pleural abnormalities in CPA compared to CCT, potentially aiding in changing and speeding up the diagnostic process.
Article
Computer Science, Artificial Intelligence
Leonardo Lucio Custode, Federico Mento, Francesco Tursi, Andrea Smargiassi, Riccardo Inchingolo, Tiziano Perrone, Libertario Demi, Giovanni Iacca
Summary: The need for automatic medical diagnosis has been raised by the COVID-19 pandemic to enhance physicians' efficiency. Lung ultrasound (LUS) has advantages such as portability, cost-effectiveness, and safety for evaluating the lung condition of COVID-19 patients. This study utilizes deep neural networks (DNNs) as feature extractors and an evolutionary algorithm to generate a decision tree (DT) that aggregates DNN predictions in an interpretable manner. The results demonstrate that this approach performs as well as or better than previous aggregation techniques based on empirical combinations of DNN predictions.
APPLIED SOFT COMPUTING
(2023)
Review
Medicine, General & Internal
Angela Rizzi, Luca Gammeri, Raffaele Cordiano, Mariagrazia Valentini, Michele Centrone, Sabino Marrone, Riccardo Inchingolo, Franziska Michaela Lohmeyer, Carlo Cavaliere, Francesco Ria, Gabriella Cadoni, Sebastiano Gangemi, Eleonora Nucera
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, characterized by Type 2 inflammatory reaction, comorbidities, and high rates of nasal polyp recurrence. Effective management includes anti-inflammatory treatment with local corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Angela Rizzi, Elena Lo Presti, Raffaella Chini, Luca Gammeri, Riccardo Inchingolo, Franziska Michaela Lohmeyer, Eleonora Nucera, Sebastiano Gangemi
Summary: Food allergies are immune reactions to ingested or contacted foods, and they are a widespread health issue. The role of inflammatory mediators in the pathogenesis of food allergies has been studied, and some of these mediators may serve as markers for the disease or response to therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Acoustics
Andrea Smargiassi, Alessandro Zanforlin, Francesco Tursi, Gino Soldati, Riccardo Inchingolo
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Acoustics
Umair Khan, Sajjad Afrakhteh, Federico Mento, Noreen Fatima, Laura De Rosa, Leonardo Lucio Custode, Zihadul Azam, Elena Torri, Gino Soldati, Francesco Tursi, Veronica Narvena Macioce, Andrea Smargiassi, Riccardo Inchingolo, Tiziano Perrone, Giovanni Iacca, Libertario Demi
Summary: This paper investigates the use of AI methods to assess the effect of COVID-19 on lungs through automated ultrasound imaging. It evaluates state-of-the-art CNN models for frame-level scoring and proposes a novel aggregation technique for video and exam-level scoring. Results show improved performances over existing methods, with ResNet-18 performing the best with an F1-Score of 0.659. The analysis was conducted on a large and validated LUS dataset from COVID-19 patients.
Review
Cell Biology
Angela Rizzi, Mario Di Gioacchino, Luca Gammeri, Riccardo Inchingolo, Raffaella Chini, Francesca Santilli, Eleonora Nucera, Sebastiano Gangemi
Summary: Celiac disease is an intestinal disease triggered by gluten ingestion in genetically predisposed individuals. It is mediated by Th17, IL-21, and IL-17A lymphocytes, resulting in intestinal inflammation and altered mucosal architecture. B cells produce antibodies against tissue transglutaminase and deamidated gliadin. Besides the adaptive immune response, the role of innate immunity cells such as alarmins (DAMPs) is poorly understood. Our study aims to evaluate the evidence regarding the involvement of ILCs and alarmins in celiac disease and their potential diagnostic and therapeutic implications.
Article
Respiratory System
Erin L. Tomaszewski, Mark J. Atkinson, Christer Janson, Niklas Karlsson, Barry Make, David Price, Helen K. Reddel, Claus F. Vogelmeier, Hana Mullerova, Paul W. Jones
Summary: The Chronic Airways Assessment Test (CAAT), a questionnaire adapted for patients with asthma and/or COPD, has been shown to be consistent and accurate in measuring overall health status in these patients.
RESPIRATORY RESEARCH
(2023)
Proceedings Paper
Acoustics
Federico Mento, Antonio Di Sabatino, Anna Fiengo, Umberto Sabatini, Veronica Narvena Macioce, Francesco Tursi, Carmelo Sofia, Chiara Di Cienzo, Andrea Smargiassi, Riccardo Inchingolo, Tiziano Perrone, Libertario Demi
Summary: Lung ultrasound imaging is crucial in evaluating patients with COVID-19 pneumonia. To enhance the reliability and reproducibility of the results, we proposed a standardized imaging protocol and scoring system, and developed artificial intelligence models capable of assessing lung ultrasound videos.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Proceedings Paper
Acoustics
Sajjad Afrakhteh, Federico Mento, Umair Khan, Laura De Rosa, Noreen Fatima, Zihadul Azam, Francesco Tursi, Andrea Smargiassi, Riccardo Inchingolo, Tiziano Perrone, Giovanni Iacca, Libertario Demi
Summary: The emergence of COVID-19 has prompted researchers to use lung ultrasound to detect and monitor patients infected with SARS-CoV 2. A novel aggregation method based on cross-correlation coefficients allows for accurate assessment of the condition of COVID-19 patients' lungs at the video level, providing valuable information for clinical evaluation.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)