Article
Clinical Neurology
Brian C. Goh, Brendan M. Striano, Alexander M. Crawford, Daniel G. Tobert, Harold A. Fogel, Thomas D. Cha, Joseph H. Schwab, Christopher M. Bono, Stuart H. Hershman
Summary: In patients with gunshot-induced spinal injuries, surgical intervention is associated with a greater likelihood of neurological recovery compared to nonoperative treatment. Specifically, patients with thoracic and lumbar injuries have a higher chance of improvement in their ASIA Impairment Scale score 1 year after injury if they undergo surgical intervention.
CLINICAL SPINE SURGERY
(2022)
Article
Clinical Neurology
Aaron M. Yengo-Kahn, Pious D. Patel, Patrick D. Kelly, Daniel Wolfson, Fakhry Dawoud, Ranbir Ahluwalia, Christopher M. Bonfield, Oscar D. Guillamondegui
Summary: This study validated the accuracy of the Baylor score in a different patient population. Results showed that the Baylor score can accurately predict mortality and good functional outcome, making it suitable for guiding family counseling and healthcare resource allocation in trauma management.
JOURNAL OF NEUROSURGERY
(2021)
Article
Critical Care Medicine
Amelia C. Van Handel, Kevin G. Shim, Danielle J. Brown, Rachael M. Payne, Damini Tandon, David Chi, Adam G. Evans, Mitchell A. Pet
Summary: This retrospective study examined 797 adult patients with upper extremity gunshot wounds over a 10-year period. The results showed that violence was the major cause of injuries, and black individuals were disproportionately affected. Shoulder injuries were the most common, while wrist injuries were the least common. There were significant demographic and injury pattern differences between patients with violent injuries and those with self-inflicted injuries. Approximately 35.3% of patients required operative intervention, with fractures being the most commonly injured structure.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Clinical Neurology
Evan M. Krueger, Ronald J. Benveniste, Victor M. Lu, Ruby R. Taylor, Rahul Kumar, Joacir G. Cordeiro, Jonathan R. Jagid
Summary: A study compared neurological outcomes and complications between civilian cranial gunshot wound (CGSW) patients treated with simple wound closure (SWC) and surgery. The SWC group had lower incidence of radiographic mass effect and involvement of the frontal sinus. There were no significant differences in neurological outcomes and complications between the two groups.
JOURNAL OF NEUROSURGERY
(2023)
Article
Neurosciences
Chelsea M. Phillips, Allison M. Johnson, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic
Summary: This study reveals that the absence of CCM3 leads to structural defects in the brain endothelial barrier, increasing the risk of vascular leakage. The upregulation of GJA1-20 k is found to disrupt the balance between gap junctions and tight junctions, destabilizing the tight junction complex and increasing brain endothelial barrier permeability.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Eijaz Ahmed Bhat, Nasreena Sajjad, Saeed Banawas, Johra Khan
Summary: CALHMs, particularly CALHM1, play crucial roles in neuronal functioning and have been associated with pathologies like Alzheimer's disease. Recent Cryo-EM research on CALHM5 has provided insights into its structure and potential functional properties.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Caroline Hempel, Rita Rosenthal, Anja Fromm, Susanne M. Krug, Michael Fromm, Dorothee Gunzel, Joerg Piontek
Summary: This study analyzed the structural and functional differences between claudin-15 and claudin-10b cation channels and identified several mutants that affect ion permeability and pore diameter. Furthermore, the study revealed that the charge at the W63/K64 position has an impact on the assembly and properties of claudin-10b channels but not claudin-15 channels.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Physiology
Tadas Kraujalis, Lukas Gudaitis, Lina Kraujaliene, Mindaugas Snipas, Nicolas Palacios-Prado, Vytas K. Verselis
Summary: Electrical synapses formed by the connexin36 (Cx36) gap junction (GJ) channel protein play a significant role in the mammalian central nervous system. This study investigates the impact of amino acid substitutions in the N-terminal (NT) domain of Cx36 GJs on their modulation by intracellular Mg2+. The results suggest that Mg2+ binding to and stabilization of the closed state in each hemichannel is the most likely mechanism for Mg2+ modulation of Cx36 GJ, and the NT domain may be involved in the coupling of conformational changes between the NT and extracellular E1 domains.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Emergency Medicine
Karolina Nyberger, Eva-Corina Caragounis, Pauline Djerf, Carl-Magnus Wahlgren
Summary: This nationwide study reveals a continuous increase in firearm-related injuries and fatalities. Firearm injuries primarily affect individuals of all ages, but are more common in young males in major cities. One in six patients succumbed to their injuries within 30 days, with the majority of deaths occurring within 24 hours of hospital admission.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Respiratory System
Tian Jiang, Rudi Samapati, Sergej Klassen, Disi Lei, Lasti Erfinanda, Vera Jankowski, Szandor Simmons, Jun Yin, Christoph Arenz, Alexander Dietrich, Thomas Gudermann, Dieter Adam, Michael Schaefer, Joachim Jankowski, Veit Flockerzi, Rolf Nuesing, Stefan Uhlig, Wolfgang M. Kuebler
Summary: The study found that EP3 receptor activation triggers pulmonary edema through Gi-dependent activation of PLC and subsequent SrcFK-dependent tyrosine phosphorylation of TRPC6. In PAF-induced lung edema, this TRPC6 activation coincides with ASMase-dependent caveolar recruitment of TRPC6, resulting in rapid endothelial Ca2+ influx and barrier failure.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Devika P. P. Jayawardena, Marcello G. G. Masciantonio, Lefeng Wang, Sanjay Mehta, Natalie DeGurse, Cynthia Pape, Sean E. E. Gill
Summary: Sepsis is a life-threatening disease caused by excessive inflammation and organ dysfunction. The disruption of inter-cellular junctions in pulmonary microvascular endothelial cells (PMVEC) contributes to barrier dysfunction during sepsis. The imbalance between metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs) is likely responsible for this barrier dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Emergency Medicine
Karolina Nyberger, Eva-Corina Caragounis, Pauline Djerf, Carl-Magnus Wahlgren
Summary: This study aimed to analyze the epidemiology of firearm-related vascular injuries. The results showed that firearm-related vascular injuries caused significant morbidity and mortality, with the lower extremity being the most common injury location and injuries to the chest and abdomen being the most lethal. Improved early hemorrhage control strategies are crucial for better treatment outcomes.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2023)
Article
Immunology
Yi Ren, Liang Li, Meng-Meng Wang, Li-Ping Cao, Zhao-Rui Sun, Zhi-Zhou Yang, Wei Zhang, Peng Zhang, Shi-Nan Nie
Summary: Pravastatin improves survival, reduces inflammation and apoptosis, and enhances junction proteins expression in septic acute lung injury, suggesting it as a potential effective candidate for treating septic ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Critical Care Medicine
Joshua Dilday, Natthida Owattanapanich, Elizabeth R. Benjamin, Subarna Biswas, Stacy Shackelford, Demetrios Demetriades
Summary: This study compared the management and outcomes of colorectal gunshot wounds in military and civilian settings. The study found differences in the use of colectomy between the two groups, but similar rates of fecal diversion, mortality, and complications. Military personnel receive similar treatment regardless of affiliation.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Critical Care Medicine
Melissa M. Lannon, Taylor Duda, Amanda Martyniuk, Paul T. Engels, Sunjay Sharma
Summary: This study aims to determine outcomes and prognostic factors in pediatric craniocerebral gunshot injury (CGI) patients. The study analyzed data from the National Trauma Data Bank and found that infant patients had lower initial Glasgow Coma Scale (GCS) scores and subsequently lower mortality rates. Linear relationship demonstrated that patients with GCS score of 3 had a mortality rate of 79%, patients with GCS scores of 4-8 had a mortality rate of 56%, patients with GCS scores of 9-12 had a mortality rate of 22%, and patients with GCS scores of 13-15 had a mortality rate of 5%. Regression analysis showed that intracranial pressure monitoring and craniotomy were associated with reduced mortality in all patients.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Endocrinology & Metabolism
Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu
JOURNAL OF PINEAL RESEARCH
(2015)
Article
Chemistry, Multidisciplinary
Guo-long Zhao, Li-ming Yu, Wen-li Gao, Wei-xun Duan, Bo Jiang, Xu-dong Liu, Bin Zhang, Zhen-hua Liu, Meng-en Zhai, Zhen-xiao Jin, Shi-qiang Yu, Yun Wang
ACTA PHARMACOLOGICA SINICA
(2016)
Article
Cardiac & Cardiovascular Systems
Jianming Wang, Jian Zuo, Shiqiang Yu, Dinghua Yi, Xiuling Yang, Xianyang Zhu, Jun Li, Lifang Yang, Lize Xiong, Shuping Ge, Jun Ren, Jian Yang
AMERICAN JOURNAL OF CARDIOLOGY
(2016)
Article
Physiology
Wen Wang, Zhi Liu, Jie Su, Wen-Sheng Chen, Xiao-Wu Wang, San-Xing Bai, Jin-Zhou Zhang, Shi-Qiang Yu
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Liming Yu, Buying Li, Meng Zhang, Zhenxiao Jin, Weixun Duan, Guolong Zhao, Yang Yang, Zhenhua Liu, Wensheng Chen, Siwang Wang, Jian Yang, Dinghua Yi, Jincheng Liu, Shiqiang Yu
Article
Engineering, Biomedical
Hong-yan Xiong, Yang Liu, Duan-chao Shu, Sheng-li Zhang, Xinhong Qian, Wei-xun Duan, Liang Cheng, Shi-qiang Yu, Zhen-xiao Jin
Article
Biochemistry & Molecular Biology
Liang Cheng, Bin Li, Xu Chen, Jie Su, Hongbing Wang, Shiqiang Yu, Qijun Zheng
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Jun Liu, Chongxi Fan, Liming Yu, Yang Yang, Shuai Jiang, Zhiqiang Ma, Wei Hu, Tian Li, Zhi Yang, Tian Tian, Weixun Duan, Shiqiang Yu
Article
Cardiac & Cardiovascular Systems
Jian Yang, Yang Liu, Weixun Duan, Dinghua Yi, Shiqiang Yu, Rui Ma, Jun Ren
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2016)
Article
Obstetrics & Gynecology
Li Wei, Tao Xue, Kai-Shan Tao, Geng Zhang, Guang-Yue Zhao, Shi-Qiang Yu, Liang Cheng, Zhao-Xu Yang, Min-Juan Zheng, Fei Li, Qiong Wang, Ying Han, Yong-Quan Shi, Hai-Long Dong, Zhi-Hong Lu, Yun Wang, Hong Yang, Xiang-Dong Ma, Shu-Juan Liu, Hai-Xia Liu, Li-Ze Xiong, Bi-Liang Chen
FERTILITY AND STERILITY
(2017)
Article
Endocrinology & Metabolism
Mengen Zhai, Zhenhua Liu, Bin Zhang, Lin Jing, Buying Li, Kaifeng Li, Xiuju Chen, Meng Zhang, Bo Yu, Kai Ren, Yang Yang, Wei Yi, Jian Yang, Jincheng Liu, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Russel J. Reiter, Weixun Duan, Shiqiang Yu
JOURNAL OF PINEAL RESEARCH
(2017)
Article
Endocrinology & Metabolism
Mengen Zhai, Buying Li, Weixun Duan, Lin Jing, Bin Zhang, Meng Zhang, Liming Yu, Zhenhua Liu, Bo Yu, Kai Ren, Erhe Gao, Yang Yang, Hongliang Liang, Zhenxiao Jin, Shiqiang Yu
JOURNAL OF PINEAL RESEARCH
(2017)
Article
Surgery
Lei Zuo, Chao Sun, Jian Yang, Bing Liu, Mengyao Zhou, Ruiqi Guo, Shiqiang Yu, Junbo Ge, Lize Xiong, Liwen Liu
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2018)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Liang Cheng, Xinhong Qian, Hailong Zhu, Weixun Duan, Shiqiang Yu, Zhenxiao Jin
JOURNAL OF CARDIAC SURGERY
(2015)
Article
Multidisciplinary Sciences
Liming Yu, Bing Gong, Weixun Duan, Chongxi Fan, Jian Zhang, Zhi Li, Xiaodong Xue, Yinli Xu, Dandan Meng, Buying Li, Meng Zhang, Bin Zhang, Zhenxiao Jin, Shiqiang Yu, Yang Yang, Huishan Wang
SCIENTIFIC REPORTS
(2017)