Article
Chemistry, Analytical
Hyuk In Yang, Wonhee Cho, Dong Hoon Lee, Sang-Hoon Suh, Justin Y. Jeon
Summary: The study aimed to develop a simple submaximal walk test protocol and equation to predict maximal oxygen consumption using heart rate responses. The equations developed showed significant correlations between heart rate variables and VO(2)max, particularly at 120 steps per minute cadence. This suggests that the 3MWT developed in the study is a promising and accurate submaximal exercise protocol for predicting VO(2)max in healthy adults.
Article
Urology & Nephrology
Jiajia Sun, Qinjuan Xu, Qing Zhang, Huagang Hu, Li Wang
Summary: This study evaluated the exercise capacity of patients on maintenance hemodialysis (MHD) and found that they had significantly reduced cardiopulmonary endurance capacity and functional walk ability. The study also concluded that the 6-minute walk test (6MWT) distance may not be an appropriate method to evaluate the cardiopulmonary endurance capacity of patients on MHD.
CLINICAL NEPHROLOGY
(2022)
Article
Pediatrics
Jiangbo Qu, Hui Shi, Yugong Guo, Xinxin Chen, Xuwen Xiao, Xiaojuan Zheng, Yanqin Cui
Summary: This study aimed to assess the validity of the 6MWT in reflecting the functional capacity of children with CHD, evaluate the correlation between 6MWT distance and CPET variables, and find a cutoff value for stratifying physical fitness in this population.
FRONTIERS IN PEDIATRICS
(2022)
Article
Chemistry, Analytical
Ivan Miguel Pires, Hanna Vitaliyivna Denysyuk, Maria Vanessa Villasana, Juliana Sa, Diogo Luis Marques, Jose Francisco Morgado, Carlos Albuquerque, Eftim Zdravevski
Summary: This paper presents a systematic review of the use of sensors to measure different physical parameters during the performance of 6MWT, focusing on various diseases, sensors, and implemented methodologies. The analysis discovered that the measurements of 6MWT are primarily performed with inertial and magnetic sensors, and most research studies related to this test focus on multiple sclerosis and pulmonary diseases.
Article
Cardiac & Cardiovascular Systems
Jaruwat Bumrungkittikul, Wilawan Thirapatarapong
Summary: This study aimed to identify the factors independently associated with the six-minute walk test (6MWT) at the 4-6-week follow-up after cardiac surgery and develop an equation to predict the 6MWT during this period. Retrospective analysis of patient data showed that 6MWT at discharge was correlated with 6MWT at the 4-6-week follow-up, as well as regular exercise, age, gender, and preoperative New York Heart Association (NYHA) classification. An equation was generated based on these factors to predict 6MWT at 4-6 weeks after hospital discharge.
Article
Health Care Sciences & Services
Dario Salvi, Emma Poffley, Lionel Tarassenko, Elizabeth Orchard
Summary: The study showed that the app-based outdoor 6MWTs in community settings are valid, repeatable, and well accepted by patients, but further research is needed to assess the benefits of using the app in clinical practice.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Oncology
Nicole Tubiana-Mathieu, Thibault Cornette, Stephane Mandigout, Sophie Leobon, Francois Vincent, Laurence Venat, Elise Deluche
Summary: Physical activity is effective for breast cancer patients, with the use of adapted target heart rate for exercise intensity. The 6MWT-HR and CPET provide useful information for prescribing exercise programs before and after treatment. This method is beneficial for patients' recovery and physical health post-treatment.
Article
Medicine, General & Internal
Yan Wang, Huijuan Li, Juan Wang, Wei Zhao, Zhipeng Zeng, Li Hao, Yifang Yuan, Yuwei Lin, Yangfeng Wu, Zhengzhen Wang
Summary: This study aimed to establish normal reference values of peak oxygen uptake (VO2peak) for cardiorespiratory fitness (CRF) in Chinese adults using cardiorespiratory exercise testing (CPET). The results showed significant differences in VO2peak between men and women, with a decrease in VO2peak as age increased.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Ori Hochwald, Lea Bentur, Yara Haddad, Moneera Hanna, Merav Zucker-Toledano, Gur Mainzer, Julie Haddad, Michal Gur, Liron Borenstein-Levin, Amir Kugelman, Ronen Bar-Yoseph
Summary: This study found that exercise capacity is lower in late preterm children compared to term children, but within the normal range, and comparable to that of early preterm children, with and without bronchopulmonary dysplasia (BPD). Lung function is only lower than normal in early preterm children.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Edem Allado, Mathias Poussel, Eliane Albuisson, Jean Paysant, Margaux Temperelli, Oriane Hily, Anthony Moussu, Noura Benhajji, Gerome C. Gauchard, Bruno Chenuel
Summary: This study evaluated the efficacy of the Six-Minute Walk Test (6MWT) in determining the physical activity capacities of patients with chronic disease. The results showed a moderate relationship between 6MWT and physical activity capacity for these patients.
Article
Rehabilitation
Alen Palackic, Stephanie Abazie, Ingrid Parry, Soman Sen, Ronald P. Mlcak, Jong O. Lee, David N. Herndon, Ludwik K. Branski, Steven E. Wolf, Heidi Spratt, Oscar E. Suman
Summary: This study compares the performance of pediatric patients with severe burns in the six-minute walk test and the Modified Bruce treadmill test. The results show that the Modified Bruce treadmill test challenges the cardiorespiratory system more, while the six-minute walk test is more clinically feasible for assessing submaximal functional exercise capacity.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Medicine, General & Internal
Roman Romero-Ortuno, Glenn Jennings, Feng Xue, Eoin Duggan, John Gormley, Ann Monaghan
Summary: Adults with long COVID may experience improved exercise tolerance over time, with younger age and longer time since infection being predictors of achieving 85% of maximum heart rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
R. S. Marinho, S. P. Jurgensen, J. F. Arcuri, C. L. Goulart, P. B. dos Santos, M. G. Roscani, R. G. Mendes, C. R. de Oliveira, F. R. Caruso, A. Borghi-Silva
Summary: The six-minute step test is a reliable and valid tool for assessing functional capacity in patients with HFrEF, and it may predict peak workload and oxygen uptake during a cardiopulmonary exercise test.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Chemistry, Analytical
Martijn Scherrenberg, Cindel Bonneux, Deeman Yousif Mahmood, Dominique Hansen, Paul Dendale, Karin Coninx
Summary: A smartphone application was developed for cardiac patients to conduct a six-minute walk test at home. Through a prospective study of 102 cardiovascular disease patients, the optimal conditions were identified, and it was demonstrated that random walk and standardized walk tests have the same accuracy.
Article
Urology & Nephrology
Francini Porcher Andrade, Heitor Siqueira Ribeiro, Heloise Benvenutti, Samantha Goncalves de Oliveira, Fernando Saldanha Thome, Francisco Verissimo Veronese, Paula Maria Eidt Rovedder
Summary: This study evaluated the agreement and reliability between directly and indirectly measured peak oxygen uptake (V?O-2peak) in patients undergoing hemodialysis. The results indicated that the 6-minute walk test is a reliable tool for estimating V?O-2peak in these patients.
RENAL REPLACEMENT THERAPY
(2023)
Article
Biochemical Research Methods
Maximilian Boesch, Martina Sykora, Silvia Gasteiger, Florent Baty, Martin H. Brutsche, Sieghart Sopper
Summary: This optimized multicolor immunofluorescence panel is designed to efficiently identify and quantify various leukocyte populations in human blood with minimal markers. It offers high performance, is suitable for whole blood, and widely applicable for immune cell identification, quantification, and characterization.
Article
Infectious Diseases
Severin Studer, Frank Rassouli, Frederike Waldeck, Martin H. Brutsche, Florent Baty, Werner C. Albrich
Article
Respiratory System
Simona Tabea Huebner, Simona Henny, Stephanie Giezendanner, Thomas Brack, Martin Brutsche, Prashant Chhajed, Christian Clarenbach, Thomas Dieterle, Adrian Egli, Martin Frey, Ingmar Heijnen, Sarosh Irani, Noriane Andrina Sievi, Robert Thurnheer, Marten Trendelenburg, Malcolm Kohler, Anne Barbara Leuppi-Taegtmeyer, Joerg Daniel Leuppi
Summary: This study found that using immunological biomarkers and clinical characteristics can predict the frequency and severity of acute exacerbations in stable COPD patients. However, clinical parameters had better discriminatory power in identifying patients likely to experience frequent AECOPD.
Article
Mathematical & Computational Biology
Florent Baty, Jemima Hegermann, Tiziana Locatelli, Claudio Rueegg, Christian Gysin, Frank Rassouli, Martin Brutsche
Summary: This study used text mining methodology to analyze polysomnographic medical reports and quantify sources of variation in the work-up of sleep-disordered breathing. The results showed that the inter-rater variability was twice as high as the variation introduced by effective diagnostic information. A simple text block standardization was found to significantly reduce the inter-rater variability and improve the diagnostic accuracy of polysomnography reports.
JOURNAL OF BIOMEDICAL SEMANTICS
(2022)
Article
Critical Care Medicine
Andrei M. Darie, Nina Khanna, Kathleen Jahn, Michael Osthoff, Stefano Bassetti, Mirjam Osthoff, Desiree M. Schumann, Werner C. Albrich, Hans Hirsch, Martin Brutsche, Leticia Grize, Michael Tamm, Daiana Stolz
Summary: Multiplex bacterial PCR examination of bronchoalveolar lavage decreases the duration of inappropriate antibiotic therapy in patients with pneumonia.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Critical Care Medicine
Tobias Sinnberg, Christa Lichtensteiger, Omar Hasan Ali, Oltin T. Pop, Ann-Kristin Jochum, Lorenz Risch, Silvio D. Brugger, Ana Velic, David Bomze, Philipp Kohler, Pietro Vernazza, Werner C. Albrich, Christian R. Kahlert, Marie-Therese Abdou, Nina Wyss, Kathrin Hofmeister, Heike Niessner, Carl Zinner, Mara Gilardi, Alexandar Tzankov, Martin Rocken, Alex Dulovic, Srikanth Mairpady Shambat, Natalia Ruetalo, Philipp K. Buehler, Thomas C. Scheier, Wolfram Jochum, Lukas Kern, Samuel Henz, Tino Schneider, Gabriela M. Kuster, Maurin Lampart, Martin Siegemund, Roland Bingisser, Michael Schindler, Nicole Schneiderhan-Marra, Hubert Kalbacher, Kathy D. McCoy, Werner Spengler, Martin H. Brutsche, Boris Macek, Raphael Twerenbold, Josef M. Penninger, Matthias S. Matter, Lukas Flatz
Summary: COVID-19 can cause severe respiratory distress syndrome, and dysregulated immune responses, including autoimmunity, play a key role. This study investigated the presence of IgA autoantibodies targeting lung-specific proteins and their effects on pulmonary surfactant in severe COVID-19 cases.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Maria Boesing, Kristin Abig, Michael Brandle, Martin Brutsche, Emanuel Burri, Bjoern C. Frye, Stephanie Giezendanner, Jan C. Grutters, Philippe Haas, Justian Heisler, Fabienne Jaun, Anne B. Leuppi-Taegtmeyer, Giorgia Luthi-Corridori, Joachim Mueller-Quernheim, Reto Nuesch, Wolfgang Pohl, Frank Rassouli, Jorg D. Leuppi
Summary: This study aims to evaluate the efficacy and safety of inhaled aviptadil in preventing ARDS in high-risk COVID-19 patients. Aviptadil's ability to regulate exaggerated pro-inflammatory proteins and orchestrate lung homeostasis may have a positive impact on improving the prognosis of ARDS in COVID-19 patients.
Article
Substance Abuse
Maciej Paciorkowski, Florent Baty, Susanne Pohle, Esther Buerki, Martin Brutsche
Summary: By conducting cluster analysis, this study identified four distinct quitting trajectory clusters, providing a method for personalized assistance needed to achieve successful and long-term cessation.
TOBACCO INDUCED DISEASES
(2022)
Article
Respiratory System
Richard Kraemer, Fabian Gardin, Hans-Juergen Smith, Florent Baty, Juerg Barandun, Andreas Piecyk, Stefan Minder, Joerg Salomon, Martin Frey, Martin H. Brutsche, Heinrich Matthys
Summary: The study found that a combination of airway dynamics parameters (such as sWOB, sReff, sGeff) and static lung volume parameters (such as FRCpleth and VTGFRC) is valuable and potentially important in discriminating between asthma, ACO, and COPD. Additionally, it was revealed that sWOB plays a significant role in diagnosing obstructive airway diseases, independent of pulmonary hyperinflation, while DLCO is useful in differentiating between the three diagnostic classes.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Respiratory System
Alexandra Lenoir, Andreas Christe, Lukas Ebner, Catherine Beigelman-Aubry, Pierre-Olivier Bridevaux, Martin Brutsche, Christian Clarenbach, Berra Erkosar, Christian Garzoni, Thomas Geiser, Sabina A. Guler, Dik Heg, Frederic Lador, Marco Mancinetti, Sebastian R. Ott, Lise Piquilloud, Maura Prella, Yok-Ai Que, Christophe von Garnier, Manuela Funke-Chambour
Summary: This study aimed to investigate lung function and radiological abnormalities over 12 months in patients after severe and non-severe COVID-19. The study found that patients with severe COVID-19 had lower lung function after one year compared to non-severe patients, although the severe disease group had a greater extent of recovery.
Review
Oncology
Maximilian Boesch, Lena Horvath, Florent Baty, Andreas Pircher, Dominik Wolf, Stephan Spahn, Ravid Straussman, Herbert Tilg, Martin H. Brutsche
Summary: This article reviews the latest research on the tumor-associated microbiome, highlighting its impact on anticancer immunity and checkpoint immunotherapy outcome. It emphasizes the need to study the tumor-associated microbiome in addition to the gut microbiome and calls for further research to understand the mechanisms involved and develop therapeutic strategies. A better understanding of the tumor microbiome can improve cancer immunotherapy and advance precision medicine for solid tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, General & Internal
Noriane A. Sievi, Jerome Sepin, Maurice Roeder, Thomas Brack, Martin H. Brutsche, Martin Frey, Sarosh Irani, Jorg D. Leuppi, Robert Thurnheer, Christian F. Clarenbach, Malcolm Kohler
Summary: This study evaluated whether longitudinal assessment of predictors provides additional information on the mortality risk in COPD compared to cross-sectional analysis. The results showed that predictors of mortality in COPD are not time dependent, and cross-sectional measured predictors still have stable effect estimates over time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Filipe Barata, David Cleres, Peter Tinschert, Chen-Hsuan Iris Shih, Frank Rassouli, Maximilian Boesch, Martin Brutsche, Elgar Fleisch
Summary: This study validated an automated smartphone-based cough counting system for continuous monitoring of coughs in hospital wards. The system showed high sensitivity and specificity in detecting coughs compared to manual counting. Therefore, it can be used for continuous hourly assessment of cough frequency in the ward.
JMIR FORMATIVE RESEARCH
(2023)
Review
Medicine, General & Internal
Lisa Jungblut, Christophe von Garnier, Milo Puhan, Yuki Tomonaga, Cornel Kaufmann, Andrea Azzola, Urs Burgi, Jens Bremerich, Martin Brutsche, Andreas Christe, Lukas Ebner, Johannes T. Heverhagen, Christine Eich, Daniel Franzen, Isabelle Schmitt-Opitz, Didier Schneiter, Jorg Spieldenner, Nigel Horwarth, Malcolm Kohler, Walter Weder, Alban Lovis, Reto Meuli, Matthias Menig, Catherine Beigelmann-Aubry, Tilo Niemann, Susanna Stohr, Peter Vock, Oliver Senn, Stefan Neuner-Jehle, Kevin Selby, Simin Laures, Sebastian Ott, Thomas Frauenfelder
Summary: This article outlines a potential lung cancer screening program in Switzerland, based on an exhaustive literature review, interviews with international experts, and workshops with national experts and stakeholders. The suggested screening approach includes involvement of general practitioners, pulmonologists, and the media, decentralized screening to improve adherence, integration of screening with lung health checks, and the use of risk calculation and nodule classification models.
SWISS MEDICAL WEEKLY
(2022)
Review
Medicine, General & Internal
Daniel P. Franzen, Martin Brutsche, Jakob Nilsson, Christian Boeni, Cecile Daccord, Oliver Distler, Dieter Elsener, Manuela Funke-Chambour, Christiane Gruner, Helen Hayward-Koennecke, Katrin E. Hostettler, Thomas Kuendig, Camillo Ribi, Joerg D. Seebach, Harald Seeger, Bart Vrugt, Antonios G. A. Kolios
Summary: Sarcoidosis is a systemic inflammatory disease characterized by diverse clinical manifestations, primarily affecting the lungs, lymph nodes, skin, and eyes. Severe cases require long-term immunosuppressive treatment, while mild symptoms can be managed with topical therapy. Treatment decisions should be based on individual factors and treatment tolerability.
SWISS MEDICAL WEEKLY
(2022)
