Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 38, Issue 1, Pages 195-205Publisher
SPRINGER
DOI: 10.1007/s11164-011-0336-5
Keywords
Cysteine derivatives; Aldol reactions; Recoverable catalyst; Large-scale reactions
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Funding
- Southwest University of China
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Highly enantioselective, recoverable and cheap cysteine derivatives have been developed with improved solubility properties in common, nonpolar organic solvents. The reactions were catalyzed using 5 mol% 1e, and the aldol products could be obtained with up to 99:1 syn/anti ratio and > 99% ee. The catalyst could be easily recovered and reused, with only a slight decrease of enantioselectivity observed for five cycles. Catalyst 1e can be efficiently used in large-scale reactions with enantioselectivity being maintained at the same level, which offers great possibility for application in industry.
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